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Profile Details
Subject Matter Expertise
Services
Data & AI
Statistical Analysis,
Algorithm Design-Non ML,
Data Visualization
Work Experience
Professor
University of California Los Angeles
- Present 
Education
Ph.D. (Physics)
Stanford University
- 1996
B.S. (Physics)
University of California Los Angeles
- 1990
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Neal K. Bennett, Mai K. Nguyen, Maxwell A. Darch, Hiroki J. Nakaoka, Derek Cousineau, Johanna ten Hoeve, Thomas G. Graeber, Markus Schuelke, Emin Maltepe, Martin Kampmann, et al.(2020). Defining the {ATPome} reveals cross-optimization of metabolic pathways . Nature Communications. 11. (1). Springer Science and Business Media {LLC}
Francoise Remacle, Thomas G. Graeber, R. D. Levine(2020). Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer . Proceedings of the National Academy of Sciences. 117. (31). p. 18880--18890. Proceedings of the National Academy of Sciences
Nicolaos Jay Palaskas, Jacob David Garcia, Roksana Shirazi, Daniel Sanghoon Shin, Cristina Puig-Saus, Daniel Braas, Antoni Ribas, Thomas Glen Graeber (2019). Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis . Cell Discovery.
Douglas W. Yao, Nikolas G. Balanis, Eleazar Eskin, Thomas G. Graeber(2019). A linear mixed model approach to gene expression-tumor aneuploidy association studies . Scientific Reports. 9. (1). Springer Science and Business Media {LLC}
Lynnea R. Waters, Fasih M. Ahsan, Johanna ten Hoeve, Jason S. Hong, Diane N. H. Kim, Aspram Minasyan, Daniel Braas, Thomas G. Graeber, Thomas A. Zangle, Michael A. Teitell(2019). Ampk regulates {IgD} expression but not energy stress with B cell activation . Scientific Reports. 9. (1). Springer Science and Business Media {LLC}
Praveen K. Dhandapani, Isabel M. Begines-Moreno, Gloria Brea-Calvo, Ulrich Gärtner, Thomas G. Graeber, Gerardo Javier Sanchez, Rory E. Morty, Kai Schönig, Johanna ten Hoeve, Astrid Wietelmann, et al.(2019). Hyperoxia but not {AOX} expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy . Scientific Reports. 9. (1). Springer Science and Business Media {LLC}
(2019). Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies . Cancer cell.
(2018). Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress . Cancer cell.
(2017). Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures . Molecular Systems Biology.
Momcilovic, M., Bailey, S.T., Lee, J.T., Fishbein, M.C., Magyar, C., Braas, D., Graeber, T., Jackson, N.J., Czernin, J., Emberley, E., et al.(2017). Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer . Cell Reports. 18. (3). p. 601-610.
Li, X., LeBlanc, J., Elashoff, D., McHardy, I., Tong, M., Roth, B., Ippoliti, A., Barron, G., McGovern, D., McDonald, K., et al.(2016). Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease . CMGH Cellular and Molecular Gastroenterology and Hepatology. 2. (5). p. 567-583.
Zaretsky, J.M., Garcia-Diaz, A., Shin, D.S., Escuin-Ordinas, H., Hugo, W., Hu-Lieskovan, S., Torrejon, D.Y., Abril-Rodriguez, G., Sandoval, S., Barthly, L., et al.(2016). Mutations associated with acquired resistance to PD-1 blockade in melanoma . New England Journal of Medicine. 375. (9). p. 819-829.
Li, W., Cohen, A., Sun, Y., Squires, J., Braas, D., Graeber, T.G., Du, L., Li, G., Li, Z., Xu, X., et al.(2016). The role of CD44 in glucose metabolism in prostatic small cell neuroendocrine carcinoma . Molecular Cancer Research. 14. (4). p. 344-353.
Moreno, B.H., Zaretsky, J.M., Garcia-Diaz, A., Tsoi, J., Parisi, G., Robert, L., Meeth, K., Ndoye, A., Bosenberg, M., Weeraratna, A.T., et al.(2016). Response to programmed cell death-1 blockade in a murine melanoma syngeneic model requires costimulation, CD4, and CD8 T cells . Cancer Immunology Research. 4. (10). p. 845-857.
