Want to hire this expert for a project? Request a quote for free.
Profile Details
Create Project
USD 100 /hr
Hire Dr. Joshua S.
United States
USD 100 /hr
Neuroscientist and biochemist with 10+ years experience. Specific expertise in -omic data analysis and drug screening.
Profile Summary
Subject Matter Expertise
Services
Writing
Technical Writing
Consulting
Scientific and Technical Consulting
Data & AI
Statistical Analysis,
Data Visualization
Work Experience
Research Associate (Research Scientist)
Tufts University
July 2020 - Present
Postdoctoral Scholar
Tufts University
September 2015 - July 2020
Postdoctoral Scholar
University of Leciester
February 2013 - September 2015
Education
Doctor of Philosophy (Ph.D)
University of Leicester
September 2008 - September 2012
Masters of Science
University of Surrey
September 2007 - September 2008
Bachelor of Science (Honours)
University of Surrey
September 2003 - July 2007
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Kontou G, Josephine Ng SF, Cardarelli RA, Howden JH, Choi C, Ren Q, Rodriguez Santos MA, Bope CE, Dengler JS, Kelley MR, et al.(2021). KCC2 is required for the survival of mature neurons but not for their development . The Journal of biological chemistry.
Kontou, G., Josephine, S.F., Cardarelli, R.A., Howden, J.H., Choi, C., Ren, Q., Rodriguez Santos, M.A., Bope, C.E., Dengler, J.S., Kelley, M.R., et al.(2021). KCC2 is required for the survival of mature neurons but not for their development . Journal of Biological Chemistry. 296.
Smalley M, Natarajan SK, Mondal J, Best D, Goldman D, Shanthappa B, Pellowe M, Dash C, Saha T, Khiste S, et al.(2020). Nanoengineered Disruption of Heat Shock Protein 90 Targets Drug-Induced Resistance and Relieves Natural Killer Cell Suppression in Breast Cancer . Cancer research.
Smalley JL, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, Santos MAR, Bope CE, Deeb TZ, Davies PA, et al.(2020). Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes . Frontiers in molecular neuroscience.
Smalley, J.L., Kontou, G., Choi, C., Ren, Q., Albrecht, D., Abiraman, K., Santos, M.A.R., Bope, C.E., Deeb, T.Z., Davies, P.A., et al.(2020). Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes . Frontiers in Molecular Neuroscience. 13.
Goldman A, Smalley JL, Mistry M, Krenzlin H, Zhang H, Dhawan A, Caldarone B, Moss SJ, Silbersweig DA, Lawler SE, et al.(2019). A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety . Translational psychiatry.
Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, et al.(2019). Identification of a Core Amino Acid Motif within the α Subunit of GABA<sub>A</sub>Rs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures . Cell reports.
Goldman, A., Smalley, J.L., Mistry, M., Krenzlin, H., Zhang, H., Dhawan, A., Caldarone, B., Moss, S.J., Silbersweig, D.A., Lawler, S.E., et al.(2019). A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety . Translational Psychiatry. 9. (1).
Nathanson, A.J., Zhang, Y., Smalley, J.L., Ollerhead, T.A., Rodriguez Santos, M.A., Andrews, P.M., Wobst, H.J., Moore, Y.E., Brandon, N.J., Hines, R.M., et al.(2019). Identification of a Core Amino Acid Motif within the α Subunit of GABA<inf>A</inf>Rs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures . Cell Reports. 28. (3). p. 670-681.e8.
Schiavon E, Smalley JL, Newton S, Greig NH, Forsythe ID(2018). Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model . PloS one.
Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ(2018). Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy . EBioMedicine.
Lucas SJ, Michel CB, Marra V, Smalley JL, Hennig MH, Graham BP, Forsythe ID(2018). Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse . The Journal of physiology.
Lucas, S.J., Michel, C.B., Marra, V., Smalley, J.L., Hennig, M.H., Graham, B.P., Forsythe, I.D.(2018). Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse . Journal of Physiology. 596. (9). p. 1699-1721.
Kelley, M.R., Cardarelli, R.A., Smalley, J.L., Ollerhead, T.A., Andrew, P.M., Brandon, N.J., Deeb, T.Z., Moss, S.J.(2018). Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy . EBioMedicine. 32. p. 62-71.
Schiavon, E., Smalley, J.L., Newton, S., Greig, N.H., Forsythe, I.D.(2018). Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model . PLoS ONE. 13. (8).
Erhardt, S., Pocivavsek, A., Repici, M., Liu, X.-C., Imbeault, S., Maddison, D.C., Thomas, M.A.R., Smalley, J.L., Larsson, M.K., Muchowski, P.J., et al.(2017). Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders . Biological Psychiatry. 82. (10). p. 756-765.
Erhardt S, Pocivavsek A, Repici M, Liu XC, Imbeault S, Maddison DC, Thomas MAR, Smalley JL, Larsson MK, Muchowski PJ, et al.(2016). Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders . Biological psychiatry.
Smalley, J.L., Breda, C., Mason, R.P., Kooner, G., Luthi-Carter, R., Gant, T.W., Giorgini, F.(2016). Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models . Journal of Molecular Medicine. 94. (2). p. 235-245.
Smalley JL, Breda C, Mason RP, Kooner G, Luthi-Carter R, Gant TW, Giorgini F(2015). Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models . Journal of molecular medicine (Berlin, Germany).
Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow SN, Giorgini F, Cohen GM(2015). The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration . Cell death and differentiation.
Varadarajan, S., Breda, C., Smalley, J.L., Butterworth, M., Farrow, S.N., Giorgini, F., Cohen, G.M.(2015). The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration . Cell Death and Differentiation. 22. (8). p. 1388-1396.
Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF(2014). Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase . Proceedings of the National Academy of Sciences of the United States of America.
Miller-Fleming, L., Antas, P., Pais, T.F., Smalley, J.L., Giorgini, F., Outeiro, T.F.(2014). Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase . Proceedings of the National Academy of Sciences of the United States of America. 111. (19). p. 7012-7017.
Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM(2013). Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis . PloS one.
Varadarajan, S., Tanaka, K., Smalley, J.L., Bampton, E.T.W., Pellecchia, M., Dinsdale, D., Willars, G.B., Cohen, G.M.(2013). Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis . PLoS ONE. 8. (2).
Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, et al.(2012). A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum . Cell death and differentiation.
Varadarajan, S., Bampton, E.T.W., Smalley, J.L., Tanaka, K., Caves, R.E., Butterworth, M., Wei, J., Pellecchia, M., Mitcheson, J., Gant, T.W., et al.(2012). A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum . Cell Death and Differentiation. 19. (12). p. 1896-1907.
Smalley, J.L., Gant, T.W., Zhang, S.-D.(2010). Application of connectivity mapping in predictive toxicology based on gene-expression similarity . Toxicology. 268. (3). p. 143-146.
Smalley JL, Gant TW, Zhang SD(2009). Application of connectivity mapping in predictive toxicology based on gene-expression similarity . Toxicology.
PREPRINT
Kontou G, Ng J, Cardarelli RA, Howden J, Choi C, Ren Q, Kittler J, Brandon N, Moss SJ, Smalley JL(2020). KCC2 is required for the survival of mature neurons but not for their development .
Smalley JL, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, Rodriguez Santos MA, Bope CE, Deeb TZ, Davies PA, et al.(2020). Isolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes .
Smalley JL, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, Rodriguez Santos MA, Bope CE, Deeb TZ, Davies PA, et al.(2020). The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products .
Ratings and Comments
Total Projects Awarded:
Comments:
