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USD 100 /hr
Hire Dr. Cristina C.
France
USD 100 /hr

Neuroscientist, 27 years in Pharma pre-clinical reasearch, drug discovery, in vitro, ex vivo, in vivo models

Profile Summary
Subject Matter Expertise
Services
Writing Technical Writing, Copywriting
Research Feasibility Study, Fact Checking, Gray Literature Search, Systematic Literature Review
Consulting Scientific and Technical Consulting
Data & AI Statistical Analysis, Data Visualization
Work Experience

Freelance consultant at Kolabtree , Pharmacology, Neuroscience, biomarker based models & assays development for drug discovery

Self employed

February 2020 - Present

Researcher in Neurobiology

Institut de Recherche Pierre Fabre, France

September 1994 - January 2020

Researcher

Pharmacology & Toxicology , University of Florence, Italy

September 2007 - August 2008

Researcher in Neurobiology

Pierre Fabre Medicament, France

September 1992 - August 1994

Research Consultant

Neurobiology Research, FIDIA Research Laboratories SpA, Italy

February 1991 - July 1992

Research Fellow

Institute of Biological Chemistry, University of Verona, Italy

September 1989 - January 1991

Fogarty Fellow

National Institute of Neurological Disorders and Stroke, Bethesda, MD, US

February 1988 - July 1989

Research Consultant

Neuroscience/Cardiovascular Research, Pharmaceuticals , CIBA_GEIGY Corp. , NJ, US

March 1986 - January 1988

Education

PhD (Molecular Pharmacology)

Université Paul Sabatier, Toulouse III, France

1994 - October 1997

Diploma of aptitude to practice the Profession of Biologist (Biology)

University of Florence, Italy

- 1990

Post-doctoral Traineeship (Dipartimento di Farmacologia Preclinica e Clinica, Facoltà di Medicina e Chirurgia and Istituto Interfacoltà di Chimica Biologica)

Preclinical and Clinical Pharmacology and Biological Chemistry , University of Florence, Italy

February 1985 - February 1986

Doctor in Biological Sciences (MSc) (Preclinical and clinical pharmacology , Faculty of Medicine)

Preclinical and Clinical Pharmacology , University of Florence, Italy

1983 - February 1985

Biological Sciences Program (courses and exams), University of Florence

October 1979 - October 1984

Maturità Classica (High school diploma in humanistic studies) (Humanistic Studies)

