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Profile Details
Contact
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USD 100 /hr
Hire Dr. Hector H.
France
USD 100 /hr

Senior Scientist in Cancer Genomics

Profile Summary
Subject Matter Expertise
Services
Writing Technical Writing, Copywriting, Newswriting
Research Market Research, Fact Checking, Gray Literature Search, Systematic Literature Review
Data & AI Statistical Analysis, Big Data Analytics
Work Experience

Senior Scientist

Centre Leon Berard

January 2018 - Present

Scientist

International Agency for Research on Cancer

November 2009 - September 2017

PostDoc

International Agency for Research on Cancer

May 2007 - November 2009

PhD Student

Centro Nacional de Investigaciones Oncológicas

2003 - 2006

Research Associate

Centro Internacional de Entrenamiento e Investigaciones Medicas

August 1997 - December 1999

Education

HDR

Université Lyon 1 IUT Lyon 1

October 2016 - October 2016

PhD (Bioquimica y Biologia Molecular)

Universidad Complutense de Madrid

February 2000 - December 2006

Medicine

Universidad de Caldas

February 1990 - July 1997

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Hector Hernandez-Vargas, Louciné Mitoyan, Véronique Chevrier, Alexane Ollivier, Zeinab Homayed, Julie Pannequin, Flora Poizat, Cécile De Biasi-Cador, Emmanuelle Charafe-Jauffret, Christophe Ginestier, et al.(2021). A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration . Nature Communications. 12. (1). Springer Science and Business Media {LLC}
Hector Hernandez-Vargas, Alexandra Lainé, Ossama Labiad, Sébastien This, Amélien Sanlaville, Sophie Léon, Stéphane Dalle, Dean Sheppard, Mark A. Travis, Helena Paidassi, et al. (2021). Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation . Nature Communications.
Hector Hernandez-Vargas, Akram Ghantous, Alexei Novoloaca, Liacine Bouaoun, Cyrille Cuenin, Marie-Pierre Cros, Ya Xu, Momodou K. Darboe, Andrew M. Prentice, Sophie E. Moore, et al.(2021). Aflatoxin Exposure during Early Life Is Associated with Differential DNA Methylation in Two-Year-Old Gambian Children . International Journal of Molecular Sciences. 22. (16). p. 8967. {MDPI} {AG}
Hector Hernandez-Vargas, Akram Ghantous, Alexei Novoloaca, Liacine Bouaoun, Cyrille Cuenin, Marie-Pierre Cros, Ya Xu, Momodou K. Darboe, Andrew Prentice, Sophie E. Moore, et al. (2021). Aflatoxin Exposure during Early Life Is Associated with Differential DNA Methylation in Two-Year-Old Gambian Children . International Journal of Molecular Sciences.
Hector Hernandez-Vargas, Chloe Goldsmith, Damien Cohen, Anaëlle Dubois, Maria Guadalupe Martinez, Kilian Petitjean, Anne Corlu, Barbara Testoni, Isabelle Chemin (2021). Cas9-targeted nanopore sequencing reveals epigenetic heterogeneity after de novo assembly of native full-length hepatitis B virus genomes . Microbial Genomics.
Hector Hernandez-Vargas, Iolanda Agliata, Nora Fernandez-Jimenez, Chloe Goldsmith, Julien C. Marie, Jose R. Bilbao, Robert Dante(2020). The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells . Epigenetics. 15. (10). p. 1068--1082. Informa {UK} Limited
Hector Hernandez-Vargas, Chloe Goldsmith, Pauline Mathot, Robert Dante(2020). Stromal-associated cytokines bias the interplay between gene expression and DNA methylation in human breast cancers . Epigenetics. 15. (5). p. 511--523. Informa {UK} Limited
Ghantous A, Hernandez-Vargas H, Herceg Z(2018). DNA Methylation Analysis from Blood Spots: Increasing Yield and Quality for Genome-Wide and Locus-Specific Methylation Analysis . Methods in molecular biology (Clifton, N.J.).
