{"id":7495,"date":"2020-05-07T09:27:56","date_gmt":"2020-05-07T09:27:56","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=7495"},"modified":"2021-09-03T09:29:17","modified_gmt":"2021-09-03T09:29:17","slug":"what-are-cannabinoids-and-how-do-they-work","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/","title":{"rendered":"What are cannabinoids and how do they work?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_45_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" area-label=\"ez-toc-toggle-icon-1\"><label for=\"item-69f19f1e3f206\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-69f19f1e3f206\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#What_are_Cannabinoids\" title=\"What are Cannabinoids?\">What are Cannabinoids?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#What_are_Synthetic_Cannabinoids\" title=\"What are Synthetic Cannabinoids?\">What are Synthetic Cannabinoids?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#What_are_Phytocannabinoids\" title=\"What are Phytocannabinoids?\">What are Phytocannabinoids?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#The_Endocannabinoid_System\" title=\"The Endocannabinoid System\">The Endocannabinoid System<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#Where_Can_They_be_Found\" title=\"Where Can They be Found?\">Where Can They be Found?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#List_of_Major_Cannabinoids_and_their_Effects\" title=\"List of Major Cannabinoids and their Effects\">List of Major Cannabinoids and their Effects<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#Difference_Between_Cannabinoids\" title=\"Difference Between Cannabinoids\">Difference Between Cannabinoids<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#Health_and_Safety\" title=\"Health and Safety\">Health and Safety<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/#Conclusion\" title=\"Conclusion\">Conclusion<\/a><\/li><\/ul><\/nav><\/div>\n<p><span style=\"font-weight: 400;\">In the last decade, many scientists have been able to find treatments and cures for certain diseases that were thought to be incurable. Each day we have more pharmacological resources to control and alleviate symptoms more efficiently. However, physicians and researchers are exploring alternative options that can help alleviate certain ailments. Today, <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/cannabis?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=Cannabinoids\">cannabinoids<\/a> are an uncharted area with potential health benefits in medical science.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_are_Cannabinoids\"><\/span><span style=\"font-weight: 400;\">What are Cannabinoids?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Cannabinoids are active substances that belong to the terpene phenolic group. Chemically speaking, they have a 21-carbon structure and are found in specific plants naturally. Nonetheless, their importance centers on the probable use in health care as an alternative treatment for certain health conditions. There are three types of cannabinoids: synthetic, phytocannabinoids, and endocannabinoids. They all differ from where they can be obtained.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_are_Synthetic_Cannabinoids\"><\/span><span style=\"font-weight: 400;\">What are Synthetic Cannabinoids?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Synthetic cannabinoids are artificially-made compounds that are able to produce neurological effects on humans and animals. They are a new group of psychoactive drugs created initially for <a href=\"https:\/\/www.kolabtree.com\/blog\/ensuring-reproducibility-in-ai-driven-research-how-freelance-experts-can-help-in-biotech-and-healthcare\/\">research<\/a> purposes to understand the mechanisms and functions of natural versions. People know them as liquid or herbal essences because they can smoke them on dried plant materials or vaporize and inhale them. However, some of these are used for clinical and recreational purposes. There are legal restrictions regarding their use in many countries.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_are_Phytocannabinoids\"><\/span><span style=\"font-weight: 400;\">What are Phytocannabinoids?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Phytocannabinoids are plant-based substances that have similar structures and functions as cannabinoids in general. However, they are produced naturally by plants. Marijuana (<\/span><i><span style=\"font-weight: 400;\">Cannabis sativa)\u00a0<\/span><\/i><span style=\"font-weight: 400;\">and hemp are the most known plant sources of these compounds. Still, other vegetables and plants do contain, but in minuscule quantities.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_Endocannabinoid_System\"><\/span><span style=\"font-weight: 400;\">The Endocannabinoid System<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The endocannabinoid system is an intercellular communication scheme composed of endocannabinoids, their receptors, and enzymes that regulate the production and degradation of these. <\/span><span style=\"font-weight: 400;\">While phytocannabinoids derived from plants, our body can produce these compounds naturally, hence their name, endocannabinoids.