{"id":2239,"date":"2017-06-26T14:18:13","date_gmt":"2017-06-26T14:18:13","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=2239"},"modified":"2017-06-26T14:57:21","modified_gmt":"2017-06-26T14:57:21","slug":"computational-biology","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/pt\/computational-biology\/","title":{"rendered":"Biologia Computacional: Uma Ci\u00eancia Interdisciplinar e Integrativa"},"content":{"rendered":"

For many years, Biology, in general, was a discipline considered to be similar to library sciences, due to the practice of collecting specimens and samples and cataloging them. (I made a herbarium \u00a0for my high school project.) However, since the 1970s, the advancements in molecular biology and in allied areas of biological pesquisa<\/a>, has made Biology diversified. It is no longer a library science. Also, the need for interdisciplinary research has become more prominent. This is evident,specifically in Computational Biology and Bioinformatics, with scientists from diverse background expertise, working on a common problem. In the current scenario, with the advent of newer technologies and techniques, interdisciplinary and integrative scientific research skills are in high demand.<\/p>\n

Biologia Computacional e Bioinform\u00e1tica \u00e9 uma das \u00e1reas, onde cientistas com diversos conhecimentos para dar resultados espetaculares<\/a>. A cita\u00e7\u00e3o seguinte resume de forma eloquente os benef\u00edcios da pesquisa interdisciplinar e integradora.<\/p>\n

Uma das quest\u00f5es mais fascinantes que encontramos s\u00e3o as diferentes maneiras de pensar que caracterizam tipicamente os bi\u00f3logos e cientistas da computa\u00e7\u00e3o.<\/a>. O bi\u00f3logo re\u00fane conhecimentos, muitas vezes descreve seu trabalho como se estivesse contando uma hist\u00f3ria, esfor\u00e7a-se para tirar conclus\u00f5es e construir modelos, e aprecia que as exce\u00e7\u00f5es s\u00e3o t\u00e3o comuns quanto as regras em nosso mundo biol\u00f3gico. Compare isto com a l\u00f3gica e o processo orientado ao cientista da computa\u00e7\u00e3o, para quem as regras e a otimiza\u00e7\u00e3o s\u00e3o os objetivos, e voc\u00ea tem o potencial de m\u00e1 comunica\u00e7\u00e3o. Os dois grupos, dado o mesmo problema, far\u00e3o perguntas diferentes, pegar\u00e3o detalhes diferentes, usar\u00e3o met\u00e1foras diferentes para descrever o problema e chegar\u00e3o \u00e0 situa\u00e7\u00e3o com pressupostos diferentes.<\/p><\/blockquote>\n

Por onde come\u00e7ar?<\/strong><\/p>\n

Em Biologia Computacional, algoritmos n\u00e3o destinados ou inventados para resolver problemas biol\u00f3gicos t\u00eam sido implementados com sucesso e as ferramentas desenvolvidas t\u00eam avan\u00e7ado imensamente no campo <\/a>[3]. Por exemplo, a programa\u00e7\u00e3o din\u00e2mica, destinada a encontrar o caminho mais curto, foi aplicada com sucesso para o alinhamento de seq\u00fc\u00eancias (alinhamento global e local). Uma extens\u00e3o do mesmo \u00e9 BLAST, uma ferramenta popular e essencial para os bi\u00f3logos identificarem hom\u00f3logos para uma determinada seq\u00fc\u00eancia. Assim, o conhecimento dos algoritmos e a atualiza\u00e7\u00e3o de um com variantes dos algoritmos \u00e9 essencial para um bi\u00f3logo computacional.<\/p>\n

\"technology-298256_1920\"

Com o advento de novas tecnologias e t\u00e9cnicas, as habilidades interdisciplinares e integrativas de pesquisa cient\u00edfica s\u00e3o muito requisitadas.<\/p><\/div>\n

Se voc\u00ea \u00e9 bi\u00f3logo, ter o tempo testado em laborat\u00f3rio de rotina, faria voc\u00ea fazer a pergunta \"Eu realmente n\u00e3o tenho tempo para isso\". E, voc\u00ea est\u00e1 certo. Mas, pense desta forma, o campo da Biologia Computacional e Bioinform\u00e1tica, foi desenvolvido e alimentado por pioneiros foram os f\u00edsicos, bi\u00f3logos, qu\u00edmicos, estat\u00edsticos, etc. Sair da zona de conforto, e ouvir pesquisadores de outras \u00e1reas sobre caf\u00e9 ou uma bebida \u00e9 uma excelente maneira de pensar fora da caixa. As confer\u00eancias s\u00e3o um campo minado, a este respeito. Em vez de ouvir algu\u00e9m falando sobre sua pesquisa (assumindo que a pesquisa se sobrep\u00f5e em grande parte a sua \u00e1rea de foco, e o mais prov\u00e1vel \u00e9 que voc\u00ea tenha ouvido sua palestra em outra ocasi\u00e3o), que eventualmente ser\u00e1 lida por mim em poucos meses; pode-se procurar palestras que tenham muito menos a ver com sua pesquisa. Tais oportunidades fornecem id\u00e9ias de brainstorming para implementar t\u00e9cnicas de outras \u00e1reas para sua pr\u00f3pria pesquisa, mais especificamente Biologia Computacional e Bioinform\u00e1tica.<\/p>\n