Liceo Ginnasio Statale, Nicolo Machiavelly, Florence , Italy

September 1974 - July 1979

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Cristina Cosi and Jean-Claude Martel and Agn{\`{e}}s L. Auclair and Ginetta Collo and Laura Cavalleri and Peter Heusler and Ludovic Leriche and Florence Gaudoux and Pierre Sokoloff and Paul C. Moser and Silvia Gatti-McArthur(2021). Pharmacology profile of F17464, a dopamine D3 receptor preferential antagonist . European Journal of Pharmacology. 890. p. 173635. Elsevier {BV}
Cristina Cosi and Michael Millar and Mariana Beltran and Lorcan Sherry and Silvia Gatti-McArthur(2021). Quantitative analysis of RNAscope staining for c-fos expression in mouse brain tissue as a measure of Neuronal Activation . MethodsX. 8. p. 101348. Elsevier {BV}
Newman-Tancredi, A., Martel, J.-C., Cosi, C., Heusler, P., Lestienne, F., Varney, M.A., Cussac, D.(2017). Distinctive in vitro signal transduction profile of NLX-112, a potent and efficacious serotonin 5-HT<inf>1A</inf> receptor agonist . Journal of Pharmacy and Pharmacology. 69. (9). p. 1178-1190.
Cosi, C., Mannaioni, G., Cozzi, A., Carl, V., Sili, M., Cavone, L., Maratea, D., Moroni, F.(2011). G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast . Neuropharmacology. 60. (7-8). p. 1227-1231.
Newman-Tancredi, A., Martel, J.-C., Assi&#233;, M.-B., Buritova, J., Lauressergues, E., Cosi, C., Heusler, P., Bruins Slot, L., Colpaert, F.C., Vacher, B., et al.(2009). Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT <inf>1A</inf> receptor agonist . British Journal of Pharmacology. 156. (2). p. 338-353.
Newman-Tancredi, A., Assi&#233;, M.-B., Martel, J.-C., Cosi, C., Slot, L.B., Palmier, C., Rauly-Lestienne, I., Colpaert, F., Vacher, B., Cussac, D.(2007). F15063, a potential antipsychotic with D <inf>2</inf>/D <inf>3</inf> antagonist, 5-HT <inf>1A</inf> agonist and D <inf>4</inf> partial agonist properties: (I) in vitro receptor affinity and efficacy profile . British Journal of Pharmacology. 151. (2). p. 237-252.
Cosi, C., Carilla-Durand, E., Assi&#233;, M.B., Ormiere, A.M., Maraval, M., Leduc, N., Newman-Tancredi, A.(2006). Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release . European Journal of Pharmacology. 535. (1-3). p. 135-144.
Cosi, C., Waget, A., Rollet, K., Tesori, V., Newman-Tancredi, A.(2005). Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: Role of 5-HT <inf>1A</inf> receptor activation . Brain Research. 1043. (1-2). p. 32-41.
Kleven, M.S., Assi&#233;, M.-B., Cosi, C., Barret-Gr&#233;voz, C., Newman-Tancredi, A.(2005). Anticataleptic properties of α<inf>2</inf> adrenergic antagonists in the crossed leg position and bar tests: Differential mediation by 5-HT <inf>1A</inf> receptor activation . Psychopharmacology. 177. (4). p. 373-380.
Newman-Tancredi, A., Assi&#233;, M.-B., Leduc, N., Ormi&#232;re, A.-M., Danty, N., Cosi, C.(2005). Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: Affinity, efficacy and potential implications for treatment of schizophrenia . International Journal of Neuropsychopharmacology. 8. (3). p. 341-356.
Cosi, C., Guerin, K., Marien, M., Koek, W., Rollet, K.(2004). The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo . Brain Research. 996. (1). p. 1-8.
Mount, H.T.J., Martel, J.-C., Fluit, P., Wu, Y., Gallo-Hendrikx, E., Cosi, C., Marien, M.R.(2004). Progressive sensorimotor impairment is not associated with reduced dopamine and high energy phosphate donors in a model of ataxia-telangiectasia . Journal of Neurochemistry. 88. (6). p. 1449-1454.
