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Profile Details
Contact
★★★★★
☆☆☆☆☆
Hire Dr. Giorgio Grasselli
Italy

Neuroscietist

Profile Summary
Subject Matter Expertise
Services
Scientific writing News article, Regulatory documents, Clinical trial documents, Educational content
Data science & analysis Statistical analysis
Academic research Internet research, Evidence-based answers, Secondary data compilation, Literature search
Work Experience

Researcher

Italian Institute of Technology (IIT)

July 2019 - Present

Senior Postdoc

Italian Institute of Technology (IIT)

July 2018 - June 2019

Staff Scientist

The University of Chicago

March 2017 - June 2018

Post-doctoral Scholar

The University of Chicago

March 2011 - February 2017

Expert Reviewer (volonteer)

AIRInforma (Italian Outreach Journal of the International Association of Italian Researchers)

February 2015 - January 2017

Post-doc

University of Rome Tor Vergata

April 2010 - January 2011

PhD student

Santa Lucia Foundation IRCCS

October 2006 - April 2010

Visiting student

RIKEN Brain Science Institute, Wako (Japan)

July 2008 - August 2008

Visiting student

Leibniz Institute for Neurobiology, Magdeburg (Germany)

August 2005 - September 2005

Education

PhD in Cellular and Molecular Biology

University of Rome Tor Vergata

2006 - 2010

MSc in Cellular and Molecular Biology

University of Rome Tor Vergata

September 2004 - July 2006

BSc in Cellular and Molecular Biology

University of Rome Tor Vergata

October 2001 - July 2004

Certifications
  • French Qualification to Associate Professor (HDR, Maître de conférences; Section: Neuroscience 69)

    French Ministry of Education (MENJS)

    February 2021 - Present

  • Scientific National Habilitation to Associate Professor in Molecular Biology (ASN II fascia, SC 05/E2 Biologia Molecolare)

    Italian Ministry of Education and Research

    January 2019 - Present

  • Scientific National Habilitation to Associate Professor in Pathology (ASN II fascia, SC 06/A2 Patologia generale e patologia clinica)

    Italian Ministry of Education and Research

    January 2018 - Present

  • Scientific National Habilitation to Associate Professor in Histology (ASN II fascia, SC 05/H2 Istologia)

    Italian Ministry of Education and Research

    January 2018 - Present

  • Scientific National Habilitation to Associate Professor in Physiology (ASN II fascia SC 05/D1 Fisiologia)

    Italian Ministry of Education and Research

    January 2018 - Present

  • Scientific National Habilitation to Associate Professor in Applied Biology (ASN II fascia SC 05/F1 Biologia Applicata)

    Italian Ministry of Education and Research

    January 2017 - Present

  • Verified Peer Reviewer

    Publons
    https://publons.com/researcher/519517/giorgio-grasselli/peer-review/

    January 2012 - Present

  • Professional Biologist Qualification

    Italian Biologist Body (Ordine Nazionale dei Biologi)

