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Hire Dr. Lee B.

United Kingdom

CEO - Chi-Squared Innovations ★ Telling Stories With Data ★ www.chi2innovations.com

Profile Summary

I have a very broad range of expertise within science, having in-depth knowledge of physics, medical physics, bioinformatics, medicine, artificial intelligence, computer programming, mathematics and statistics. Having left academia to form a start-up company, I now work as CEO and Chief Data Scientist for Chi-Squared Innovations - an innovative company that creates automated, visually intuitive statistical applications that save time and money.

Subject Matter Expertise

• ☆ Biostatistics
• ☆ Data Analysis
• ☆ Data Visualization
• ☆ Artificial Intelligence
• ☆ Statistics
• ☆ Health Data Analysis
• ☆ Bioinformatics
• ☆ Physics
• ☆ Mathematics
• ☆ Medicine
• ☆ Health Informatics
• ☆ User Research
• ☆ Quantitative User Research
• ☆ Qualitative User Research
• ☆ Medical Writing
• ☆ Medical Content Writing
• ☆ Medical Copywriting
• ☆ Technical & Scientific Writing
• ☆ Textbook Content Writing
• ☆ Science Communication
• ☆ Copywriting
• ☆ Emails & Newsletters
• ☆ Marketing Copy
• ☆ Social Media Copy
• ☆ Web Copy
• ☆ Blog Posts

Services

• Writing
• Research
• Data & AI

Writing Medical Writing, Technical Writing

Research Feasibility Study

Data & AI Predictive Modeling, Statistical Analysis

Work Experience

CEO & Chief Data Scientist

Chi-Squared Innovations

May 2012 - Present

Statistical Programmer

University of Dundee

May 2006 - March 2013

Data Analyst

University of Abertay Dundee

November 2004 - April 2006

Education

PhD Artificial Intelligence (Computing)

University of Abertay Dundee

September 2001 - November 2005

MSc Bioinformatics (Computing)

University of Abertay Dundee

September 2000 - September 2001

MSc Medical Physics (Medical Physics)

University of Aberdeen

September 1999 - September 2000

BSc Physics (Physics)

Swansea University

September 1991 - June 1994

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Ghaemi, Joseph and El-Mokadem, Ismail and Coles, Bernadette and Baker, Lee and Dahm, Philipp and Canfield, Steven E and Nabi, Ghulam(2015). Safety and diagnostic accuracy of image guided biopsies in patients with small renal masses. The Cochrane Library. John Wiley \& Sons, Ltd

Dayal, JHS and Sales, MJ and Corver, WE and Purdie, CA and Jordan, LB and Quinlan, PR and Baker, L and ter Haar, NT and Pratt, NR and Thompson, AM(2013). Multiparameter DNA content analysis identifies distinct groups in primary breast cancer. British journal of cancer. 108. (4). p. 873--880. Nature Publishing Group

Lekanidi, K and Evans, AL and Shah, J and Jaspan, T and Baker, L and Evans, AJ(2013). Pattern of brain metastatic disease according to HER-2 and ER receptor status in breast cancer patients. Clinical radiology. 68. (10). p. 1070--1073. Elsevier

Palmer, TJ and Nicoll, SM and McKean, ME and Park, AJ and Bishop, D and Baker, L and Imrie, JEA(2013). Prospective parallel randomized trial of the MultiCyte™ ThinPrep® imaging system: the Scottish experience. Cytopathology. 24. (4). p. 235--245. Wiley Online Library

Kelly, P and Paulin, F and Lamont, D and Baker, L and Clearly, S and Exon, D and Thompson, A(2012). Pre-treatment plasma proteomic markers associated with survival in oesophageal cancer. British journal of cancer. 106. (5). p. 955--961. Nature Publishing Group

Macaskill, EJ and Dewar, S and Purdie, CA and Brauer, K and Baker, L and Brown, DC(2012). Sentinel node biopsy in breast cancer has a greater node positivity rate than axillary node sample: results from a retrospective analysis. European Journal of Surgical Oncology (EJSO). 38. (8). p. 662--669. Elsevier

Paterson, F and Buchanan, D and Macivor, F and Baker, L and Levack, P(2012). Short-stay, specialist beds in a UK teaching hospital as a model to integrate palliative care into the acute hospital culture. The journal of the Royal College of Physicians of Edinburgh. 42. (1). p. 8--14.