Cosi, C.(2002). New inhibitors of poly(ADP-ribose) polymerase and their potential therapeutic targets . Expert Opinion on Therapeutic Patents. 12. (7). p. 1047-1071.
Colpaert, F.C., Tarayre, J.P., Koek, W., Pauwels, P.J., Bardin, L., Xu, X.-J., Wiesenfeld-Hallin, Z., Cosi, C., Carilla-Durand, E., Assi&#233;, M.B., et al.(2002). Large-amplitude 5-HT<inf>1A</inf> receptor activation: A new mechanism of profound, central analgesia . Neuropharmacology. 43. (6). p. 945-958.
Koek, W., Vacher, B., Cosi, C., Assi&#233;, M.-B., Patoiseau, J.-F., Pauwels, P.J., Colpaert, F.C.(2001). 5-HT<inf>1A</inf> receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential . European Journal of Pharmacology. 420. (2-3). p. 103-112.
Cosi, C., Koek, W.(2001). Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT<inf>1A</inf> receptors expressed in HeLa cells . European Journal of Pharmacology. 433. (1). p. 55-62.
Cosi, C., Cavalieri, E., Carcereri de Prati, A., Marien, M., Suzuki, H.(2000). Effects of kainic acid lesioning on poly(ADP-ribose) polymerase (PARP) activity in the rat striatum in vivo . Amino Acids. 19. (1). p. 229-237.
Cosi, C., Koek, W.(2000). The putative &lt;&lt;silent&gt;&gt; 5-HT(1A) receptor antagonist, WAY 100635, has inverse agonist properties at cloned human 5-HT(1A) receptors . European Journal of Pharmacology. 401. (1). p. 9-15.
Vacher, B., Bonnaud, B., Funes, P., Jubault, N., Koek, W., Assi&#233;, M.-B., Cosi, C., Kleven, M.(1999). Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT(1A) receptors . Journal of Medicinal Chemistry. 42. (9). p. 1648-1660.
Assi&#233;, M.-B., Cosi, C., Koek, W.(1999). Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity . European Journal of Pharmacology. 386. (1). p. 97-103.
Cosi, C., Marien, M.(1998). Decreases in mouse brain NAD<sup>+</sup> and ATP induced by 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP): Prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide . Brain Research. 809. (1). p. 58-67.
Koek, W., Patoiseau, J.-F., Assie, M.-B., Cosi, C., Kleven, M.S., Dupont-Passelaigue, E., Carilla-Durand, E., Palmier, C., Valentin, J.-P., John, G., et al.(1998). F 11440, a potent, selective, high efficacy 5-HT(1A) receptor agonist with marked anxiolytic and antidepressant potential . Journal of Pharmacology and Experimental Therapeutics. 287. (1). p. 266-283.
Vacher, B., Bonnaud, B., Funes, P., Jubault, N., Koek, W., Assi&#233;, M.-B., Cosi, C.(1998). Design and synthesis of a series of 6-substituted-2- pyridinylmethylamine derivatives as novel, high-affinity, selective agonists at 5-HT(1A) receptors . Journal of Medicinal Chemistry. 41. (25). p. 5070-5083.
Assi&#233;, M.-B., Cosi, C., Koek, W.(1997). 5-HT(1A) receptor agonist properties of the antipsychotic, nemonapride: Comparison with bromerguride and clozapine . European Journal of Pharmacology. 334. (2-3). p. 141-147.
Cosi, C., Colpaert, F., Koek, W., Degryse, A., Marien, M.(1996). Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice . Brain Research. 729. (2). p. 264-269.
Cosi, C., Chopin, P., Marien, M.(1996). Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse . Brain Research. 735. (2). p. 343-348.
Cosi, C., Suzuki, H., Milani, D., Facci, L., Menegazzi, M., Vantini, G., Kanai, Y., Skaper, S.D.(1994). Poly(ADP‐ribose) polymerase: Early involvement in glutamate‐induced neurotoxicity in cultured cerebellar granule cells . Journal of Neuroscience Research. 39. (1). p. 38-46.
