{"id":8630,"date":"2020-12-09T09:06:32","date_gmt":"2020-12-09T09:06:32","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=8630"},"modified":"2023-04-18T11:08:15","modified_gmt":"2023-04-18T11:08:15","slug":"top-10-biotech-innovations-you-should-know-about","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/","title":{"rendered":"Top 10 Biotech Innovations You Should Know About"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_45_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" area-label=\"ez-toc-toggle-icon-1\"><label for=\"item-69f89baad7525\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-69f89baad7525\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#_1_Single_Cell_Technologies\" title=\"\u00a01. Single Cell Technologies\">\u00a01. Single Cell Technologies<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#2_Aptamer_biosensors\" title=\"2. Aptamer biosensors\u00a0\">2. Aptamer biosensors\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#3_Current_Cell_Therapies\" title=\"3. Current Cell Therapies\u00a0\">3. Current Cell Therapies\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#4_Stem_Cell_Applications\" title=\"4. Stem Cell Applications\">4. Stem Cell Applications<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#5_CRISPR-based_Platforms\" title=\"5. CRISPR-based Platforms\">5. CRISPR-based Platforms<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#6_Directed_Evolution_Platforms\" title=\"6. Directed Evolution Platforms\">6. Directed Evolution Platforms<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#7_Microbiome-based_Innovations\" title=\"7. Microbiome-based Innovations\u00a0\">7. Microbiome-based Innovations\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#8_DNA_Hard_Drives\" title=\"8. DNA Hard Drives\">8. DNA Hard Drives<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#9_DNA_Origami\" title=\"9. DNA Origami\u00a0\">9. DNA Origami\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#10_Artificial_Intelligence_in_Medicine\" title=\"10. Artificial Intelligence in Medicine\">10. Artificial Intelligence in Medicine<\/a><\/li><\/ul><\/nav><\/div>\n<p><em><a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/jennifer-huen\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=BiotechInnovations\">Jennifer Huen<\/a>, <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/biochemistry\">freelance biochemist<\/a> on Kolabtree, outlines the top 10 biotech innovations in the market today. Read about the top life science products &amp; services and the companies behind them.\u00a0\u00a0<\/em><\/p>\n<p><span style=\"font-weight: 400;\">Biotechnological innovations have grown steadily in the past 10 years, not only in the medical arenas but also in agriculture, environment, and energy sectors. Almost all of these <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/biotechnology-and-bioengineering\" target=\"_blank\" rel=\"noopener\">biotech<\/a> innovations involve genetic engineering, diagnostics, or assays, reflecting on the importance of synthetic biology on current biotechnological developments. Here are the top 10 biotech innovations that are transforming the industry.\u00a0<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"_1_Single_Cell_Technologies\"><\/span><strong>\u00a01. Single Cell Technologies<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Single cell technologies provide detailed views of cellular environments and are important tools used in drug discovery and clinical research. Together with <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/next-generation-sequencing\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=BiotechInnovations\">next generation sequencing<\/a>, single cell technologies reveal a more realistic picture of a cell population, which is especially important in understanding the heterogeneity of the tumor environment. As these technologies are mainly used in the research setting, a number of contract research companies offer single cell sequencing and analysis platforms with specific DNA panels. For example, <strong>Mission Bio<\/strong> offers their Tapestri Platform for researchers to genetically profile each cell in a given population using a two-step microfluidic workflow combined with single cell sequencing [1]. Disease-specific profiling can be achieved by using specific DNA panels, such as the acute lymphoblastic leukemia panel [1]. Single cell analyses usually require multiple machines with separate protocols but Berkeley Lights has taken a step further by developing a single machine that can process and analyze cells one-by-one, simultaneously. The Beacon is capable of multiple single cell manipulations in one optofluidic chip containing tens of thousands of tiny cell chambers [2]. By using light induced dielectrophoresis, specific cells are partitioned for further analysis, such as antibody repertoire screening as demonstrated by the drug discovery company,<strong> Aldevron<\/strong> [2, 3]. The Lightning was also recently launched to cater to T-cell specific research [4].