Shojaee, S., Chan, L.N., Buchner, M., Cazzaniga, V., Cosgun, K.N., Geng, H., Qiu, Y.H., Von Minden, M.D., Ernst, T., Hochhaus, A., et al.(2016). PTEN opposes negative selection and enables oncogenic transformation of pre-B cells . Nature Medicine. 22. (4). p. 379-387.
Hong, C.S., Graham, N.A., Gu, W., Espindola Camacho, C., Mah, V., Maresh, E.L., Alavi, M., Bagryanova, L., Krotee, P.A.L., Gardner, B.K., et al.(2016). MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4 . Cell Reports. 14. (7). p. 1590-1601.
Wu, T.-H., Sagullo, E., Case, D., Zheng, X., Li, Y., Hong, J.S., Teslaa, T., Patananan, A.N., McCaffery, J.M., Niazi, K., et al.(2016). Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells . Cell Metabolism. 23. (5). p. 921-929.
Knight, D.A., Ngiow, S.F., Li, M., Parmenter, T., Mok, S., Cass, A., Haynes, N.M., Kinross, K., Yagita, H., Koya, R.C., et al.(2016). Erratum: Host immunity contributes to the anti-melanoma activity of BRAF inhibitors (American Society for Clinical Investigation (2013) 123:3 (1371-1381) DOI 10.1172/JCI66236) . Journal of Clinical Investigation. 126. (1). p. 402-403.
TeSlaa, T., Chaikovsky, A.C., Lipchina, I., Escobar, S.L., Hochedlinger, K., Huang, J., Graeber, T.G., Braas, D., Teitell, M.A.(2016). α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells . Cell Metabolism. 24. (3). p. 485-493.
Krall, A.S., Xu, S., Graeber, T.G., Braas, D., Christofk, H.R.(2016). Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor . Nature Communications. 7.
Atefi, M., Titz, B., Tsoi, J., Avramis, E., Le, A., Ng, C., Lomova, A., Lassen, A., Friedman, M., Chmielowski, B., et al.(2016). CRAF R391W is a melanoma driver oncogene . Scientific Reports. 6.
Drake, J.M., Paull, E.O., Graham, N.A., Lee, J.K., Smith, B.A., Titz, B., Stoyanova, T., Faltermeier, C.M., Uzunangelov, V., Carlin, D.E., et al.(2016). Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer . Cell. 166. (4). p. 1041-1054.
Ankeny, J.S., Court, C.M., Hou, S., Li, Q., Song, M., Wu, D., Chen, J.F., Lee, T., Lin, M., Sho, S., et al.(2016). Circulating tumour cells as a biomarker for diagnosis and staging in pancreatic cancer . British Journal of Cancer. 114. (12). p. 1367-1375.
Court, C.M., Ankeny, J.S., Sho, S., Hou, S., Li, Q., Hsieh, C., Song, M., Liao, X., Rochefort, M.M., Wainberg, Z.A., et al.(2016). Reality of Single Circulating Tumor Cell Sequencing for Molecular Diagnostics in Pancreatic Cancer . Journal of Molecular Diagnostics. 18. (5). p. 688-696.
Chen, Z., Shojaee, S., Buchner, M., Geng, H., Lee, J.W., Klemm, L., Titz, B., Graeber, T.G., Park, E., Tan, Y.X., et al.(2016). Erratum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia (Nature (2015) 521 (357-361) DOI:10.1038/nature14231) . Nature. 534. (7605).
Hu-Lieskovan, S., Mok, S., Homet Moreno, B., Tsoi, J., Robert, L., Goedert, L., Pinheiro, E.M., Koya, R.C., Graeber, T.G., Comin-Anduix, B., et al.(2015). Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF<sup>V600E</sup> melanoma . Science Translational Medicine. 7. (279).
Ploper, D., Taelman, V.F., Robert, L., Perez, B.S., Titz, B., Chen, H.-W., Graeber, T.G., Von Euw, E., Ribas, A., De Robertis, E.M., et al.(2015). MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells . Proceedings of the National Academy of Sciences of the United States of America. 112. (5). p. E420-E429.
Fu, X., Chin, R.M., Vergnes, L., Hwang, H., Deng, G., Xing, Y., Pai, M.Y., Li, S., Ta, L., Fazlollahi, F., et al.(2015). 2-hydroxyglutarate inhibits ATP synthase and mTOR Signaling . Cell Metabolism. 22. (3). p. 508-515.
