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Hire Dr. Marcelo O.

Argentina

USD 30 /hr

Computational Chemistry - Drug discovery - Evolutionary Biology

Profile Summary

I have 35 years of experience as a scientist. I’m a biochemist, pharmacolgist and evolutionary biologist. I'm also involved in several computational chemistry projects with pharma companies. A brief description of my current and former activities can be found in: 1) https://www.linkedin.com/in/marceloortells/ 2) http://www.conicet.gov.ar/new_scp/detalle.php?id=29695 3) www.researchgate.net/profile/Marcelo_Ortells 4) http://scholar.google.com.ar/citations?user=U8cHvE4AAAAJ&hl=en 5) http://www.webometrics.info/es/node/93 6) https://orcid.org/0000-0003-4910-9798. I have also 25 years of experience modelling market research data in Argentina with the French company Ipsos (www.ipsos.com), where I was manager of the Data processing Department (from 1996 to 2006). I was also involved in data modelling for a direct sales (like Avon) company in Argentina, where I was the manager of the Production Planning and Sales forecasting department (2006-2011).

Subject Matter Expertise

• ★ Computational Biology
• ★ Neurochemistry
• ★ Drug Development
• ☆ Natural Product Chemistry
• ☆ Molecular Modeling
• ☆ Molecular Docking
• ☆ Supramolecular Chemistry
• ☆ Biochemistry
• ☆ Molecular Evolution
• ☆ Neuroscience
• ☆ Computational Neuroscience
• ☆ Neuropsychology
• ☆ Neuropharmacology
• ☆ Neurobiology
• ☆ Biophysics
• ☆ Computer Simulation/Computational Modeling
• ☆ SPSS
• ☆ Drug Design
• ☆ Alzheimer's Disease
• ☆ Tobacco Use Prevention & Control
• ☆ Drug Addiction Treatment
• ☆ Depression
• ☆ Neuropsychiatry
• ☆ Psychoactive Drugs

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Market Research, Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis

Work Experience

RESEARCH SCIENTIST

CONICET BUENOS AIRES

July 1994 - Present

RESEARCH OFFICER

British Council

October 1993 - July 1994

POSTDOC FELLOW

CONICET BUENOS AIRES

August 1991 - September 1993

POSTDOC FELLOW

British Council

June 1991 - August 1991

FELLOW

CONICET BUENOS AIRES

January 1989 - May 1991

FELLOW

CONCEJO DE INVESTIGACIONES CIENTIFICAS PCIA BUENOS AIRES

January 1985 - December 1988

TECHNICIANT

INIDEP - NATIONAL INSTITUTE OF FISHERY

July 1978 - January 1979

Education

PhD

University of Buenos Aires

March 1985 - September 1990

LICENCIADO (FACULTY OF SCIENCES)

UNIVERSITY OF MAR DEL PLATA

April 1976 - March 1981

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Arias, H.R., Ortells, M.O., Feuerbach, D., Burgos, V., Paz, C.(2019). Alkaloids Purified from Aristotelia chilensis Inhibit the Human α3β4 Nicotinic Acetylcholine Receptor with Higher Potencies Compared with the Human α4β2 and α7 Subtypes . Journal of Natural Products. 82. (7). p. 1953-1960.

Arias, H.R., Jin, X.-T., Gallino, S., Peng, C., Feuerbach, D., García-Colunga, J., Elgoyhen, A.B., Drenan, R.M., Ortells, M.O.(2019). Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes . Neurochemistry International. 131.

(2018). Bupropion inhibits human $\upalpha$3$\upbeta$4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites . Neurotransmitter. 5. Smart Science and Technology

Arias, H.R., Feuerbach, D., Schmidt, B., Heydenreich, M., Paz, C., Ortells, M.O.(2018). Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes . Journal of Natural Products. 81. (4). p. 811-817.

Arias, H.R., Vázquez-Gómez, E., Hernández-Abrego, A., Gallino, S., Feuerbach, D., Ortells, M.O., Elgoyhen, A.B., García-Colunga, J.(2018). Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms . International Journal of Biochemistry and Cell Biology. 100. p. 1-10.

(2016). Structure and function development during evolution of pentameric ligand gated ion channels . Neurotransmitter. Smart Science and Technology

Arias, H.R., Feuerbach, D., Ortells, M.O.(2016). Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors . Neurochemistry International. 100. p. 67-77.

Arias, H.R., Feuerbach, D., Ortells, M.(2015). Functional and structural interaction of (-)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes . International Journal of Biochemistry and Cell Biology. 64. p. 15-24.

