{"id":2586,"date":"2017-11-06T14:36:39","date_gmt":"2017-11-06T14:36:39","guid":{"rendered":"https:\/\/blog.kolabtree.com\/?p=2586"},"modified":"2021-10-04T19:26:39","modified_gmt":"2021-10-04T19:26:39","slug":"crispr-food-the-road-to-a-better-future","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/","title":{"rendered":"CRISPR Food: The Road to a Better Future?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_45_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" area-label=\"ez-toc-toggle-icon-1\"><label for=\"item-69f43ac4e9e5b\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-69f43ac4e9e5b\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/#1_Using_CRISPR_for_food_production_doesnt_require_FDA_approval\" title=\"1. Using CRISPR for food production doesn&#8217;t require FDA approval\">1. Using CRISPR for food production doesn&#8217;t require FDA approval<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/#2_Eventually_the_dairy_industry_can_benefit_from_CRISPR\" title=\"2. Eventually, the dairy industry can benefit from CRISPR\">2. Eventually, the dairy industry can benefit from CRISPR<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/#3_The_primary_advantage_of_using_CRISPR_is_increasing_the_success_of_other_GMO_foods\" title=\"3. The primary advantage of using CRISPR is increasing the success of other GMO foods\">3. The primary advantage of using CRISPR is increasing the success of other GMO foods<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/#4_CRISPRCas_systems_have_been_discovered_specifically_to_enhance_meat_quality\" title=\"4. CRISPR\/Cas systems have been discovered specifically to enhance meat quality\">4. CRISPR\/Cas systems have been discovered specifically to enhance meat quality<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/#5_CRISPR_has_spurred_the_entry_of_biotech_startups\" title=\"5. CRISPR has spurred the entry of biotech startups\">5. CRISPR has spurred the entry of biotech startups<\/a><\/li><\/ul><\/nav><\/div>\n<p>CRISPR,\u00a0the acronym for Clustered Regularly Interspaced Palindromic Repeats, is\u00a0a collection of prokaryotic DNA sequences that solely serve as a cellular defence system.<a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/?search=crispr&amp;utm_source=Blog_CRISPRfood\"> CRISPR<\/a>\/Cas systems are used by bacteria to sense and eliminate irregularities in DNA base pairs to protect DNA from bacteriophages. Its application to a myriad of gene sequences has led to the development of successful treatment strategies, especially for congenital and inheritable diseases. <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/crispr\">CRISPR<\/a> food, in particular, is becoming increasingly popular, as scientists and farmers tap into the various advantages it offers.<\/p>\n<p>In 2017, a groundbreaking report came in from the Broad Institute at the MIT and Harvard University <a href=\"http:\/\/www.foxnews.com\/tech\/2017\/10\/30\/gene-editing-about-to-get-lot-more-powerful.html\" target=\"_blank\" rel=\"noopener\">stating<\/a> the discovery of a new CRISPR\/<em>Cas<\/em> system that cleaves DNA as well as RNA. Around the same time, the MIT Technology Review published reports of a CRISPR\/<em>Cas<\/em>\u00a0system that <a href=\"https:\/\/www.technologyreview.com\/s\/609203\/crispr-20-is-here-and-its-way-more-precise\/\" target=\"_blank\" rel=\"noopener\">cleaves the minutest DNA <\/a>fragments with ease and precision.<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-2620\" src=\"https:\/\/blog.kolabtree.com\/wp-content\/uploads\/2017\/11\/CRISPR800px-GRNA-Cas9.png\" alt=\"\" width=\"500\" height=\"335\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/CRISPR800px-GRNA-Cas9.png 800w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/CRISPR800px-GRNA-Cas9-300x201.png 300w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/CRISPR800px-GRNA-Cas9-768x515.png 768w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/CRISPR800px-GRNA-Cas9-300x201@2x.png 600w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p>The range of spectacular results with CRISPR\/Cas systems coming in from University <a href=\"https:\/\/www.kolabtree.com\/blog\/ensuring-reproducibility-in-ai-driven-research-how-freelance-experts-can-help-in-biotech-and-healthcare\/\">research<\/a> laboratories is immense. CRISPR&#8217;s rise stands apart from that of other genetic engineering tools owing to its accuracy, manoeuvrability and versatility with other genomes as well. Just a few weeks back, <a href=\"http:\/\/www.npr.org\/sections\/thesalt\/2017\/10\/23\/559060166\/crispr-bacon-chinese-scientists-create-genetically-modified-low-fat-pigs\">scientists<\/a> at the Chinese Academy of Sciences altered gene sequences in pigs to produce what is being called as &#8220;CRISPR Bacon&#8221;. In fact, scientists at the Broad Institute call it &#8220;molecular scissors&#8221; useful for developing pest-resistant crops.<\/p>\n<p>The scope of applying CRISPR to crops, poultry and other edibles isn&#8217;t unheard of; since 2015, CRISPR\/<em>Cas<\/em> systems are being used for growing corn, wheat, tomatoes and culturing livestock with better dairy yield. No wonder CRISPR is being touted as the next big thing for food manufacturing companies.