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These compounds help maintain a balance in our body and modulate certain functions of our nervous system. Anandamide and 2-AG are the most known and studied endocannabinoids.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">How does this work? When our body releases these substances, they circulate through our bloodstream and reach target tissues, such as our brain, spinal cord, and peripheric nerves. Here, they attach to specific sites known as cannabinoid receptors. There are two types of receptors: CB1 and CB2. CB1 receptors are located mainly in our nervous system, while CB2 receptors are distributed in the rest of the body.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Think of them as keys and keyholes. The endocannabinoids bind to the receptors and unlock them to produce different physiological effects on our organism. These effects range from regulating neurotransmitter release, modulating pain perception, and influencing cardiovascular, digestive, and liver functions. Nonetheless, both synthetic and phytocannabinoids can bind to these receptors and cause the same effects as the endocannabinoids.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Where_Can_They_be_Found\"><\/span><span style=\"font-weight: 400;\">Where Can They be Found?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As said previously, synthetic cannabinoids are made in laboratories, while our body produces endocannabinoids. However, phytocannabinoids are extracted from plant sources. The plants that contain the highest concentrations of phytocannabinoids are marijuana and hemp.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cannabidiol (CBD) is one of the most known cannabinoids due to its potential therapeutical value, and it is legal for purchase (as an oil or creams) in many countries, like Canada and certain regions of the United States. You can <\/span><a href=\"http:\/\/formulaswiss.com\/\"><span style=\"font-weight: 400;\">buy CBD products from here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Further investigations have found other cannabinoid-like compounds in different kinds of vegetables, like cloves and black pepper.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, broccoli, cauliflower, Brussels sprouts, and cabbage contain a compound called Diindolylmethane, that attaches to CB2 receptors.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Certain herbs, like Echinacea and Kava plant, also contain certain phytocannabinoids that may have negative effects on our body.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"List_of_Major_Cannabinoids_and_their_Effects\"><\/span><span style=\"font-weight: 400;\">List of Major Cannabinoids and their Effects<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">How many cannabinoids are there? The cannabis plant contains more than 113 known phytocannabinoids that may have many health benefits and could treat many health hazards. However, researchers are focusing on the following compounds:<\/span><\/p>\n<p><b>Tetrahydrocannabinol (THC)<\/b><span style=\"font-weight: 400;\">: It can be found in marijuana concentrations of up to 30 to 40% as one of the main psychoactive compounds. It can alter the state of consciousness, change the user&#8217;s perceptions, and affect short-term memory. Even more, it can stimulate appetite, reduce coordination and cause mood swings. Some people experience paranoia, anxiety, and panic attacks.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, evidence has demonstrated that it can have some clinical uses, such as pain reduction, decrease nausea and vomiting, and has antioxidant and anti-inflammatory properties. Currently, a study revealed that it could be used in Tourette&#8217;s Syndrome due to its potential effect in reducing spastic movements.<\/span><\/p>\n<p><b>Cannabidiol (CBD):<\/b><span style=\"font-weight: 400;\">\u00a0It is another cannabinoid extracted from marijuana. However, it has no psychoactive properties. Cannabidiol can decrease the effects of THC. Because of this, scientists are evaluating their therapeutical advantages. Up to date, evidence shows that it can be used to decrease inflammation, relieve muscle spasms, alleviate certain psychotic disorders, and reduce epileptic seizures. Additionally, it has antioxidant capabilities.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CBD is commercialized as oil and topical presentations (lotions, creams, and ointments) in certain parts of the world. Since it has no psychoactive effects, it is legal for possession and purchase as long as it has a concentration of 0.3%.<\/span><\/p>\n<p><b>Cannabinol (CBN):<\/b><span style=\"font-weight: 400;\">\u00a0It is a metabolite produced from the THC; therefore, it is not actually present in cannabis. CBN has low psychoactivity, but its primary effect focuses on reducing sleeping disorders, such as insomnia and sleep apnea. Many studies theorize that it could be used as a natural sedative.