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Hire Dr. Rosario R.

Spain

USD 25 /hr

Chemist specialized in structural biology, with special interest in computational work and rational drug design.

Profile Summary

I studied organic chemistry at the university of Barcelona and I specialized in Protein X-ray crystallography, working on the study of relevant molecules involved in human diseases and taking part in structural-based drug design.

Subject Matter Expertise

• ★ Structural Biology
• ☆ Crystallography
• ☆ X-Ray Crystallography
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Biophysics
• ☆ Computational Sciences
• ☆ Drug Discovery
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Technical & Scientific Writing

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Market Research, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Data Visualization, Data Processing

Work Experience

PostdoctoralResearcher

CIC bioGUNE

October 2022 - Present

Postdoctoral Researcher

University of Oulu

May 2019 - Present

Scientific consultant

Freelance

April 2017 - Present

Senior Researcher

Latvian Institute of Organic Synthesis

January 2014 - March 2017

Reseach Associate

Centro Nacional de Biotecnología

January 2012 - December 2013

Reseach Associate

University of Cambridge

July 2008 - December 2011

Reseach Associate

Trinity College Dublin

July 2004 - June 2008

Visitor Scientist

Institut de Génétique et de Biologie Moléculaire et Cellulaire

April 2003 - May 2004

Reseach Associate

European Molecular Biology Organization

March 2001 - March 2003

Reseach Associate

University of Alabama at Birmingham

September 1997 - January 2001

Education

Doctor (Enginyeria Quimica)

Universitat Politècnica de Catalunya

September 1992 - October 1996

Licenciada (Organic Chemistry)

Universitat de Barcelona

October 1985 - March 1992

Certifications

• PhD

  Polytechnique University of Catalonia

  October 1996 - Present

Publications

JOURNAL ARTICLE

(2020). A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein . PLOS Genetics.

Santiago C, Mudgal G, Reguera J, Recacha R, Albrecht S, Enjuanes L, Casasnovas JM(2017). Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection . Scientific reports.

Recacha R, Jaudzems K, Akopjana I, Jirgensons A, Tars K(2016). Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins . Acta crystallographica. Section F, Structural biology communications.

(2015). Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV . Journal of medicinal chemistry.

(2015). Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors . Acta crystallographica. Section F, Structural biology communications.

Recacha R, Jiménez D, Tian L, Barredo R, Gahmberg CG, Casasnovas JM(2014). Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions . Acta Crystallographica Section D: Biological Crystallography.

Fernandes H, Franklin E, Recacha R, Houdusse A, Goud B, Khan AR(2009). Structural aspects of Rab6-effector complexes . Biochemical Society transactions.

(2009). Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain . Structure (London, England : 1993).

Costanzo MJ, Yabut SC, Almond HR, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D, et al.(2003). Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone . Journal of medicinal chemistry.

(2002). Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design . Journal of the American Chemical Society.

Recacha R, Costanzo MJ, Maryanoff BE, Chattopadhyay D(2002). Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate . The Biochemical journal.

(2000). Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop . Acta Crystallographica Section D: Biological Crystallography.

(2000). Structure of the nucleotide-binding domain of Plasmodium falciparum rab6 in the GDP-bound form . Acta Crystallographica Section D: Biological Crystallography.

(2000). Toxoplasma gondii adenosine kinase: expression, purification, characterization, crystallization and preliminary crystallographic analysis . Acta Crystallographica Section D: Biological Crystallography.

Recacha R, Carson M, Costanzo MJ, Maryanoff B, DeLucas LJ, Chattopadhyay D(1999). Structure of the RWJ-51084-bovine pancreatic beta-trypsin complex at 1.8 A . Acta Crystallographica Section D: Biological Crystallography.

Recacha R, Verdaguer N, Subirana JA(1997). Structure and supramolecular packing features of the dipeptide Arg-Val acetate . The journal of peptide research : official journal of the American Peptide Society.