Wong, D.J.L., Robert, L., Atefi, M.S., Lassen, A., Avarappatt, G., Cerniglia, M., Avramis, E., Tsoi, J., Foulad, D., Graeber, T.G., et al.(2015). Erratum to: Activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma [Mol Cancer. 13, (2014) 194] DOI: 10.1186/1476-4598-13-194 . Molecular Cancer. 14. (1).
Inkeles, M.S., Scumpia, P.O., Swindell, W.R., Lopez, D., Teles, R.M.B., Graeber, T.G., Meller, S., Homey, B., Elder, J.T., Gilliet, M., et al.(2015). Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis . Journal of Investigative Dermatology. 135. (1). p. 151-159.
Mok, S., Tsoi, J., Koya, R.C., Hu-Lieskovan, S., West, B.L., Bollag, G., Graeber, T.G., Ribas, A.(2015). Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition . BMC Cancer. 15. (1).
Robert, L., Tsoi, J., Wang, X., Emerson, R., Homet, B., Chodon, T., Mok, S., Huang, R.R., Cochran, A.J., Comin-Anduix, B., et al.(2015). Erratum: CTLA4 blockade broadens the peripheral T-cell receptor repertoire (Clinical Cancer Research (2014) 20 (2424-2432)) . Clinical Cancer Research. 21. (14).
Thai, M., Thaker, S.K., Feng, J., Du, Y., Hu, H., Ting Wu, T., Graeber, T.G., Braas, D., Christofk, H.R.(2015). MYC-induced reprogramming of glutamine catabolism supports optimal virus replication . Nature Communications. 6.
Chen, Z., Shojaee, S., Buchner, M., Geng, H., Lee, J.W., Klemm, L., Titz, B., Graeber, T.G., Park, E., Tan, Y.X., et al.(2015). Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia . Nature. 521. (7552). p. 357-361.
Goodwin, J., Kothari, V., Drake, J., Zhao, S., Dylgjeri, E., Dean, J., Schiewer, M., McNair, C., Jones, J., Aytes, A., et al.(2015). DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis . Cancer Cell. 28. (1). p. 97-113.
Ting, P.Y., Damoiseaux, R., Titz, B., Bradley, K.A., Graeber, T.G., Fernández-Vega, V., Bannister, T.D., Chase, P., Nair, R., Scampavia, L., et al.(2015). Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1 . PLoS ONE. 10. (3).
Ting, P.Y., Johnson, C.W., Fang, C., Cao, X., Graeber, T.G., Mattos, C., Colicelli, J., Ting, P.Y., Johnson, C.W., Fang, C., et al.(2015). Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding . FASEB Journal. 29. (9). p. 3750-3761.
Atefi, M., Titz, B., Avramis, E., Ng, C., Wong, D.J.L., Lassen, A., Cerniglia, M., Escuin-Ordinas, H., Foulad, D., Comin-Anduix, B., et al.(2015). Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma . Molecular Cancer. 14. (1).
Thai, M., Graham, N.A., Braas, D., Nehil, M., Komisopoulou, E., Kurdistani, S.K., McCormick, F., Graeber, T.G., Christofk, H.R.(2014). Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication . Cell Metabolism. 19. (4). p. 694-701.
Robert, L., Tsoi, J., Wang, X., Emerson, R., Homet, B., Chodon, T., Mok, S., Huang, R.R., Cochran, A.J., Comin-Anduix, B., et al.(2014). CTLA4 blockade broadens the peripheral T-cell receptor repertoire . Clinical Cancer Research. 20. (9). p. 2424-2432.
Müller, J., Krijgsman, O., Tsoi, J., Robert, L., Hugo, W., Song, C., Kong, X., Possik, P.A., Cornelissen-Steijger, P.D.M., Foppen, M.H.G., et al.(2014). Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma . Nature Communications. 5.
Escuin-Ordinas, H., Atefi, M., Fu, Y., Cass, A., Ng, C., Huang, R.R., Yashar, S., Comin-Anduix, B., Avramis, E., Cochran, A.J., et al.(2014). COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors . Molecular Oncology. 8. (2). p. 250-260.
