Profile Details

Create Project

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Hire Dr. Michelle N.

Profile Summary

I am currently a Visiting Fellow at the Harvard School of Public Health, working with Andrea Baccarelli on environmental epigenetics and mitochondriomics. www.hsph.harvard.edu/michelle-north As a Post-Doctoral Fellow at Queen’s University, I developed a human birth cohort study focused on developmental biology and the prenatal and early life origins of allergic disease. During my graduate research at the University of Toronto, I studied the role of L-arginine metabolism in asthma and the cardiopulmonary response to air pollution.

Subject Matter Expertise

• ☆ Biology/Life Sciences
• ☆ Developmental Biology
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Epigenetics
• ☆ Biotechnology & Bioengineering
• ☆ Pollution Control & Waste Management
• ☆ Air Pollution
• ☆ Environmental Health
• ☆ Immunogenetics
• ☆ Public Health
• ☆ Asthma

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

Work information not provided.

Education

Post Doctoral Fellowship (Allergy & Immunology, Medicine, Biomedical & Molecular Sciences)

Queen's University

January 2011 - Present

PhD Medical Sciences, Specializations in Biomedical Toxicology & Environmental Health (Institute of Medical Science, Pharmacology & Toxicology and School of the Environment)

University of Toronto

January 2006 - March 2011

Hons. BSc Biochemistry (Biochemistry)

University of Waterloo

September 2000 - June 2005

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Michelle North, Anne K. Ellis(2017). Book Review . Annals of Allergy, Asthma & Immunology. 118. (2). p. 238. Elsevier {BV}

Jeremy Alexander Scott, Michelle L. North, Mahroukh Rafii, Hailu Huang, Paul Pencharz, Hartmut Grasemann. Plasma arginine metabolites reflect airways dysfunction in a murine model of allergic airways inflammation. Journal of Applied Physiology Published 2 April 2015 Vol. no. , DOI: 10.1152/japplphysiol.00865.2014 .

Anne K. Ellis, Michelle L. North. Expanding role of controlled allergen challenge facilities in allergic rhinitis research. Ann Allergy Asthma Immunol. 2015 Mar;114(3):159-60. doi: 10.1016/j.anai.2014.12.018 .

North ML, Alexis NE, Ellis AK, Carlsten C. Air Pollution and Asthma: How Can a Public Health Concern Inform the Care of Individual Patients? 2014 Oct;113(4):343-6. doi: 10.1016/j.anai.2014.07.019 .

(2014). Air pollution and asthma: how can a public health concern inform the care of individual patients? . Annals of Allergy, Asthma & Immunology.

Mena Soliman, Michelle L. North, Lisa M. Steacy, Jenny Thiele, Daniel E. Adams, and Anne K. Ellis. Nasal Allergen Challenge Studies of Allergic Rhinitis - A guide for clinicians. Ann Allergy Asthma Immunol. 2014 Sep;113(3):250-256.

6. Michelle L. North, Terry Walker, Lisa M. Steacy, Barnaby G. Hobsbawn, Richard J. Allan, Frances Hackman, Xiaoqun Sun, Andrew G. Day, and Anne K. Ellis. A Double Blind Randomized Crossover Trial of PF-03654764 ± Fexofenadine in the Environmental Exposure Unit. Allergy Asthma Clin Immunol. 2014 Jul 3;10(1):33.

Michelle L. North (2014). Effects of phthalates on the development and expression of allergic disease and asthma. Ann Allergy Asthma Immunol.

2. Anne K. Ellis, Michelle L. North, Terry Walker, and Lisa M. Steacy. Environmental Exposure Unit: A sensitive, specific and reproducible methodology for allergen challenge. Ann Allergy Asthma Immunol (2013) Nov; 111(5):323-8.

