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Profile Details
Contact
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USD 40 /hr
Hire Dr. Peter Sarkies
United Kingdom
USD 40 /hr
Profile Summary
Subject Matter Expertise
Services
Work Experience

Junior Research Fellow

Imperial College London

October 2015 - Present

Principal Investigator

MRC Clinical Sciences Centre

October 2014 - Present

Postdoctoral Researcher

University of Cambridge

December 2011 - September 2014

Education

PhD

MRC Laboratory of Molecular Biology

October 2008 - May 2012

MBiochem (Biochemistry)

University of Oxford

October 2004 - July 2008

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Peter Sarkies, Toni Beltran, Vahid Shahrezaei, Vaishali Katju (2020). Epimutations driven by small RNAs arise frequently but most have limited duration in Caenorhabditis elegans . Nature Ecology & Evolution.
Peter Sarkies, Samuel H. Lewis, Wolf Reik, Laura Ross, Stevie A. Bain, Eleni Pahita, Stephen A. Smith, Richard Cordaux, Eric A. Miska, Boris Lenhard, et al.(2020). {\-}{\-}{\-}{\-}{\-}{\-}Widespread conservation and lineage-specific diversification of genome-wide {DNA} methylation patterns across arthropods . {PLOS} Genetics. 16. (6). p. e1008864. Public Library of Science ({PLoS})
Peter Sarkies, Ricardo J. Cordeiro Rodrigues, António Miguel de Jesus Domingues, Svenja Hellmann, Sabrina Dietz, Bruno F.M. de Albuquerque, Christian Renz, Helle D. Ulrich, Falk Butter, René F. Ketting(2019). {PETISCO} is a novel protein complex required for 21U {RNA} biogenesis and embryonic viability . Genes {\&} Development. 33. (13-14). p. 857--870. Cold Spring Harbor Laboratory
Peter Sarkies(2019). Molecular mechanisms of epigenetic inheritance: Possible evolutionary implications . Seminars in Cell {\&} Developmental Biology. Elsevier {BV}
Peter Sarkies, Tony Belicard, Pree Jareosettasin(2018). The {piRNA} pathway responds to environmental signals to establish intergenerational adaptation to stress . {BMC} Biology. 16. (1). Springer Nature
Rošić S, Amouroux R, Requena CE, Gomes A, Emperle M, Beltran T, Rane JK, Linnett S, Selkirk ME, Schiffer PH, et al.(2018). Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity . Nature genetics.
Osman GA, Fasseas MK, Koneru SL, Essmann CL, Kyrou K, Srinivasan MA, Zhang G, Sarkies P, Félix MA, Barkoulas M(2018). Natural Infection of C. elegans by an Oomycete Reveals a New Pathogen-Specific Immune Response . Current biology : CB.
Lewis SH, Quarles KA, Yang Y, Tanguy M, Frézal L, Smith SA, Sharma PP, Cordaux R, Gilbert C, Giraud I, et al.(2018). Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements . Nature ecology & evolution.
Peter Sarkies, Alyson Ashe, Jérémie Le Pen, Mélanie Tanguy, Eric A. Miska, A. Simon(2015). Antiviral {RNA} Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans . J. Virol. 89. (23). p. 12035--12046. American Society for Microbiology
Peter Sarkies, Alper Akay, Eric A. Miska(2015). E. coli {OxyS} non-coding {RNA} does not trigger {RNAi} in C. elegans . Sci. Rep. 5. p. 9597. Nature Publishing Group
Peter Sarkies, Alexandra Sapetschnig, Nicolas J. Lehrbach, Eric A. Miska, Nelson C Lau(2015). Tertiary {siRNAs} Mediate Paramutation in C. elegans . {PLoS} Genet. 11. (3). p. e1005078. Public Library of Science ({PLoS})
Peter Sarkies, Murray E. Selkirk, John T. Jones, Vivian Blok, Thomas Boothby, Bob Goldstein, Ben Hanelt, Alex Ardila-Garcia, Naomi M. Fast, Phillip M. Schiffer, et al.(2015). Ancient and Novel Small {RNA} Pathways Compensate for the Loss of {piRNAs} in Multiple Independent Nematode Lineages . {PLOS} Biology. 13. (2). p. e1002061. Public Library of Science ({PLoS})
D. Schiavone, G. Guilbaud, P. Murat, C. Papadopoulou, P. Sarkies, M.-N. Prioleau, S. Balasubramanian, J. E. Sale(2014). Determinants of G quadruplex-induced epigenetic instability in {REV}1-deficient cells . The {EMBO} Journal. 33. (21). p. 2507--2520. {EMBO}
A. Sakaguchi, P. Sarkies, M. Simon, A.-L. Doebley, L. D. Goldstein, A. Hedges, K. Ikegami, S. M. Alvares, L. Yang, J. R. LaRocque, et al.(2014). Caenorhabditis elegans {RSD}-2 and {RSD}-6 promote germ cell immortality by maintaining small interfering {RNA} populations . Proceedings of the National Academy of Sciences. 111. (41). p. E4323--E4331. Proceedings of the National Academy of Sciences
Peter Sarkies, Alexander Frey, Tamar Listovsky, Guillaume Guilbaud, Julian E. Sale(2014). Histone H3.3 Is Required to Maintain Replication Fork Progression after {UV} Damage . Current Biology. 24. (18). p. 2195--2201. Elsevier {BV}