Arias, H.R., Ortells, M.O., Feuerbach, D.(2013). (-)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites . Neurochemistry International. 63. (5). p. 423-431.

Arias, H.R., Fedorov, N.B., Benson, L.C., Lippiello, P.M., Gatto, G.J., Feuerbach, D., Ortells, M.O.(2013). Functional and structural interaction of (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor . Journal of Pharmacology and Experimental Therapeutics. 344. (1). p. 113-123.

Arias, H.R., López, J.J., Feuerbach, D., Fierro, A., Ortells, M.O., Pérez, E.G.(2013). Novel 2-(substituted benzyl)quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms . International Journal of Biochemistry and Cell Biology. 45. (11). p. 2420-2430.

Ortells, M.O., Arias, H.R.(2010). Molecular mechanisms of nicotine dependence . Journal of Pediatric Biochemistry. 1. (2). p. 75-89.

Arias, H.R., Feuerbach, D., Bhumireddy, P., Ortells, M.O.(2010). Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors . International Journal of Biochemistry and Cell Biology. 42. (5). p. 712-724.

Ortells, M.O., Arias, H.R.(2010). Neuronal networks of nicotine addiction . International Journal of Biochemistry and Cell Biology. 42. (12). p. 1931-1935.

Ortells, M.O., Barrantes, G.E.(2010). Tobacco addiction: A biochemical model of nicotine dependence . Medical Hypotheses. 74. (5). p. 884-894.

Ortells, M.O., Arias, H.R.(2010). Molecular mechanisms of nicotine dependence . Journal of Pediatric Biochemistry. 1. (2). p. 75-89.

Arias, HR, Feuerbach, D, Ortells, MO. 2018 Bupropion inhibits human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurotransmiter 5: e1631. doi: 10.14800/nt.1631 .

Ortells, M.O., Barrantes, G.E.(2008). A model for the assembly of nicotinic receptors based on subunit-subunit interactions . Proteins: Structure, Function and Genetics. 70. (2). p. 473-488.

Barrantes, GE, & Ortells, MO. 2007 Receptores nicotínicos y tabaquismo: una trampa evolutiva Psicofarmacología, 7 (47): 18-26.

Barrantes, GE, & Ortells, MO. 2006 A working hypothesis on the interactions between antipsychotics and nicotinic receptors in schizophrenia. Psicofarmacología, 6 (39:) 16-22.

Ortells, M.O., Barrantes, G.E.(2002). Molecular modelling of the interactions of carbamazepine and a nicotinic receptor involved in the autosomal dominant nocturnal frontal lobe epilepsy . British Journal of Pharmacology. 136. (6). p. 883-895.

Ortells, M.O., Barrantes, G.E.(2001). Understanding channel blocking in the nicotinic acetylcholine receptor . Receptors and Channels. 7. (4). p. 273-288.

Ortells, M.O., Barrantes, G.E., Wood, C., Lunt, G.G., Barrantes, F.J.(1997). Molecular modelling of the nicotinic acetylcholine receptor transmembrane region in the open state . Protein Engineering. 10. (5). p. 511-517.

Ortells, M.O.(1997). Prediction of the secondary structure of the nicotinic acetylcholine receptor nontransmembrane regions. Proteins: Structure, Function and Genetics. 29. (3). p. 391-398.

Barrantes, G.E., Ortells, M.O., Barrantes, F.J.(1997). Screening structural-functional relationships of neuropharmacologically active organic compounds at the nicotonic acetylcholine receptor . Neuropharmacology. 36. (3). p. 269-279.

Ortells, M.O., Lunt, G.G.(1996). A mixed helix-beta-sheet model of the transmembrane region of the nicotinic acetylcholine receptor . Protein Engineering. 9. (1). p. 51-59.

10) Otero, AR & Ortells, MO, 1995 Intravenous blood extracting method in penguins: a detailed description in Pygoscelis papua. Contribuciones Instituto Antártico Argentino, 444:1-6.

Massarini A I, Barros, M A, Ortells, MO & Reig, O A, 1995 Chromosome variability in Ctenomys talarum (Rodentia, Octodontidae) from Argentina. Revista Chilena de Historia Natural, 68(2):207-214.

Ortells, M.O., Lunt, G.G.(1995). Evolutionary history of the ligand-gated ion-channel superfamily of receptors . Trends in Neurosciences. 18. (3). p. 121-127.

Ortells, M.O., Lunt, G.G.(1995). Reply . Trends in Neurosciences. 18. (7). p. 298-299.

Ortells, M.O.(1995). Phylogenetic analysis of G-banded karyotypes among the South American subterranean rodents of the genus Ctenomys (Caviomorpha: Octodontidae), with special reference to chromosomal evolution and speciation . Biological Journal of the Linnean Society. 54. (1). p. 43-70.