3. Andrea Bellavia, Bruce Urch, Mary Speck, Robert D. Brook, Jeremy A. Scott, Benedetta Albetti, Behrooz Behbod, Michelle L. North, Linda Valeri, Pier Alberto Bertazzi, Frances Silverman, Diane Gold, and Andrea Baccarelli. DNA Hypomethylation, Ambient Particulate Matter and Increased Blood Pressure: Findings from Controlled Human Exposure Experiments. J Am Heart Assoc. (2013) Jun 19;2(3):e0002122.

4. Michelle L. North, Hartmut Grasemann, Nivedita Khanna, Mark D. Inman, Gail M. Gauvreau and Jeremy A. Scott. Increased Ornithine-Derived Polyamines cause Airways Hyperresponsiveness in a Mouse Model of Asthma. Am J Respir Cell Mol Biol. 2013 Jun;48(6):694-702.

Michelle L. North (2013). Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma. J Allergy Clin Immunol.

Nina Lakhani, Michelle L. North, and Anne K. Ellis. Clinical Manifestations of Allergic Rhinitis. J Aller Ther. Jun (2012) S5-007 .

Pamela Plant, Michelle L. North, Andrew Ward, Nivedita Khanna, Judy Correa, Jeremy A. Scott and Jane Batt. Hypertrophic Airway Smooth Muscle Mass Correlates with Increased Airway Responsiveness in a Murine Model of Asthma. Am. J. Respir. Cell Mol. Biol. (2012) Apr; 46(4):532-40.

Hajera Amatullah, Michelle L. North, Umme S. Akhtar, Neeraj Rastogi, Bruce Urch, Frances S. Silverman, Chung-Wai Chow, Greg J. Evans, and Jeremy A. Scott. Comparative Cardiopulmonary Effects of Size-Fractionated Airborne Particulate Matter. Inhalation Toxicology. (2012) Feb;24(3):161-71.

16. Michelle L. North, and Jeremy A. Scott. L-arginine Metabolic Pathways in the Airways. The Open Nitric Oxide Journal. 21 Oct (2011), 3 .

9. Jeremy A. Scott, Michelle L. North, Mahroukh Rafii, Hailu Huang, Paul Pencharz, Padmaja Subbarao, Jaques Belik, & Hartmut Grasemann. Asymmetric dimethylarginine is increased in asthma. Am J Respir Crit Care Med. 2011. Oct 1;184(7): 779-85.

11. Michelle L. North and Anne K. Ellis. The role of epigenetics in the developmental origins of allergic disease. Ann Allergy Asthma Immunol. (2011) May;106(5):355-61.

12. Michelle L. North, Hajera Amatullah, Nivedita Khanna, Hartmut Grasemann, Frances Silverman, and Jeremy A. Scott. Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma. Respir Res. (2011) Feb 3;12:19.

13. Monica Ilies, Luigi Di Costanzo, Michelle L. North, Jeremy A. Scott, and David W. Christianson. 2-Aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase 1. J. Med. Chem., (2010) May 27;53(10):4266-76.

20. Michelle L. North, Herman Meurs, Johan Zaagsma, Jeremy A. Scott & Harm Maarsingh. Arginase in Asthma – Recent Developments in Animal and Human Studies. The Open Nitric Oxide Journal, 2:20-36, (2010) .

15. Michelle L. North, Nivedita Khanna, Philip A. Marsden, Hartmut Grasemann, and Jeremy A. Scott. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am J Physiol Lung Cell Mol Physiol (2009) Jun;296(6) L911-20.

16. Christine Lau, Xiaomin Wang, Lihua Song, Michelle L. North, Shahina Wiehler, David Proud and Chung-Wai Chow. Syk associates with clathrin and mediates PI3-kinase activation during human rhinovirus internalization. J Immunol. (2008) Jan 15;180(2):870-80.

2. Jennifer L. Shelton, Lefeng Wang, Gediminas Cepinskas, Martin Sandig, Jeremy A. Scott, Michelle L. North, Richard Inculet and Sanjay Mehta. Inducible NO synthase (iNOS) in human neutrophils but not pulmonary microvascular endothelial cells (PMVEC) mediates septic protein leak in vitro. Microvasc Res. (2007) Jul;74(1):23-31.