<\/p>\n<p>Although the issue of genetic modification of foods has raised a tough battle between companies and regulatory bodies, CRISPR doesn&#8217;t seem to be facing much strife.\u00a0This leads us to the question then, whether CRISPR is going to be the technology of choice for ensuring better food &amp; nutrition for the world? Also, will CRISPR-based food be affordable enough for the most far-reaching consumers?\u00a0Here are some insights which might lead us to some answers.<\/p>\n<h5><span class=\"ez-toc-section\" id=\"1_Using_CRISPR_for_food_production_doesnt_require_FDA_approval\"><\/span>1. Using CRISPR for food production doesn&#8217;t require FDA approval<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<p>Yes, you heard that right. A letter from the US Department of Agriculture stated that mushrooms produced with CRISPR-based modifications reduced its browning tendencies with no external protein or antibody additions. This means CRISPR isn&#8217;t to do with modifying genes directly, rather only removing the parts that could be harmful. It doesn&#8217;t involve modifying gene sequences per se, which is why it doesn&#8217;t need strong vigilance the way GMOs used as foods did in the past. CRISPR based foods that are almost market-ready include cabbages with stronger long-staying flavours, tender red meat, drought-tolerant corn and non-browning mushrooms. Moreover, <a href=\"https:\/\/www.fooddive.com\/news\/how-crispr-is-changing-the-food-industry\/432848\/\">regular staples<\/a> like rice, soy, potatoes, oranges and wheat are checked for possible genome modifications by CRISPR specialists. Agriculture experts reported that CRISPR can be applied to bigger plants and a wider range of crops than what was available before!<\/p>\n<h5><span class=\"ez-toc-section\" id=\"2_Eventually_the_dairy_industry_can_benefit_from_CRISPR\"><\/span>2. Eventually, the dairy industry can benefit from CRISPR<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<p>As research progresses swiftly on CRISPR\/Cas systems, new <em>Cas<\/em> enzymes are being studied. Initially, Cas9 received glorious attention, soon after which scientists isolated <em>Cas13<\/em> that cleaves RNA that is useful for repairing genomes with rare genetic diseases. Various probiotic foods using <em>Cas<\/em> enzymes in bacteria are being applied to enhance the protein content, shelf life and flavours of cheese and creamy yoghurts. Its utility in the preservation of active bacterial cultures used in the manufacture of dairy products is also being tested. The fact that CRISPR tools are faster and cheaper has got various food and dairy companies interested in implementing them. So it won&#8217;t be long before fortified cheese, milk and butter with zero spoilage arrive at the market, all thanks to CRISPR.<\/p>\n<p><a href=\"https:\/\/i.ytimg.com\/vi\/2pp17E4E-O8\/maxresdefault.jpg\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/i.ytimg.com\/vi\/2pp17E4E-O8\/maxresdefault.jpg\" alt=\"Related image\" width=\"1920\" height=\"1080\" \/><\/a><\/p>\n<h5><span class=\"ez-toc-section\" id=\"3_The_primary_advantage_of_using_CRISPR_is_increasing_the_success_of_other_GMO_foods\"><\/span>3. The primary advantage of using CRISPR is increasing the success of other GMO foods<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<p>The technology, although deemed controversial among bioethics experts, is a fascinating method for enhancing the marketability of other genetically modified foodstuffs. Earlier, edibles were checked for irregularities at RNA-protein levels and <span style=\"text-decoration: underline;\">replaced<\/span> with superior quality protein strands to increase product quality. Now, the site of repair is acted upon faster, it&#8217;s cleaved by CRISPR at the exact location and repaired much faster. So foods need not undergo enhancements with protein injections, instead, desirable alterations can be done before the early stages of growth itself.\u00a0Plant breeding activities are undergoing massive changes with expert selection strategies, eliminating the need for R &amp; D for systematic gene isolations, seed selections and breeding cycles. Now, genes that inhibit antibiotic resistance can be directly removed, weak genes prone to low protein expression can be repaired and pest-resistance can be conferred to plants with much simpler mechanisms.<\/p>\n<p><iframe loading=\"lazy\" title=\"Genome Editing with CRISPR-Cas9\" width=\"702\" height=\"395\" src=\"https:\/\/www.youtube.com\/embed\/2pp17E4E-O8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<h5><span class=\"ez-toc-section\" id=\"4_CRISPRCas_systems_have_been_discovered_specifically_to_enhance_meat_quality\"><\/span>4. CRISPR\/Cas systems have been discovered specifically to enhance meat quality<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<p>CRISPR&#8217;s applicability is enormous, owing to its ability to cut open any organism&#8217;s genome. Touted to be a &#8216;molecular scalpel&#8217; or &#8216;molecular scissors&#8217;, scientists have reported Cas enzymes for every kind of genetic enhancement possible. Today, there are <em>Cas<\/em> enzymes for engineering cord blood cells, immune cells, drug discovery, livestock breeding, fish culturing, etc. Not too long ago, FDA approved genetically modified salmon as safe to be eaten. The good news is that CRISPR-edited edibles are not transgenic organisms, hence they are not GMOs, they are gene-edited foods such as the CRISPR Bacon!