Lees, G., Ortells, M.O., Lunt, G.G.(1994). Molecular biology and fine structure of ion channels: Potential targets for general anaesthetics in the central nervous system . Anaesthetic Pharmacology Review. 2. (1). p. 11-28.

Ortells, M.O., Lunt, G.G.(1994). The transmembrane region of the nicotinic acetylcholine receptor: Is it an all-helix bundle? . Receptors and Channels. 2. (1). p. 53-59.

ORTELLS, M.O., BARRANTES, G.E.(1994). A study of genetic distances and variability in several species of the genus Ctenomys (Rodentia: Octodontidae) with special references to a probable causal role of chromosomes in speciation . Biological Journal of the Linnean Society. 53. (2). p. 189-208.

Ortells, M.O., Cockcroft, V.B., Lunt, G.G.(1993). Cedit: A c interface and macro facility for protein sequence alignment editing in colour with microsoft word 5.0 for pcs . Bioinformatics. 9. (6). p. 741-744.

Cockcroft, V.B., Ortells, M.O., Thomas, P., Lunt, G.G.(1993). Homologies and disparities of glutamate receptors: A critical analysis . Neurochemistry International. 23. (6). p. 583-594.

Barrantes, G.E., Ortells, M.O., Reig, O.A.(1993). New studies on allozyme genetic distance and variability in akodontine rodents (Cricetidae) and their systematic implications . Biological Journal of the Linnean Society. 48. (4). p. 283-298.

Reig, O.A., Massarini, A.I., Ortells, M.O., Barros, M.A., Dyzenchauz, F.J., Tiranti, S.I.(1992). New karyotypes and C-banding patterns of the subterranean rodents of the genus Ctenomys (Caviomorpha, Octodontidae) from Argentina . Mammalia. 56. (4). p. 603-624.

Massarini, A.I., Barros, M.A., Ortells, M.O., Reig, O.A.(1991). Chromosomal polymorphism and small karyotypic differentiation in a group of Ctenomys species from Central Argentina (Rodentia: Octodontidae) . Genetica. 83. (2). p. 131-144.

Reig, O.A., Busch, C., Ortells, M.O., Contreras, J.R.(1990). An overview of evolution, systematics, population biology, cytogenetics, molecular biology and speciation in Ctenomys . Progress in clinical and biological research. 335. p. 71-96.

Ortells, M.O., Contreras, J.R., Reig, O.A.(1990). New Ctenomys karyotypes (Rodentia, Octodontidae) from north-eastern Argentina and from Paraguay confirm the extreme chromosomal multiformity of the genus . Genetica. 82. (3). p. 189-201.

Ortells, M. O.; Reig, O. A.; Wainberg, R. L.; Hurtado De Catalfo, G. E.; Gentile De Fronza, T. M. L. (1989): Cytogenetics and karyosystematics of Phyllotine rodens (Cricetidae, Sigmodontinae). II. Chromosome multiformity and autosomal polymorphism in Eligmodontia. Z. Saugetierkunde 54, 129–140.

Ortells, M.O., Reig, O.A., Brum-Zorrilla, N., Scaglia, O.A.(1988). Cytogenetics and karyosystematics of phyllotine rodents (Cricetidae, Sigmodontinae) I. Chromosome multiformity and gonosomal-autosomal translocation in Reithrodon . Genetica. 77. (1). p. 53-63.

BOOK CHAPTER

Ortells, MO & Arias, HR 2011 Neurochemical mechanisms underlying nicotine dependence. In: Pharmacology of Nicotinic Acetylcholine Receptors from the Basic and Therapeutic Perspectives. Research Signpost, Kerala, India, Chapter 10: 199-221.

Marcelo O. Ortells(1998). Evolution of the AChR and Other Ligand-Gated Ion Channels . The Nicotinic Acetylcholine Receptor. p. 11--30. Springer Berlin Heidelberg

(1998). Molecular Modeling of the Nicotinic Acetylcholine Receptor . The Nicotinic Acetylcholine Receptor.

M. O. Ortells and V. B. Cockcroft and G. G. Lunt and D. Marsh and F. J. Barrantes(1992). The Nicotinic Acetylcholine Receptor and its Lipid Microenvironment . The Jerusalem Symposia on Quantum Chemistry and Biochemistry. p. 185--198. Springer Netherlands

BOOK

COCKCROFT, V., ORTELLS, M., LUNT, G.(1995). Ligands, Receptor Models, and Evolution . Annals of the New York Academy of Sciences. 757. (1). p. 40-47.