    January 2007 - Present

Publications
JOURNAL ARTICLE
Giorgio Grasselli, Alberto Bacci, Henk-Jan Boele, Heather K. Titley, Nora Bradford, Lisa van Beers, Lindsey Jay, Gerco C. Beekhof, Silas E. Busch, Chris I. De Zeeuw, et al.(2020). {SK}2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning{\textendash}specific memory traces . {PLOS} Biology. 18. (1). p. e3000596. Public Library of Science ({PLoS})
Grasselli, Giorgio, DiFrancesco, Mattia Lorenzo, Lodola, Francesco, Colombo, Elisabetta, Maragliano, Luca, Bramini, Mattia, Paterno, Giuseppe Maria, Baldelli, Pietro, Dalla Serra, Mauro, Lunelli, Lorenzo, et al. (2020). Neuronal firing modulation by a membrane-targeted photoswitch . Nature Nanotechnology.
Du X, Wei C, Hejazi Pastor DP, Rao ER, Li Y, Grasselli G, Godfrey J, Palmenberg AC, Andrade J, Hansel C, et al.(2019). α1ACT Is Essential for Survival and Early Cerebellar Programming in a Critical Neonatal Window . Neuron.
Giorgio Grasselli, Claire Piochon, Heather K. Titley, Dana H. Simmons, Ype Elgersma, Christian Hansel(2016). Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal . Proceedings of the National Academy of Sciences. 113. (46). p. 13221--13226. Proceedings of the National Academy of Sciences
Catanzaro, G and Pucci, M and Viscomi, MT and Lanuti, M and Feole, M and Angeletti, S and Grasselli, G and Mandolesi, G and Bari, M andCentonze, D and others(2016). Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis . Journal of Neuroimmunology. 294. p. 32--40. Elsevier
Grasselli, Giorgio and He, Qionger and Wan, Vivian and Adelman, John P and Ohtsuki, Gen and Hansel, Christian(2016). Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells . Cell Report. 14. (11). p. 2546--2553. Elsevier
Giorgio Grasselli, Alexander D Kloth, Aleksandra Badura, Amy Li, Adriana Cherskov, Sara G Connolly, Andrea Giovannucci, M Ali Bangash, Olga Peñagarikano, Claire Piochon, et al.(2015). Cerebellar associative sensory learning defects in five mouse autism models . {eLife}. 4. {eLife} Sciences Organisation, Ltd.
Kloth, A.D., Badura, A., Li, A., Cherskov, A., Connolly, S.G., Giovannucci, A., Bangash, M.A., Grasselli, G., Agarikano, O.P., Piochon, C., et al.(2015). Cerebellar associative sensory learning defects in five mouse autism models . eLife. 4. (JULY 2015).
Piochon, C., Kloth, A.D., Grasselli, G., Titley, H.K., Nakayama, H., Hashimoto, K., Wan, V., Simmons, D.H., Eissa, T., Nakatani, J., et al.(2014). Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism . Nature Communications. 5.
Grasselli, G., Rossi, S., Musella, A., Gentile, A., Loizzo, S., Muzio, L., Di Sanza, C., Errico, F., Musumeci, G., Haji, N., et al.(2013). Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis . British Journal of Pharmacology. 168. (2). p. 502-517.
Grasselli, G., Strata, P.(2013). Structural plasticity of climbing fibers and the growth-associated protein GAP-43 . Frontiers in Neural Circuits. (FEBRUARY 2013).
Grasselli, G., Hansel, C., He, Q., Piochon, C., Titley, H.(2013). Ethanol affects NMDA receptor signaling at climbing fiber-Purkinje cell synapses in mice and impairs cerebellar LTD . Journal of Neurophysiology. 109. (5). p. 1333-1342.
Centonze, D., De Chiara, V., Di Sanza, C., Errico, F., Fresegna, D., Furlan, R., Gentile, A., Grasselli, G., Haji, N., Loizzo, S., et al.(2013). Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis . British Journal of Pharmacology. 168. (2). p. 502-517.
He, Q., Titley, H., Grasselli, G., Piochon, C., Hansel, C.(2013). Ethanol affects NMDA receptor signaling at climbing fiber-Purkinje cell synapses in mice and impairs cerebellar LTD . Journal of Neurophysiology. 109. (5). p. 1333-1342.
Gentile, A., Rossi, S., Studer, V., Motta, C., De Chiara, V., Musella, A., Sepman, H., Fresegna, D., Musumeci, G., Grasselli, G., et al.(2013). Glatiramer acetate protects against inflammatory synaptopathy in experimental autoimmune encephalomyelitis . Journal of Neuroimmune Pharmacology. 8. (3). p. 651-663.
Mascaro, A.L.A., Cesare, P., Sacconi, L., Grasselli, G., Mandolesi, G., MacO, B., Knott, G.W., Huang, L., De Paola, V., Strata, P., et al.(2013). In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex . Proceedings of the National Academy of Sciences of the United States of America. 110. (26). p. 10824-10829.
