Profile Details

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Hire Dr. Jose Ulloa Allendes

USD 80 per hour

United Kingdom

Scientific Consultant - Imaging Sciences and Data Analysis

Summary

I am an MRI physicist and imaging scientist with more than 15 years of experience developing imaging biomarkers for the pharmaceutical and medical device industries. I can offer a set of well developed skills to support innovation programs at different scales, from exploratory single-site pilot studies up to international multi-disciplinary public-private consortia. Given my strong background in engineering, biomedical imaging and computer sciences, I have a set of technical, analytical and experimental skills to understand and develop in-vivo imaging applications and transfer them into commercial products. Given my experience working in highly regulated industries, setting up academic collaborations, line managing scientist and providing strategic input into organisational R&D objectives, I can offer a set of well developed skills to support healthcare innovations throughout their whole cycle, from defining study requirements up to reporting and publication of findings, including hands-on support for data analysis. I can also support healthcare innovations to reach the Latin American market. I offer bilingual (English-Spanish) support to communicate your brand to local markets, scientific expertise to ensure compliance with local market regulations, technical expertise to provide direct customer service, cultural background to understand subtleties in usage of trade and a commercial platform (located in Chile) to represent your brand across Latin America.

Subject Matter Expertise

• Simulation Methods & Models
• Clinical Trials
• Medical Imaging
• Experiential Education
• Data Analysis
• Mathematical Optimization
• Mathematical Models
• Signal Processing
• Research Methodology
• Medical Sciences
• Computational Physics
• Computer Software
• Biomedical Engineering
• Pharmaceutical Industry
• Applied Sciences
• Imaging Technology
• Imaging
• Spanish
• Biomarkers
• Compliance
• MRI

Services

• Scientific consulting
• Data Science
• Secondary Research
• Clinical Research Consulting
• Experiment design
• Other

Work Experience

• Independent Consultant Imaging Sciences and Expert Data Analysis

  Self Employed

  December 2017 - Present

• Head of Imaging Physics

  Bioxydyn

  September 2016 - November 2017

• Imaging Physicist

  Bioxydyn

  March 2013 - August 2016

• Senior Research Scientist

  AstraZeneca

  June 2012 - February 2013

• Senior Research Scientist

  AstraZeneca

  June 2007 - May 2012

• Project Engineer

  DICTUC S.A.

  May 2006 - May 2007

Education

• PhD (Electrical Engineering)

  Pontificia Universidad Católica de Chile

  April 2002 - April 2006

• MSc (Electrical Engineering)

  Pontificia Universidad Católica de Chile

  March 1999 - April 2002

• BSc Industrial Engineering, Major in Electrical Engineering (Electrical Engineering)

