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Profile Details
Contact
★★★★★
☆☆☆☆☆
USD 140 /hr
Hire Dr. Lawrence Segal
Spain
USD 140 /hr

Freelance Regulatory Toxicologist (chemical and pharmaceutical)

Profile Summary
Subject Matter Expertise
Services
Writing Journal article, Regulatory documents, Clinical trial documents
Research Internet research, Secondary data compilation, Literature search
Work Experience

Senior Toxicologist (freelance)

Freelance

January 2018 - Present

Senior Toxcologist

Penman Consulting

September 2015 - December 2017

Director, Nonclinical Toxicology & Pharmacology, Global Regulatory Affairs

GSK Vaccines

April 2006 - August 2015

Global Toxicology & Regulatory Specialist

GE Advanced Materials

September 2004 - March 2006

Senior Toxicologist/Team Leader, Hazard Assessment

Huntsman Europe

April 2000 - August 2004

Senior Toxicologist and Head, WHMIS Evaluation Section

Health Canada, Product Safety Bureau, WMIS Division

January 1990 - March 2000

Education

PhD

University of Saskatchewan

September 1984 - October 1987

M.Sc.

Carleton University

September 1978 - September 1980

B.Sc. Hons

Carleton University

September 1974 - June 1978

Certifications
Publications
JOURNAL ARTICLE
Delannois F, Planty C, Giordano G, Destexhe E, Stanislaus D, Da Silva FT, Stegmann JU, Thacker K, Reynaud L, Garçon N, et al.(2017). Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits . Reproductive toxicology (Elmsford, N.Y.).
Segal L, Thacker K, Fochesato M, Giordano G, Garçon N, Destexhe E(2017). Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre- and post-natal development in Sprague-Dawley rats . Reproductive toxicology (Elmsford, N.Y.).
Giordano G, Segal L, Prinsen M, Wijnands MV, Garçon N, Destexhe E(2016). Non-clinical safety assessment of single and repeated administration of gE/AS01 zoster vaccine in rabbits . Journal of applied toxicology : JAT.
Gérard C, Baudson N, Ory T, Segal L, Louahed J(2015). A Comprehensive Preclinical Model Evaluating the Recombinant PRAME Antigen Combined With the AS15 Immunostimulant to Fight Against PRAME-expressing Tumors . Journal of immunotherapy (Hagerstown, Md. : 1997).
Segal L, Roger V, Williams C, Destexhe E, Garçon N(2015). Effects of Adjuvant Systems on the cardiovascular and respiratory functions in telemetered conscious dogs and anaesthetised rats . Regulatory toxicology and pharmacology : RTP.
Garçon N, Silvano J, Kuper CF, Baudson N, Gérard C, Forster R, Segal L(2015). Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys . Journal of applied toxicology : JAT.
Segal L, Morelle D, Kaaber K, Destexhe E, Garçon N(2015). Non-clinical safety assessment of single and repeated intramuscular administration of a human papillomavirus-16/18 vaccine in rabbits and rats . Journal of applied toxicology : JAT.
Segal L, Wouters S, Morelle D, Gautier G, Le Gal J, Martin T, Kuper F, Destexhe E, Didierlaurent AM, Garçon N(2015). Non-clinical safety and biodistribution of AS03-adjuvanted inactivated pandemic influenza vaccines . Journal of applied toxicology : JAT.
Destexhe E, Stannard D, Wilby OK, Grosdidier E, Baudson N, Forster R, Gérard CM, Garçon N, Segal L(2014). Nonclinical reproductive and developmental safety evaluation of the MAGE-A3 Cancer Immunotherapeutic, a therapeutic vaccine for cancer treatment . Reproductive toxicology (Elmsford, N.Y.).
Segal L, Morelle D, Blee M, Moore E, Damsten M, Liu KC, Destexhe E, Garçon N(2014). Local tolerance and systemic toxicity of single and repeated intramuscular administrations of two different formulations of the RTS,S malaria candidate vaccine in rabbits . Regulatory toxicology and pharmacology : RTP.
Destexhe E, Grosdidier E, Baudson N, Forster R, Gerard C, Garçon N, Segal L(2014). Non-clinical safety evaluation of single and repeated intramuscular administrations of MAGE-A3 Cancer Immunotherapeutic in rabbits and cynomolgus monkeys . Journal of applied toxicology : JAT.
Destexhe E, Prinsen MK, van Schöll I, Kuper CF, Garçon N, Veenstra S, Segal L(2013). Evaluation of C-reactive protein as an inflammatory biomarker in rabbits for vaccine nonclinical safety studies . Journal of pharmacological and toxicological methods.
Lorin C, Segal L, Mols J, Morelle D, Bourguignon P, Rovira O, Mettens P, Silvano J, Dumey N, Le Goff F, et al.(2012). Toxicology, biodistribution and shedding profile of a recombinant measles vaccine vector expressing HIV-1 antigens, in cynomolgus macaques . Naunyn-Schmiedeberg's archives of pharmacology.
Garçon N, Segal L, Tavares F, Van Mechelen M(2011). The safety evaluation of adjuvants during vaccine development: the AS04 experience . Vaccine.
Cote R, Davis H, Dimock C, Korpan M, Loewen K, Segal LM(1998). The evaluation and hazard classification of toxicological information for workplace hazardous materials information system material safety data sheets . Regulatory toxicology and pharmacology : RTP.
Lipnick RL, Cotruvo JA, Hill RN, Bruce RD, Stitzel KA, Walker AP, Chu I, Goddard M, Segal L, Springer JA(1995). Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures . Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.