<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"2_Aptamer_biosensors\"><\/span><strong>2. Aptamer biosensors<\/strong><span style=\"font-weight: 400;\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Glucose monitors, pregnancy tests, and heavy-metal sensors are just a few of the biosensor-based detectors developed and used since the 1960s [5]. Biosensors consist of enzymes, antibodies, or microbes that enable a readout of the compound that is detected. Newer sensor technologies have focused on nucleic acid aptamer-based methods as they have the potential to be more sensitive, stable, and cost effective than earlier methods. <strong>Aptamer biosensors<\/strong> are typically developed by systematic evolution of ligands using exponential enrichment (SELEX,[6]), which generate stable DNA or RNA molecules that are highly selective to its target. For environmental testing or medical diagnostics where sample complexity is high, aptamers might just be the right type of molecule and a number of companies have focused on developing aptamers for these purposes. For example, South Korea-based Aptamer Sciences has developed an in vitro diagnostic test called the AptoDetect-Lung that assesses the risk of a patient developing lung cancer by detecting seven lung cancer biomarkers [7]. The test was shown to improve diagnostic accuracy compared to CT scan examination [8]. AptoDetect-Lung was recently granted diagnostic approval by the Korean Ministry of Food and Drug Safety [7].<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"3_Current_Cell_Therapies\"><\/span><strong>3. Current Cell Therapies\u00a0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Management of chronic illnesses sometimes requires repeated drug treatments but imagine if there was a way for drugs to be delivered where it needs to be, <\/span><i><span style=\"font-weight: 400;\">when<\/span><\/i><span style=\"font-weight: 400;\"> it is needed, automatically. This is where scientists are developing drug delivering cell therapies [9]. In type-1 diabetic patients, impaired pancreatic \u03b2-cells lead to insulin deficiency and a build up of blood glucose, resulting in symptoms such as frequent urination, excessive thirst, and headache [10]. A possible solution is being developed by <strong>Seraxis<\/strong>: an implantable device composed of lab-grown pancreatic cells that directly respond to a patient\u2019s blood glucose levels [11]. The device contains islet cells manufactured from induced pluripotent stem cells (iPSCs) and is intended to eliminate drug treatments for these patients. Another company currently developing implantable one-time treatments is Auckland-based <strong>Living Cell Technologies<\/strong>. Their NTCell therapy consists of an alginate-coated capsule containing neonatal choroid plexus cells that is implanted into the brains of Parkinson\u2019s patients [12]. Choroid plexus cells supply cerebrospinal fluid, mitogens, and other factors that support neuronal growth and function [12]. In 2013, Living Cell Technologies sponsored the world\u2019s first clinical trial for regenerative cell therapy for Parkinson\u2019s disease and is currently evaluating NTCell for further studies.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"4_Stem_Cell_Applications\"><\/span><strong>4. Stem Cell Applications<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Since the early 1980s, scientists have been studying the conditions and controlling the identity of which <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/Stem-Cells\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=BiotechInnovations\">stem cells<\/a> differentiate. The ability to generate the desired cell type by controlled differentiation proved to be industrially important in areas such as drug development, regenerative medicine, and the manufacture of valuable bio-materials. For example, one Canadian-based company, <strong>NovoHeart<\/strong>, developed a solution for researchers looking to conduct drug tests for cardiac diseases. Their MyHeart platform utilizes iPSCs to generate human cardiac tissue or organ models, such as their human ventricular cardiac organoid chamber (or human heart-in-a-jar), which more closely mimics the actual human heart environment than animal models typically used during preclinical development [13, 14]. MyHeart is intended to predict, more accurately, the effects of new drugs before they head to clinical trials. Another company is focused on bringing stem cell technology directly to the point of need. <strong>Platelet BioGenesis<\/strong>, a 2014 startup based in Massachusetts, is developing an on-demand, mobile bioreactor for in-field cell therapy, such as in military medical posts [15, 16]. The bioreactor manufactures iPSC-derived platelet-like cells that are currently being developed to treat blood-clotting diseases like immune thrombocytopenia [16].