Se voc\u00ea n\u00e3o gosta de conhecer pessoas, ent\u00e3o seguir o Twitter, blogs de pesquisa e participar de f\u00f3runs de discuss\u00e3o s\u00e3o as melhores alternativas.<\/p>\n

N\u00e3o \u00e9 necess\u00e1rio se tornar um especialista em tudo. O objetivo \u00e9 estar ciente de ferramentas, recursos e m\u00e9todos que se destinam a outro prop\u00f3sito, mas que se modifica de acordo com suas necessidades. Por exemplo, os algoritmos gen\u00e9ticos (AG) s\u00e3o inspirados pelos eventos de recombina\u00e7\u00e3o que s\u00e3o observados na biologia. Assim, tornando as t\u00e9cnicas baseadas em AG mais otimizadas e bastante populares. Tamb\u00e9m \u00e9 not\u00e1vel que os m\u00e9todos de acoplamento molecular baseados em AG s\u00e3o igualmente populares em Biologia Computacional e Bioinform\u00e1tica, especificamente para a concep\u00e7\u00e3o de medicamentos.<\/p>\n

O potencial de utiliza\u00e7\u00e3o de estat\u00edsticas, matem\u00e1tica, inform\u00e1tica e processamento de sinais em biologia \u00e9 imenso. A chave para desenvolver uma pesquisa integrativa \u00e9 a comunica\u00e7\u00e3o. A comunica\u00e7\u00e3o com colegas de outros departamentos \u00e9 a chave. Al\u00e9m disso, um jeito de olhar para onde o campo est\u00e1 se deslocando ajuda. Algumas pesquisas interdisciplinares em biologia computacional que produzem resultados in\u00e9ditos ser\u00e3o discutidas em cargos subseq\u00fcentes.<\/p>\n

A hora das ci\u00eancias integrativas \u00e9 agora!<\/p>","protected":false},"excerpt":{"rendered":"

For many years, Biology, in general, was a discipline considered to be similar to library sciences, due to the practice of collecting specimens and samples and cataloging them. (I made a herbarium \u00a0for my high school project.) However, since the 1970s, the advancements in molecular biology and in allied areas of biological research, has made<\/p>\n

Leia mais<\/a><\/div>","protected":false},"author":26,"featured_media":2274,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[247],"tags":[],"acf":[],"yoast_head":"\nComputational Biology: An Interdisciplinary, Integrative Science<\/title>\n<meta name=\"description\" content=\"Computational biology and bioinformatics - how interdisciplinary research can be used to solve problems\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/pt\/zh\/computational-biology\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Computational Biology: An Interdisciplinary, Integrative Science\" \/>\n<meta property=\"og:description\" content=\"Computational biology and bioinformatics - how interdisciplinary research can be used to solve problems\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/pt\/zh\/computational-biology\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" \/>\n<meta property=\"article:published_time\" content=\"2017-06-26T14:18:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-06-26T14:57:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/06\/jigsaw-shutterstock.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"664\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ragothaman Yennamalli\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:site\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ragothaman Yennamalli\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutos\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Computational Biology: An Interdisciplinary, Integrative Science","description":"Computational biology and bioinformatics - 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He conducted postdoctoral research at Iowa State University (2009-2011), University of Wisconsin-Madison (2011-2012), and Rice University (2012-2014). Currently he is an Assistant Professor at Jaypee University of Information Technology, Waknaghat, Himachal Pradesh, India.","url":"https:\/\/www.kolabtree.com\/blog\/pt\/author\/ragothaman\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/posts\/2239"}],"collection":[{"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/comments?post=2239"}],"version-history":[{"count":14,"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/posts\/2239\/revisions"}],"predecessor-version":[{"id":2278,"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/posts\/2239\/revisions\/2278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/media\/2274"}],"wp:attachment":[{"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/media?parent=2239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/categories?post=2239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/pt\/wp-json\/wp\/v2\/tags?post=2239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}