Paterson, Fiona and Buchanan, Deans and MacIvor, Frances and Lundie, Susan and Levack, Pamela and Baker, Lee(2012). Changing hospital culture: the role of an acute palliative care unit. BMJ Supportive & Palliative Care. 2. (Suppl 1). p. A88--A89. British Medical Journal Publishing Group

Evans, A and Whelehan, P and Thomson, K and Brauer, K and Jordan, L and Purdie, C and McLean, D and Baker, L and Vinnicombe, S and Thompson, A(2012). Differentiating benign from malignant solid breast masses: value of shear wave elastography according to lesion stiffness combined with greyscale ultrasound according to BI-RADS classification. British journal of cancer. 107. (2). p. 224--229. Nature Publishing Group

Evans, Andrew and Whelehan, Patsy and Thomson, Kim and McLean, Denis and Brauer, Katrin and Purdie, Colin and Baker, Lee and Jordan, Lee and Rauchhaus, Petra and Thompson, Alastair(2012). Invasive breast cancer: relationship between shear-wave elastographic findings and histologic prognostic factors. Radiology. 263. (3). p. 673--677. Radiological Society of North America, Inc.

Groves, Michael J and Sales, Mark and Baker, Lee and Griffiths, Michael and Pratt, Norman and Tauro, Sudhir(2011). Factors influencing a second myeloid malignancy in patients with Philadelphia-negative-7 or del (7q) clones during tyrosine kinase inhibitor therapy for chronic myeloid leukemia. Cancer genetics. 204. (1). p. 39--44. Elsevier

Hadad, Sirwan and Iwamoto, Takayuki and Jordan, Lee and Purdie, Colin and Bray, Susan and Baker, Lee and Jellema, Gera and Deharo, Steve and Hardie, D Grahame and Pusztai, Lajos and others(2011). Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast cancer research and treatment. 128. (3). p. 783--794. Springer US

Nabi, Ghulam and Nicolson, Donald J and Tait, Campbell and El-Mokadem, Ishmail and Chuen, Chi and Baker, Lee(2011). Evidence based recommendations for examining the usefulness of image guided renal biopsies in the management of small/indeterminate renal mass. Journal of Endourology. 25. (Suppl. 1). p. A67--A68. Mary Ann Liebert Inc.

Hadad, Sirwan and Iwamoto, Takayuki and Jordan, Lee and Purdie, Colin and Bray, Susan and Baker, Lee and Jellema, Gera and Deharo, Steve and Hardie, D Grahame and Pusztai, Lajos and others(2011). Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast cancer research and treatment. 128. (3). p. 783--794. Springer

Martin, Amy J and Grant, Andrew and Ashfield, Alison M and Palmer, Colin N and Baker, Lee and Quinlan, Philip R and Purdie, Colin A and Thompson, Alastair M and Jordan, Lee B and Berg, Jonathan N(2011). FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype. BMC research notes. 4. (1). p. 72. BioMed Central Ltd

Eadie, A and Whelehan, P and Baker, L and Berg, J and Evans, A(2011). Improving the validity of breast density assessment. Breast Cancer Research. 13. p. 1--13. BioMed Central

Tait, Campbell and Tandon, Salil and Baker, Lee and Goodman, Chris and Townell, Nicholas and Nabi, Ghulam(2011). Long-term oncologic outcomes of laparoscopic radical nephrectomy for kidney cancer resection: Dundee cohort and metaanalysis of observational studies. Surgical endoscopy. 25. (10). p. 3154--3161. Springer

Purdie, CA and Quinlan, P and Jordan, LB and Ashfield, A and Baker, L and Dewar, JA and Thompson, AM(2011). P4-02-06: Progesterone Receptor Expression Predicts Poor Outcome in Estrogen Receptor Positive, Lymph Node Negative Breast Cancer--A Population Based Study. Cancer Research. 71. (24 Supplement). p. P4--02. American Association for Cancer Research

Buchanan, D and Milroy, R and Baker, L and Thompson, AM and Levack, P(2011). Prevalence and predictors of supportive care needs in lung cancer patients. BMJ Supportive & Palliative Care. 1. (Suppl 1). p. A18--A19. British Medical Journal Publishing Group

Bourdon, Jean-Christophe and Khoury, Marie P and Diot, Alexandra and Baker, Lee and Fernandes, Kenneth and Aoubala, Mustapha and Quinlan, Philip and Purdie, Colin A and Jordan, Lee B and Prats, Anne-Catherine and others(2011). p53 mutant breast cancer patients expressing p53g have as good a prognosis as wild-type p53 breast cancer patients. Breast Cancer Res. 13. (1). p. R7.