<\/span><\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\">&quot;By integrating <a href=\"https:\/\/twitter.com\/Harvard?ref_src=twsrc%5Etfw\">@Harvard<\/a>&#39;s valved bioreactor technology with our own proprietary human heart-in-a-jar, Novoheart will advance its disease modeling capabilities to an unprecedented level of biofidelity for in vitro human cardiac assays&quot; &#8211; Kevin Costa<a href=\"https:\/\/t.co\/zBwXX48EPL\">https:\/\/t.co\/zBwXX48EPL<\/a><\/p>\n<p>&mdash; Novoheart (@Novoheart) <a href=\"https:\/\/twitter.com\/Novoheart\/status\/1207711402439434243?ref_src=twsrc%5Etfw\">December 19, 2019<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0Stem cells technologies are certainly not limited to medical research and treatments, and this is shown by the number of companies investing in cultured meats and alternative protein. Using cellular agriculture, companies like <strong>Future Fields<\/strong>, <strong>Memphis Meats<\/strong>, and <strong>Super Meat<\/strong> are developing lab-grown chicken, beef, duck, eggs, and milk. The first hamburger patty was produced in 2013 in Mark Post\u2019s lab at Maastricht University, but for the colossal price of around $300,000 USD [17, 18]. Since then, companies have raced to reduce the manufacturing costs with Israel-based Super Meat potentially leading the race: the launch of the first lab-grown chicken tasting menu this October at their restaurant, The Chicken [19, 20].<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"5_CRISPR-based_Platforms\"><\/span><strong>5. CRISPR-based Platforms<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Since the discovery of the <\/span><i><span style=\"font-weight: 400;\">Streptococcus pyogenes<\/span><\/i><span style=\"font-weight: 400;\"> CRISPR-Cas9 adaptive immune response by the groups of Jennifer Doudna and Emmanuelle Charpentier [21], both of whom are this year\u2019s Nobel prize recipients in chemistry, a number of CRISPR-based companies have been established. However, the first commercial application actually began in 2007 when scientists at Danisco (acquired by DuPont in 2011) discovered short repeat sequences in the genome of one of their yogurt bacteria, <\/span><i><span style=\"font-weight: 400;\">Streptococcus thermophilus<\/span><\/i><span style=\"font-weight: 400;\"> [22, 23]. They identified that these were clustered regularly interspaced short palindromic repeats (CRISPR), used by <\/span><i><span style=\"font-weight: 400;\">S. thermophilus<\/span><\/i><span style=\"font-weight: 400;\"> to fend off bacteriophage infections [23]. Dupont later used their discovery to engineer phage-resistant strains in their yogurt making process [22, 23]. Roughly a decade after, various CRISPR-Cas systems have been characterized, down to the atomic structure, with CRISPR-Cas9 being the most widely studied.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The trend of developing industrially important organisms has continued to this day and, using CRISPR-Cas9 technology, is faster than ever before. <strong>Synthetic Genomics<\/strong>, in partnership with Exxon Mobile, is developing CRISPR-edited microalgae with enhanced lipid output, which would improve oil manufacturing by potentially reducing CO<\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\"> emissions and reliance on fossil fuels [24, 25]. PLANTeDit and Toolgen are using CRISPR-Cas9 to engineer sustainable crops such as soybean without introducing foreign DNA [26]. This is called DNA-free genome editing and although their crops will be modified genetically, they would bypass the regulatory hurdles of GMOs [26].<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The first companies to enter human clinical trials with a CRISPR-based therapeutic were <strong>CRISPR Therapeutics<\/strong> and<strong> Vertex Pharmaceuticals<\/strong> in 2018 [27-29]. CTX001 is an <\/span><i><span style=\"font-weight: 400;\">ex vivo<\/span><\/i><span style=\"font-weight: 400;\"> therapy being investigated for the treatment of \u03b2-thalassemia and sickle cell anemia [30]. The therapy involves extracting patient blood stem cells, gene modification using CRISPR-Cas9, and reintroducing the cells back into the patient. Although clinical evaluation of CTX001 is still early, preliminary results (presented this June) showed potential benefits of the treatment in patients with hemoglobinopathies [31].<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"6_Directed_Evolution_Platforms\"><\/span><strong>6. Directed Evolution Platforms<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In 2018, Frances Arnold, George Smith, and Gregory Winter were awarded the Nobel Prize in chemistry for their research in the directed evolution of enzymes, peptides, and antibodies [32]. Directed evolution platforms typically involve the generation of large, randomized genetic libraries that express variants of the gene of interest. These libraries are screened by selecting for those protein variants exhibiting desired properties such as increased ligand-binding or catalytic activity. This process is usually repeated by screening additional libraries based on the selected variants until a selection cut-off is reached. A number of protein-based therapeutics have been developed using this process: Humira (AbbVie), <\/span><span style=\"font-weight: 400;\">Lumoxiti<\/span><span style=\"font-weight: 400;\"> (MedImmune), and <\/span><span style=\"font-weight: 400;\">Gamifant (NovImmune) [33].