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Hire Dr. Thomas Gallagher

United States

Summary

Subject Matter Expertise

Services

Work Experience

Postdoctoral Research Fellow

University of Utah

June 2014 - Present

Education

Ph.D. (Biochemistry and Molecular Biology)

Virginia Commonwealth University

August 2008 - December 2013

Publications

JOURNAL ARTICLE

{"ProfilePublicationId":8012,"Type":"journal-article","Citation":"@article{Gallagher05062013, author= {Gallagher, Thomas and Kim, Jeongho and Oldenbroek, Marieke and Kerr, Rex and You, Young-Jai}, title= {ASI Regulates Satiety Quiescence in C. elegans}, volume= {33}, number= {23}, pages= {9716-9724}, year= {2013}, doi= {10.1523/JNEUROSCI.4493-12.2013}, abstract= {In Caenorhabditis elegans, satiety quiescence mimics behavioral aspects of satiety and postprandial sleep in mammals. On the basis of calcium-imaging, genetics, and behavioral studies, here we report that a pair of amphid neurons, ASI, is activated by nutrition and regulates worms\u0026#39; behavioral states specifically promoting satiety quiescence; ASI inhibits the switch from quiescence to dwelling (a browsing state) and accelerates the switch from dwelling to quiescence. The canonical TGFβ pathway, whose ligand is released from ASI, regulates satiety quiescence. The mutants of a ligand, a receptor and SMADs in the TGFβ pathway all eat more and show less quiescence than wild-type. The TGFβ receptor in downstream neurons RIM and RIC is sufficient for worms to exhibit satiety quiescence, suggesting neuronal connection from ASI to RIM and RIC is essential for feeding regulation through the TGFβ pathway. ASI also regulates satiety quiescence partly through cGMP signaling; restoring cGMP signaling in ASI rescues the satiety quiescence defect of cGMP signaling mutants. From these results, we propose that TGFβ and cGMP pathways in ASI connect nutritional status to promotion of satiety quiescence, a sleep-like behavioral state.}, URL= {http://www.jneurosci.org/content/33/23/9716.abstract}, eprint= {http://www.jneurosci.org/content/33/23/9716.full.pdf+html}, journal= {The Journal of Neuroscience}}\n\n","JournalTitle":"The Journal of Neuroscience","Title":"ASI Regulates Satiety Quiescence in C. elegans","CitationType":"bibtex","DOI":"10.1523/JNEUROSCI.4493-12.2013","Date":"2013-00-00","Url":"http://www.jneurosci.org/content/33/23/9716.abstract","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}
{"ProfilePublicationId":8013,"Type":"journal-article","Citation":"@article{10.1371/journal.pone.0059865, author= {Gallagher, Thomas AND Bjorness, Theresa AND Greene, Robert AND You, Young-Jai AND Avery, Leon}, journal= {PLoS ONE}, publisher= {Public Library of Science}, title= {The Geometry of Locomotive Behavioral States in \u0026lt;italic\u0026gt;C. elegans\u0026lt;/italic\u0026gt;}, year= {2013}, month= {03}, volume= {8}, url= {http://dx.doi.org/10.1371%2Fjournal.pone.0059865}, pages= {1-19}, abstract= {\u0026lt;p\u0026gt;We develop a new hidden Markov model-based method to analyze \u0026lt;italic\u0026gt;C elegans\u0026lt;/italic\u0026gt; locomotive behavior and use this method to quantitatively characterize behavioral states. In agreement with previous work, we find states corresponding to roaming, dwelling, and quiescence. However, we also find evidence for a continuum of intermediate states. We suggest that roaming, dwelling, and quiescence may best be thought of as extremes which, mixed in any proportion, define the locomotive repertoire of \u0026lt;italic\u0026gt;C elegans\u0026lt;/italic\u0026gt; foraging and feeding behavior.\u0026lt;/p\u0026gt;}, number= {3}, doi= {10.1371/journal.pone.0059865}}\n\n","JournalTitle":"PLoS ONE","Title":"The Geometry of Locomotive Behavioral States in \u0026lt;italic\u0026gt;C. elegans\u0026lt;/italic\u0026gt;","CitationType":"bibtex","DOI":"10.1371/journal.pone.0059865","Date":"2013-03-00","Url":"http://dx.doi.org/10.1371%2Fjournal.pone.0059865","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}
{"ProfilePublicationId":8014,"Type":"journal-article","Citation":"@article{doi:10.4161/worm.27938, author= {Thomas Gallagher and Young-Jai You}, title= {Falling asleep after a big meal}, journal= {Worm}, volume= {3}, number= {1}, pages= {e27938}, year= {2014}, doi= {10.4161/worm.27938}, note= {PMID: 25057453}, URL= {http://dx.doi.org/10.4161/worm.27938\n \n}, eprint= {http://dx.doi.org/10.4161/worm.27938\n \n}}\n\n","JournalTitle":"Worm","Title":"Falling asleep after a big meal","CitationType":"bibtex","DOI":"10.4161/worm.27938","Date":"2014-00-00","Url":"http://dx.doi.org/10.4161/worm.27938","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}
{"ProfilePublicationId":8015,"Type":"journal-article","Citation":"@article{DVDY:DVDY24118, author= {Cox-Paulson, Elisabeth and Cannataro, Vincent and Gallagher, Thomas and Hoffman, Corey and Mantione, Gary and Mcintosh, Matthew and Silva, Malan and Vissichelli, Nicole and Walker, Rachel and Simske, Jeffrey and Ono, Shoichiro and Hoops, Harold}, title= {The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestine}, journal= {Developmental Dynamics}, volume= {243}, number= {6}, issn= {1097-0177}, url= {http://dx.doi.org/10.1002/dvdy.24118}, doi= {10.1002/dvdy.24118}, pages= {753--764}, keywords= {tubulogenesis, terminal web, actomyosin contractility}, year= {2014}}\n\n","JournalTitle":"Developmental Dynamics","Title":"The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestine","CitationType":"bibtex","DOI":"10.1002/dvdy.24118","Date":"2014-00-00","Url":"http://dx.doi.org/10.1002/dvdy.24118","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}

Hire Dr. Thomas Gallagher

Postdoctoral Research Fellow

University of Utah

Ph.D. (Biochemistry and Molecular Biology)

Virginia Commonwealth University