Cesare, P., De Paola, V., Grasselli, G., Huang, L., Knott, G.W., MacO, B., Mandolesi, G., Mascaro, A.L.A., Pavone, F.S., Sacconi, L., et al.(2013). In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex . Proceedings of the National Academy of Sciences of the United States of America. 110. (26). p. 10824-10829.
Grasselli, G., Strata, P.(2013). Structural plasticity of climbing fibers and the growth-associated protein GAP-43 . Frontiers in Neural Circuits. (FEBRUARY 2013).
Centonze, D., De Chiara, V., Fresegna, D., Gentile, A., Grasselli, G., Haji, N., Hayardeny, L., Mandolesi, G., Motta, C., Musella, A., et al.(2013). Glatiramer acetate protects against inflammatory synaptopathy in experimental autoimmune encephalomyelitis . Journal of Neuroimmune Pharmacology. 8. (3). p. 651-663.
Mandolesi, G., Musella, A., Gentile, A., Grasselli, G., Haji, N., Sepman, H., Fresegna, D., Bullitta, S., De Vito, F., Musumeci, G., et al.(2013). Interleukin-1β alters glutamate transmission at Purkinje cell synapses in a mouse model of multiple sclerosis . Journal of Neuroscience. 33. (29). p. 12105-12121.
Allegra Mascaro, A.L., Cesare, P., De Paola, V., Grasselli, G., Huang, L., Knott, G., Maco, B., Mandolesi, G., Pavone, F.S., Sacconi, L., et al.(2013). In vivo reactive neural plasticity investigation by means of correlative two photon: Electron microscopy . Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 8588.
Grasselli, G., Strata, P.(2013). Structural plasticity of climbing fibers and the growth-associated protein GAP-43 . Frontiers in neural circuits. 7.
Mandolesi, G., Grasselli, G., Musella, A., Gentile, A., Musumeci, G., Sepman, H., Haji, N., Fresegna, D., Bernardi, G., Centonze, D.(2012). GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis . Neurobiology of Disease. 46. (2). p. 414-424.
Rossi, S., Muzio, L., De Chiara, V., Grasselli, G., Musella, A., Musumeci, G., Mandolesi, G., De Ceglia, R., Maida, S., Biffi, E., et al.(2011). Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis . Brain, Behavior, and Immunity. 25. (5). p. 947-956.
Musumeci, G., Grasselli, G., Rossi, S., De Chiara, V., Musella, A., Motta, C., Studer, V., Bernardi, G., Haji, N., Sepman, H., et al.(2011). Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis . Neurobiology of Disease. 43. (3). p. 669-677.
Mandolesi, G., Grasselli, G., Musumeci, G., Centonze, D.(2010). Cognitive deficits in experimental autoimmune encephalomyelitis: Neuroinflammation and synaptic degeneration . Neurological Sciences. 31. (SUPPL. 2).
Mandolesi, G., Vanni, V., Cesa, R., Grasselli, G., Puglisi, F., Cesare, P., Strata, P.(2009). Distribution of the SNAP25 and SNAP23 synaptosomal-associated protein isoforms in rat cerebellar cortex . Neuroscience. 164. (3). p. 1084-1096.
BOOK
Grasselli, G., Hansel, C.(2014). Cerebellar long-term potentiation. cellular mechanisms and role in learning . International Review of Neurobiology. 117. p. 39-51.
CONFERENCE PAPER
Allegra Mascaro, A.L., Cesare, P., Sacconi, L., Grasselli, G., Mandolesi, G., Maco, B., Knott, G.W., De Paola, V., Strata, P., Pavone, F.S.(2013). In vivo two-photon imaging of climbing fibers plasticity after laser axotomy . Optics InfoBase Conference Papers.
Allegra Mascaro, A.L., Cesare, P., Sacconi, L., Grasselli, G., Mandolesi, G., Maco, B., Knott, G., Huang, L., De Paola, V., Strata, P., et al.(2013). In vivo reactive neural plasticity investigation by means of correlative two photon: Electron microscopy . Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 8588.
Allegra Mascaro, A.L., Cesare, P., Sacconi, L., Grasselli, G., Mandolesi, G., Maco, B., Knott, G.W., De Paola, V., Strata, P., Pavone, F.S.(2013). In vivo two-photon imaging of climbing fibers plasticity after laser axotomy . Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 8804.
Allegra, M.A.L., Sacconi, L., Pavone, F.S., Cesare, P., Grasselli, G., Strata, P.(2011). Laser axotomy on cerebellar climbing fibers . 2011 International Workshop on Biophotonics, BIOPHOTONICS 2011.
Sacconi, L., Allegra, L., Buffelli, M., Cesare, P., Dangelo, E., Gandolfi, D., Grasselli, G., Lotti, J., Mapelli, J., Strata, P., et al.(2010). Brain plasticity and functionality explored by nonlinear optical microscopy . Proceedings of SPIE - The International Society for Optical Engineering. 7589.
Allegra Mascaro, A.L., Cesare, P., Sacconi, L., Grasselli, G., Strata, P., Pavone, F.S.(2010). Plasticity of climbing fibers after laser axotomy . Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 7548.