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Hire Dr. Arndt B.

Germany

USD 120 /hr

Pharma-professional with 17 years of experience in cancer target discovery and biomarker development

Profile Summary

Ph.D. in Molecular Genetics Basic research experience in functional genome analysis, cell cycle and apoptosis Oncology target discovery in pharma (Novartis) Bioinformatics in preclinical and clinical research in pharma R programming Data mining Data visualization Biomarker discovery in clinical phases II and III in various indications Biomarker strategies Clinical study protocol contributions Patient stratification / personalized medicine Diagnostic test development Transcriptomics, proteomics I have developed a proprietary method to generate diagnostic/predictive algorithms, based on -omics data. These algorithms are highly robust across independent cohorts and technical batches. They are particularly suited for heterogeneous patient (sub-) populations.

Subject Matter Expertise

• ★ Biomarkers
• ☆ Computational Biology
• ☆ Microbiology
• ☆ Phycology/Algae
• ☆ Biostatistics
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Comparative Genomics
• ☆ Proteomics
• ☆ Genomics
• ☆ Next Generation Sequencing (NGS)
• ☆ Gene Expression Analysis
• ☆ Biological Systems Engineering
• ☆ Data Science
• ☆ Data Visualization
• ☆ Health Data Analysis
• ☆ Bioinformatics
• ☆ Biomarker Discovery
• ☆ Industrial Biotechnology
• ☆ Synthetic Biology
• ☆ Agricultural Biotechnology
• ☆ R
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ Pharmacogenomics
• ☆ In vitro Diagnostics
• ☆ In vitro Diagnostic Design
• ☆ Biomarker Analysis
• ☆ Clinical Trials
• ☆ Clinical Trials Data Analysis
• ☆ Precision Medicine

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Technical Writing

Research Market Research, User Research, Meta-Research, Feasibility Study, Fact Checking, Gap Analysis, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Algorithm Design-Non ML, Data Visualization, Big Data Analytics, Data Processing, Data Insights

Product Development Formulation, Product Evaluation, Product Validation, Concept Development, Prototyping

Work Experience

Managing Director

VeViVas GmbH

June 2017 - Present

Biomarker expert / Senior investigator

Novartis Institutes for BioMedical Research Basel

July 2008 - March 2017

Section head

Novartis Institutes for BioMedical Research Basel

April 2007 - June 2008

labhead computatonal biology

Novartis Pharma AG

April 2001 - March 2007

Postdoc

Novartis

February 1999 - March 2001

Postdoc

Biozentrum

August 1997 - December 1998

Education

PhD Genetics, summa cum laude

Biozentrum der Universität Basel, Switzerland

January 1994 - June 1997

Diplom Biologie

Ludwig Maximilian University of Munich

September 1987 - June 1993

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2017). Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy . Arthritis research & therapy.

(2015). Gene-expression analysis of adult-onset Still's disease and systemic juvenile idiopathic arthritis is consistent with a continuum of a single disease entity . Pediatric rheumatology online journal.

(2013). Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial . Lancet (London, England).

(2011). A microarray analysis of full depth knee cartilage of ovariectomized rats . BMC research notes.

(2008). Modulation of drug resistance by artificial transcription factors . Molecular cancer therapeutics.

(2006). PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway . Experimental cell research.

(2005). Genetic reprogramming of tumor cells by zinc finger transcription factors . Proceedings of the National Academy of Sciences of the United States of America.

(2004). Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis . Cancer research.

(2002). A microarray-based, integrated approach to identify novel regulators of cancer drug response and apoptosis . Oncogene.

(2002). Reorientation of mispositioned spindles in short astral microtubule mutant spc72Delta is dependent on spindle pole body outer plaque and Kar3 motor protein . Molecular biology of the cell.

(2000). Comparative microarray analysis of gene expression during apoptosis-induction by growth factor deprivation or protein kinase C inhibition . Oncogene.

(2000). Time-lapse video microscopy analysis reveals astral microtubule detachment in the yeast spindle pole mutant cnm67 . Molecular biology of the cell.

(2000). Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames. Yeast (Chichester, England).

(1998). Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (Chichester, England).

(1998). Saccharomyces cerevisiae cells with defective spindle pole body outer plaques accomplish nuclear migration via half-bridge-organized microtubules . Molecular biology of the cell.

(1997). Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae. Yeast (Chichester, England).

(1996). Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase . Proceedings of the National Academy of Sciences of the United States of America.

(1994). New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae . Yeast (Chichester, England).