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Hire Dr. Khoa N.

Vietnam

USD 200 /hr

Life Sciences Expert with 15-Year Experience in Immunology, Metabolism, Neuroscience, and Biotech Entrepreuneuship

Profile Summary

Dr. Nguyen is currently available for scientific consulting (technical due diligence, biotech startup strategy, preclinical study design, etc.) as well as scientific writing and editing projects. Dr. Nguyen is an experienced immunologist who specializes in studies of cellular and molecular mechanisms by which innate immunity and energy metabolic pathways regulate disease development. He has more than 15 years of experience in building innovative preclinical research programs to investigate neurological, metabolic, and inflammatory diseases as well as 7 years of experience in early stage biotechnology R&D (including drug screening, pharmacology and toxicology). His PhD thesis work at the intersection of immunology and metabolism resulted in the discovery of the critical role of innate immunity in the development of metabolic diseases. These findings were highlighted in two seminal publications in Nature and Science and a series of other publications in high profile journals such as Cell, Nature Immunology, Nature Medicine, and Nature Reviews Immunology; and are of great clinical interest with regard to the understanding of the complex pathways that contribute to metabolic syndromes as well as the development of new cures for the treatment of these disorders. In his post-graduate career, Dr. Nguyen applied his technical expertise in cellular immunology and molecular biology; and his knowledge-based strength in innate immunity and metabolism into the field of neurobiology. His pioneering neuro-immunology research program in the last seven years led to the discovery of the role of distinct metabolic pathways in innate immune cells of the brain in the development of neurological diseases. Propelled by these exciting findings was the development of drug candidates to treat neuroinflammation and neurodegeneration, which is currently moving toward clinical development stage for the treatment of Amyotrophic Lateral Sclerosis and Multiple Sclerosis by Tranquis Therapeutics, an early-stage biotechnology company, of which Dr. Nguyen is a scientific founder.

Subject Matter Expertise

• ★ Neurobiology
• ★ Clinical Immunology
• ★ Oncology
• ☆ Microbiology
• ☆ Zoology
• ☆ Animal Science
• ☆ Animal Biotechnology
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Neuroscience
• ☆ Neuropharmacology
• ☆ Biotechnology & Bioengineering
• ☆ Statistics
• ☆ Study Design
• ☆ Statistical Review
• ☆ Ecology
• ☆ Pathogenesis
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Surface Receptors
• ☆ Intellectual Giftedness & Gifted Education
• ☆ Drug Discovery
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ Allergy & Clinical Immunology
• ☆ Neurology
• ☆ Multiple Sclerosis
• ☆ Pulmonology/Respiratory Disease
• ☆ Healthcare
• ☆ Medical Sciences
• ☆ Inflammation
• ☆ Asthma
• ☆ Metabolism & Metabolic Disease
• ☆ Sclerosis & Demyelinating Diseases
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Literature Review
• ☆ Scientific Proofreading & Editing

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Copywriting, General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Fact Checking, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Big Data Analytics, Text Mining & Analytics, Data Insights

Work Experience

Scientific Advisor

Tochikunda

January 2020 - Present

Research Assistant Professor of Neuroimmunology

Hong Kong University of Science and Technology

January 2019 - June 2020

Founder

Tranquis Therapeutics

January 2016 - February 2019

Senior Research Scientist

Stanford University

February 2014 - January 2019

Education

PhD in Immunology

Stanford University

August 2008 - December 2013

BSc. in Biological Sciences

Stanford University

August 2004 - June 2006

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2018). In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by LC-MS/MS . Rapid communications in mass spectrometry : RCM.

(2015). Altered signaling in systemic juvenile idiopathic arthritis monocytes . Clinical immunology (Orlando, Fla.).

(2015). Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance . Cell metabolism.

(2015). Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture . Nature Methods.

(2015). Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance . Mediators of inflammation.

(2014). Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat . Cell.

(2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin . Nature Immunology.

(2014). Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation . Molecular immunology.

(2013). Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes . Science (New York, N.Y.).

(2013). Eosinophils secrete IL-4 to facilitate liver regeneration . Proceedings of the National Academy of Sciences of the United States of America.

(2011). Alternative activation in systemic juvenile idiopathic arthritis monocytes . Clinical immunology (Orlando, Fla.).

(2011). Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis . Nature.

(2011). Macrophage-mediated inflammation in metabolic disease . Nature Reviews Immunology.

(2011). Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways . Blood.

(2010). Plasma profiles in active systemic juvenile idiopathic arthritis: Biomarkers and biological implications . Proteomics.

(2010). Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements . Journal of immunology (Baltimore, Md. : 1950).

(2010). TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway . Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.

(2009). Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing . Science translational medicine.

(2009). Oligoarticular and polyarticular JIA: epidemiology and pathogenesis . Nature Reviews Rheumatology.

(2009). PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance . Nature Medicine.

(2009). Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states . Clinical immunology (Orlando, Fla.).

(2009). Impaired IL-10-dependent induction of tolerogenic dendritic cells by CD4+CD25hiCD127lo/- natural regulatory T cells in human allergic asthma . American journal of respiratory and critical care medicine.

(2009). Selective deregulation in chemokine signaling pathways of CD4+CD25(hi)CD127(lo)/(-) regulatory T cells in human allergic asthma . The Journal of allergy and clinical immunology.

(2008). The effects of interleukin-8 on airway smooth muscle contraction in cystic fibrosis . Respiratory research.

(2008). Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma . European journal of immunology.

(2007). Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids . The Journal of allergy and clinical immunology.

(1996). Production, automatic delivery and bolus injection of [15O]water for positron emission tomography studies . Nuclear medicine and biology.