Gonzaga IM, Soares Lima SC, Nicolau MC, Nicolau-Neto P, da Costa NM, de Almeida Simão T, Hernandez-Vargas H, Herceg Z, Ribeiro Pinto LF(2017). TFF1 hypermethylation and decreased expression in esophageal squamous cell carcinoma and histologically normal tumor surrounding esophageal cells . Clinical epigenetics.
Hector Hernandez-Vargas, Nora Fernandez-Jimenez, Athena Sklias, Szilvia Ecsedi, Vincent Cahais, Davide Degli-Esposti, Antonin Jay, Pierre Benoit Ancey, Hae Dong Woo, Zdenko Herceg(2017). Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer . Epigenetics. p. 1--9. Informa {UK} Limited
Hector Hernandez-Vargas, Vasily N. Aushev, Eunjee Lee, Jun Zhu, Kalpana Gopalakrishnan, Qian Li, Susan L. Teitelbaum, James G. Wetmur, Davide Degli Esposti, Zdenko Herceg, et al.(2017). Novel predictors of breast cancer survival derived from miRNA activity analysis . Clinical Cancer Research. p. clincanres.0996.2017. American Association for Cancer Research ({AACR})
Hector Hernandez-Vargas, Davide Degli Esposti, Vasily N. Aushev, Eunjee Lee, Marie-Pierre Cros, Jun Zhu, Zdenko Herceg, Jia Chen(2017). miR-500a-5p regulates oxidative stress response genes in breast cancer and predicts cancer survival . Scientific Reports. 7. (1). Springer Nature
Kettunen, E., Hernandez-Vargas, H., Cros, M.-P., Durand, G., Le Calvez-Kelm, F., Stuopelyte, K., Jarmalaite, S., Salmenkivi, K., Anttila, S., Wolff, H., et al.(2017). Asbestos-associated genome-wide DNA methylation changes in lung cancer . International Journal of Cancer. 141. (10). p. 2014-2029.
Narváez, D.M., Groot, H., Diaz, S.M., Palma, R.M., Muñoz, N., Cros, M.-P., Hernández-Vargas, H.(2017). Oxidative stress and repetitive element methylation changes in artisanal gold miners occupationally exposed to mercury . Heliyon. 3. (9).
Ancey, P.-B., Ecsedi, S., Lambert, M.-P., Talukdar, F.R., Cros, M.-P., Glaise, D., Narvaez, D.M., Chauvet, V., Herceg, Z., Corlu, A., et al.(2017). TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors . Stem Cell Reports. 9. (1). p. 264-278.
Degli Esposti, D., Sklias, A., Lima, S.C., Beghelli-de la Forest Divonne, S., Cahais, V., Fernandez-Jimenez, N., Cros, M.-P., Ecsedi, S., Cuenin, C., Bouaoun, L., et al.(2017). Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas . Genome Medicine. 9. (1).
Ambatipudi, S., Horvath, S., Perrier, F., Cuenin, C., Hernandez-Vargas, H., Le Calvez-Kelm, F., Durand, G., Byrnes, G., Ferrari, P., Bouaoun, L., et al.(2017). DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility . European Journal of Cancer. 75. p. 299-307.
Herceg, Z., Ghantous, A., Wild, C.P., Sklias, A., Casati, L., Duthie, S.J., Fry, R., Issa, J.-P., Kellermayer, R., Koturbash, I., et al.(2017). Roadmap for investigating epigenome deregulation and environmental origins of cancer . International Journal of Cancer.
Hernandez-Vargas, H., Gruffat, H., Cros, M.P., Diederichs, A., Sirand, C., Vargas-Ayala, R.C., Jay, A., Durand, G., Le Calvez-Kelm, F., Herceg, Z., et al.(2017). Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines . Scientific Reports. 7. (1).
Joubert, B.R., Felix, J.F., Yousefi, P., Bakulski, K.M., Just, A.C., Breton, C., Reese, S.E., Markunas, C.A., Richmond, R.C., Xu, C.-J., et al.(2016). DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis . American Journal of Human Genetics. 98. (4). p. 680-696.
Vuong, T., Mallet, J.-F., Ouzounova, M., Rahbar, S., Hernandez-Vargas, H., Herceg, Z., Matar, C.(2016). Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation . Journal of Translational Medicine. 14. (1).
Ambatipudi, S., Cuenin, C., Hernandez-Vargas, H., Ghantous, A., Le Calvez-Kelm, F., Kaaks, R., Barrdahl, M., Boeing, H., Aleksandrova, K., Trichopoulou, A., et al.(2016). Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study . Epigenomics. 8. (5). p. 599-618.
