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Hire Dr. Jeffery T.

United States

USD 150 /hr

Biological Chemist | 10+ years of experience in synthetic biology, peptide/small-molecule synthesis, and drug discovery.

Profile Summary

I am a biological chemist with expertise in synthetic and molecular biology, protein expression & purification, peptide/small-molecule synthesis & purification, high-throughput assays, and drug discovery. I earned my PhD in Chemistry from Texas A&M University. I have three of postdoctoral training at Yale University.

Subject Matter Expertise

• ★ Chemical Biology
• ★ Protein/Enzyme Engineering
• ★ Drug Development
• ☆ Organic Chemistry
• ☆ Peptide Synthesis
• ☆ Molecular Biology
• ☆ Molecular Evolution
• ☆ PCR
• ☆ Recombinant Protein Expression
• ☆ Genetic Engineering
• ☆ Technical & Scientific Writing
• ☆ Science Communication
• ☆ Grant Writing

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Copywriting, Newswriting

Research Market Research, User Research, Feasibility Study, Fact Checking, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Digital Strategy Consulting, Scientific and Technical Consulting, Regulatory Consulting

Data & AI Big Data Analytics

Product Development Formulation, Stability/Shelf Life Testing, Product Evaluation, Product Validation, Manufacturing, Concept Development

Work Experience

Postdoctoral Associate

Yale University

July 2018 - Present

Graduate Research Assistant

Texas A&M University, College Station, TX, USA

August 2012 - June 2018

National Science Foundation REU Student

Texas A&M University, College Station, TX, USA

May 2011 - August 2011

National Science Foundation SURE Student

Indiana State University

May 2010 - August 2010

Education

Ph.D. (Chemistry)

Texas A&M University

August 2012 - May 2018

B.S. (Chemistry and Physics)

Indiana State University

August 2008 - July 2012

Certifications

• Certificate of College Teaching Preparation

  Poorvu Center for Teaching and Learning, Yale University

  September 2018 - Present

Publications

OTHER

Jeffery M. Tharp, Oscar Vargas-Rodriguez, Alanna Schepartz, Dieter Söll(2020). Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons . Cold Spring Harbor Laboratory

JOURNAL ARTICLE

Jeffery M. Tharp, J. Trae Hampton, Catrina A. Reed, Andreas Ehnbom, Peng-Hsun Chase Chen, Jared S. Morse, Yadagirri Kurra, Lisa M. Pérez, Shiqing Xu, Wenshe Ray Liu(2020). An amber obligate active site-directed ligand evolution technique for phage display . Nature Communications. 11. (1). Springer Science and Business Media {LLC}

Jeffery M. Tharp, Natalie Krahn, Umesh Varshney, Dieter Söll(2020). Front Cover: Hijacking Translation Initiation for Synthetic Biology (ChemBioChem 10/2020) . ChemBioChem. 21. (10). p. 1383--1383. Wiley

Jeffery M. Tharp, Natalie Krahn, Umesh Varshney, Dieter Söll(2020). Hijacking Translation Initiation for Synthetic Biology . ChemBioChem. 21. (10). p. 1387--1396. Wiley

Jeffery M. Tharp, Omer Ad, Kazuaki Amikura, Fred R. Ward, Emma M. Garcia, Jamie H. D. Cate, Alanna Schepartz, Dieter Söll(2020). Initiation of Protein Synthesis with Non‐Canonical Amino Acids In Vivo . Angewandte Chemie International Edition. 59. (8). p. 3122--3126. Wiley

Jeffery M. Tharp, Omer Ad, Kazuaki Amikura, Fred R. Ward, Emma M. Garcia, Jamie H. D. Cate, Alanna Schepartz, Dieter Söll(2020). Initiation of Protein Synthesis with Non‐Canonical Amino Acids In Vivo . Angewandte Chemie. 132. (8). p. 3146--3150. Wiley

(2019). A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library . Angewandte Chemie International Edition.

Jeffery M. Tharp, Andreas Ehnbom, Wenshe R. Liu(2017). tRNAPyl: Structure, function, and applications . RNA Biology. p. 1--12. Informa {UK} Limited

Wang, Z.A., Zeng, Y., Kurra, Y., Wang, X., Tharp, J.M., Vatansever, E.C., Hsu, W.W., Dai, S., Fang, X., Liu, W.R.(2017). A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation . Angewandte Chemie - International Edition. 56. (1). p. 212-216.

Tharp, J.M., Liu, W.R.(2017). Synthetases pick up the pace . Nature Chemical Biology. 13. (12). p. 1205-1206.

Lee, Y.-J., Schmidt, M.J., Tharp, J.M., Weber, A., Koenig, A.L., Zheng, H., Gao, J., Waters, M.L., Summerer, D., Liu, W.R.(2016). Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader . Chemical Communications. 52. (85). p. 12606-12609.

Tharp, J.M., Liu, W.R.(2016). The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification . ChemBioChem. 17. (10). p. 883-885.

Piscotta, F.J., Tharp, J.M., Liu, W.R., Link, A.J.(2015). Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids . Chemical Communications. 51. (2). p. 409-412.

Tharp, J.M., Wang, Y.-S., Lee, Y.-J., Yang, Y., Liu, W.R.(2014). Genetic incorporation of seven ortho-substituted phenylalanine derivatives . ACS Chemical Biology. 9. (4). p. 884-890.

Wan, W., Tharp, J.M., Liu, W.R.(2014). Pyrrolysyl-tRNA synthetase: An ordinary enzyme but an outstanding genetic code expansion tool . Biochimica et Biophysica Acta - Proteins and Proteomics. 1844. (6). p. 1059-1070.

Cooper, B.S., Tharp, J.M., Jernberg, I.I., Angilletta, M.J.(2012). Developmental plasticity of thermal tolerances in temperate and subtropical populations of Drosophila melanogaster . Journal of Thermal Biology. 37. (3). p. 211-216.

BOOK

Tharp, J.M., Liu, W.R.(2018). Using amber and ochre nonsense codons to code two different noncanonical amino acids in one protein gene . Methods in Molecular Biology. 1728. p. 147-154.