Profile Details

Contact

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Hire Dr. Orion Furmanski

United States

Neurobiologist

Profile Summary

Central nervous system dysfunction often results from aberrant neuronal development processes. For example, chronic pain is associated with excessive neuronal excitation and dendrite growth, whereas autism-associated mutations diminish excitability and dendrite complexity. Central nervous system injuries in adults often fail to repair effectively due to expression of growth inhibitory molecules. In my research career, I have looked to developmental biology for solutions to overcoming neurologic disorders. I directed the in vitro differentiation of neural stem cells, which were subsequently able to combat pain from spinal cord injury. I used a mouse model of a developmental disorder to investigate whether the biochemistry of autism could be used to combat chronic pain. My recent findings suggest that anesthesia impairs hippocampal neuron development and leads to memory deficits during adulthood. I am interested in research positions involving nervous system development and repair which will allow me to gain additional experience in mentorship and teaching of undergraduate and graduate students as well as junior investigators.

Subject Matter Expertise

• ☆ Developmental Biology
• ☆ Animal Behavior/Ethology
• ☆ Mutagenesis
• ☆ Stem Cell Research
• ☆ Anesthesiology
• ☆ Pain Management

Services

• Consulting
• Product development
• Writing
• Data science & analysis
• Research

Writing Grant proposal, Journal article, Educational content

Research Internet research, Evidence-based answers, Secondary data compilation, Literature search

Work Experience

Postdoctoral Researcher

Uniformed Services University of the Health Sciences

July 2016 - Present

Postdoctoral Fellow

Johns Hopkins Medicine

February 2010 - August 2015

Education

Ph.D. (Neuroscience)

University of Miami School of Medicine

August 2000 - December 2009

B.S. (Biological Science)

Purdue University

August 1993 - December 1998

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2017). Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/∆c mutant mouse model. Neurotoxicology and Teratology.

Orion Furmanski, Eunchai Kang, Daniel A. Berg, William M. Jackson, Yun Kyoung Ryu, Christy D. Gray, C. David Mintz(2017). Neurogenesis and developmental anesthetic neurotoxicity . Neurotoxicology and Teratology. 60. p. 33--39. Elsevier {BV}

Orion Furmanski, Minhye Kwak, Sanghee Lim, Eunchai Kang, Hongjun Song, Yun Kyoung Ryu, C. David Mintz(2015). Effects of Neonatal Hypoxic-Ischemic Injury and Hypothermic Neuroprotection on Neural Progenitor Cells in the Mouse Hippocampus . Developmental Neuroscience. 37. (4-5). p. 428--439. S. Karger {AG}

Orion Furmanski, Changsheng Li, Ya Yang, Sufang Liu, Huaqiang Fang, Yong Zhang, John Skinner, Ying Xing, Roger A. Johns, Richard L. Huganir, et al.(2014). Stress Induces Pain Transition by Potentiation of {AMPA} Receptor Phosphorylation . The Journal of Neuroscience. 34. (41). p. 13737--13746. Society for Neuroscience

Li C, Yang Y, Liu S, Fang H, Zhang Y, Furmanski O, Skinner J, Xing Y, Johns RA, Huganir RL, Tao F, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, vol. 34, no. 41, pp. 13737-13746 .

Orion Furmanski, Feng Tao, Qun Li, Su Liu, Haiying Wu, John Skinner, Andres Hurtado, Visar Belegu, Ya Yang, John W. McDonald, et al.(2012). Role of Neuregulin-1/{ErbB} Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain . {STEM} {CELLS}. 31. (1). p. 83--91. Wiley-Blackwell

Orion Furmanski, Jeung Woon Lee, Stanislava Jergova, Shyam Gajavelli, Jacqueline Sagen(2012). Predifferentiated {GABAergic} Neural Precursor Transplants for Alleviation of Dysesthetic Central Pain Following Excitotoxic Spinal Cord Injury . Frontiers in Physiology. 3. Frontiers Media {SA}

Orion Furmanski, Shyam Gajavelli, Jeung Woon Lee, Maria E. Collado, Stanislava Jergova, Jacqueline Sagen(2009). Combined extrinsic and intrinsic manipulations exert complementary neuronal enrichment in embryonic rat neural precursor cultures: An in vitro and in vivo analysis . The Journal of Comparative Neurology. 515. (1). p. 56--71. Wiley-Blackwell

Orion Furmanski, Jeung Woon Lee, Daniel A. Castellanos, Linda A. Daniels, Aldric T. Hama, Jacqueline Sagen(2008). Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury . Neuroscience Letters. 439. (2). p. 212--215. Elsevier {BV}

Gajavelli S, Castellanos DA, Furmanski O, Schiller PC, Sagen J, Cell transplantation, 2008, vol. 17, no. 4, pp. 445-455 .