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Profile Details
Contact
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USD 200 /hr
Hire Dr. Rachida Nachat-Kappes, Ph.D.
France
USD 200 /hr

R&D expertise in Skin Biology, Active ingredient development, assays for supporting Claim substantiation

Profile Summary
Subject Matter Expertise
Services
Work Experience

Scientific consulting and communication

InnoSkin

October 2016 - Present

R&D project manager

Greentech SA

July 2012 - October 2016

R&D project manager

Greentech Biotechnologies

July 2012 - October 2016

Researcher

INRA Centre Clermont-Ferrand-Theix-Lyon

February 2011 - July 2012

Associate Assistant of Universities

Epidermis Differentiation and Rheumatoid Autoimmunity (UMR 5165)

October 2008 - October 2010

Postdoctoral Fellow

Cancer Research UK

January 2006 - October 2008

Postdoctoral fellow

Cancer Research UK

January 2006 - October 2008

PhD Student

CNRS UMR 5165, University Paul Sabatier

October 2000 - May 2005

PhD Student

Department of Dermatology, Asahikawa Medical College

July 2004 - August 2004

PhD student

INSERM U346/CNRS

June 2003 - July 2003

Master 2

Université de Limoges

June 1998 - August 1999

Education

PhD

Université Paul Sabatier, Toulouse, France

October 2000 - April 2005

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Jean-Yves Berthon, Rachida Nachat-Kappes, Mathieu Bey, Jean-Paul Cadoret, Isabelle Renimel, Edith Filaire(2017). Marine algae as attractive source to skin care . Free Radical Research. 51. (6). p. 555--567. Informa {UK} Limited
Valérie Pendaries, Jeremy Malaisse, Laurence Pellerin, Marina Le Lamer, Rachida Nachat, Sanja Kezic, Anne-Marie Schmitt, Carle Paul, Yves Poumay, Guy Serre, et al.(2014). Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte Differentiation . Journal of Investigative Dermatology. 134. (12). p. 2938--2946. Elsevier {BV}
Bruno Lamas, Rachida Nachat-Kappes, Nicolas Goncalves-Mendes, Florence Mishellany, Adrien Rossary, Marie-Paule Vasson, Marie-Chantal Farges(2013). Dietary fat without body weight gain increases in vivo {MCF}-7 human breast cancer cell growth and decreases natural killer cell cytotoxicity . Molecular Carcinogenesis. 54. (1). p. 58--71. Wiley
Bruno Lamas, Nicolas Goncalves-Mendes, Rachida Nachat-Kappes, Adrien Rossary, Florence Caldefie-Chezet, Marie-Paule Vasson, Marie-Chantal Farges(2013). Leptin modulates dose-dependently the metabolic and cytolytic activities of {NK}-92 cells . Journal of Cellular Physiology. 228. (6). p. 1202--1209. Wiley
Samar Basu, Rachida Nachat-Kappes, Florence Caldefie-Chézet, Marie-Paule Vasson(2013). Eicosanoids and Adipokines in Breast Cancer: From Molecular Mechanisms to Clinical Considerations . Antioxidants {\&} Redox Signaling. 18. (3). p. 323--360. Mary Ann Liebert Inc
Mariya K. Chhatriwala, Sara Cipolat, Lisa M. Sevilla, Rachida Nachat, Fiona M. Watt(2012). Exons 5{\textendash}15 of Kazrin Are Dispensable for Murine Epidermal Morphogenesis and Homeostasis . Journal of Investigative Dermatology. 132. (8). p. 1977--1987. Elsevier {BV}
Rachida Nachat-Kappes, Alexandre Pinel, Kristell Combe, Bruno Lamas, Marie-Chantal Farges, Adrien Rossary, Nicolas Goncalves-Mendes, Florence Caldefie-Chezet, Marie-Paule Vasson, Samar Basu, et al.(2012). Effects of Enriched Environment on {COX}-2, Leptin and Eicosanoids in a Mouse Model of Breast Cancer . {PLoS} {ONE}. 7. (12). p. e51525. Public Library of Science ({PLoS})
Julie Henry, Chiung-Yueh Hsu, Marek Haftek, Rachida Nachat, Heleen D. de Koning, Isabelle Gardinal-Galera, Kiyotaka Hitomi, Stéfana Balica, Catherine Jean-Decoster, Anne-Marie Schmitt, et al.(2011). Hornerin is a component of the epidermal cornified cell envelopes . The {FASEB} Journal. 25. (5). p. 1567--1576. {FASEB}
Marie-Claire Méchin, Rachida Nachat, Fanny Coudane, Véronique Adoue, Jacques Arnaud, Guy Serre, Michel Simon(2011). La d{\'{e}}simination ou citrullination . m{\'{e}}decine/sciences. 27. (1). p. 49--54. {EDP} Sciences