Esposti, D.D., Hernandez-Vargas, H., Voegele, C., Fernandez-Jimenez, N., Forey, N., Bancel, B., Le Calvez-Kelm, F., McKay, J., Merle, P., Herceg, Z.(2016). Identification of novel long non-coding RNAs deregulated in hepatocellular carcinoma using RNA-sequencing . Oncotarget. 7. (22). p. 31862-31877.
Lambert, M.-P., Ancey, P.-B., Esposti, D.D., Cros, M.-P., Sklias, A., Scoazec, J.-Y., Durantel, D., Hernandez-Vargas, H., Herceg, Z.(2015). Aberrant dna methylation of imprinted loci in hepatocellular carcinoma and after in vitro exposure to common risk factors . Clinical Epigenetics. 7. (1).
Ghantous, A., Hernandez-Vargas, H., Byrnes, G., Dwyer, T., Herceg, Z.(2015). Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk . Mutagenesis. 30. (6). p. 733-742.
Accardi, R., Gruffat, H., Sirand, C., Fusil, F., Gheit, T., Hernandez-Vargas, H., Le Calvez-Kelm, F., Traverse-Glehen, A., Cosset, F.-L., Manet, E., et al.(2015). The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models . Carcinogenesis. 36. (11). p. 1440-1451.
Hernandez-Vargas, H., Castelino, J., Silver, M.J., Dominguez-Salas, P., Cros, M.-P., Durand, G., Le Calvez-Kelm, F., Prentice, A.M., Wild, C.P., Moore, S.E., et al.(2015). Exposure to aflatoxin B<inf>1</inf> in Utero is associated with DNA methylation in white blood cells of infants in The Gambia . International Journal of Epidemiology. 44. (4). p. 1238-1248.
Kuasne, H., de Syllos C&#243;lus, I.M., Busso, A.F., Hernandez-Vargas, H., Barros-Filho, M.C., Marchi, F.A., Scapulatempo-Neto, C., Faria, E.F., Lopes, A., Guimar&#227;es, G.C., et al.(2015). Genome-wide methylation and transcriptome analysis in penile carcinoma: Uncovering new molecular markers . Clinical Epigenetics. 7. (1).
Pierre-Benoit Ancey, Testoni, B., Gruffaz, M., Cros, M.-P., Durand, G., Le Calvez-Kelm, F., Durantel, D., Herceg, Z., Hernandez-Vargas, H.(2015). Genomic responses to hepatitis B virus (HBV) infection in primary human hepatocytes . Oncotarget. 6. (42). p. 44877-44891.
Silver, M.J., Kessler, N.J., Hennig, B.J., Dominguez-Salas, P., Laritsky, E., Baker, M.S., Coarfa, C., Hernandez-Vargas, H., Castelino, J.M., Routledge, M.N., et al.(2015). Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment . Genome Biology. 16. (1).
Ichim, G., Mola, M., Finkbeiner, M.G., Cros, M.-P., Herceg, Z., Hernandez-Vargas, H.(2014). The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle . Oncogene. 33. (2). p. 181-192.
Ecsedi, S., Hernandez-Vargas, H., Lima, S.C., Vizkeleti, L., Toth, R., Lazar, V., Koroknai, V., Kiss, T., Emri, G., Herceg, Z., et al.(2014). DNA methylation characteristics of primary melanomas with distinct biological behaviour . PLoS ONE. 9. (5).
Ghantous, A., Saffery, R., Cros, M.-P., Ponsonby, A.-L., Hirschfeld, S., Kasten, C., Dwyer, T., Herceg, Z., Hernandez-Vargas, H.(2014). Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling . BMC biotechnology. 14.
Martin, M., Ancey, P.-B., Cros, M.-P., Durand, G., Le Calvez-Kelm, F., Hernandez-Vargas, H., Herceg, Z.(2014). Dynamic imbalance between cancer cell subpopulations induced by Transforming Growth Factor Beta (TGF-β) is associated with a DNA methylome switch . BMC Genomics. 15. (1).
Accardi, R., Fathallah, I., Gruffat, H., Mariggi&#242;, G., Le Calvez-Kelm, F., Voegele, C., Bartosch, B., Hernandez-Vargas, H., McKay, J., Sylla, B.S., et al.(2013). Epstein - Barr Virus Transforming Protein LMP-1 Alters B Cells Gene Expression by Promoting Accumulation of the Oncoprotein ΔNp73α . PLoS Pathogens. 9. (3).
Ouzounova, M., Vuong, T., Ancey, P.-B., Ferrand, M., Durand, G., Le-Calvez Kelm, F., Croce, C., Matar, C., Herceg, Z., Hernandez-Vargas, H.(2013). MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells . BMC Genomics.