<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One company has expanded on the directed evolution technology. <strong>Carmot Therapeutics<\/strong>, a drug discovery company based in Berkeley, developed the Chemotype Evolution platform to identify novel drugs. During Chemotype Evolution, a set of small molecules are linked to a proprietary fragment collection to generate a library of candidate drugs. The library is screened against a human target and selected candidate drugs are submitted to further rounds of linkage and selection until the candidate drug has evolved into an high-affinity binding molecule [34]. Using Chemotype Evolution, Carmot identified two candidate compounds that are currently in clinical trials [34]. Other companies are using directed evolution to generate microbial platforms. Primordial Genetics, a San Diego-based biotech, is developing a platform that produces large microbial libraries through combinatorial genetics called the Function Generator [35]. Function Generator allows them to select for specific microbes that can potentially address a range of issues, from identifying stress tolerant yeasts for biofuel production to microbes capable of degrading plastics efficiently [35].<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"7_Microbiome-based_Innovations\"><\/span><strong>7. Microbiome-based Innovations\u00a0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In 2007, the United States National Institutes of Health launched the Human Microbiome Project (HMP) to provide funding support, reference databases, and other resources for microbiome research [36]. Accordingly, the establishment of HMP fostered a bloom in research output along with a significant increase in funding aid [36]. What was produced over the years were largely computational and statistical research tools (due to the huge datasets that were generated) and a number of microbiome companies. Many of these companies focused on human disease treatments, such as topical solutions that restore skin microbiome (AOBiome, [37]) or drug delivery using gut bacteria (Blue Turtle Bio, [38]), while some companies used microbiome technologies in other ways. <strong>Aster Bio<\/strong> developed the Environmental Genomics platform to assist their clients in monitoring liquid waste output and prevent contamination of natural water bodies [39]. The platform profiles waste samples by detecting genetic biomarkers that are specific to key microbes, informs on potential operational issues (such as insufficient ammonia removal), and directs waste water treatment [39]. Sunnyvale-based <strong>Floragraph<\/strong> is also examining waste but intends to bring microbiome analysis directly into the home [40]. Their portable microbiome device is designed for customers who are interested in self-monitoring of chronic disease or track the health of companion animals by analyzing the microbiome from stool samples [40]. Although it is uncertain how many people would want to analyze their own poop at home, the Floragraph brings portability, cost-efficiency, and accessibility to microbiome analysis. For in-field medical and research applications, this device might just fulfill the need.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"8_DNA_Hard_Drives\"><\/span><strong>8. DNA Hard Drives<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">We\u2019ve come a long way from the early days of electronic data storage systems like the magnetic drum and floppy disks. Technological advancements have increased our data storage capacity by huge orders of magnitude, from tens of kilobytes (magnetic drum) to the petabyte range (cloud servers) [41]. With this tremendous storage space also comes the need for tremendous physical space to house the server farms which support the cloud. Scientists first looked at using DNA molecules for data storage in 1988, with the insertion of 35 bits of ones and zeros encoding a 5 by 7 square-bit image into the <\/span><i><span style=\"font-weight: 400;\">E. coli<\/span><\/i><span style=\"font-weight: 400;\"> genome [42, 43]. Since then, various institutions and corporations have invested their efforts into developing DNA-based data storage systems, given that cost, energy usage, and space is significantly reduced compared to that of maintaining server farms [42]. Remarkably, it is estimated that storing all of the world\u2019s data would compress into a mere 1 kg of DNA [42]. So how does one \u2018upload\u2019 their photos or music into DNA? Scientists at the <strong>University of Washington and Microsoft<\/strong> tried to address this in their proof-of-concept study for an automated DNA storage system [44]. They demonstrated that their device was able to encode a 5-byte \u201cHello\u201d into a DNA sequence, synthesize, store, sequence the DNA and retrieve \u201cHello\u201d [44]. The entire process took 21 hours and would not be practical today to store a single photo. But given the speed at which such technologies are being developed, it will be no surprise to see it available in the very near future.