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★★★★★

☆☆☆☆☆

Hire Dr. Rajesha R.

United States

USD 100 /hr

Expert in cancer research, scientific editing, technical research and writing summaries

Profile Summary

Research scientist with expertise in designing, managing preclinical studies, drug discovery, RNA therapeutics. Data analytics and experiment design for efficiently achieving goal is key asset. Looking forward for free lance opportunities in oncology and disease research, preclinical project design.

Subject Matter Expertise

• ☆ Molecular Biology
• ☆ RNA Sequencing
• ☆ Small Molecule Drug Development
• ☆ Medicine
• ☆ Oncology
• ☆ Gene Therapy

Services

• Research
• Data & AI

Research Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Work Experience

Senior Scientist

Shepherd Therapeutics

April 2018 - Present

Research fellow

Harvard Medical School

July 2015 - March 2018

Education

Ph.D. (NA)

University of Texas Health Science Center at Houston

August 2009 - December 2014

M.S (Biology)

University of Texas at San Antonio

August 2007 - July 2009

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Rupaimoole, Rajesha, Nagaraja, Archana S., Dorniak, Piotr L., Sadaoui, Nouara C., Kang, Yu, Lin, Tan, Armaiz-Pena, Guillermo, Wu, Sherry Y., Allen, Julie K., Gharpure, Kshipra M.(2016). Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. Oncogene. 35. (18). p. 2390-2397.

Rupaimoole, Rajesha, Slack, Frank J.(2016). A role for miR-34 in colon cancer stem cell homeostasis. Stem Cell Investigation. 3. (8).

Rupaimoole, Rajesha, Kang, Yu, Nagaraja, Archana S., Armaiz-Pena, Guillermo N., Dorniak, Piotr L., Hu, Wei, Liu, Tao, Gharpure, Kshipra M., Previs, Rebecca A., Hansen, Jean M.(2016). Adrenergic stimulation of DUSP1 impairs chemotherapy response in ovarian cancer . Clinical Cancer Research. 22. (7). p. 1713-1724.

Rupaimoole, Rajesha, Wu, Sherry Y., Shen, Fangrong, Pradeep, Sunila, Pecot, Chad V., Ivan, Cristina, Nagaraja, Archana S., Gharpure, Kshipra M., Pham, Elizabeth, Hatakeyama, Hiroto(2016). A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer . Nature communications. 7.

Rupaimoole, Rajesha, Whiting, Nicholas, Hu, Jingzhe, Zacharias, Niki M., Lokesh, Ganesh L. R., Volk, David E., Menter, David G., Previs, Rebecca, Sood, Anil K., Bhattacharya, Pratip(2016). Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. Journal of Medical Imaging. 3. (3). p. 036001.

Rupaimoole, Rajesha, Huang, Jie, Hu, Wei, Hu, Limin, Previs, Rebecca A., Dalton, Heather J., Yang, Xiao-Yun, Sun, Yunjie, McGuire, Michael, Nagaraja, Archana S.(2016). Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth . Molecular cancer therapeutics. 15. (6). p. 1344-1352.

Rupaimoole, R., Ivan, C., Yang, D., Gharpure, K. M., Wu, S. Y., Pecot, C. V., Previs, R. A., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M.(2016). Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. Oncogene.

Haemmerle, Monika, Bottsford-Miller, Justin, Pradeep, Sunila, Taylor, Morgan L., Choi, Hyun-Jin, Hansen, Jean M., Dalton, Heather J., Stone, Rebecca L., Cho, Min Soon, Nick, Alpa M.(2016). FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal . The Journal of clinical investigation. 126. (5). p. 1885-1896.

Rupaimoole, Rajesha, Zand, Behrouz, Previs, Rebecca A., Zacharias, Niki M., Mitamura, Takashi, Nagaraja, Archana Sidalaghatta, Guindani, Michele, Dalton, Heather J., Yang, Lifeng, Baddour, Joelle(2016). Role of increased n-acetylaspartate levels in cancer. Journal of the National Cancer Institute. 108. (6). p. djv426.