Zimman, A., Titz, B., Komisopoulou, E., Biswas, S., Graeber, T.G., Podrez, E.A., Zimman, A., Titz, B., Komisopoulou, E., Biswas, S., et al.(2014). Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin . PLoS ONE. 9. (1).
Atefi, M., Avramis, E., Lassen, A., Wong, D.J.L., Robert, L., Foulad, D., Cerniglia, M., Titz, B., Chodon, T., Graeber, T.G., et al.(2014). Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma . Clinical Cancer Research. 20. (13). p. 3446-3457.
Graham, N.A., Graeber, T.G., Graham, N.A., Graeber, T.G.(2014). Complexity of metastasis-associated SDF-1 ligand signaling in breast cancer stem cells . Proceedings of the National Academy of Sciences of the United States of America. 111. (21). p. 7503-7504.
Mok, S., Koya, R.C., Tsui, C., Xu, J., Robert, L., Wu, L., Graeber, T.G., West, B.L., Bollag, G., Ribas, A.(2014). Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy . Cancer Research. 74. (1). p. 153-161.
Wong, D.J.L., Robert, L., Atefi, M.S., Lassen, A., Avarappatt, G., Cerniglia, M., Avramis, E., Tsoi, J., Foulad, D., Graeber, T.G., et al.(2014). Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma . Molecular Cancer. 13. (1).
Anderson, J.L., Titz, B., Akiyama, R., Komisopoulou, E., Park, A., Tap, W.D., Graeber, T.G., Denny, C.T., Anderson, J.L., Titz, B., et al.(2014). Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors . Molecular Cancer Research. 12. (12). p. 1740-1754.
Tong, M., McHardy, I., Ruegger, P., Goudarzi, M., Kashyap, P.C., Haritunians, T., Li, X., Graeber, T.G., Schwager, E., Huttenhower, C., et al.(2014). Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism . ISME Journal. 8. (11). p. 2193-2206.
Kidani, Y., Elsaesser, H., Hock, M.B., Vergnes, L., Williams, K.J., Argus, J.P., Marbois, B.N., Komisopoulou, E., Wilson, E.B., Osborne, T.F., et al.(2013). Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity . Nature Immunology. 14. (5). p. 489-499.
Rohle, D., Popovici-Muller, J., Palaskas, N., Turcan, S., Grommes, C., Campos, C., Tsoi, J., Clark, O., Oldrini, B., Komisopoulou, E., et al.(2013). An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells . Science. 340. (6132). p. 626-630.
Teles, R.M.B., Graeber, T.G., Krutzik, S.R., Montoya, D., Schenk, M., Lee, D.J., Komisopoulou, E., Kelly-Scumpia, K., Chun, R., Iyer, S.S., et al.(2013). Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses . Science. 339. (6126). p. 1448-1453.
Ahler, E., Sullivan, W.J., Cass, A., Braas, D., York, A.G., Bensinger, S.J., Graeber, T.G., Christofk, H.R., Ahler, E., Sullivan, W.J., et al.(2013). Doxycycline Alters Metabolism and Proliferation of Human Cell Lines . PLoS ONE. 8. (5).
Drake, J.M., Graham, N.A., Lee, J.K., Stoyanova, T., Faltermeier, C.M., Sud, S., Titz, B., Huang, J., Pienta, K.J., Graeber, T.G., et al.(2013). Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets . Proceedings of the National Academy of Sciences of the United States of America. 110. (49).
Knight, D.A., Ngiow, S.F., Li, M., Parmenter, T., Mok, S., Cass, A., Haynes, N.M., Kinross, K., Yagita, H., Koya, R.C., et al.(2013). Host immunity contributes to the anti-melanoma activity of BRAF inhibitors (Journal of Clinical Investigation (2013) 123, 3, (1371-1381) DOI: 10.1172/JCI66236) . Journal of Clinical Investigation. 123. (7).
Williams, K.J., Argus, J.P., Zhu, Y., Wilks, M.Q., Marbois, B.N., York, A.G., Kidani, Y., Pourzia, A.L., Akhavan, D., Lisiero, D.N., et al.(2013). An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity . Cancer Research. 73. (9). p. 2850-2862.
McHardy, I.H., Goudarzi, M., Tong, M., Ruegger, P.M., Schwager, E., Weger, J.R., Graeber, T.G., Sonnenburg, J.L., Horvath, S., Huttenhower, C., et al.(2013). Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships . Microbiome. 1. (1).