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other studies have shown the following effects:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Antiemetic effect<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Reduces pain<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">promotes bone regeneration<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Anticonvulsant property (probable health benefit in Parkinson&#8217;s disease, epilepsy, and multiple sclerosis)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Reduced intraocular pressure<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Treat burns and skin conditions, like psoriasis.<\/span><\/li>\n<\/ul>\n<p><b>Cannabichromene (CBC):<\/b><span style=\"font-weight: 400;\">\u00a0This Cannabinoid received recent recognition because it has more potent anti-depressive and anti-inflammatory properties than CBD. However, it still has psychoactive effects like THC. CBD could also be used as a neuroprotective compound, treat bacterial and fungus infections, and reduce acne.<\/span><\/p>\n<p><b>Cannabigerol (CBG):<\/b><span style=\"font-weight: 400;\">\u00a0The majority of the phytocannabinoids that are contained in cannabis originate from cannabigerol as it is broken down and transformed into THC, CBD, CBC, and many more. CBG is not widely studied like Cannabinoid, but it has no psychoactive effect. Certain investigations have shown evidence that it could help to treat certain conditions:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Cancer<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Huntington&#8217;s disease<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Multiple Sclerosis<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Severe bacterial infections<\/span><\/li>\n<\/ul>\n<p><b>Other Cannabinoids:\u00a0<\/b><span style=\"font-weight: 400;\">2-arachidonoylglycerol (2-AG), tetrahydrocannabivarin (THCV), and cannabidivarin (CBV) are other phytocannabinoids that are recent phases of investigation that show promising clinical uses.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Difference_Between_Cannabinoids\"><\/span><span style=\"font-weight: 400;\">Difference Between Cannabinoids<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">These substances have similar molecular structures, but their true difference centers on their psychoactive property. Unfortunately, cannabidiol and cannabigerol are the only components investigated with no psychoactive properties. Therefore, the use of THC, CBN, and CBC is limited to probable therapeutical purposes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, further advances in technology could be able to eliminate this effect or counteract it and use them as alternative treatments.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Health_and_Safety\"><\/span><span style=\"font-weight: 400;\">Health and Safety<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Despite the potential properties of these compounds, no reported death has been declared because of their use. When smoked, these substances produce short-term effects that last from 2 to 4 hours. Oral ingestion can cause effects up to 6 hours after drinking it. It is known that psychological effects, such as anxiety, euphoria, and paranoia, are documented as potential side effects. Still, apart from that, they are relatively safe. Research does not reveal long-term effects on health.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span><span style=\"font-weight: 400;\">Conclusion<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Although cannabinoids carry in properties, uses, and benefits, all of them offer the chance to potentially treat certain health afflictions, reduce pain, control anxiety, and many more, without the use of custom medications. Alternative treatment is gaining prominence and you should be considered in certain situations. However, it is best to seek professional help before selecting these options.<\/span><\/p>\n<p><em>The views and opinions expressed in this article are those of the authors and do not necessarily reflect the policy or position of Kolabtree. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the last decade, many scientists have been able to find treatments and cures for certain diseases that were thought to be incurable. Each day we have more pharmacological resources to control and alleviate symptoms more efficiently. However, physicians and researchers are exploring alternative options that can help alleviate certain ailments. Today, cannabinoids are an<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/what-are-cannabinoids-and-how-do-they-work\/\" title=\"Read More\">Read More<\/a><\/div>\n","protected":false},"author":12,"featured_media":7524,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[435],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What are cannabinoids and how do they work? - The Kolabtree Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/que-son-los-cannabinoides-y-como-funcionan\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What are cannabinoids and how do they work?\" \/>\n<meta property=\"og:description\" content=\"In the last decade, many scientists have been able to find treatments and cures for certain diseases that were thought to be incurable. 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