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Hire Dr. Hsih-Yin T.

Singapore

USD 80 /hr

Microfluidic researcher with 10+yr experience

Profile Summary

My research interests are mainly in development of organs-on-chips platforms to answer intriguing biological questions (such as interactions of microbiome with intestinal cells, cell-cell communication etc.) and/or studying of drug delivery and related diseases. I have experiences working with organ specific cells such as Caco-2 cells (for my PhD studies and postdoc) for developing a gut-on-chip device and brain cells to develop a blood-brain-barrier platform. I also did some initial E. coli co-culture studies with my gut-chip system. The microfluidic chips I developed had integrated electrodes. Prior to that, I have experiences in designing and fabrication of plastic microdevices with integrated micropumps and immbolised enzymes for human blood sampling and analysis. Research interests: 1. organs-on-chips 2. microfluidics 3. material science 4. sensors for biological applications 5. cell culture (2D & 3D) 6. biochemistry 7. bioengineering 8. drug transport, nanomedicine

Subject Matter Expertise

• ★ Microfluidics
• ☆ Biomedical Engineering
• ☆ Tissue Engineering

Services

• Writing
• Consulting

Writing Clinical Trial Documentation, Technical Writing, Copywriting, Newswriting

Consulting Scientific and Technical Consulting

Work Experience

Postdoc research fellow

National University of Singapore

January 2018 - Present

Postdoc intern

National University of Singapore

July 2017 - January 2018

Postdoc

Danmarks Tekniske Universitet

December 2015 - November 2016

Research Engineer

DSO National Laboratories

July 2005 - August 2012

Education

PhD (Nanotechnology)

Technical University of Denmark

September 2012 - April 2016

Master in Engineering (Mechanical and Aerospace Engineering)

Nanyang Technological University

2008 - 2010

Bachelors of Mechanical & Production Engineering (Mechanical and Production Engineering)

Nanyang Technological University

July 2001 - July 2005

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Hsih-Yin Tan and Yi-Chin Toh(2020). What can microfluidics do for human microbiome research? . Biomicrofluidics. 14. (5). p. 051303. {AIP} Publishing

(2018). A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies . PLOS ONE.

Tan, H.-Y., Trier, S., Rahbek, U.L., Dufva, M., Kutter, J.P., Andresen, T.L.(2018). A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies . PLoS ONE. 13. (5).

Tan, H.Y., Loke, W.K., Nguyen, N.-T., Tan, S.N., Tay, N.B., Wang, W., Ng, S.H.(2014). Lab-on-a-chip for rapid electrochemical detection of nerve agent Sarin . Biomedical Microdevices. 16. (2). p. 269-275.

Tan, S.N., Ge, L., Tan, H.Y., Loke, W.K., Gao, J., Wang, W.(2012). Paper-based enzyme immobilization for flow injection electrochemical biosensor integrated with reagent-loaded cartridge toward portable modular device . Analytical Chemistry. 84. (22). p. 10071-10076.

Tan, H.Y., Loke, W.K., Nguyen, N.-T.(2010). A reliable method for bonding polydimethylsiloxane (PDMS) to polymethylmethacrylate (PMMA) and its application in micropumps . Sensors and Actuators, B: Chemical. 151. (1). p. 133-139.

Tan, H.Y., Loke, W.K., Tan, Y.T., Nguyen, N.-T.(2008). A lab-on-a-chip for detection of nerve agent sarin in blood . Lab on a Chip - Miniaturisation for Chemistry and Biology. 8. (6). p. 885-891.

Hsih-Yin Tan, 2007, 'Lab-on-a-chip detector developed for Sarin', <i>SPIE Newsroom</i> .

CONFERENCE PAPER

(2019). Assessing Gut Microbiome-Liver Crosstalk With A Modular Microfluidic Platform. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019.

Tan, H.Y., Hemmingsen, M., Lafleur, J.P., S&#248;ndergaard, R.V., Kutter, J.P., Dufva, M., Andresen, T.L.(2014). Multi-chamber and multi-layer thiol-ene microchip for cell culture . 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. p. 1749-1751.

(2010). Integration of PDMS and PMMA for batch fabrication of microfluidic devices. 6th World Congress of Biomechanics (WCB 2010).

Nguyen, N.T., Sun, Y., Kwok, Y.C., Tan, H.Y., Loke, W.K.(2010). Lab on a chip application in life sciences . IFMBE Proceedings. 27. p. 303-307.

Nguyen, N.-T., Kwok, Y.-C., Tan, H.Y., Loke, W.K.(2010). Polymeric labs on a chip for sustainable development . Proceedings of the ASME Micro/Nanoscale Heat and Mass Transfer International Conference 2009, MNHMT2009. 1. p. 53-57.

Tan, H.Y., Nguyen, N.-T., Loke, W.K., Tan, Y.T.(2007). Microfluidic chip with optical sensor for rapid detection of nerve agent Sarin in water samples . Proceedings of SPIE - The International Society for Optical Engineering. 6416.