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"9_DNA_Origami\"><\/span><strong>9. DNA Origami<\/strong><span style=\"font-weight: 400;\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The base pairing of nucleotides in DNA and RNA make them an appealing biomolecular material with \u2018self-assembling\u2019 abilities. This was demonstrated by various groups in the mid-2000s [45-47], including Paul Rothemund who presented a method for assembling DNA into two-dimensional squares, triangles, happy faces, and other forms [48]. In 2017, several research labs were able to construct the largest DNA nanostructures: large nanorods, bricks, and tiles that came together to form huge structures with lengths in the range of hundreds of nanometers to over a micron [49-51]. These studies present clear, 3-dimensional images of the DNA nanostructures showing that nucleic acids can be designed to assemble into any number of structures with application potential in medicine, electronics, and bio-materials. Currently, DNA origami is being developed to generate drug delivery platforms (<strong>Genisphere<\/strong>), diagnostic nanorobots (<strong>Nanovery<\/strong>), and enzyme-embedded nanofabrics for applications such as metabolite production (<strong>FabricNano<\/strong>) [52]. Nanovery\u2019s nanorobots are designed using <a href=\"https:\/\/www.kolabtree.com\/blog\/ensuring-reproducibility-in-ai-driven-research-how-freelance-experts-can-help-in-biotech-and-healthcare\/\">artificial intelligence<\/a> to detect circulating tumor DNA (ctDNA) [53]. Their diagnostic nanorobot is intended to replace current liquid biopsy tests for ctDNA, which require extensive time and cost. The nanorobot is inserted into a blood sample and if cancerous DNA is detected, lights up within 1-2 hours. As mutations continue to accumulate in cancerous DNA, Nanovery intends to continuously evolve their nanorobots to detect these new mutations [53].<\/span><\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\"><a href=\"https:\/\/twitter.com\/hashtag\/DNA?src=hash&amp;ref_src=twsrc%5Etfw\">#DNA<\/a> Origami Creates the World&#39;s Smallest Mona Lisa: <a href=\"https:\/\/t.co\/v06eXUt0rU\">https:\/\/t.co\/v06eXUt0rU<\/a> <a href=\"https:\/\/t.co\/oAR1naVEvW\">pic.twitter.com\/oAR1naVEvW<\/a><\/p>\n<p>&mdash; Genetic Engineering &amp; Biotechnology News (@GENbio) <a href=\"https:\/\/twitter.com\/GENbio\/status\/939871107263483905?ref_src=twsrc%5Etfw\">December 10, 2017<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"10_Artificial_Intelligence_in_Medicine\"><\/span><strong>10. Artificial Intelligence in Medicine<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although artificial intelligence and machine learning are not considered biotechnologies, they deserve a mention due to their impact in the medical field. Research interest in AI-based medical applications has grown significantly over the past decade, as shown by the 20-fold increase in relevant publications from 2010 (596 papers) to 2019 (12422) [54]. At the time of writing, there were a little over 70 market approved AI algorithms for medical applications, according to a study conducted by the University of Groningen and the Medical Futurist Institute [54, 55]. A number of these applications use image-based machine learning algorithms for the analysis, diagnosis, or assessment of disease.<strong> Qlarity Imaging\u2019s QuantX<\/strong> software is an aid for radiologists to more quickly and accurately identify abnormal spots on breast MRI images [56]. In a clinical study assessing the ability of a radiologist to correctly identify malignant lesions in MRI images, radiologists performed better when using the QuantX software [57]. Research interest has especially grown for developing fully autonomous medical robots, which currently are being trained to complete very specific tasks. The IDx-DR device, developed by <strong>Digital Diagnostics<\/strong>, captures retinal images to diagnose diabetic retinopathy, a cause of blindness in diabetic patients [58]. The images are analyzed by the AI machine trained to detect biomarkers such as protein deposits and exudates, and outputs a diagnostic report within 30 seconds. Efforts are also currently ongoing in developing fully autonomous surgical robots, at-home medical assistants, and mental health support robots.<\/span><\/p>\n<p><strong>References<\/strong><\/p>\n<ol>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Mission Bio<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/missionbio.com\/products\/platform\/\"> <span style=\"font-weight: 400;\">https:\/\/missionbio.com\/products\/platform\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Mocciaro, A., et al., <\/span><i><span style=\"font-weight: 400;\">Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device.<\/span><\/i><span style=\"font-weight: 400;\"> Commun Biol, 2018. 1: p. 41.