Grassi‐Zucconi, G., Menegazzi, M., De Prati, A.C., Bassetti, A., Montagnese, P., Mandile, P., Cosi, C., Bentivoglio, M.(1993). C‐fos mRNA is Spontaneously Induced in the Rat Brain During the Activity Period of the Circadian Cycle . European Journal of Neuroscience. 5. (8). p. 1071-1078.
Cosi, C., Spoerri, P.E., Comelli, M.C., Guidolin, D., Skaper, S.D.(1993). Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones . NeuroReport. 4. (5). p. 527-530.
Mitsuo, K., Cosi, C., Harvey-White, J.D., Schwartz, J.P.(1993). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) effects on enkephalinergic neurons in various regions of mouse brain . Neurochemistry International. 22. (2). p. 175-182.
Zucconi, G.G., Cosi, C., Palmieri, M., Furia, A., Bassetti, M.A., Carsana, A.(1992). A pancreatic-like ribonuclease is synthesized in rat brain . Molecular Brain Research. 14. (1-2). p. 1-6.
Sasso, M.P., Carsana, A., Confalone, E., Cosi, C., Sorrentino, S., Viola, M., Palmier, M., Russo, E., Furia, A.(1991). Molecular cloning of the gene encoding the bovine brain ribonucelase and its expression in different regions of the brain . Nucleic Acids Research. 19. (23). p. 6469-6474.
Shinoda, H., Marini, A.M., Cosi, C., Schwartz, J.P.(1989). Brain region and gene specificity of neuropeptide gene expression in cultured astrocytes . Science. 245. (4916). p. 415-417.
Cosi, C., Altar, A.C., Wood, P.L.(1989). Effect of cholecystokinin on acetylcholine turnover and dopamine release in the rat striatum and cortex . European Journal of Pharmacology. 165. (2-3). p. 209-214.
Cosi, C., Wood, P.L.(1988). Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus . Neuroscience Letters. 87. (3). p. 293-296.
Wood, P.L., Kim, H.S., Cheney, D.L., Cosi, C., Marien, M., Rao, T.S., Martin, L.L.(1988). Constant infusion of [<sup>13</sup>C<inf>6</inf>]glucose: Simultaneous measurement of turnover of GABA and glutamate in defined regions of the brain of individual animals . Neuropharmacology. 27. (7). p. 669-676.
Wood, P.L., Kim, H.S., Cosi, C., Iyengar, S.(1987). The endogenous kappa agonist, dynorphin(1-13), does not alter basal or morphine-stimulated dopamine metabolism in the nigrostriatal pathway of the rat . Neuropharmacology. 26. (11). p. 1585-1588.
Casamenti, F., Cosi, C., Pepeu, G.(1986). Effect of BM-5, a presynaptic antagonist-postsynaptic agonist, on cortical acetylcholine release . European Journal of Pharmacology. 122. (2). p. 288-290.
Pepeu, G., Casamenti, F., Pedata, F., Cosi, C., Pepeu, I.M.(1986). Are the neurochemical and behavioral changes induced by lesions of the nucleus basalis in the rat a model of Alzheimer's disease? . Progress in Neuropsychopharmacology and Biological Psychiatry. 10. (3-5). p. 541-551.
CONFERENCE PAPER
(2020). Neurotrophins in pain models . SMI'S 20TH ANNUAL PAIN THERAPEUTICS CONFERENCE 11TH MAY TO 12TH MAY 2020, UNITED KINGDOM.
(2009). L-kynurenine sulfate has antinociceptive effects in the writhing test in mice that are possibly mediated by kynurenic acid interaction with GPR35. 12° meeting of the International Society for Typtophan Research (ISTRY), Florence, Italy.
(2007). The excitotoxic hypothesis of schizophrenia and antipsychotic drugs as neuroprotective agents. 10th International Congress on Amino Acids and Proteins (ICAAP), Kallithea, Chalkidiki, Greece.