Peter Sarkies, Eric A. Miska(2014). Small {RNAs} break out: the molecular cell biology of mobile small {RNAs} . Nature Reviews Molecular Cell Biology. 15. (8). p. 525--535. Nature Publishing Group
Peter Sarkies, Matt Simon, Kohta Ikegami, Anna-Lisa Doebley, Leonard D. Goldstein, Jacinth Mitchell, Aisa Sakaguchi, Eric A. Miska, Shawn Ahmed(2014). Reduced Insulin/{IGF}-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants . Cell Reports. 7. (3). p. 762--773. Elsevier {BV}
Peter Sarkies, Katharina Gapp, Ali Jawaid, Johannes Bohacek, Pawel Pelczar, Julien Prados, Laurent Farinelli, Eric Miska, Isabelle M Mansuy(2014). Implication of sperm {RNAs} in transgenerational inheritance of the effects of early trauma in mice . Nature Neuroscience. 17. (5). p. 667--669. Nature Publishing Group
Peter Sarkies, Alyson Ashe, Tony Bélicard, Jérémie Le Pen, Lise Frézal, Nicolas J Lehrbach, Marie-Anne Félix, Eric A Miska(2013). A deletion polymorphism in the Caenorhabditis elegans {RIG}-I homolog disables viral {RNA} dicing and antiviral immunity . {eLife}. 2. {eLife} Sciences Organisation, Ltd.
P. Sarkies, E. A. Miska(2013). Is There Social {RNA}? . Science. 341. (6145). p. 467--468. American Association for the Advancement of Science ({AAAS})
P. Sarkies, E. A. Miska(2013). Is There Social {RNA}? . Science. 341. (6145). p. 467--468. American Association for the Advancement of Science ({AAAS})
Peter Sarkies, Eric A. Miska(2013). {RNAi} pathways in the recognition of foreign {RNA}: antiviral responses and host{\textendash}parasite interactions in nematodes: Figure 1 . Biochm. Soc. Trans. 41. (4). p. 876--880. Portland Press Ltd.
P. Sarkies, A. Ashe, J. Le Pen, M. A. McKie, E. A. Miska(2013). Competition between virus-derived and endogenous small {RNAs} regulates gene expression in Caenorhabditis elegans . Genome Research. 23. (8). p. 1258--1270. Cold Spring Harbor Laboratory Press
Peter Sarkies, Alyson Ashe, Alexandra Sapetschnig, Eva-Maria Weick, Jacinth Mitchell, Marloes P. Bagijn, Amy C. Cording, Anna-Lisa Doebley, Leonard D. Goldstein, Nicolas J. Lehrbach, et al.(2012). {piRNAs} Can Trigger a Multigenerational Epigenetic Memory in the Germline of C.~elegans . Cell. 150. (1). p. 88--99. Elsevier {BV}
Peter Sarkies, Julian E. Sale(2012). Cellular epigenetic stability and cancer . Trends in Genetics. 28. (3). p. 118--127. Elsevier {BV}
Peter Sarkies, Julian E. Sale(2011). Propagation of histone marks and epigenetic memory during normal and interrupted {DNA} replication . Cell. Mol. Life Sci. 69. (5). p. 697--716. Springer Science $\mathplus$ Business Media
P. Sarkies, P. Murat, L. G. Phillips, K. J. Patel, S. Balasubramanian, J. E. Sale(2011). {FANCJ} coordinates two pathways that maintain epigenetic stability at G-quadruplex {DNA} . Nucleic Acids Research. 40. (4). p. 1485--1498. Oxford University Press ({OUP})
Peter Sarkies, Charlie Reams, Laura J. Simpson, Julian E. Sale(2010). Epigenetic Instability due to Defective Replication of Structured {DNA} . Molecular Cell. 40. (5). p. 703--713. Elsevier {BV}
I. Vakonakis, D. Staunton, I. R. Ellis, P. Sarkies, A. Flanagan, A. M. Schor, S. L. Schor, I. D. Campbell(2009). Motogenic Sites in Human Fibronectin Are Masked by Long Range Interactions . Journal of Biological Chemistry. 284. (23). p. 15668--15675. American Society for Biochemistry {\&} Molecular Biology ({ASBMB})
Peter Sarkies, Jennifer J. Paynter, Isabelle Andres-Enguix, Stephen J. Tucker(2008). Genetic selection of activatory mutations in {KcsA} . Channels. 2. (6). p. 413--418. Informa {UK} Limited
OTHER
Peter Sarkies, Toni Beltran, Elena Pahita, Subhanita Ghosh, Boris Lenhard(2020). Integrator terminates promoter-proximal Pol {II} to generate C. elegans {piRNA} precursors . Cold Spring Harbor Laboratory
Peter Sarkies, Peter J. Taylor, Jana Hagen, Farid N. Faruqu, Khuloud T. Al-Jamal, Bonnie Quigley, Morgan Beeby, Murray E. Selkirk(2020). Trichinella spiralis secretes abundant unencapsulated small {RNAs} with potential effects on host gene expression . Cold Spring Harbor Laboratory
S. Lewis, L. Ross, S.A. Bain, E. Pahita, S.A. Smith, R. Cordaux, E.M. Miska, B. Lenhard, F.M. Jiggins, P. Sarkies(2020). Widespread conservation and lineage-specific diversification of genome-wide {DNA} methylation patterns across arthropods . Cold Spring Harbor Laboratory
Peter Sarkies, Toni Beltran, Vahid Shahrezaei, Vaishali Katju(2019). Epimutations driven by small {RNAs} arise frequently but have limited duration in a metazoan organism . Cold Spring Harbor Laboratory
REPORT
A. Akay, P. Sarkies, E. A. Miska(2014). E. coli {OxyS} non-coding {RNA} does not trigger {RNAi} in C. elegans . Cold Spring Harbor Laboratory Press