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Shafer, E., <\/span><i><span style=\"font-weight: 400;\">Aldevron now utilizing Berkeley Lights&#8217; Beacon\u00ae platform &#8211; Aldevron News<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Berkeley Lights &#8211;\u00a0 The Lightning&#x2122; Optofluidic System<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.berkeleylights.com\/systems\/lightning\/\"> <span style=\"font-weight: 400;\">https:\/\/www.berkeleylights.com\/systems\/lightning\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Mehrotra, P., <\/span><i><span style=\"font-weight: 400;\">Biosensors and their applications &#8211; A review.<\/span><\/i><span style=\"font-weight: 400;\"> J Oral Biol Craniofac Res, 2016. 6(2): p. 153-9.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">McConnell, E.M., J. Nguyen, and Y. Li, <\/span><i><span style=\"font-weight: 400;\">Aptamer-Based Biosensors for Environmental Monitoring.<\/span><\/i><span style=\"font-weight: 400;\"> Front Chem, 2020. 8: p. 434.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Aptamer Sciences &#8211; AptoDetect&#x2122;-Lung<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"http:\/\/aptsci.com\/en\/diagnosis\/aptodetect-lung\/\"> <span style=\"font-weight: 400;\">http:\/\/aptsci.com\/en\/diagnosis\/aptodetect-lung\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Aptamer Sciences &#8211; Product introduction<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"http:\/\/aptodetect-lung.com\/en\/aptodetect-lung\/\"> <span style=\"font-weight: 400;\">http:\/\/aptodetect-lung.com\/en\/aptodetect-lung\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Lee, S.Y., <\/span><i><span style=\"font-weight: 400;\">Implantable Drug-Making Cells<\/span><\/i><span style=\"font-weight: 400;\">, in <\/span><i><span style=\"font-weight: 400;\">Scientific American<\/span><\/i><span style=\"font-weight: 400;\">. 2018.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Katsarou, A., et al., <\/span><i><span style=\"font-weight: 400;\">Type 1 diabetes mellitus.<\/span><\/i><span style=\"font-weight: 400;\"> Nat Rev Dis Primers, 2017. 3: p. 17016.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Seraxis Technologies &#8211; An innovative approach to cell replacement<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.seraxis.com\/seraxis-technology\/\"> <span style=\"font-weight: 400;\">https:\/\/www.seraxis.com\/seraxis-technology\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Living Cell Technologies &#8211; NTCell<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/lctglobal.com\/research\/ntcell#click-here\"> <span style=\"font-weight: 400;\">https:\/\/lctglobal.com\/research\/ntcell#click-here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Li, R.A., et al., <\/span><i><span style=\"font-weight: 400;\">Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.<\/span><\/i><span style=\"font-weight: 400;\"> Biomaterials, 2018. 163: p. 116-127.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">NovoHeart<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"http:\/\/www.novoheart.com\/hk\/product5\"> <span style=\"font-weight: 400;\">http:\/\/www.novoheart.com\/hk\/product5<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Platelet BioGenesis Receives $2.3 Million Award from the Medical Technology Enterprise Consortium to Accelerate Development of Donor-Independent Platelet Production<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Platelet BioGenesis<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.plateletbio.com\/product-development\"> <span style=\"font-weight: 400;\">https:\/\/www.plateletbio.com\/product-development<\/span><\/a><span style=\"font-weight: 400;\"> &lt;p class=&#8221;MsoListParagraph&#8221; style=&#8221;margin-bottom:0cmAvailable from: text-indent:-18.0pt.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Datar, I.<\/span><\/i> <i><span style=\"font-weight: 400;\">MARK POST&#8217;S CULTURED BEEF<\/span><\/i><span style=\"font-weight: 400;\">. Available from: new-harvest.org\/mark_post_cultured_beef.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Fountain, H., <\/span><i><span style=\"font-weight: 400;\">Building a $325,000 Burger<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">The Chicken<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Super Meat Press video<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/vimeo.com\/473309639\"> <span style=\"font-weight: 400;\">https:\/\/vimeo.com\/473309639<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Jinek, M., et al., <\/span><i><span style=\"font-weight: 400;\">A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.<\/span><\/i><span style=\"font-weight: 400;\"> Science, 2012. 337(6096): p. 816-21.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Cohen, J., <\/span><i><span style=\"font-weight: 400;\">How the battle lines over CRISPR were drawn<\/span><\/i><span style=\"font-weight: 400;\">, in <\/span><i><span style=\"font-weight: 400;\">Science Magazine<\/span><\/i><span style=\"font-weight: 400;\">. 2017.