Christie, Lesley J and MacKenzie, Carol and Palmer, Timothy J and Baker, Lee and Goodlad, John R(2011). Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders. Histopathology. 59. (3). p. 421--432. Wiley Online Library

Martin, AJ and White, S and Onen, A and Gale, J and Dunlop, J and Baker, L and Thompson, AM and Pharoah, PDP and Berg, JN(2010). Abstract P3-12-11: Combining Genotype at Low Penetrance Breast Cancer Loci with Family History Risk Leads to Significant Risk Reclassification. Cancer Research. 70. (24 Supplement). p. P3--12. AACR

Whelehan, Patsy and Baker, Lee and Evans, Andy(2010). An audit of pain in ultrasound-guided breast core biopsy. Breast Cancer Research. 12. p. 1--1. BioMed Central

Evans, Andrew and Whelehan, Patsy and Thomson, Kim and McLean, Denis and Brauer, Katrin and Purdie, Colin and Jordan, Lee and Baker, Lee and Thompson, Alastair(2010). Quantitative shear wave ultrasound elastography: initial experience in solid breast masses. Breast Cancer Res. 12. (6). p. R104.

Lem{\'e}e, Fanny and Bergoglio, Val{\'e}rie and Fernandez-Vidal, Anne and Machado-Silva, Alice and Pillaire, Marie-Jeanne and Bieth, Anne and Gentil, Catherine and Baker, Lee and Martin, Anne-Laure and Leduc, Claire and others(2010). DNA polymerase $θ$ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proceedings of the National Academy of Sciences. 107. (30). p. 13390--13395. National Acad Sciences

Kelly, P and Appleyard, V and Murray, K and Paulin, F and Lamont, D and Baker, L and Suttie, S and Exon, D and Thompson, A(2010). Detection of oesophageal cancer biomarkers by plasma proteomic profiling of human cell line xenografts in response to chemotherapy. British journal of cancer. 103. (2). p. 232--238. Nature Publishing Group

Tauro, Sudhir and Cochrane, Lynda and Lauritzsen, Grete Fossum and Baker, Lee and Delabie, Jan and Roberts, Claudia and Mahendra, Premini and Holte, Harald(2010). Dose-intensified treatment of Burkitt lymphoma and B-cell lymphoma unclassifiable,(with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma) in young adults (< 50 years): a comparison of two adapted BFM protocols. Am J Hematol. 85. (4). p. 261--3.

Bray, Susan E and Paulin, Fiona EM and Fong, Siew Chinn and Baker, Lee and Carey, Frank A and Levison, David A and Steele, Robert JC and Kernohan, Neil M(2010). Gene expression in colorectal neoplasia: modifications induced by tissue ischaemic time and tissue handling protocol. Histopathology. 56. (2). p. 240--250. Wiley Online Library

Roy, Pankaj G and Pratt, Norman and Purdie, Colin A and Baker, Lee and Ashfield, Alison and Quinlan, Phil and Thompson, Alastair M(2010). High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancer. International Journal of Cancer. 127. (2). p. 355--360. Wiley Online Library

Purdie, CA and Baker, L and Ashfield, A and Chatterjee, S and Jordan, LB and Quinlan, P and Adamson, DJA and Dewar, JA and Thompson, AM(2010). Increased mortality in HER2 positive, oestrogen receptor positive invasive breast cancer: a population-based study. British journal of cancer. 103. (4). p. 475--481. Nature Publishing Group

Buchanan, D and Milroy, R and Baker, L and Thompson, AM and Levack, PA(2010). Perceptions of anxiety in lung cancer patients and their support network. Supportive care in cancer. 18. (1). p. 29--36. Springer

Moore, Hayley C and Jordan, Lee B and Bray, Susan E and Baker, Lee and Quinlan, Philip R and Purdie, Colin A and Thompson, Alastair M and Bourdon, Jean-Christophe and Fuller-Pace, Frances V(2010). The RNA helicase p68 modulates expression and function of the $Δ$133 isoform (s) of p53, and is inversely associated with $Δ$133p53 expression in breast cancer. Oncogene. 29. (49). p. 6475--6484. Nature Publishing Group

Baker, L and Quinlan, PR and Patten, N and Ashfield, A and Birse-Stewart-Bell, LJ and McCowan, C and Bourdon, JC and Purdie, CA and Jordan, LB and Dewar, JA and others(2010). p53 mutation, deprivation and poor prognosis in primary breast cancer. British journal of cancer. 102. (4). p. 719--726. Nature Publishing Group

Quinlan, PR and Sreseli, R and Quinlan, RA and Hadad, S and Bray, SE and Kernohan, N and Kellock, D and Baker, L and Purdie, C and Jordan, L and others(2009). $α$B-crystallin, vimentin and increased p53 expression levels in breast cancer is associated with poor prognosis. Cancer Research. 69. (2 Supplement). p. 5070. American Association for Cancer Research