Knight, D.A., Ngiow, S.F., Li, M., Parmenter, T., Mok, S., Cass, A., Haynes, N.M., Kinross, K., Yagita, H., Koya, R.C., et al.(2013). Host immunity contributes to the antimelanoma activity of BRAF inhibitors . Journal of Clinical Investigation. 123. (3). p. 1371-1381.
Swaminathan, S., Huang, C., Geng, H., Chen, Z., Harvey, R., Kang, H., Ng, C., Titz, B., Hurtz, C., Sadiyah, M.F., et al.(2013). BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint . Nature Medicine. 19. (8). p. 1014-1022.
Schenk, M., Krutzik, S.R., Sieling, P.A., Lee, D.J., Teles, R.M.B., Ochoa, M.T., Komisopoulou, E., Sarno, E.N., Rea, T.H., Graeber, T.G., et al.(2012). NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy . Nature Medicine. 18. (4). p. 555-563.
Tran, L.M., Chang, C.-J., Plaisier, S., Wu, S., Dang, J., Mischel, P.S., Liao, J.C., Graeber, T.G., Wu, H.(2012). Determining PTEN functional status by network component deduced transcription factor activities . PLoS ONE. 7. (2).
Liu, P.T., Wheelwright, M., Teles, R., Komisopoulou, E., Edfeldt, K., Ferguson, B., Mehta, M.D., Vazirnia, A., Rea, T.H., Sarno, E.N., et al.(2012). MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy . Nature Medicine. 18. (2). p. 267-273.
Koya, R.C., Mok, S., Otte, N., Blacketor, K.J., Comin-Anduix, B., Tumeh, P.C., Minasyan, A., Graham, N.A., Graeber, T.G., Chodon, T., et al.(2012). BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy . Cancer Research. 72. (16). p. 3928-3937.
Drake, J.M., Graham, N.A., Stoyanova, T., Sedghi, A., Goldstein, A.S., Cai, H., Smith, D.A., Zhangh, H., Komisopoulou, E., Huang, J., et al.(2012). Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression . Proceedings of the National Academy of Sciences of the United States of America. 109. (5). p. 1643-1648.
Graham, N.A., Tahmasian, M., Kohli, B., Komisopoulou, E., Zhu, M., Vivanco, I., Teitell, M.A., Wu, H., Ribas, A., Lo, R.S., et al.(2012). Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death . Molecular Systems Biology. 8.
Zuber, J., Rappaport, A.R., Luo, W., Wang, E., Chen, C., Vaseva, A.V., Shi, J., Weissmueller, S., Fellman, C., Taylor, M.J., et al.(2011). An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance . Genes and Development. 25. (15). p. 1628-1640.
Duy, C., Hurtz, C., Shojaee, S., Cerchietti, L., Geng, H., Swaminathan, S., Klemm, L., Kweon, S.-M., Nahar, R., Braig, M., et al.(2011). BCL6 enables Ph<sup>+</sup> acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition . Nature. 473. (7347). p. 384-391.
Remacle, F., Graeber, T.G., Levine, R.D.(2011). Whose Entropy: A Maximal Entropy Analysis of Phosphorylation Signaling . Journal of Statistical Physics. 144. (2). p. 429-442.
Rubbi, L., Titz, B., Brown, L., Galvan, E., Komisopoulou, E., Chen, S.S., Low, T., Tahmasian, M., Skaggs, B., Müschen, M., et al.(2011). Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling . Science Signaling. 4. (166).
Li, X., LeBlanc, J., Truong, A., Vuthoori, R., Chen, S.S., Lustgarten, J.L., Roth, B., Allard, J., Ippoliti, A., Presley, L.L., et al.(2011). A metaproteomic approach to study human-microbial ecosystems at the mucosal luminal interface . PLoS ONE. 6. (11).
Palaskas, N., Larson, S.M., Schultz, N., Komisopoulou, E., Wong, J., Rohle, D., Campos, C., Yannuzzi, N., Osborne, J.R., Linkov, I., et al.(2011). <sup>18</sup>F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers . Cancer Research. 71. (15). p. 5164-5174.