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Barrangou, R., et al., <\/span><i><span style=\"font-weight: 400;\">CRISPR provides acquired resistance against viruses in prokaryotes.<\/span><\/i><span style=\"font-weight: 400;\"> Science, 2007. 315(5819): p. 1709-12.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Verruto, J., et al., <\/span><i><span style=\"font-weight: 400;\">Unrestrained markerless trait stacking in.<\/span><\/i><span style=\"font-weight: 400;\"> Proc Natl Acad Sci U S A, 2018. 115(30): p. E7015-E7022.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Synthetic Genomics: Algal Cell Factories<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/syntheticgenomics.com\/algal-cell-factories\/\"> <span style=\"font-weight: 400;\">https:\/\/syntheticgenomics.com\/algal-cell-factories\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">PLANTeDit &#8211;\u00a0 NON-TRANSGENIC HIGH OLEIC SOYA<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/plantedit.com\/index.php\/products\/\"> <span style=\"font-weight: 400;\">https:\/\/plantedit.com\/index.php\/products\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Saey, T.H., <\/span><i><span style=\"font-weight: 400;\">CRISPR enters its first human clinical trials<\/span><\/i><span style=\"font-weight: 400;\">. 2019.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">CRISPR Therapeutics and Vertex Announce Progress in Clinical Development Programs for the Investigational CRISPR\/Cas9 Gene-Editing Therapy CTX001 &#8211; Press Release CRISPR Therapeutics<\/span><\/i><span style=\"font-weight: 400;\">. 2019.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Clinical Trial:\u00a0 NCT03655678<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03655678\"> <span style=\"font-weight: 400;\">https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03655678<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">CRISPR Therapeutics &#8211; Hemoglobinopathies<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"http:\/\/www.crisprtx.com\/programs\/hemoglobinopathies\"> <span style=\"font-weight: 400;\">http:\/\/www.crisprtx.com\/programs\/hemoglobinopathies<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">CRISPR Therapeutics and Vertex Announce New Clinical Data for Investigational Gene-Editing Therapy CTX001&#x2122; in Severe Hemoglobinopathies at the 25th Annual European Hematology Association (EHA) Congress &#8211; Press Release CRIPSR Therapeutics<\/span><\/i><span style=\"font-weight: 400;\">. 2020.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">The Nobel Prize in Chemistry 2018&lt;source data-srcset=&#8221;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">&#8221; media=&#8221;(min-width: 220px)&#8221; srcset=&#8221;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">&#8221; style=&#8221;-webkit-font-smoothing: antialiased;&#8221;&gt;&lt;source data-srcset=&#8221;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">&#8221; media=&#8221;(min-width: 900px)&#8221; srcset=&#8221;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">&#8221; style=&#8221;-webkit-font-smoothing: antialiased;&#8221;&gt;&lt;source data-srcset=&#8221;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">&#8221; media=&#8221;(min-width: 1400px)&#8221; srcset=&#8221;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">&#8221; style=&#8221;-webkit-font-smoothing: antialiased;&#8221;&gt;<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.nobelprize.org\/prizes\/chemistry\/2018\/summary\/\"> <span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/prizes\/chemistry\/2018\/summary\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Lu, R.M., et al., <\/span><i><span style=\"font-weight: 400;\">Development of therapeutic antibodies for the treatment of diseases.<\/span><\/i><span style=\"font-weight: 400;\"> J Biomed Sci, 2020. 27(1): p. 1.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Carmot Therapeutics &#8211; Technology<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/carmot-therapeutics.us\/science\/\"> <span style=\"font-weight: 400;\">https:\/\/carmot-therapeutics.us\/science\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Primordial Genetics &#8211; Function Generator&#x2122;<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.primordialgenetics.com\/our-platform\/\"> <span style=\"font-weight: 400;\">https:\/\/www.primordialgenetics.com\/our-platform\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Team, N.H.M.P.A., <\/span><i><span style=\"font-weight: 400;\">A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016.<\/span><\/i><span style=\"font-weight: 400;\"> Microbiome, 2019. 7(1): p. 31.