(2003). Implication of PARP in neurodegeneration and PARP inhibitors as potential neuroprotective agents. International meeting on Poly (ADP-ribose) polymerases as novel therapeutic targets, Lisbon, Portugal.
(2001). Further evidence for the involvement of PARP in excitotoxicity : The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the striatum in the mouse brain. 13th International Symposium on ADP-ribosylation 2001 : Targeting ADP-ribosylation for Development of New Therapies, NewYork, USA.
(1999). Implication of poly(ADP-ribose) polymerase (PARP) in excitotoxicity. 6th International Congress on Amino Acids, Bonn.
Koek W., Cosi C., Kleven, M.S., F.C.Colpaert. Efficacy-dependent effects of 5-HT1A agonists. European Behavioural Pharmacology Society (EBPS), 5-HT1A Workshop. Brno, Czech Republic. 1998.
(1996). Poly(ADP-ribose) polymerase (PARP) revisited. A new role for an old enzyme: PARP involvement in neurodegeneration and PARP inhibitors as possible neuroprotective agents. Third International Conference on Neuroprotective Agents, Clinical and Experimental Aspects. Varenna, Lago di Como, Italy.
CONFERENCE ABSTRACT
Cosi, C., N’Guyen, V., Consul-Denjean, N., Auclair, A., Heusler, P., Martel, J., . . . Gatti-McArthur, S. (2017). F17464 a new antipsychotic with preferential D3 antagonist, 5-HT1A partial agonist properties. Neurochemical studies. European Psychiatry, 41(S1), S807-S807. doi:10.1016/j.eurpsy.2017.01.1562 .
TY - JOUR AU - Cosi, Cristina AU - Marty, Fabien AU - Maillos, Philippe AU - Moser, Paul PY - 2013/10/01 SP - 1226 T1 - Effects of positive allosteric modulators (PAMs) of nicotinic receptors on intracellular Ca2+ concentration [Ca2+]i in mouse embryonic mesencephalic neurons in primary culture VL - 86 DO - 10.1016/j.bcp.2013.08.034 JO - Biochemical Pharmacology ER - .
TY - JOUR AU - Cosi, Cristina AU - Bardin, L. AU - Marien, M. AU - Boyer, S. AU - Deportere, R. AU - Newmann-Tancredi, A. PY - 2009/01/01 SP - 27 EP - 27 T1 - Effects of Milnacipran, Duloxetine and Pregabalin on the changes in BDNF levels elicited by repeated restraint stress in the rat VL - 13 JO - International Journal of Psychiatry in Clinical Practice ER -.
G. MANNAIONI, L. CAVONE, M. SILI, A. COZZI, R. BERLINGUER PALMINI, C. COSI, A. MASI, F. MORONI;. Astrocytes express functionally active GPR35: Is this the molecular mechanism of kynurenic acid effects on excitatory synapses?. Program No. XXX.XX. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online.
C. COSI, L. BARDIN, M. MARIEN, S. BOYER, R. DEPOORTÈRE, A. NEWMAN-TANCREDI;. Repeated restraint stress increases BDNF plasma levels in rat: Effects of milnacipran, pregabalin and duloxetine. Program No. XXX.XX. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online.
Newman-Tancredi A., Martel J.C., Assie M.B., Cosi C., Bruins Slot L., Cussac D. F15599, a highly selective serotonin 5-HT1A receptor agonist: I) in vitro affinity and efficacy profile at native rat and recombinant human 5-HT1A receptors. ECNP, Paris, France 2006.
Cosi, C. ; Carilla-Durand, E. ; Assié, M. ; Ormiere, A. ; Maraval, M. ; Leduc, N. ; Newman-Tancredi, A.. Partial agonism of the antipsychotics SSR181507, aripiprazole, and bifeprunox at dopamine D2 receptors: G-protein activation and prolactin release.. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