Poulikakos, P.I., Persaud, Y., Janakiraman, M., Kong, X., Ng, C., Moriceau, G., Shi, H., Atefi, M., Titz, B., Gabay, M.T., et al.(2011). RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) . Nature. 480. (7377). p. 387-390.
Mulholland, D., Tran, L., Li, Y., Cai, H., Morim, A., Wang, S., Plaisier, S., Garraway, I., Huang, J., Graeber, T., et al.(2011). Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth . Cancer Cell. 19. (6). p. 792-804.
Titz, B., Low, T., Komisopoulou, E., Chen, S.S., Rubbi, L., Graeber, T.G., Titz, B., Low, T., Komisopoulou, E., Chen, S.S., et al.(2010). The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization . Oncogene. 29. (44). p. 5895-5910.
Zimman, A., Chen, S.S., Komisopoulou, E., Titz, B., Martínez-Pinna, R., Kafi, A., Berliner, J.A., Graeber, T.G., Zimman, A., Chen, S.S., et al.(2010). Activation of aortic endothelial cells by oxidized phospholipids: A phosphoproteomic analysis . Journal of Proteome Research. 9. (6). p. 2812-2824.
Tumeh, P.C., Koya, R.C., Chodon, T., Graham, N.A., Graeber, T.G., Comin-Anduix, B., Ribas, A.(2010). The impact of ex vivo clinical grade activation protocols on human t-cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy . Journal of Immunotherapy. 33. (8). p. 759-768.
Sun, J., Masterman-Smith, M.D., Graham, N.A., Jiao, J., Mottahedeh, J., Laks, D.R., Ohashi, M., DeJesus, J., Kamei, K.-I., Lee, K.-B., et al.(2010). A microfluidic platform for systems pathology: Multiparameter single-cell signaling measurements of clinical brain tumor specimens . Cancer Research. 70. (15). p. 6128-6138.
Graeber, T.G., Heath, J.R., Skaggs, B.J., Phelps, M.E., Remacle, F., Levine, R.D.(2010). Maximal entropy inference of oncogenicity from phosphorylation signaling . Proceedings of the National Academy of Sciences of the United States of America. 107. (13). p. 6112-6117.
Fang, C., Wang, Y., Vu, N.T., Lin, W.-Y., Hsieh, Y.-T., Rubbi, L., Phelps, M.E., Müschen, M., Kim, Y.-M., Chatziioannou, A.F., et al.(2010). Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples . Cancer Research. 70. (21). p. 8299-8308.
Plaisier, S.B., Taschereau, R., Wong, J.A., Graeber, T.G.(2010). Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures . Nucleic acids research. 38. (17).
Lu, K.V., Zhu, S., Cvrljevic, A., Huang, T.T., Sarkaria, S., Ahkavan, D., Dang, J., Dinca, E.B., Plaisier, S.B., Oderberg, I., et al.(2009). Fyn and Src are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients . Cancer Research. 69. (17). p. 6889-6898.
Zimman, A., Mouillesseaux, K.P., Le, T., Gharavi, N.M., Ryvkin, A., Graeber, T.G., Chen, T.T., Watson, A.D., Berliner, J.A.(2007). Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids . Arteriosclerosis, Thrombosis, and Vascular Biology. 27. (2). p. 332-338.
Skaggs, B.J., Gorre, M.E., Ryvkin, A., Burgess, M.R., Xie, Y., Han, Y., Komisopoulou, E., Brown, L.M., Loo, J.A., Landaw, E.M., et al.(2006). Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants . Proceedings of the National Academy of Sciences of the United States of America. 103. (51). p. 19466-19471.
Graeber, T.G., Sawyers, C.L.(2005). Cross-species comparisons of cancer signaling . Nature Genetics. 37. (1). p. 7-8.
Krutzik, S.R., Tan, B., Li, H., Ochoa, M.T., Liu, P.T., Sharfstein, S.E., Graeber, T.G., Sieling, P.A., Liu, Y.-J., Rea, T.H., et al.(2005). TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells . Nature Medicine. 11. (6). p. 653-660.
Ellwood-Yen, K., Graeber, T.G., Wongvipat, J., Iruela-Arispe, M.L., Zhang, J., Matusik, R., Thomas, G.V., Sawyers, C.L., Ellwood-Yen, K., Graeber, T.G., et al.(2005). Erratum: Myc-driven murine prostate cancer shares molecular features with human prostate tumors (Cancer Cell (September 2003) 4 (223-238)) . Cancer Cell. 8. (6).
