{"id":9205,"date":"2021-06-07T05:59:33","date_gmt":"2021-06-07T05:59:33","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=9205"},"modified":"2021-09-30T12:07:09","modified_gmt":"2021-09-30T12:07:09","slug":"vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/pt\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/","title":{"rendered":"Vibhor Mishra: Montagem de um complexo sintetizador dsRNA"},"content":{"rendered":"<p><a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/vibhor-mishra\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=VibhorMishra\">Vibhor Mishra<\/a>, freelance scientist on Kolabtree, has recently published a <a href=\"https:\/\/www.kolabtree.com\/blog\/pt\/ensuring-reproducibility-in-ai-driven-research-how-freelance-experts-can-help-in-biotech-and-healthcare\/\">pesquisa<\/a> paper titled,<\/p>\n<blockquote><p>\"Montagem de um complexo sintetizador dsRNA: RNA-DEPENDENTE RNA POLIMERASE 2 contacta a maior subunidade de RNA POLIMERASE IV NUCLEAR\".<\/p><\/blockquote>\n<p>Aqui est\u00e1 o resumo do artigo:<\/p>\n<blockquote><p>Nas plantas, a transcri\u00e7\u00e3o de elementos gen\u00e9ticos ego\u00edstas, como transposons e v\u00edrus de DNA, \u00e9 suprimida pela metila\u00e7\u00e3o do DNA dirigido por RNA. Este processo \u00e9 guiado por RNAs (siRNAs) de curta-interfer\u00eancia 24-nt, cujos precursores de dupla cadeia s\u00e3o sintetizados por RNA NUCLEAR POLIMERASE IV (Pol IV) e RNA-DEPENDENTE RNA POLIMERASE 2 (RDR2) dependentes de DNA. Pol IV e RDR2 coimunoprecipitam, e suas atividades est\u00e3o estreitamente ligadas, mas a base para sua associa\u00e7\u00e3o \u00e9 desconhecida. Aqui, mostramos que um intervalo pr\u00f3ximo ao local ativo do RDR2 entra em contato com a subunidade catal\u00edtica Pol IV, NRPD1, a maior das 12 subunidades da Pol IV. Os contatos entre as regi\u00f5es catal\u00edticas das duas enzimas sugerem que o RDR2 est\u00e1 posicionado para rapidamente acoplar as pontas livres 3\u2032 das transcri\u00e7\u00f5es de Pol IV e converter estas transcri\u00e7\u00f5es de uma s\u00f3 cadeia em RNAs de cadeia dupla (dsRNAs).<\/p><\/blockquote>\n<p><a href=\"https:\/\/www.pnas.org\/content\/118\/13\/e2019276118.long\"><strong>Leia a publica\u00e7\u00e3o completa sobre PNAS.\u00a0<\/strong><\/a><\/p>\n<blockquote class=\"modern-quote full\"><p>O <a href=\"https:\/\/facultyopinions.com\/prime\/739839216\">a publica\u00e7\u00e3o foi recomendada<\/a> sobre FacultyOpinions pelo Dr. Z Jeffrey Chen, Universidade do Texas, Austin.<\/p><\/blockquote>\n<p><a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/vibhor-mishra\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=VibhorMishra\">Vibhor Mishra<\/a> \u00e9 cientista do Hospital de Pesquisa Infantil St. Jude e co-fundador da SciAdvis,<br \/>\numa consultoria cient\u00edfica. Tem doutorado em Biologia Molecular e Estrutural. Vibhor passou um<br \/>\nd\u00e9cada compreendendo o funcionamento interno dos reguladores moleculares envolvidos no silenciamento de genes. Seu<br \/>\nA presente pesquisa se concentra na explora\u00e7\u00e3o das prote\u00ednas das principais vias regulat\u00f3rias implicadas no<br \/>\ndiferentes tipos de c\u00e2nceres pedi\u00e1tricos, uma das principais causas de mortalidade infantil em todo o mundo. Ele acredita que<br \/>\nh\u00e1 uma necessidade urgente de estudar os complexos mecanismos moleculares dos fatores causadores do c\u00e2ncer<br \/>\npara encontrar novas solu\u00e7\u00f5es para este problema antigo. Vibhor \u00e9 um autor de destaque, uma faculdade associada<br \/>\nmembro para Pareceres da Faculdade e revisor ad-hoc para v\u00e1rias revistas cient\u00edficas e bolsas<br \/>\npain\u00e9is.<\/p>\n<p>Em Kolabtree, Vibhor est\u00e1 procurando se conectar com os l\u00edderes da ind\u00fastria em design e engenharia de prote\u00ednas terap\u00eauticas. Ele pode fornecer solu\u00e7\u00f5es especializadas para projeto, engenharia, desenvolvimento, produ\u00e7\u00e3o e caracteriza\u00e7\u00e3o de prote\u00ednas\/pept\u00eddeos. Ele tem 9 anos de experi\u00eancia em liderar e gerenciar profissionais de pesquisa em projetos colaborativos, resultando em 12 publica\u00e7\u00f5es e $10 milh\u00f5es de financiamento de subs\u00eddios de laborat\u00f3rio. Ele comunicou\/publicou independentemente suas pesquisas em 5 revistas cient\u00edficas internacionais e publica\u00e7\u00f5es cient\u00edficas revisadas por pares. <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/vibhor-mishra\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=VibhorMishra\"><strong>CONSULT\u00c1-LO AQUI<\/strong><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Vibhor Mishra, cientista freelance em Kolabtree, publicou recentemente um trabalho de pesquisa intitulado \"Assembl\u00e9ia de um complexo sintetizador dsRNA\": RNA-DEPENDENTE RNA POLYMERASE 2 contacta a maior subunidade de RNA POLYMERASE IV NUCLEAR\" Aqui est\u00e1 o resumo do artigo: Nas plantas, a transcri\u00e7\u00e3o de elementos gen\u00e9ticos ego\u00edstas, como transposons e v\u00edrus de DNA, \u00e9 suprimida por<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/pt\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/\" title=\"Leia mais\">Leia mais<\/a><\/div>","protected":false},"author":12,"featured_media":9208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[662,661],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vibhor Mishra: Assembly of a dsRNA synthesizing complex<\/title>\n<meta name=\"description\" content=\"Kolabtree scientist Vibhor Mishra&#039;s latest publication on assembly of a dsRNA synthesizing complex has been published in PNAS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/pt\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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