<\/p>\n<h5><span class=\"ez-toc-section\" id=\"5_CRISPR_has_spurred_the_entry_of_biotech_startups\"><\/span>5. CRISPR has spurred the entry of biotech startups<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<p>News is that major pharma companies are investing heavily in this novel gene-editing technology. There have been big industry-academia collaborations happening between companies like DuPont Pioneer, Novartis, Monsanto, AstraZeneca and Wellcome Trust\u00a0Sanger Institute, Innovative Genomics Initiative, the Broad and Whitehead Institutes in Massachusetts, and Thermo Fisher Scientific. These deals have initiated a surge in CRISPR&#8217;s already existing scope.<\/p>\n<p>Some CRISPR pioneers have started off companies on their own, such as Editas Medicine by Feng Zhang and Caribou Biosciences by Emmanuelle Charpentier. Then in 2017, there were more start-ups particularly focussed on investigating Cas enzymes for genetic treatments, such as Crispr Therapeutics and Intellia Therapeutics.<\/p>\n<p><a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/crispr\">CRISPR<\/a> has already been through a long journey to make it through government regulations and environmentalists&#8217; opinions. While CRISPR foods can be dismissed as trivial and frivolous by genome researchers, a tremendous amount of research is underway to produce CRISPR foods in <em>days<\/em> as compared to the months taken by farmers to harvest a fully utilizable GMO crop. The best part is that compared to GMO foods, gene-edited foods are actually cheaper to manufacture!<\/p>\n<p>So, let&#8217;s just say that CRISPR&#8217;s role in food and agriculture has barely unfolded. A whole new arena of<a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/food-science-and-technology?utm_source=Blog_CRISPRfood\"> food science<\/a> developments await and with that, a world devoid of malnourishment is just around the corner!<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CRISPR,\u00a0the acronym for Clustered Regularly Interspaced Palindromic Repeats, is\u00a0a collection of prokaryotic DNA sequences that solely serve as a cellular defence system. CRISPR\/Cas systems are used by bacteria to sense and eliminate irregularities in DNA base pairs to protect DNA from bacteriophages. Its application to a myriad of gene sequences has led to the development<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/\" title=\"Read More\">Read More<\/a><\/div>\n","protected":false},"author":32,"featured_media":2627,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[397],"tags":[374],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CRISPR Food: The Road to a Better Future? - The Kolabtree Blog<\/title>\n<meta name=\"description\" content=\"CRISPR food is gene-edited crops and food that have a longer shelf life, enhanced flavour, quick growth, and can potentially end world hunger.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CRISPR Food: The Road to a Better Future?\" \/>\n<meta property=\"og:description\" content=\"CRISPR food is gene-edited crops and food that have a longer shelf life, enhanced flavour, quick growth, and can potentially end world hunger.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/crispr-food-the-road-to-a-better-future\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-06T14:36:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-10-04T19:26:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/Helix-orgineel.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2048\" \/>\n\t<meta property=\"og:image:height\" content=\"1536\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mahasweta Pal\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:site\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mahasweta Pal\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"CRISPR Food: The Road to a Better Future? 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She is a biotechnologist at heart with research experience in Tissue Engineering, Medical Imaging Devices and Industrial Microbiology. She majored in Biomedical Engineering from Vellore Institute of Technology and has served as an editor for journal publications from Elsevier, Wolters Kluwer Health and the Royal Society for Chemistry.","url":"https:\/\/www.kolabtree.com\/blog\/author\/mahasweta-pal\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/posts\/2586"}],"collection":[{"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/comments?post=2586"}],"version-history":[{"count":18,"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/posts\/2586\/revisions"}],"predecessor-version":[{"id":9597,"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/posts\/2586\/revisions\/9597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/media\/2627"}],"wp:attachment":[{"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/media?parent=2586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/categories?post=2586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/wp-json\/wp\/v2\/tags?post=2586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}