Freedland, S.J., Pantuck, A.J., Paik, S.H., Zisman, A., Graeber, T.G., Eisenberg, D., McBride, W.H., Nguyen, D., Tso, C.-L., Belldegrun, A.S.(2003). Heterogeneity of molecular targets on clonal cancer lines derived from a novel hormone-refractory prostate cancer tumor system . Prostate. 55. (4). p. 299-307.
Strong, M., Graeber, T.G., Beeby, M., Pellegrini, M., Thompson, M.J., Yeates, T.O., Eisenberg, D., Strong, M., Graeber, T.G., Beeby, M., et al.(2003). Visualization and intepretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps . Nucleic Acids Research. 31. (24). p. 7099-7109.
Bleharski, J.R., Li, H., Meinken, C., Graeber, T.G., Ochoa, M.-T., Yamamura, M., Burdick, A., Sarno, E.N., Wagner, M., Röllinghoff, M., et al.(2003). Use of genetic profiling in leprosy to discriminate clinical forms of the disease . Science. 301. (5639). p. 1527-1530.
Ellwood-Yen, K., Graeber, T.G., Wongvipat, J., Iruela-Arispe, M.L., Zhang, J., Matusik, R., Thomas, G.V., Sawyers, C.L.(2003). Myc-driven murine prostate cancer shares molecular features with human prostate tumors . Cancer Cell. 4. (3). p. 223-238.
Matei, D., Graeber, T.G., Baldwin, R.L., Karlan, B.Y., Rao, J., Chang, D.D.(2002). Gene expression in epithelial ovarian carcinoma . Oncogene. 21. (41). p. 6289-6298.
Graeber, T.G., Eisenberg, D.(2001). Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles . Nature Genetics. 29. (3). p. 295-300.
Graeber, T.G., Shuai, K.(2000). Rapid gene repression triggered by interleukin-6 at the onset of monocyte differentiation . Biochemical and Biophysical Research Communications. 267. (3). p. 863-869.
Kim, C.Y., Tsai, M.H., Osmanian, C., Graeber, T.G., Lee, J.E., Giffard, R.G., DiPaolo, J.A., Peehl, D.M., Giaccia, A.J., Kim, C.Y., et al.(1997). Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions . Cancer Research. 57. (19). p. 4200-4204.
Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W., Giaccia, A.J.(1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours . Nature. 379. (6560). p. 88-91.
Alarcon, R.M., Rupnow, B.A., Graeber, T.G., Knox, S.J., Giaccia, A.J.(1996). Modulation of c-Myc activity and apoptosis in vivo . Cancer Research. 56. (19). p. 4315-4319.
Girinsky, T., Koumenis, C., Graeber, T.G., Giaccia, A.J., Peehl, D.M.(1995). Attenuated Response of p53 and p21 in Primary Cultures of Human Prostatic Epithelial Cells Exposed to DNA-damaging Agents . Cancer Research. 55. (17). p. 3726-3731.
Graeber, T.G., Peterson, J.F., Tsai, M., Monica, K., Fornace Jr., A.J., Giaccia, A.J., Graeber, T.G., Peterson, J.F., Tsai, M., Monica, K., et al.(1994). Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status . Molecular and Cellular Biology. 14. (9). p. 6264-6277.
DATA SET
CONFERENCE PAPER
Graham, N.A., Drake, J.M., Tahmasian, M., Pienta, K.J., Witte, O.N., Graeber, T.G.(2013). Phospho-proteomics reveals oncogenic phospho-tyrosine signaling networks in cancers lacking mutated or amplified tyrosine kinases . Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. p. 297-298.
Kamei, K.-i., Ohashi, M., Graham, N.A., Chen, Y., Clark, A.T., Witte, O.N., Graeber, T.G., Pyle, A.D., Tseng, H.-R.(2011). Quantitative cytological feature analysis by microfluidic image cytometry reveals phenotypic differences among human pluripotent stem cell lines . 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 1. p. 148-150.
BOOK
Zimman, A., Berliner, J.A., Graeber, T.G.(2013). Phosphoproteomic analysis of aortic endothelial cells activated by oxidized phospholipids . Methods in Molecular Biology. 1000. p. 53-69.
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