Levack, Pamela and Allan, Lynsay and Baker, Lee and McLeay, Trudy and Houston, Graeme and Dewar, John and Eljamel, Sam and Grant, Robert and Munro, Alastair(2009). Coordination improves outcomes in malignant cord compression. BMJ. 338. p. a3151. British Medical Journal Publishing Group

Chatterjee, JS and Lee, A and Anderson, W and Baker, L and Stevenson, JH and Dewar, JA and Thompson, AM(2009). Effect of postoperative radiotherapy on autologous deep inferior epigastric perforator flap volume after immediate breast reconstruction. British Journal of Surgery. 96. (10). p. 1135--1140. Wiley Online Library

Hadad, Sirwan M and Baker, Lee and Quinlan, Philip R and Robertson, Katherine E and Bray, Susan E and Thomson, George and Kellock, David and Jordan, Lee B and Purdie, Colin A and Hardie, David G and others(2009). Histological evaluation of AMPK signalling in primary breast cancer. BMC cancer. 9. (1). p. 1. BioMed Central

Sreseli, R and Quinlan, P and Quinlan, R and Bray, S and Kellok, D and Baker, L and Jordan, L and Purdie, C and Thompson, A(2009). NF-kB Complex Activation and Association of $α$B-Crystallin and Vimentin with Poor Prognosis in Primary Breast Cancer. Cancer research. 69. (24 Supplement). p. 2143--2143. AACR

Sreseli, R and Quinlan, P and Quinlan, R and Hadad, S and Bray, S and Kellock, D and Baker, L and Jordan, L and Purdie, C and Thompson, A(2009). PP59 Prognostic significance of aB-crystallin, vimentin and HSP 27 association in primary breast cancer. European Journal of Cancer Supplements. 7. (4). p. 31. Elsevier

Sreseli, R and Quinlan, P and Quinlan, R and Hadad, S and Bray, S and Kellock, D and Baker, L and Jordan, L and Purdie, C and Thompson, A(2009). PP59 Prognostic significance of aB-crystallin, vimentin and HSP 27 association in primary breast cancer. European Journal of Cancer Supplements. 7. (4). p. 31. Elsevier

Shah, R and Smith, P and Purdie, C and Quinlan, P and Baker, L and Aman, P and Thompson, AM and Crook, T(2009). The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer. British journal of cancer. 100. (10). p. 1687--1696. Nature Publishing Group

Allan, L and Baker, L and Dewar, J and Eljamel, S and Grant, RM and Houston, JG and McLeay, T and Munro, AJ and Levack, P(2009). Suspected malignant cord compression--improving time to diagnosis via a ‘hotline’: a prospective audit. British journal of cancer. 100. (12). p. 1867--1872. Nature Publishing Group

Staples, Oliver D and Hollick, Jonathan J and Campbell, Johanna and Higgins, Maureen and McCarthy, Anna R and Appleyard, Virginia and Murray, Karen E and Baker, Lee and Thompson, Alastair and Ronseaux, Sebastien and others(2008). Characterization, chemical optimization and anti-tumor activity of a tubulin poison identified by a p53-based phenotypic screen. Cell Cycle. 7. (21). p. 3417--3427. Taylor \& Francis

Lain, Sonia and Hollick, Jonathan J and Campbell, Johanna and Staples, Oliver D and Higgins, Maureen and Aoubala, Mustapha and McCarthy, Anna and Appleyard, Virginia and Murray, Karen E and Baker, Lee and others(2008). Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer cell. 13. (5). p. 454--463. Elsevier

Paulin, Fiona EM and O'Neill, Mary and McGregor, Gillian and Cassidy, Andrew and Ashfield, Alison and Ali, Clinton W and Munro, Alastair J and Baker, Lee and Purdie, Colin A and Lane, David P and others(2008). MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism. BMC cancer. 8. (1). p. 1. BioMed Central

Baker, L and Ellison, D(2008). Optimisation of pedotransfer functions using an artificial neural network ensemble method. Geoderma. 144. (1). p. 212--224. Elsevier

Levack, P and Buchanan, D and Dryden, H and Baker, L(2008). Specialist palliative care provision in a major teaching hospital and cancer centre-an eight-year experience. JOURNAL-ROYAL COLLEGE OF PHYSICIANS OF EDINBURGH. 38. (2). p. 112. Royal College of Physicians of Edinburgh.

