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Hire Dr. Chun Lai T.

Japan

USD 20 /hr

Protein Design, Protein Structure Analysis, Machine Learning and NGS Data Analysis

Profile Summary

5+ years wet-lab plus 4+ years dry-lab experience in molecular biology and bioinformatics, Tam possesses the most in-demand experimental techniques (NGS library preparation, recombinant protein expression and purification, high-throughput assay design) and skills in bioinformatics data analysis (e.g. NGS data analysis, computational protein design). Tam is now a Ph.D. student at the University of Tokyo and concurrently an International Program Associate at the research institute RIKEN, Japan, working on his projects on structure-based computational protein design, an emerging field that delivers de novo designed proteins (e.g. enzymes and antibodies) with novel functions. Tam is now exploring different possibilities in his future career in molecular biology and bioinformatics, either in the context of biotech business or the academia. Tam is particularly interested in biotech companies related to applications of NGS and protein design (e.g. enzyme design and antibody design). If you have any questions, feel free to contact Tam for more discussions. Publications/ Conferences Tam, C.; Kumar, A.; Zhang, K.Y.J. NbX: Machine Learning-Guided Re-Ranking of Nanobody–Antigen Binding Poses. Pharmaceuticals 2021, 14, 968. Tam, C.; Yuen, M.H.; Nim, Y.S.; Xu, Y.F.; Au, S.W.N.; Ngo, J.C.K.; Huang, P.; Wong, K.B. Structure-based discovery of inhibitors of Helicobacter pylori urease: abridged secondary publication. Hong Kong Med. J. 2020, 26 Suppl 4, 29–31. Tam, C., Zhang, K.Y.J. FPredX: interpretable models for the prediction of spectral maxima, brightness and oligomeric states of fluorescent proteins. (manuscript under review) Wang, S.; Tam, C.; Naito, I.; Nishiyama, S.; Tao, R. Frequent reversion and continuous size variation in the small fruit mutant ‘Totsutanenashi’ persimmon. Acta Hortic. 2021, 117–122. Li, C.; Huang, P.; Wong, K.; Xu, Y.; Tan, L.; Chen, H.; Lu, Q.; Luo, C.; Tam, C.; Zhu, L.; et al. Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process. J. Enzyme Inhib. Med. Chem. 2018, 33, 1362–1375. 西山総一郎, Wang, S., Tam, C., 田尾龍太郎 カキ’平核無’に生じた小果変異の起源と多面発現. 園芸学会令和3年度春季大会 2021

Subject Matter Expertise

• ★ Bioinformatics
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Next Generation Sequencing (NGS)
• ☆ Recombinant Protein Expression
• ☆ Data Science
• ☆ Machine Learning
• ☆ Artificial Intelligence
• ☆ Deep Learning
• ☆ Protein/Enzyme Engineering
• ☆ Python
• ☆ Drug Design

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing

Research Market Research, User Research, Feasibility Study, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Algorithm Design-Non ML, Data Visualization, Big Data Analytics, Data Processing, Data Insights

Product Development Formulation, Stability/Shelf Life Testing, Product Evaluation, Material Sourcing, Product Validation, Concept Development, Prototyping

Work Experience

International Program Associate

RIKEN

September 2018 - Present

Junior research assistant

The Chinese University of Hong Kong

August 2014 - September 2016

Lab Technician

Beijing Genomics Institute

December 2013 - July 2014

Education

Ph.D. Computational Biology and Medical Sciences

Tokyo University

October 2018 - December 2021

MSc. Agronomy and Horticultural Sciences

Kyoto University

October 2016 - September 2018

BSc. Food and Nutritional Sciences

The Chinese University of Hong Kong

September 2010 - August 2018

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Chunlai Tam and Ashutosh Kumar and Kam Y. J. Zhang(2021). NbX: Machine Learning-Guided Re-Ranking of Nanobody–Antigen Binding Poses . Pharmaceuticals. 14. (10). p. 968. {MDPI} {AG}

S. Wang and C.L. Tam and I. Naito and S. Nishiyama and R. Tao(2021). Frequent reversion and continuous size variation in the small fruit mutant ‘Totsutanenashi’ persimmon . Acta Horticulturae. (1312). p. 117--122. International Society for Horticultural Science ({ISHS})

(2020). Structure-based discovery of inhibitors of <i>Helicobacter pylori</i> urease: abridged secondary publication. Hong Kong medical journal = Xianggang yi xue za zhi.

(2018). Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process . Journal of enzyme inhibition and medicinal chemistry.