Lee, H.-S., Barraza-Villarreal, A., Hernandez-Vargas, H., Sly, P.D., Biessy, C., Ramakrishnan, U., Romieu, I., Herceg, Z.(2013). Modulation of DNA methylation states and infant immune system by dietary supplementation with v-3 PUFA during pregnancy in an intervention study . American Journal of Clinical Nutrition. 98. (2). p. 480-487.
Aury-Landas, J., Bougeard, G., Castel, H., Hernandez-Vargas, H., Drouet, A., Latouche, J.-B., Schouft, M.-T., F&#233;rec, C., Leroux, D., Lasset, C., et al.(2013). Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours . European Journal of Human Genetics. 21. (12). p. 1369-1376.
Sawan, C., Hernandez-Vargas, H., Murr, R., Lopez, F., Vaissi&#232;re, T., Ghantous, A.Y., Cuenin, C., Imbert, J., Wang, Z.-Q., Ren, B., et al.(2013). Histone acetyltransferase cofactor Trrap maintains self-renewal and restricts differentiation of embryonic stem cells . Stem Cells. 31. (5). p. 979-991.
(2013). Transposable hypomethylation is associated with metastatic capacity of primary melanomas . International journal of clinical and experimental pathology.
Saidj, D., Cros, M.-P., Hernandez-Vargas, H., Guarino, F., Sylla, B.S., Tommasino, M., Accardi, R.(2013). Oncoprotein E7 from beta human papillomavirus 38 induces formation of an inhibitory complex for a subset of p53-regulated promoters . Journal of Virology. 87. (22). p. 12139-12150.
Xu, X., Gammon, M.D., Hernandez-Vargas, H., Herceg, Z., Wetmur, J.G., Teitelbaum, S.L., Bradshaw, P.T., Neugut, A.I., Santella, R.M., Chen, J.(2012). DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study . FASEB Journal. 26. (6). p. 2657-2666.
Lima, S.C.S., Hernandez-Vargas, H., Sim&#227;o, T., Durand, G., Kruel, C.D.P., le Clvez-Kelm, F., Pinto, F.R.L., Herceg, Z.(2011). Identifcation of a DNA methylome signature of esophageal squamous cell carcinoma and potential epigenetic biomarkers . Epigenetics. 6. (10). p. 1217-1227.
Hernandez-Vargas, H., Ouzounova, M., le Calvez-Kelm, F., Lambert, M.-P., McKay-Chopin, S., Tavtigian, S.V., Puisieux, A., Matar, C., Herceg, Z.(2011). Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells . Epigenetics. 6. (4). p. 429-440.
Lima, S.C., Hernandez-Vargas, H., Herceg, Z.(2010). Epigenetic signatures in cancer: Implications for the control of cancer in the clinic . Current Opinion in Molecular Therapeutics. 12. (3). p. 316-324.
Hernandez-Vargas, H., Lambert, M.-P., Le Calvez-Kelm, F., Gouysse, G., McKay-Chopin, S., Tavtigian, S.V., Scoazec, J.-Y., Herceg, Z.(2010). Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors . PLoS ONE. 5. (3).
Hernandez-Vargas, H., Sincic, N., Ouzounova, M., Herceg, Z.(2009). Epigenetic signatures in stem cells and cancer stem cells . Epigenomics. 1. (2). p. 261-280.
Hern&#225;ndez-Vargas, H., Rodr&#237;guez-Pinilla, S.M., Juli&#225;n-Tendero, M., S&#225;nchez-Rovira, P., Cuevas, C., Ant&#243;n, A., R&#237;os, M.J., Palacios, J., Moreno-Bueno, G.(2007). Gene expression profiling of breast cancer cells in response to gemcitabine: NF-κB pathway activation as a potential mechanism of resistance . Breast Cancer Research and Treatment. 102. (2). p. 157-172.
Hern&#225;ndez-Vargas, H., Von Kobbe, C., S&#225;nchez-Est&#233;vez, C., Juli&#225;n-Tendero, M., Palacios, J., Moreno-Bueno, G.(2007). Inhibition of paclitaxel-induced proteasome activation influences paclitaxel cytotoxicity in breast cancer cells in a sequence-dependent manner . Cell Cycle. 6. (21). p. 2662-2668.
Hern&#225;ndez-Vargas, H., Palacios, J., Moreno-Bueno, G.(2007). Molecular profiling of docetaxel cytotoxicity in breast cancer cells: Uncoupling of aberrant mitosis and apoptosis . Oncogene. 26. (20). p. 2902-2913.
Hern&#225;ndez-Vargas, H., Ballestar, E., Carmona-Saez, P., Von Kobbe, C., Ba&#241;&#243;n-Rodr&#237;guez, I., Esteller, M., Moreno-Bueno, G., Palacios, J.(2006). Transcriptional profiling of MCF7 breast cancer cells in response to 5-flouracil: Relationship with cell cycle changes and apoptosis, and identification of novel targets of p53 . International Journal of Cancer. 119. (5). p. 1164-1175.