  Pontificia Universidad Católica de Chile

  March 1994 - March 1999

Publications

JOURNAL ARTICLE
• {"ProfilePublicationId":30714,"Type":"journal-article","Citation":"@article{PMID:25672978,\n\ttitle = {Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography.},\n\tauthor = {Jamin Y and Boult JKR and Li J and Popov S and Garteiser P and Ulloa JL and Cummings C and Box G and Eccles SA and Jones C and Waterton JC and Bamber JC and Sinkus R and Robinson SP},\n\tdoi = {10.1158/0008-5472.can-14-1997},\n\tjournal = {Cancer research},\n\tmonth = {04},\n\tyear = {2015}\n}","JournalTitle":"Cancer research","Title":"Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography.","CitationType":"bibtex","DOI":"10.1158/0008-5472.can-14-1997","Date":"2015-04-00","Url":"http://europepmc.org/abstract/med/25672978","PublicationContributors":null,"ContributorNames":"Jamin Y, Boult JKR, Li J, Popov S, Garteiser P, Ulloa JL, Cummings C, Box G, Eccles SA, Jones C, et al.","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30715,"Type":"journal-article","Citation":"@article{Ulloa2015,title = {Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography},journal = {Cancer Research},year = {2015},volume = {75},number = {7},pages = {1216-1224},author = {Jamin, Y. and Boult, J.K.R. and Li, J. and Popov, S. and Garteiser, P. and Ulloa, J.L. and Cummings, C. and Box, G. and Eccles, S.A. and Jones, C. and Waterton, J.C. and Bamber, J.C. and Sinkus, R. and Robinson, S.P.}}","JournalTitle":"Cancer Research","Title":"Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography","CitationType":"bibtex","DOI":"10.1158/0008-5472.CAN-14-1997","Date":"2015-00-00","Url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-84941619851\u0026partnerID=MN8TOARS","PublicationContributors":null,"ContributorNames":"Jamin, Y., Boult, J.K.R., Li, J., Popov, S., Garteiser, P., Ulloa, J.L., Cummings, C., Box, G., Eccles, S.A., Jones, C., et al.","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30716,"Type":"journal-article","Citation":"@article{Ulloa2014,title = {Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma},journal = {Magnetic Resonance in Medicine},year = {2014},volume = {71},number = {5},pages = {1854-1862},author = {Linnik, I.V. and Scott, M.L.J. and Holliday, K.F. and Woodhouse, N. and Waterton, J.C. and O{\u0026#39;}Connor, J.P.B. and Barjat, H. and Liess, C. and Ulloa, J. and Young, H. and Dive, C. and Hodgkinson, C.L. and Ward, T. and Roberts, D. and Mills, S.J. and Thompson, G. and Buonaccorsi, G.A. and Cheung, S. and Jackson, A. and Naish, J.H. and Parker, G.J.M.}}","JournalTitle":"Magnetic Resonance in Medicine","Title":"Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma","CitationType":"bibtex","DOI":"10.1002/mrm.24826","Date":"2014-00-00","Url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-84899429750\u0026partnerID=MN8TOARS","PublicationContributors":null,"ContributorNames":"Linnik, I.V., Scott, M.L.J., Holliday, K.F., Woodhouse, N., Waterton, J.C., O\u0026amp;#39;Connor, J.P.B., Barjat, H., Liess, C., Ulloa, J., Young, H., et al.","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30717,"Type":"journal-article","Citation":"@article{Ulloa2014,title = {Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography},journal = {British Journal of Cancer},year = {2014},volume = {110},number = {7},pages = {1727-1732},author = {Li, J. and Jamin, Y. and Boult, J.K.R. and Cummings, C. and Waterton, J.C. and Ulloa, J. and Sinkus, R. and Bamber, J.C. and Robinson, S.P.}}","JournalTitle":"British Journal of Cancer","Title":"Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography","CitationType":"bibtex","DOI":"10.1038/bjc.2014.76","Date":"2014-00-00","Url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-84897569887\u0026partnerID=MN8TOARS","PublicationContributors":null,"ContributorNames":"Li, J., Jamin, Y., Boult, J.K.R., Cummings, C., Waterton, J.C., Ulloa, J., Sinkus, R., Bamber, J.C., Robinson, S.P.","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30718,"Type":"journal-article","Citation":"@article{PMID:23564602,\n\ttitle = {Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition.},\n\tauthor = {Ulloa JL and Stahl S and Yates J and Woodhouse N and Kenna JG and Jones HB and Waterton JC and Hockings PD},\n\tdoi = {10.1002/nbm.2946},\n\tjournal = {NMR in biomedicine},\n\tmonth = {10},\n\tyear = {2013}\n}","JournalTitle":"NMR in biomedicine","Title":"Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition.","CitationType":"bibtex","DOI":"10.1002/nbm.2946","Date":"2013-10-00","Url":"http://europepmc.org/abstract/med/23564602","PublicationContributors":null,"ContributorNames":"Ulloa JL, Stahl S, Yates J, Woodhouse N, Kenna JG, Jones HB, Waterton JC, Hockings PD","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30719,"Type":"journal-article","Citation":"@article{Ulloa2010,title = {Magnetic resonance imaging in conscious rats},journal = {Animal Technology and Welfare},year = {2010},volume = {9},number = {3},pages = {177-178},author = {Barker, D. and Doherty, A. and Waterton, J. and Ulloa, J.}}","JournalTitle":"Animal Technology and Welfare","Title":"Magnetic resonance imaging in conscious rats","CitationType":"bibtex","DOI":"","Date":"2010-00-00","Url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-78650737430\u0026partnerID=MN8TOARS","PublicationContributors":null,"ContributorNames":"Barker, D., Doherty, A., Waterton, J., Ulloa, J.","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30720,"Type":"journal-article","Citation":"@article{PMID:15554131,\n\ttitle = {Chebyshev series for designing RF pulses employing an optimal control approach.},\n\tauthor = {Ulloa JL and Guarini M and Guesalaga A and Irarrazaval P},\n\tdoi = {10.1109/tmi.2004.835602},\n\tjournal = {IEEE transactions on medical imaging},\n\tmonth = {11},\n\tyear = {2004}\n}","JournalTitle":"IEEE transactions on medical imaging","Title":"Chebyshev series for designing RF pulses employing an optimal control approach.","CitationType":"bibtex","DOI":"10.1109/tmi.2004.835602","Date":"2004-11-00","Url":"http://europepmc.org/abstract/med/15554131","PublicationContributors":null,"ContributorNames":"Ulloa JL, Guarini M, Guesalaga A, Irarrazaval P","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30721,"Type":"journal-article","Citation":"@article{Ulloa2004,title = {Chebyshev series for designing RF pulses employing an optimal control approach},journal = {IEEE Transactions on Medical Imaging},year = {2004},volume = {23},number = {11},pages = {1445-1452},author = {Ulloa, J.L. and Guarini, M. and Guesalaga, A. and Irarrazaval, P.