Rupaimoole, Rajesha, Moritz, Robert J., LeBaron, Richard G., Phelix, Clyde F., Kim, Hong Seok, Tsin, Andrew, Asmis, Reto(2016). Macrophage TGF-β1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions. International Journal of Clinical Medicine. 7. (07). p. 496.

Rupaimoole, Rajesha, Calin, George A., Lopez-Berestein, Gabriel, Sood, Anil K.(2016). miRNA deregulation in cancer cells and the tumor microenvironment . Cancer discovery. 6. (3). p. 235-246.

Complement Component 3 Is Regulated by TWIST1 and Mediates Epithelial–Mesenchymal Transition @article{RID:0921161744486-237, title = {Complement Component 3 Is Regulated by TWIST1 and Mediates Epithelial–Mesenchymal Transition}, journal = {The Journal of Immunology}, year = {2016}, author = {Cho, Min Soon and Rupaimoole, Rajesha and Choi, Hyun-Jin and Noh, Kyunghee and Chen, Jichao and Hu, Qianghua and Sood, Anil K. and Afshar-Kharghan, Vahid}, volume = {196}, number = {3}, pages = {1412-1418} } . The Journal of Immunology.

Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma @article{RID:0921161744488-255, title = {Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma}, journal = {Hepatology}, year = {2016}, author = {Park, Yun‐Yong and Sohn, Bo Hwa and Johnson, Randy L. and Kang, Myoung‐Hee and Kim, Sang Bae and Shim, Jae‐Jun and Mangala, Lingegowda S. and Kim, Ji Hoon and Yoo, Jeong Eun and Rodriguez‐Aguayo, Cristian}, volume = {63}, number = {1}, pages = {159-172} } . Hepatology.

MiR‐506 inhibits multiple targets in the epithelial‐to‐mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer @article{RID:0921161744490-272, title = {MiR‐506 inhibits multiple targets in the epithelial‐to‐mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer}, journal = {The Journal of pathology}, year = {2015}, author = {Sun, Yan and Hu, Limei and Zheng, Hong and Bagnoli, Marina and Guo, Yuhong and Rupaimoole, Rajesha and Rodriguez‐Aguayo, Cristian and Lopez‐Berestein, Gabriel and Ji, Ping and Chen, Kexin}, volume = {235}, number = {1}, pages = {25-36} } . The Journal of pathology.

Rupaimoole, Rajesha, Liu, Guoyan, Yang, Da, Pecot, Chad V., Sun, Yan, Mangala, Lingegowda S., Li, Xia, Ji, Ping, Cogdell, David, Hu, Limei(2015). Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers. Journal of the National Cancer Institute. 107. (7). p. djv108.

Rupaimoole, Rajesha, Pradeep, Sunila, Huang, Jie, Mora, Edna M., Nick, Alpa M., Cho, Min Soon, Wu, Sherry Y., Noh, Kyunghee, Pecot, Chad V., Stein, Martin A.(2015). Erythropoietin stimulates tumor growth via EphB4 . Cancer cell. 28. (5). p. 610-622.

Seviour, E. G., Sehgal, V., Lu, Y., Luo, Z., Moss, T., Zhang, F., Hill, S. M., Liu, W., Maiti, S. N., Cooper, L.(2015). Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer . Oncogene.

Rupaimoole, Rajesha, Moss, Tyler J., Luo, Zijun, Seviour, Elena G., Sehgal, Vasudha, Lu, Yiling, Hill, Steven M., Lee, Ju-Seog, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel(2015). Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers. npj Systems Biology and Applications. 1. p. 15001.

Rupaimoole, Rajesha, Lee, Jaehyuk, Haemmerle, Monika, Ling, Hui, Previs, Rebecca A., Pradeep, Sunila, Wu, Sherry Y., Ivan, Cristina, Ferracin, Manuela, Dennison, Jennifer B.(2015). Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis . Cell reports. 13. (11). p. 2395-2402.