Molina-Arcas, M., Moreno-Bueno, G., Cano-Soldado, P., Hern&#225;ndez-Vargas, H., Casado, F.J., Palacios, J., Pastor-Anglada, M.(2006). Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells . Biochemical Pharmacology. 72. (12). p. 1646-1656.
(2004). Initial drug resistance as a threat for tuberculosis control: the case of Buenaventura, Colombia. Biomedica.
Le&#243;n, B., Mart&#237;nez Del Hoyo, G., Parrillas, V., Hern&#225;ndez Vargas, H., S&#225;nchez-Mateos, P., Longo, N., L&#243;pez-Bravo, M., Ardav&#237;n, C.(2004). Dendritic cell differentiation potential of mouse monocytes: Monocytes represent immediate precursors of CD8<sup>-</sup> and CD8<sup>+</sup> splenic dendritic cells . Blood. 103. (7). p. 2668-2676.
Mart&#237;nez Del Hoyo, G., Mart&#237;n, P., Hern&#225;ndez Vargas, H., Ruiz, S., Fern&#225;ndez Arias, C., Ardav&#237;n, C.(2002). Characterization of a common precursor population for dendritic cells . Nature. 415. (6875). p. 1043-1047.
(2001). Origin and differentiation of dendritic cells. Trends in Immunology.
(2000). Clinical and programmatic mismanagement rather than community outbreak as the cause of chronic, drug-resistant tuberculosis in Buenaventura, Colombia, 1998. The International Journal of Tuberculosis and Lung Disease.
(1998). Acquired multidrug-resistant tuberculosis--Buenaventura, Colombia, 1998. MMWR. Morbidity and Mortality Weekly Report.
OTHER
Hector Hernandez-Vargas, Pac&#244;me Lecot, Maude Ardin, S&#233;bastien Dussurgey, Vincent Alcazer, Lyvia Moudombi, Margaux Hubert, Aur&#233;lie Swalduz, Alain Viari, Christophe Caux, et al.(2021). Gene signature of circulating platelet-bound neutrophils is associated with poor prognosis in cancer patients . Cold Spring Harbor Laboratory
Hector Hernandez-Vargas, Deborah Fanfone, Zhi Chong Wu, Jade Mammi, Kevin Berthenet, David Neves, Kathrin Weber, Andrea Halaburkova, Fran&#231;ois Virard, F&#233;lix Bunel, et al.(2021). Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness . Cold Spring Harbor Laboratory
Hector Hernandez-Vargas, Alexandra Laine, Ossama Labiad, Sebastien This, Am&#233;lien Sanlaville, Sophie Leon, St&#233;phane Dalle, Dean Sheppard, Mark Travis, Helena Paidassi, et al.(2021). Cooperation between Cancer Cells and Regulatory T Cells to Promote Immune-escape through Integrin αvβ8-Mediated TGF-β Activation . Research Square
Hector Hernandez-Vargas, Chloe Goldsmith, Jes&#250;s Rafael Rodr&#237;guez-Aguilera, Ines El-Rifai, Adrien Jarretier, Val&#233;rie Hervieu, Victoria Chagoya de S&#225;nchez, Robert Dante, Gabriel Ichim(2020). Minimal detection and low biological fluctuation of mitochondrial CpG methylation at the single-molecule level . Cold Spring Harbor Laboratory
K. Berthenet, C. Castillo Ferrer, N. Popgeorgiev, H. Hernandez-Vargas, G. Ichim(2019). Failed apoptosis enhances melanoma cancer cells aggressiveness . Cold Spring Harbor Laboratory
Hector Hernandez-Vargas, Iolanda Agliata, Nora Fernandez-Jimenez, Chloe Goldsmith, Julien C. Marie, Jose Ramon Bilbao, Robert Dante(2019). The DNA Methylome of Inflammatory Bowel Disease (IBD) reflects intrinsic and extrinsic factors in intestinal epithelial cells . Cold Spring Harbor Laboratory
Vargas-Ayala RC, Jay A, Hernandez-Vargas H, Diederichs A, Robitaille A, Sirand C, Ceraolo MG, Romero M, Cros MP, Cuenin C, et al.(2018). Interplay between the epigenetic enzyme lysine (K)-specific demethylase 2B and Epstein-Barr virus infection .
Hector Hernandez-Vargas, Maria Ouzounova, Zdenko Herceg(2010). Epigenetic Identity in Cancer Stem Cells . Stem Cells & Regenerative Medicine. p. 127--139. Humana Press