}}","JournalTitle":"IEEE Transactions on Medical Imaging","Title":"Chebyshev series for designing RF pulses employing an optimal control approach","CitationType":"bibtex","DOI":"10.1109/TMI.2004.835602","Date":"2004-00-00","Url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-9244261574\u0026partnerID=MN8TOARS","PublicationContributors":null,"ContributorNames":"Ulloa, J.L., Guarini, M., Guesalaga, A., Irarrazaval, P.","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30708,"Type":"journal-article","Citation":"@article{UlloaA221, author= {Ulloa, JL and Morgan, AR and Lacey, T and Roberts, C and Parker, GJM}, title= {P284 V/Q scanning using oxygen-enhanced Magnetic Resonance Imaging}, volume= {70}, number= {Suppl 3}, pages= {A221--A221}, year= {2015}, doi= {10.1136/thoraxjnl-2015-207770.420}, publisher= {BMJ Publishing Group Ltd}, abstract= {Ventilation-perfusion (V/Q) scan is an established technique used to monitor lung dysfunction in conditions such as pulmonary embolism.1 However, there are safety concerns regarding its use in several important populations e.g. pregnant women and children. Recent advances have transformed the use of standard clinical MRI equipment in functional lung imaging.2 We recently presented a clinically appropriate dynamic oxygen-enhanced MRI (dOE-MRI) protocol.3 In this work, we interpret dOE-MRI data with a novel physiological model of gas exchange4 that maps the regional distribution of lung ventilation and perfusion, simulating results from a standard V/Q scan.3D dOE-MRI data were acquired using a 1.5 T Philips scanner as in:3 a 5 min baseline T1 acquisition, followed by a 15 min dynamic acquisition, during which the subject breathed 100\\% O2 for the middle 5 min. Total scan time is under 30 min throughout which the subject breathes normally. The partial pressure of oxygen in the alveolar compartment was derived as proposed in5 and maps of regional alveolar ventilation and perfusion were produced using a novel two-compartmental model of gas exchange based on.4Figure 1 shows an example of whole-chest ventilation and perfusion maps from a healthy subject overlaid on a single volume of the acquired MRI (left column). The same maps are displayed as anterior/posterior and right/left anterior oblique projections (right column), equivalent to those achieved with V/Q scintigraphy.1Abstract P284 Figure 1 ~Estimation of alveolar ventilation and perfusion distribution from 3D dynamic OE-MRI is feasible and can be obtained under clinically acceptable conditions using standard radiological equipment without ionising radiation risks. This approach opens the possibility for regional assessment of lung physiology using a single short scanning session.References 1 Bajc, et al. Eur J Nucl Med Mol Imaging 2009;36(8):1356{\\textendash}702 Wild, et al. Insights Imaging 2012;3(4):345{\\textendash}533 Ulloa, et al. Proc Intl Soc Mag Reson Med. 2015;23:39734 Naish, et al. Proc Intl Soc Mag Reson Med. 2010;18:25165 Kershaw, et al. MRM 2010;64:1838{\\textendash}42}, issn= {0040-6376}, URL= {http://thorax.bmj.com/content/70/Suppl_3/A221}, eprint= {http://thorax.bmj.com/content/70/Suppl_3/A221.full.pdf}, journal= {Thorax}}\n\n","JournalTitle":"Thorax","Title":"P284 V/Q scanning using oxygen-enhanced Magnetic Resonance Imaging","CitationType":"bibtex","DOI":"10.1136/thoraxjnl-2015-207770.420","Date":"2015-00-00","Url":"http://thorax.bmj.com/content/70/Suppl_3/A221","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30709,"Type":"journal-article","Citation":"@article{Ulloa1724, author= {Ulloa, Jose and Morgan, Alexandra and Parker, Geoff}, title= {Evaluation of whole lung 3D dynamic oxygen-enhanced MRI}, volume= {44}, number= {Suppl 58}, year= {2014}, publisher= {European Respiratory Society}, abstract= {RATIONALE: Dynamic oxygen-enhanced MRI (dOEMRI) provides imaging biomarkers of regional lung ventilation and perfusion1. Previously, dOEMRI has been limited to single slice imaging. Capturing the whole lung within a single breathing cycle increases the utility of dOEMRI in identifying regional alterations in lung function. In this work, we evaluate a novel quantitative whole lung 3D dOEMRI protocol based on a single-shot 3D MPRAGE sequence available on many scanners2.METHODS: Sequence parameters were optimised to maximise contrast in the lung when switching from air to O2 during free breathing. The protocol was evaluated on a 1.5T Philips Achieva scanner in 4 healthy volunteers (3 which had repeat scans). Baseline T1 maps were acquired while subjects breathed medical air. This was followed by a 15min dynamic scan (temporal resolution 10s), during which gas supply was switched from air to 100\\% O2, and back to air. Dynamic data were converted to ΔPO2 maps and parameterised with an exponential model of O2 wash-in and wash-out1.RESULTS: Figure 1 shows an image volume overlaid with a map of O2 wash-in and ΔPO2 time series of all the subjects scanned. The same exponential model was applied to the group average ΔPO2.CONCLUSIONS: These results are the first to show the feasibility of volumetric whole lung dynamic OEMRI.REFERENCES: 1 Kershaw et al. MRM 64:1838-1842;2010. 2 Deichmann et al. Neuroimage 12:112-127;2000. Thanks to University of Manchester, MRIF.}, issn= {0903-1936}, URL= {http://erj.ersjournals.com/content/44/Suppl_58/1724}, eprint= {http://erj.ersjournals.com/content/44/Suppl_58/1724}, journal= {European Respiratory Journal}}\n\n","JournalTitle":"European Respiratory Journal","Title":"Evaluation of whole lung 3D dynamic oxygen-enhanced MRI","CitationType":"bibtex","DOI":"","Date":"2014-00-00","Url":"http://erj.ersjournals.com/content/44/Suppl_58/1724","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}