Cosi, C.*1 ; Waget, A.1 ; Rollet, K.1 ; Tesori, V.1 ; Newman-Tancredi, A.1. Clozapine, ziprasidone and aripiprazole, but not haloperidol, protect against kainic acid-induced lesion of the mouse striatum, in vivo: Role of 5-HT1A receptor activation.. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Cosi, C.; Assie, M. B. ; Leduc, N. ; Ormiere, A. M. ; Newman-Tancredi, A.. in vitro affinity and efficacy of novel antipsychotics having mixed D2 antagonist/5-HT1A agonist properties.. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
Mount, H. T. J. ; Martel, J. C. ; Fluit, P.1 ; Wu, Y. J. ; Cosi,C ; Marien, M. R. Mild sensorimotor impairment is not associated with depletion of energetic charge or monoamine transmitter levels in a mouse model of ataxia telangiectasia.. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
Cosi, C. ; Marien, M. .KAINIC ACID LESIONING OF MOUSE STRIATUM CAUSES TIME-DEPENDENT CHANGES IN ENERGY METABOLITES THAT ARE PREVENTED BY THE PARP INHIBITOR BENZAMIDE . Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
Guerin, K. ; Koek, W. ; Cosi, C.. The PARP inhibitor benzamide protects against kainic acid lesioning of the striatum in the mouse brain.. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
Cosi, C.; Assie, M. B. ; Koek, W. Agonist, antagonist, and inverse agonist properties of antipsychotics at 5-HT1A receptors measured by [35S]GTPγS binding in HA7 cells. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
Cosi C., Cavalieri E., Carcereri de Prati A., Marien M., Suzuki H. Implication of poly (ADP- ribose) polymerase (PARP)in excitotoxicity. Amino Acids 17 (1) : 5-6 (1999).
Cosi C., Marien M. Cortical noradrenaline depletions by DSP4: lack of protection by acute co-treatment with the poly(ADP-ribose)polymerase (PARP) inhibitor, benzamide (BNZ). Soc. Neurosci. Abstr. 24: 2155.
Dupont-Passelaigue E., Patoiseau J.-F., Koek W., Assie N., Cosi C., Kleven M., Rouais C., Blettery J.-L., Colpaert F.C. S.A.R. of a novel series of high efficacy 5-HT1A agonists with antidepressant and anxiolytic potential. 15th International Symposium on Medicinal Chemistry, 8-12 September, Edinburg. 1998.
Koek W., Cosi C., Carilla-Durand E., France C.P. The use of irreversible antagonists for the characterization of 5-HT1A agonist effects. European Behavioural Pharmacology Society (EBPS), 5-HT1A Workshop. Brno, Czech Republic. 1998.
Cosi C., Koek W. Inverse agonist properties of way 100635 at cloned human 5-HT1A receptors. Fourth IUPHAR Satellite Meeting on Serotonin. Rotterdam, The Netherlands. 1998.
Assie M.B., Cosi C., and Koek W. Characterization of 5-HT1A receptor-mediated effects of nemonapride, bromerguride and clozapine. Soc. Neurosci. Abstr. 23: 1223. New Orleans, USA, 1997.
Suzuki H., Cavalieri E., Marien M., Fernandez-Sanchez and Cosi C. Effects of kainic acid lesioning on poly(ADP-ribose) polymerase (PARP) activity in the rat striatum in vivo. Soc. Neurosci. Abstr. 23: 2296. New Orleans, USA, 1997.
Cosi C. and Marien M. MPTP-induced decrease in mouse brain NAD+ and ATP are prevented in vivo by the poly(ADP-ribose) polymerase (PARP) inhibitor, benzamide (BNZ). Soc. Neurosci. Abstr. 23: 275. New Orleans, USA, 1997.
Marien M., Chopin P. and Cosi C. Benzamide protects against methamphetamine-induced dopamine depletion in C57Bl/6 mice. Soc. Neurosci. Abstr. 22: 1914. Washington, D.C. USA. 1996.
Cosi C., Colpaert F., Koek W. and Marien M. Benzamide prevents MPTP-induced neurotoxicity in C57Bl/6 mice. Soc. Neurosci. Abstr. 21: 560. San Diego, CA, USA. 1995.
Cosi C., Suzuki H., Facci L., Milani D. and Skaper S.D. Poly(ADP-ribose) polymerase: an early marker of glutamate mediated neuronal death. Soc. Neurosci. Abstr. 18: 46. Anaheim, CA, USA. 1992.