Rupaimoole, Rajesha, Thanapprapasr, Duangmani, Previs, Rebecca A., Hu, Wei, Ivan, Cristina, Armaiz-Pena, Guillermo N., Dorniak, Piotr L., Hansen, Jean M., Huang, Jie, Dalton, Heather J.(2015). PTEN expression as a predictor of response to focal adhesion kinase inhibition in uterine cancer . Molecular cancer therapeutics. 14. (6). p. 1466-1475.

Rupaimoole, Rajesha, Aslan, Burcu, Monroig, Paloma, Hsu, Ming-Chuan, Pena, Guillermo Armaiz, Rodriguez-Aguayo, Cristian, Gonzalez-Villasana, Vianey, Nagaraja, Archana Sidalaghatta, Mangala, Selanere, Han, Hee-Dong(2015). The ZNF304-integrin axis protects against anoikis in cancer . Nature communications. 6.

Rupaimoole, Rajesha, Miyake, Takahito, Pradeep, Sunila, Wu, Sherry Y., Zand, Behrouz, Wen, Yunfei, Gharpure, Kshipra M., Nagaraja, Archana S., Hu, Wei, Cho, Min Soon(2015). XPO1/CRM1 inhibition causes antitumor effects by mitochondrial accumulation of eIF5A . Clinical Cancer Research. 21. (14). p. 3286-3297.

Wen, Yunfei, Zand, Behrouz, Ozpolat, Bulent, Szczepanski, Miroslaw J., Lu, Chunhua, Yuca, Erkan, Carroll, Amy R., Alpay, Neslihan, Bartholomeusz, Chandra, Tekedereli, Ibrahim(2014). Antagonism of tumoral prolactin receptor promotes autophagy-related cell death . Cell reports. 7. (2). p. 488-500.

Rupaimoole, Rajesha, Cho, Min Soon, Vasquez, Hernan G., Pradeep, Sunila, Wu, Sherry, Zand, Behrouz, Han, Hee-Dong, Rodriguez-Aguayo, Cristian, Bottsford-Miller, Justin, Huang, Jie(2014). Autocrine effects of tumor-derived complement . Cell reports. 6. (6). p. 1085-1095.

Reusser, Nicole M., Dalton, Heather J., Pradeep, Sunila, Gonzalez-Villasana, Vianey, Jennings, Nicholas B., Vasquez, Hernan G., Wen, Yunfei, Rupaimoole, Rajesh, Nagaraja, Archana S., Gharpure, Kshipra(2014). Clodronate inhibits tumor angiogenesis in mouse models of ovarian cancer . Cancer biology & therapy. 15. (8). p. 1061-1067.

Rupaimoole, Rajesha, Chaluvally-Raghavan, Pradeep, Zhang, Fan, Pradeep, Sunila, Hamilton, Mark P., Zhao, Xi, Moss, Tyler, Lu, Yiling, Yu, Shuangxing, Pecot, Chad V.(2014). Copy number gain of hsa-miR-569 at 3q26. 2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers . Cancer cell. 26. (6). p. 863-879.

Rupaimoole, Rajesha, Joshi, Hemant P., Subramanian, Indira V., Schnettler, Erica K., Ghosh, Goutam, Evans, Colleen, Saluja, Manju, Jing, Yawu, Cristina, Ivan, Roy, Sabita(2014). Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis . Proceedings of the National Academy of Sciences. 111. (14). p. 5331-5336.

Huang, Jie, Hu, Wei, Bottsford-Miller, Justin, Liu, Tao, Han, Hee Dong, Zand, Behrouz, Pradeep, Sunila, Roh, Ju-Won, Thanapprapasr, Duangmani, Dalton, Heather J.(2014). Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib . Clinical Cancer Research. 20. (7). p. 1846-1855.