Baker, L and Ellison, D(2008). The wisdom of crowds—ensembles and modules in environmental modelling. Geoderma. 147. (1). p. 1--7. Elsevier

Thompson, A and Patten, N and Diot, A and Truong, SC and Bray, S and Ashfield, A and Baker, L and Quinlan, P and Wu, L and Bourdon, J(2007). The clinical relevance of p53 isoforms modifying the effects of p53 mutation on survival from breast cancer. ASCO Annual Meeting Proceedings. 25. (18\_suppl). p. 10505.

Hadad, Sirwan M and Vaidya, Jayant S and Baker, Lee and Koh, Hoey C and Heron, Timothy P and Thompson, Alastair M(2007). Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis. World journal of surgery. 31. (6). p. 1300--1303. Springer

McCallum, Stephen J and Welch, Andrew E and Baker, Lee(2001). A digital phantom of the axilla based on the Visible Human Project data set. Nuclear Science, IEEE Transactions on. 48. (4). p. 1418--1422. IEEE

Eadie, A and Whelehan, P and Baker, L and Berg, J and Evans, AAn audit of Intra and Inter-observer Variability in Breast Density Assessment using BI-RADS and VAS.

CONFERENCE PAPER

Thompson, AM and Iwamoto, T and Jordan, L and Purdie, C and Bray, SE and Baker, L and Hardie, G and Pusztai, L and Moulder, SL and Dewar, JA and others(2011). Final analysis of the NEOMET trial of neoadjuvant metformin: examining effects on Ki67, gene expression, and pathway analysis in primary operable breast cancer. JOURNAL OF CLINICAL ONCOLOGY. 29. (15).

Merrick, C and Dunlop, J and Baker, L and Gellatly, E and Martin, A and Quinlan, P and Tavendale, R and Thompson, AM and Palmer, C and Reis, M and others(2011). Identifying women at increased risk of breast cancer; Can we use genotyping at low penetrance loci?. JOURNAL OF CLINICAL ONCOLOGY. 29. (27).

Coats, MV and Walsh, SV and Baker, L and Jordan, L and Thompson, AM and Exon, DJ(2011). Prognostic impact of P53 expression in oesophageal adenocarcinoma. BRITISH JOURNAL OF SURGERY. 98. p. 24--25.

Sreseli, R and Quinlan, PR and Quinlan, RA and Hadad, S and Bray, S and Kellock, D and Baker, L and Purdie, C and Jordan, L and Thompson, AM(2009). ASSOCIATION OF AB-CRYSTALLIN, VIMENTIN WITH POOR PROGNOSIS IN PRIMARY BREAST CANCER. ANNALS OF ONCOLOGY. 20. p. 53--53.

Bergoglio, V and Lemee, F and Machado-Silva, A and Pillaire, MJ and Gentil, C and Baker, L and Martin, AL and Leduc, C and Lam, E and Magdeleine, E and others(2009). Gene expression of 3R in breast tumors from the CAPS01 protocol. BULLETIN DU CANCER. 96. p. S32--S33.

Purdie, CA and Baker, L and Ashfield, A and Chatterjee, S and Jordan, L and Quinlan, P and Adamson, D and Dewar, J and Thompson, A(2009). INFLUENCE OF HER2 STATUS ON CLINICAL OUTCOME IN BREAST CANCER: A POPULATION BASED STUDY. ANNALS OF ONCOLOGY. 20. p. 51--51.

Chatleree, J and Lee, A and Baker, L and Anderson, W and Dewar, JA and Stevenson, JH and Thompson, AM(2007). Post-operative radiotherapy does not adversely affect the outcome of autologous free abdominal nap breast reconstruction. BREAST CANCER RESEARCH AND TREATMENT. 106. p. S195--S195.

Hadad, SM and Robertson, KE and Baker, L and Bray, SE and Purdie, CA and Jordan, L and Vendrell, JA and Cohen, PA and Thomson, AM(2007). Identification of IGFBP4 as a marker of tamoxifen failure in primary breast cancer. BREAST CANCER RESEARCH AND TREATMENT. 106. p. S64--S64.

Paulin, FE and O'Neill, M and McGregor, G and Cassidy, A and Ashfield, A and Ali, CW and Baker, L and Munro, AJ and Lane, DP and Thompson, AM(2007). Novel Mdm2 intron 1 single nucleotide polymorphisms and their role in breast cancer. BREAST CANCER RESEARCH AND TREATMENT. 106. p. S285--S285.

DISSERTATION THESIS

Baker, L(2005). Optimisation of pedotransfer function models for soil hydraulic properties using an artificial neural network ensemble method.