CONFERENCE PAPER
• {"ProfilePublicationId":30712,"Type":"conference-paper","Citation":"@inproceedings{Soares_2017,doi = {10.1183/1393003.congress-2017.pa801},url = {https://doi.org/10.1183%2F1393003.congress-2017.pa801},year = 2017,month = {sep},publisher = {European Respiratory Society},author = {Marcia Soares and Jose Ulloa and Joanne Wormleighton and Barnes Daniel and Parker Geoff and Salman Siddiqui},title = {The impact of a high fine particle fraction inhaled long acting $\\upbeta$2 agonist (Formoterol) on airway function in asthma: evaluation with oxygen enhanced {MRI} and multiple breath washout},booktitle = {Imaging}}","JournalTitle":"Imaging","Title":"The impact of a high fine particle fraction inhaled long acting β2 agonist (Formoterol) on airway function in asthma: evaluation with oxygen enhanced MRI and multiple breath washout","CitationType":"bibtex","DOI":"10.1183/1393003.congress-2017.pa801","Date":"2017-09-00","Url":"","PublicationContributors":null,"ContributorNames":"Marcia Soares, Jose Ulloa, Joanne Wormleighton, Barnes Daniel, Parker Geoff, Salman Siddiqui","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30713,"Type":"conference-paper","Citation":"@inproceedings{Martini_2016,doi = {10.1183/13993003.congress-2016.oa1492},url = {https://doi.org/10.1183%2F13993003.congress-2016.oa1492},year = 2016,month = {sep},publisher = {European Respiratory Society},author = {Katharina Martini and Christian Benden and Geoff Parker and Stephan Baum\u0026#195;\u0026#188;ller and Jose Ulloa and Alex Morgan and Thomas Frauenfelder},title = {Oxygen-enhanced {MR} ({OE}-{MR}): Correlation to {CT} Brody score in cystic fibrosis patients},booktitle = {7.3 Cystic Fibrosis}}","JournalTitle":"7.3 Cystic Fibrosis","Title":"Oxygen-enhanced MR (OE-MR): Correlation to CT Brody score in cystic fibrosis patients","CitationType":"bibtex","DOI":"10.1183/13993003.congress-2016.oa1492","Date":"2016-09-00","Url":"","PublicationContributors":null,"ContributorNames":"Katharina Martini, Christian Benden, Geoff Parker, Stephan Baum\u0026amp;#252;ller, Jose Ulloa, Alex Morgan, Thomas Frauenfelder","TotalNumberOfPublications":0}