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">AOBiome<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.aobiome.com\/\"> <span style=\"font-weight: 400;\">https:\/\/www.aobiome.com\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Blue Turtle Bio<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/blueturtlebio.com\/\"> <span style=\"font-weight: 400;\">https:\/\/blueturtlebio.com\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">AsterBio<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.asterbio.com\/\"> <span style=\"font-weight: 400;\">https:\/\/www.asterbio.com\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Floragraph<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"http:\/\/www.floragraph.me\/technology-overview.html\"> <span style=\"font-weight: 400;\">http:\/\/www.floragraph.me\/technology-overview.html<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Computer History Museum &#8211;\u00a0 Timeline of Computer History<\/span><\/i><span style=\"font-weight: 400;\">. 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Qian, <\/span><i><span style=\"font-weight: 400;\">Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns.<\/span><\/i><span style=\"font-weight: 400;\"> Nature, 2017. 552(7683): p. 67-71.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Praetorius, F., et al., <\/span><i><span style=\"font-weight: 400;\">Biotechnological mass production of DNA origami.<\/span><\/i><span style=\"font-weight: 400;\"> Nature, 2017. 552(7683): p. 84-87.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Dunn, K.E., <\/span><i><span style=\"font-weight: 400;\">The Business of DNA Nanotechnology: Commercialization of Origami and Other Technologies.<\/span><\/i><span style=\"font-weight: 400;\"> Molecules, 2020. 25(2).<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Nanovery &#8211; Nanorobots<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.nanovery.co.uk\/science\"> <span style=\"font-weight: 400;\">https:\/\/www.nanovery.co.uk\/science<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Benjamens, S., P. Dhunnoo, and B. Mesk\u00f3, <\/span><i><span style=\"font-weight: 400;\">The state of artificial intelligence-based FDA-approved medical devices and algorithms: an online database.<\/span><\/i><span style=\"font-weight: 400;\"> NPJ Digit Med, 2020. 3: p. 118.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">The Medical Futurist &#8211; FDA-approved A.I.-based algorithms<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/medicalfuturist.com\/fda-approved-ai-based-algorithms\/\"> <span style=\"font-weight: 400;\">https:\/\/medicalfuturist.com\/fda-approved-ai-based-algorithms\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Qlarity Imaging &#8211; Education<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/www.qlarityimaging.com\/education\"> <span style=\"font-weight: 400;\">https:\/\/www.qlarityimaging.com\/education<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Jiang, Y., A.V. Edwards, and G.M. Newstead, <\/span><i><span style=\"font-weight: 400;\">Artificial Intelligence Applied to Breast MRI for Improved Diagnosis.<\/span><\/i><span style=\"font-weight: 400;\"> Radiology, 2020: p. 200292.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Digital Diagnostics &#8211; IDx-DR Overview: Close Care Gaps, Prevent Blindness<\/span><\/i><span style=\"font-weight: 400;\">. Available from:<\/span><a href=\"https:\/\/dxs.ai\/products\/idx-dr\/idx-dr-overview-2\/\"> <span style=\"font-weight: 400;\">https:\/\/dxs.ai\/products\/idx-dr\/idx-dr-overview-2\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jennifer Huen, freelance biochemist on Kolabtree, outlines the top 10 biotech innovations in the market today. Read about the top life science products &amp; services and the companies behind them.\u00a0\u00a0 Biotechnological innovations have grown steadily in the past 10 years, not only in the medical arenas but also in agriculture, environment, and energy sectors. Almost<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/\" title=\"Read More\">Read More<\/a><\/div>\n","protected":false},"author":12,"featured_media":8692,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[442,516],"tags":[753],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Top 10 Biotech Innovations You Should Know About - The Kolabtree Blog<\/title>\n<meta name=\"description\" content=\"From DNA origami and biosensors, from CRISPR platforms to a &quot;heart-in-a-jar&quot;, a detailed look at the top 10 biotech innovations today.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Top 10 Biotech Innovations You Should Know About\" \/>\n<meta property=\"og:description\" content=\"From DNA origami and biosensors, from CRISPR platforms to a &quot;heart-in-a-jar&quot;, a detailed look at the top 10 biotech innovations today.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-09T09:06:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-18T11:08:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/12\/biotech-innovations.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"626\" \/>\n\t<meta property=\"og:image:height\" content=\"442\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ramya Sriram\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:site\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ramya Sriram\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"15 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Top 10 Biotech Innovations You Should Know About - 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