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Hire Dr. Neil C.

United Kingdom

USD 40 /hr

Profile Summary

I maintain my research interests on gene regulation by the NF-kappaB family of transcription factors. The very nature of this process necessitates that I must understand the fundamental molecular biology of eukaryotic gene transcription. The corollary, therefore, is that my expertise in this area is regularly sought by colleagues from across the Medical School working in fields such as oncology, immunology and cardiovascular science. See https://www.sheffield.ac.uk/oncology-metabolism/staff/chapman for further details 1) Understanding how NF-kappaB and epigenetic markers function to regulate genome function in human myometrium using ChIP-on-chip/ChIP-seq. Funded by the Sheffield Teaching Hospital Charitable Trust, The Medical Faculty Research and Innovation Fund and The Department of Human Metabolism. The work is published in Cookson et al. (2015). Mol. Hum. Reprod. 21:864. 2) Investigating how NF-kappaB and other inflammatory mediators regulate ion channel expression in human myometrium and decidua. Funded by a Wellcome Trust grant of £280,000 to Dr. Raheela Khan (PI University of Nottingham at Derby) and me. This work has been successful and is ongoing. A paper describing the physiological impacts of inflammation on ion channel function is currently being prepared by Dr. Khan. Aspects of the molecular biology data contributed by my lab are now published Waite et al., (2014). Front. Physiol. 5:26. 3) Defining the mechanism by which NF-kappaB-induced inflammation controls Gs expression in the human myometrium. Funded by my first MRC project grant of £447,201. That work is published in J. Biol. Chem. The work is published in Webster et al. (2013) J. Biol. Chem. 288:6704 and was the focus of a BBC science article (www.bbc.co.uk/news/health-216289). I have also developed interest in biomedical science education for both medical undergraduates and post-graduates. I have already developed new lines of interest, two of which have resulted in peer-reviewed papers. 1) SBAs for the Part 1 MRCOG. Andrew Sizer and Neil Chapman. RCOG Press, London 2012. ISBN: 978-1-906985-58-5 2) Describing a framework of simple clinical skills for the medical elective placements. The work is published: [Chapman and Press, Student BMJ 2016;24:i2049]. 3) Accidental hypothermia - examining the effectiveness of mountain rescue casualty bags for casualty insulation. This work was part a Phase 3A medical student project. It is now published: [Press et al. (2017). Extreme Physiology and Medicine, DOI: 10.1186/s13728-017-0055-7].

Subject Matter Expertise

• ★ Molecular Biology
• ★ Reproductive Medicine
• ★ Medical Sciences
• ☆ Epigenetics
• ☆ ChIP-Seq
• ☆ Cardiovascular Disease
• ☆ Medical Education
• ☆ Inflammation
• ☆ Audio Transcription

Services

• Writing

Work Experience

Senior University Teacher

University of Sheffield

January 2018 - Present

Lecturer - Reproductive Medicine

University of Sheffield

July 2005 - Present

Post-Doctoral Research Fellow

University of Newcastle-upon-Tyne

October 2003 - June 2005

Post-Doctoral Research Associate

University of Dundee

June 1997 - September 2003

Education

Education details not provided.

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Neil Chapman, Christopher Press, Christopher Duffy, Jonathan Williams, Ben Cooper (2017). Measurements of rates of cooling of a manikin insulated with different mountain rescue casualty bags . Extreme Physiology & Medicine.

(2016). Immediate Care Skills for Your Elective . Student BMJ.

(2015). Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions ofPHM1-31myometrial smooth muscle cells . Molecular Human Reproduction. 21. (11). p. 865-883.

Waite, S.L., Gandhi, S.V., Khan, R.N., Chapman, N.R.(2014). The effect of trichostatin-A and tumor necrosis factor on expression of splice variants of the MaxiK and L-type channels in human myometrium . Frontiers in Physiology. 5 JUL.

(2013). Human Trophoblast Cells Modulate Endometrial Cells Nuclear Factor κB Response to Flagellin In Vitro . PLoS ONE. 8. (1).