Pradeep, Sunila, Kim, Seung W., Wu, Sherry Y., Nishimura, Masato, Chaluvally-Raghavan, Pradeep, Miyake, Takahito, Pecot, Chad V., Kim, Sun-Jin, Choi, Hyun Jin, Bischoff, Farideh Z.(2014). Hematogenous metastasis of ovarian cancer: rethinking mode of spread . Cancer Cell. 26. (1). p. 77-91.

Rupaimoole, Rajesha, Van Den Beucken, Twan, Koch, Elizabeth, Chu, Kenneth, Prickaerts, Peggy, Adriaens, Michiel, Voncken, Jan Willem, Harris, Adrian L., Buffa, Francesca M., Haider, Syed(2014). Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER . Nature communications. 5.

Rupaimoole, Rajesha, Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Pecot, Chad V., Gharpure, Kshipra M., Nagaraja, Archana S., Armaiz-Pena, Guillermo N., McGuire, Michael, Zand, Behrouz(2014). Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression . Nature communications. 5.

Rupaimoole, Rajesha, Gharpure, Kshipra M., Chu, Kevin S., Bowerman, Charles J., Miyake, Takahito, Pradeep, Sunila, Mangala, Selanere L., Han, Hee-Dong, Armaiz-Pena, Guillermo N., Rahhal, Tojan B.(2014). Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer . Molecular cancer therapeutics. 13. (7). p. 1750-1757.

Tucker, Susan L., Gharpure, Kshipra, Herbrich, Shelley M., Unruh, Anna K., Nick, Alpa M., Crane, Erin K., Coleman, Robert L., Guenthoer, Jamie, Dalton, Heather J., Wu, Sherry Y.(2014). Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer . Clinical Cancer Research. 20. (12). p. 3280-3288.

Hu, Wei, Liu, Tao, Ivan, Cristina, Sun, Yunjie, Huang, Jie, Mangala, Lingegowda S., Miyake, Takahito, Dalton, Heather J., Pradeep, Sunila, Rupaimoole, Rajesh(2014). Notch3 pathway alterations in ovarian cancer . Cancer research. 74. (12). p. 3282-3293.

Rupaimoole, Rajesha, Pecot, Chad V., Wu, Sherry Y., Bellister, Seth, Filant, Justyna, Hisamatsu, Takeshi, Bhattacharya, Rajat, Maharaj, Anshumaan, Azam, Salma, Rodriguez-Aguayo, Cristian(2014). Therapeutic silencing of KRAS using systemically delivered siRNAs . Molecular cancer therapeutics. 13. (12). p. 2876-2885.

2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity @article{RID:0921161744491-279, title = {2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity}, journal = {Nature communications}, year = {2014}, author = {Wu, Sherry Y. and Yang, Xianbin and Gharpure, Kshipra M. and Hatakeyama, Hiroto and Egli, Martin and McGuire, Michael H. and Nagaraja, Archana S. and Miyake, Takahito M. and Rupaimoole, Rajesha and Pecot, Chad V.}, volume = {5} } . Nature communications.

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer @article{RID:0921161744494-281, title = {Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer}, journal = {Molecular systems biology}, year = {2014}, author = {Yang, Lifeng and Moss, Tyler and Mangala, Lingegowda S. and Marini, Juan and Zhao, Hongyun and Wahlig, Stephen and Armaiz‐Pena, Guillermo and Jiang, Dahai and Achreja, Abhinav and Win, Julia}, volume = {10}, number = {5} } . Molecular systems biology.

Role of focal adhesion kinase in regulating YB–1–mediated paclitaxel resistance in ovarian cancer @article{RID:0921161744497-245, title = {Role of focal adhesion kinase in regulating YB–1–mediated paclitaxel resistance in ovarian cancer}, journal = {Journal of the National Cancer Institute}, year = {2013}, author = {Kang, Yu and Hu, Wei and Ivan, Cristina and Dalton, Heather J. and Miyake, Takahito and Pecot, Chad V. and Zand, Behrouz and Liu, Tao and Huang, Jie and Jennings, Nicholas B.}, pages = {djt210} }. Journal of the National Cancer Institute.