Cosi C., Libonati M. and Suzuki H. Possible involvement of poly(ADP-ribose) polymerase in glutamate-induced neuronal death. Oji International Seminar on ADP-ribosylation reaction. Mechanisms and Biological Function. Abstr. 51. Tsukuba, Japan. September, 1992.
Grassi-Zucconi G., Menegazzi H., Carcerieri Di Prati A., Cosi C. and Bentivoglio M. c-Fos is spontaneously induced in the rat brain in the activity period of the circadian cycle. Soc. Neurosci. Abstr. 17: 381. New Orleans, USA. 1991.
Vantini G., Schiavo N., Cosi C., Gabellini N., Leon A. and M.A. Tria. Intracerebroventricular (icv) administration of NGF to newborn rat induces an increase of acetylcholinesterase (AChE) activity in forebrain regions. Soc. Neurosci. Abstr. 17: 1313. New Orleans, USA. 1991.
Grassi-Zucconi G., Carcerieri Di Prati A., Menegazzi H., Cosi C. and Suzuki H. DNA repair enzymes in the brain: DNA polymerase B and poly(ADP-ribose)polymerase. New York Academy of Sciences Congress on Aging and Cellular Defense Mechanisms, Modena, Italy. September 1991.
Cosi C., Suzuki H., Vantini G., dal Toso R., Leon A. and S.D. Skaper. Poly (ADP-ribose) polymerase: an early marker of glutamate-mediated neuronal death. New York Academy of Sciences Congress on Aging and Cellular Defense Mechanisms, Modena, Italy. September 1991.
Sasso M.P., Sorrentino S., Viola M., Cosi C., Confalone E., Palmieri, Carsana A. and A. Furia. Structure and expression of the bovine brain ribonuclease gene. Abstr. Soc. Ital. Biochimica, Minerva Biotecnologia (Suppl.) 2(3): 299. 1990.
Cosi, C., Carsana, A., Furia, A., Palmieri, M. and Grassi-Zucconi, G. Pancreatic ribonuclease mRNA in rat brain. Soc. Neurosci. Abstr. 16: 345. St. Louis, USA. 1990.
Grassi-Zucconi, G., Menegazzi, M., Carcerieri De Prati, A., Poltronieri, Cosi, C. and Suzuki, H. ADP-ribosilazione nel sistema nervoso. Atti Ital. Biol. Sperim. Fisiologia Nutrizione Umana. Perugia, Italy. 1990.
Carsana A., Cosi C., Furia A., Palmieri M. and G. Grassi- Zucconi. Espressione del gene della ribonucleasi pancreatica nel cervello e in altri organi del ratto. Atti Soc. Ital. Biol. Sperim. Fisiologia Nutrizione Umana. Perugia, Italy. 1990.
Carsana A., Furia A., Palmieri M., Confalone E., Sasso M.P., Sorrentino S., Viola M., Merola M., Cosi C. and M. Libonati. Genes coding for pancreatic-type ribonucleases. Intl. Meeting on Structure, Mechanism and Function of Ribonucleases. Abstr. L18, pp. 36. Sant Feliu de Guixols, Spain. 1990.
Cosi C., Shinoda H., Harvey-White J.D., Zuddas A., and Schwartz J.P. Effect of MPTP on proenkephalin mRNA and met-enkephalin content in the mouse striatum. Soc. Neurosci. Abstr. 15: 138. Phoenix, AZ, USA. 1989.
Schwartz, J.P., Shinoda, H., Marini, A.M. and Cosi, C. Neuro-peptide gene expression in cultured astrocytes: Brain region and gene specificity. Soc. Neurosci. Abstr. 15: 690. Phoenix, AZ, USA. 1989.
Cosi C., Kim H.S., and Wood P.L. Serotoninergic (5HT2) regulation of plasma corticosterone and prolactin. Soc. Neurosci. Abstr. 14: 846. Toronto, Canada. 1988.
Cosi C. and Wood P.L. Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus. Soc. Neurosci. Abstr. 13: 1193. New Orleans, USA. 1987.
Rowan G.A., Flaherty C.F., Kim H.S., Cosi C., Cheney D.L., and Wood P.L. Comparison of action of the GABA-A agonist, muscimol and benzodiazepine receptor agonist, CGS 9896 and diazepam on GABA and glutamate turnover in the rat cortex and cerebellum. Soc. Neurosci. Abstr. 13: 959. New Orleans, USA. 1987.