Webster, S.J., Waite, S.L., Cookson, V.J., Warren, A., Khan, R., Gandhi, S.V., Europe-Finner, G.N., Chapman, N.R.(2013). Regulation of GTP-binding Protein (Gαs) Expression in human myometrial cells: A role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes . Journal of Biological Chemistry. 288. (9). p. 6704-6716.

(2010). The expression of inducible nitric oxide synthase in the human fallopian tube during the menstrual cycle and in ectopic pregnancy . Fertility and Sterility. 94. (3). p. 833-840.

Cookson, V.J., Cookson, V.J., Chapman, N.R., Cookson, V.J., Chapman, N.R.(2010). NF-κB function in the human myometrium during pregnancy and parturition . Histology and Histopathology. 25. (7). p. 945-956.

Refaat, B., Amer, S., Ola, B., Chapman, N., Ledger, W.(2008). The expression of activin-βA- and -βB-subunits, follistatin, and activin type II receptors in fallopian tubes bearing an ectopic pregnancy . Journal of Clinical Endocrinology and Metabolism. 93. (1). p. 293-299.

Chapman, N.R., Kennelly, M.M., Harper, K.A., Europe-Finner, G.N., Chapman, N.R., Kennelly, M.M., Harper, K.A., Europe-Finner, G.N., Chapman, N.R., Kennelly, M.M., et al.(2006). Examining the spatio-temporal expression of mRNA encoding the membrane-bound progesterone receptor-alpha isoform in human cervix and myometrium during pregnancy and labour . Molecular Human Reproduction. 12. (1). p. 19-24.

(2005). Expression and interaction of the transcriptional coregulators, CBP/p300, in the human myometrium during pregnancy and labor . Journal of the Society for Gynecologic Investigation. 12. (2). p. 92-97.

(2005). Expression of the GTP-binding protein (Gαs) is repressed by the nuclear factor κB RelA subunit in human myometrium . Endocrinology. 146. (11). p. 4994-5002.

Chapman, N.R., Europe-Finner, G.N., Robson, S.C.(2004). Expression and deoxyribonucleic acid-binding activity of the nuclear factor κB family in the human myometrium during pregnancy and labor . Journal of Clinical Endocrinology and Metabolism. 89. (11). p. 5683-5693.

(2002). A novel form of the RelA nuclear factor κB subunit is induced by and forms a complex with the proto-oncogene c-Myc . Biochemical Journal. 366. (2). p. 459-469.

Campbell, K.J., Chapman, N.R., Perkins, N.D.(2001). UV stimulation induces nuclear factor κB (NF-κB) DNA-binding activity but not transcriptional activation . Biochemical Society Transactions. 29. (6). p. 688-691.

Chapman, N.R., Perkins, N.D.(2000). Inhibition of the RelA(p65) NF-κB subunit by Egr-1 . Journal of Biological Chemistry. 275. (7). p. 4719-4725.

Chapman, N.R., Kessopoulou, E., Chapman, N.R., Kessopoulou, E., Andrews, P.D., Hornby, D.P., Barratt, C.L.R.(1998). The polypeptide backbone of recombinant human zona pellucida glycoprotein-3 initiates acrosomal exocytosis in human spermatozoa in vitro . Biochemical Journal. 330. (2). p. 839-845.

Chapman, N.R., Chapman, N.R., Chapman, N.R., Barratt, C.L.R.(1997). 2. Sperm-zona interaction and recombinant DNA technology . Molecular Human Reproduction. 3. (8). p. 646-650.

Chapman, N.R., Barratt, C.L.R.(1996). The role of carbohydrate in sperm-ZP3 adhesion . Molecular Human Reproduction. 2. (10). p. 767-774.

BOOK

(2012). SBAs for the Part 1 MRCOG.

(2002). Chapter 5 NF-κB function in inflammation, cellular stress and disease . Cell and Molecular Response to Stress. 3. (C). p. 61-73.