Shibo Ying, Toshio Kojima, Akira Kawada, Rachida Nachat, Guy Serre, Michel Simon, Hidenari Takahara(2010). An Intronic Enhancer Driven by {NF}-$\upkappa$B Contributes to Transcriptional Regulation of Peptidylarginine Deiminase Type I Gene in Human Keratinocytes . Journal of Investigative Dermatology. 130. (11). p. 2543--2552. Elsevier {BV}
R. Nachat, S. Cipolat, L. M. Sevilla, M. Chhatriwala, K. R. Groot, F. M. Watt(2009). {KazrinE} is a desmosome-associated liprin that colocalises with acetylated microtubules . Journal of Cell Science. 122. (22). p. 4035--4041. The Company of Biologists
L. M. Sevilla, R. Nachat, K. R. Groot, F. M. Watt(2008). Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation . Journal of Cell Science. 121. (21). p. 3561--3569. The Company of Biologists
A.-A. Raymond, M.-C. Méchin, R. Nachat, E. Toulza, R. Tazi-Ahnini, G. Serre, M. Simon(2007). Nine procaspases are expressed in normal human epidermis, but only caspase-14 is fully processed . British Journal of Dermatology. 156. (3). p. 420--427. Wiley
Lisa M. Sevilla, Rachida Nachat, Karen R. Groot, John F. Klement, Jouni Uitto, Philippe Djian, Arto Määttä, Fiona M. Watt(2007). Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier . The Journal of Cell Biology. 179. (7). p. 1599--1612. Rockefeller University Press
Céline Foulquier, Mireille Sebbag, Cyril Clavel, Sabine Chapuy-Regaud, Roula Al Badine, Marie-Claire Méchin, Christian Vincent, Rachida Nachat, Michiyuki Yamada, Hidenari Takahara, et al.(2007). Peptidyl arginine deiminase type 2 ({PAD}-2) and {PAD}-4 but not {PAD}-1, {PAD}-3, and {PAD}-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation . Arthritis {\&} Rheumatism. 56. (11). p. 3541--3553. Wiley
Stéphane Chavanas, Marie-Claire Méchin, Rachida Nachat, Véronique Adoue, Fanny Coudane, Guy Serre, Michel Simon(2006). Peptidylarginine deiminases and deimination in biology and pathology: Relevance to skin homeostasis . Journal of Dermatological Science. 44. (2). p. 63--72. Elsevier {BV}
M. C. Méchin, M. Enji, R. Nachat, S. Chavanas, M. Charveron, A. Ishida-Yamamoto, G. Serre, H. Takahara, M. Simon(2005). The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations . Cellular and Molecular Life Sciences. 62. (17). p. 1984--1995. Springer Nature
Rachida Nachat, Marie-Claire Méchin, Marie Charveron, Guy Serre, Jacques Constans, Michel Simon(2005). Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages . Journal of Investigative Dermatology. 125. (1). p. 34--41. Elsevier {BV}
Rachida Nachat, Marie-Claire Méchin, Hidenari Takahara, Stéphane Chavanas, Marie Charveron, Guy Serre, Michel Simon(2005). Peptidylarginine Deiminase Isoforms 1{\textendash}3 Are Expressed in the Epidermis and Involved in the Deimination of K1 and Filaggrin . Journal of Investigative Dermatology. 124. (2). p. 384--393. Elsevier {BV}
Stéphane Chavanas, Marie-Claire Méchin, Hidenari Takahara, Akira Kawada, Rachida Nachat, Guy Serre, Michel Simon(2004). Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, {PADI}6 . Gene. 330. p. 19--27. Elsevier {BV}
Marina GUERRIN, Akihito ISHIGAMI, Marie-Claire MÉCHIN, Rachida NACHAT, Séverine VALMARY, Mireille SEBBAG, Michel SIMON, Tatsuo SENSHU, Guy SERRE(2003). {cDNA} cloning, gene organization and expression analysis of human peptidylarginine deiminase type I . Biochemical Journal. 370. (1). p. 167--174. Portland Press Ltd.
Rachida Nachat, Stéphane Sermadiras, Marc Dumas, Frédéric Bonté, Marie-Hélène Ratinaud(1999). Regulation of the {BCL}-2 family members and betal integrin by cultured normal human keratinocytes treated with all-trans-retinoic acid ({ATRA}) . Biology of the Cell. 91. (7). p. 560--560. Wiley
Y Denizot, A Besse, S Raher, R Nachat, F Trimoreau, V Praloran, A Godard(1999). Interleukin-4 ({IL}-4), but not {IL}-10, regulates the synthesis of {IL}-6, {IL}-8 and leukemia inhibitory factor by human bone marrow stromal cells . Biochimica et Biophysica Acta ({BBA}) - Molecular Cell Research. 1449. (1). p. 83--92. Elsevier {BV}