Wood P.L., Kim H.S., and Cosi C. Kappa receptor modulation of the nigro-collicular GABA pathway in the rat. Soc. Neurosci. Abstr. 13: 1445. New Orleans, USA, 1987.
Peoples L.L., Cosi C., Gerhardt S.C., Wood P.L., and Boast C.A. Gerbil forebrain ischemia increases acetylcholine turnover in the hippocampus but not in the striatum. Soc. Neurosci. Abstr. 13: 497. New Orleans, USA. 1987.
Cosi C. and Wood P.L. Effect of cholecystokinin on acetylcholine turnover in the rat striatum and cortex. International Symposium on Brain Acetylcholine: From Preclinical to Clinical Investigations. Abstr. 38. Taormina, Italy. September 1987.
BOOK
Marien, M., Cosi, C.(1999). Central noradrenergic neurotoxicity of DSP4 in mice. Studies on the neuroprotective potential of the poly(ADP-ribose) polymerase inhibitor, benzamide . Annals of the New York Academy of Sciences. 890. p. 336-339.
Cosi, C., Marien, M.(1999). Implication of poly(ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism: Decreases in mouse brain NAD<sup>+</sup> and ATP caused by MPTP are prevented by the PARP inhibitor benzamide . Annals of the New York Academy of Sciences. 890. p. 227-239.
Cosi, C., Suzuki, H., Skaper, S.D., Milani, D., Facci, L., Menegazzi, M., Vantini, G., Kanai, Y., Degryse, A., Colpaert, F., et al.(1997). Poly(ADP-Ribose) polymerase (PARP) revisited. A new role for an old enzyme: PARP involvement in neurodegeneration and PARP inhibitors as possible neuroprotective agents . Annals of the New York Academy of Sciences. 825. p. 366-379.
ZUCCONI, G.G., PRATI, A.C.D., MENEGAZZI, M., COSI, C., SUZUKI, H.(1992). DNA Repair Enzymes in the Brain: DNA polymerase β and Poly (ADP‐ribose) polymerase . Annals of the New York Academy of Sciences. 663. (1). p. 432-435.
LECTURE SPEECH
(1998). Poli(ADP-riboso) polimerasi (PARP): un nuovo ruolo per un vecchio enzima. Implicazione della PARP nella neurodegenerazione e possibile uso dei suoi inibitori come agenti protettivi. Faculty of Medecine, University of Florence, Florence, Italy.
(1997). Poly(ADP-ribose) polymerase (PARP) revisited. A new role for an old enzyme: PARP involvement in neurodegeneration. Faculty of Medicine, University of Oviedo, Oviedo, Spain.
(1993). Poly(ADP-ribose) polymerase: early involvement in glutamate induced neurotoxicity in cultured cerebellar granule cells. Workshops and Summer School on "Developmental neurobiology and regeneration: neuroimmunology, neurogenetics and neurotoxicology", organised by the Institute of Developmental Neurosciences and Ageing (IDNA, USA) and SIGMA-TAU (Italy), Elba, Italy.
(1991). Poly(ADP-ribose) polymerase : possible involvement in glutamate-mediated neurotoxicity in cerebellar granule cells in culture. Department of Biochemistry, University of Verona, Italy.
(1990). MPTP neurotoxicity as a tool for the study of central dopaminergic regulation of enkephalin synthesis in vivo. Research Laboratories, Farmitalia-Carlo Erba, Nerviano (Milano), Italy.
(1988). Effects of cholecystokinin on acetylcholine turnover and dopamine release in the rat brain in vivo. Synthelabo LERS, Paris, France.
RESEARCH TECHNIQUE
(1992). 1. Use of double stranded DNA probes in situ hybridization histochemistry; 2. Combination of in situ hybridization with immunohistochemistry. Internal mini-course on techniques in molecular biology, FIDIA S.p.a., Abano Terme, PD, Italy.