BOOK CHAPTER
• {"ProfilePublicationId":30710,"Type":"book-chapter","Citation":"@inbook{doi:10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A4317, author= {Jose L Ulloa and Weijuan Zhang and Alexandra R. Morgan and Josephine H. Naish and Geoff J. Parker }, title= {Population-Based Parameterization Of The Oxygen Input Function For Dynamic Oxygen-Enhanced MRI}, booktitle= {C36. IMAGING AND THE LUNG: A RAPIDLY EVOLVING FIELD}, chapter= {}, pages= {A4317-A4317}, doi= {10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A4317}, URL= {https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A4317}, eprint= {https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A4317}}\n\n","JournalTitle":"C36. IMAGING AND THE LUNG: A RAPIDLY EVOLVING FIELD","Title":"Population-Based Parameterization Of The Oxygen Input Function For Dynamic Oxygen-Enhanced MRI","CitationType":"bibtex","DOI":"","Date":"0000-00-00","Url":"https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A4317","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}
• {"ProfilePublicationId":30711,"Type":"book-chapter","Citation":"@inbook{doi:10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A6692, author= {Jose L. Ulloa and Alexandra R. Morgan and Geoffrey J. Parker }, title= {Whole Lung 3D Dynamic Oxygen-Enhanced MRI Protocol}, booktitle= {C36. IMAGING AND THE LUNG: A RAPIDLY EVOLVING FIELD}, chapter= {}, pages= {A6692-A6692}, doi= {10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A6692}, URL= {https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A6692}, eprint= {https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A6692}}\n\n","JournalTitle":"C36. IMAGING AND THE LUNG: A RAPIDLY EVOLVING FIELD","Title":"Whole Lung 3D Dynamic Oxygen-Enhanced MRI Protocol","CitationType":"bibtex","DOI":"","Date":"0000-00-00","Url":"https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A6692","PublicationContributors":null,"ContributorNames":"","TotalNumberOfPublications":0}