Miller, David F. B., Yan, Pearlly S., Buechlein, Aaron, Rodriguez, Benjamin A., Yilmaz, Ayse S., Goel, Shokhi, Lin, Hai, Collins-Burow, Bridgette, Rhodes, Lyndsay V., Braun, Chris(2013). A new method for stranded whole transcriptome RNA-seq . Methods. 63. (2). p. 126-134.

Rupaimoole, Rajesha, Moreno-Smith, Myrthala, Halder, J. B., Meltzer, Paul S., Gonda, Tamas A., Mangala, Lingegowda S., Lu, Chunhua, Nagaraja, Archana S., Gharpure, Kshipra M., Kang, Yu(2013). ATP11B mediates platinum resistance in ovarian cancer . The Journal of clinical investigation. 123. (5). p. 2119-2130.

Rupaimoole, Rajesha, Moreno-Smith, Myrthala, Lee, Sun Joo, Lu, Chunhua, Nagaraja, Archana S., He, Guangan, Han, Hee Dong, Jennings, Nicholas B., Roh, Ju-Won, Nishimura, Masato(2013). Biologic effects of dopamine on tumor vasculature in ovarian carcinoma. Neoplasia. 15. (5). p. 502-IN15.

Rupaimoole, Rajesha, Yang, Da, Sun, Yan, Hu, Limei, Zheng, Hong, Ji, Ping, Pecot, Chad V., Zhao, Yanrui, Reynolds, Sheila, Cheng, Hanyin(2013). Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer . Cancer cell. 23. (2). p. 186-199.

Rupaimoole, Rajesha, Pecot, Chad V., Yang, Da, Akbani, Rehan, Ivan, Cristina, Lu, Chunhua, Wu, Sherry, Han, Hee-Dong, Shah, Maitri Y., Rodriguez-Aguayo, Cristian(2013). Tumour angiogenesis regulation by the miR-200 family . Nature communications. 4.

Rupaimoole, Rajesha, Stone, Rebecca L., Nick, Alpa M., McNeish, Iain A., Balkwill, Frances, Han, Hee Dong, Bottsford-Miller, Justin, Armaiz-Pena, Guillermo N., Pecot, Chad V., Coward, Jermaine(2012). Paraneoplastic thrombocytosis in ovarian cancer . New England Journal of Medicine. 366. (7). p. 610-618.

Rupaimoole, Rajesha, Han, Hee-Dong, Lopez-Berestein, Gabriel, Sood, Anil K.(2011). MicroRNA therapeutics: principles, expectations, and challenges. Chinese journal of cancer. 30. (6). p. 368.

Zhou, Yang, You, Lu, Wang, Shiwei, Ku, Zhiliang, Fan, Hongjin, Schmidt, Daniel, Rusydi, Andrivo, Chang, Lei, Wang, Le, Ren, Peng(2011). Nature Communications. In vitro.

Sathyanarayana, N., Vikas, P. B., Rajesha, R.(2010). In vitro clonal propagation of Mucuna pruriens var. utilis and its evaluation of genetic stability through RAPD markers . African Journal of Biotechnology. 7. (8).

Sathyanarayana, N., Vikas, P. B., Kumar, T. N., Rajesha, R.(2010). RAPD markers for genetic characterization in Mucuna species . The Indian Journal of Genetics and Plant Breeding. 70. (3). p. 296-298.

Rupaimoole, Rajesha, Zamilpa, Rogelio, Phelix, Clyde F., Somaraki-Cormier, Maria, Haskins, William, Asmis, Reto, LeBaron, Richard G.(2009). C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells . Matrix Biology. 28. (6). p. 347-353.

Sathyanarayana, N., Rajesha, R., Vikas, P. B., Bharath Kumar, T. N.(2008). Somatic embryogenesis and plant regeneration from stem explants of Leptadenia reticulate (Rez) Wight and Arn . Indian journal of Biotechnology. 7. p. 250-254.