{"id":8630,"date":"2020-12-09T09:06:32","date_gmt":"2020-12-09T09:06:32","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=8630"},"modified":"2023-04-18T11:08:15","modified_gmt":"2023-04-18T11:08:15","slug":"top-10-biotech-innovations-you-should-know-about","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/","title":{"rendered":"\u77e5\u3063\u3066\u304a\u304d\u305f\u3044\u30d0\u30a4\u30aa\u30c6\u30c3\u30af\u306e\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3TOP10"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_45_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">table of contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" area-label=\"ez-toc-toggle-icon-1\"><label for=\"item-69f490c89bd22\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-69f490c89bd22\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#_1_Single_Cell_Technologies\" title=\"\u00a01. Single Cell Technologies\">\u00a01. Single Cell Technologies<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#2_Aptamer_biosensors\" title=\"2.\u30a2\u30d7\u30bf\u30de\u30fc\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u00a0\">2.\u30a2\u30d7\u30bf\u30de\u30fc\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#3_Current_Cell_Therapies\" title=\"3. Current Cell Therapies\u00a0\">3. Current Cell Therapies\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#4_Stem_Cell_Applications\" title=\"4. Stem Cell Applications\">4. Stem Cell Applications<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#5_CRISPR-based_Platforms\" title=\"5. CRISPR-based Platforms\">5. CRISPR-based Platforms<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#6_Directed_Evolution_Platforms\" title=\"6. Directed Evolution Platforms\">6. Directed Evolution Platforms<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#7_Microbiome-based_Innovations\" title=\"7. Microbiome-based Innovations\u00a0\">7. Microbiome-based Innovations\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#8_DNA_Hard_Drives\" title=\"8. DNA Hard Drives\">8. DNA Hard Drives<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#9_DNA_Origami\" title=\"9. DNA Origami\u00a0\">9. DNA Origami\u00a0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/#10_Artificial_Intelligence_in_Medicine\" title=\"10. Artificial Intelligence in Medicine\">10. Artificial Intelligence in Medicine<\/a><\/li><\/ul><\/nav><\/div>\n<p><em><a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/jennifer-huen\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=BiotechInnovations\">\u30b8\u30a7\u30cb\u30d5\u30a1\u30fc\u30fb\u30d2\u30e5\u30fc\u30f3<\/a>, <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/biochemistry\">\u30d5\u30ea\u30fc\u30e9\u30f3\u30b9\u30fb\u30d0\u30a4\u30aa\u30b1\u30df\u30b9\u30c8<\/a> \u306eKolabtree\u3067\u306f\u3001\u73fe\u5728\u5e02\u5834\u306b\u51fa\u56de\u3063\u3066\u3044\u308b\u30d0\u30a4\u30aa\u30c6\u30c3\u30af\u30fb\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u306e\u30c8\u30c3\u30d710\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002\u30e9\u30a4\u30d5\u30b5\u30a4\u30a8\u30f3\u30b9\u5206\u91ce\u306e\u30c8\u30c3\u30d7\u88fd\u54c1\u30fb\u30b5\u30fc\u30d3\u30b9\u3068\u3001\u305d\u306e\u80cc\u5f8c\u306b\u3042\u308b\u4f01\u696d\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002\u00a0\u00a0<\/em><\/p>\n<p><span style=\"font-weight: 400;\">\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u9769\u65b0\u306f\u3001\u533b\u7642\u5206\u91ce\u3060\u3051\u3067\u306a\u304f\u3001\u8fb2\u696d\u3001\u74b0\u5883\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u5206\u91ce\u3067\u3082\u3001\u3053\u306e10\u5e74\u3067\u7740\u5b9f\u306b\u6210\u9577\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u304c <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/biotechnology-and-bioengineering\" target=\"_blank\" rel=\"noopener\">\u30d0\u30a4\u30aa\u30c6\u30c3\u30af<\/a> \u306e\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u907a\u4f1d\u5b50\u5de5\u5b66\u3001\u8a3a\u65ad\u3001\u30a2\u30c3\u30bb\u30a4\u3092\u542b\u3080\u3082\u306e\u3067\u3001\u73fe\u5728\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u958b\u767a\u306b\u304a\u3051\u308b\u5408\u6210\u751f\u7269\u5b66\u306e\u91cd\u8981\u6027\u3092\u53cd\u6620\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u696d\u754c\u306b\u5909\u9769\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u308b\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u306e\u30c8\u30c3\u30d710\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u00a0<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"_1_Single_Cell_Technologies\"><\/span><strong>\u00a01. Single Cell Technologies<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u6280\u8853\u306f\u3001\u7d30\u80de\u74b0\u5883\u306e\u8a73\u7d30\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3001\u5275\u85ac\u3084\u81e8\u5e8a\u7814\u7a76\u306e\u91cd\u8981\u306a\u30c4\u30fc\u30eb\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3068\u5171\u306b <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/next-generation-sequencing\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=BiotechInnovations\">\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc<\/a>\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u6280\u8853\u306f\u3001\u7d30\u80de\u96c6\u56e3\u306e\u3088\u308a\u73fe\u5b9f\u7684\u306a\u59ff\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u3053\u308c\u306f\u816b\u760d\u74b0\u5883\u306e\u4e0d\u5747\u4e00\u6027\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u7279\u306b\u91cd\u8981\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u6280\u8853\u306f\u4e3b\u306b\u7814\u7a76\u306e\u5834\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u591a\u304f\u306e\u53d7\u8a17\u7814\u7a76\u4f01\u696d\u304c\u7279\u5b9a\u306eDNA\u30d1\u30cd\u30eb\u3092\u5099\u3048\u305f\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u30b7\u30fc\u30b1\u30f3\u30b9\u304a\u3088\u3073\u5206\u6790\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070 <strong>\u30df\u30c3\u30b7\u30e7\u30f3\u30fb\u30d0\u30a4\u30aa<\/strong> \u306f\uff0c2\u6bb5\u968e\u306e\u30de\u30a4\u30af\u30ed\u6d41\u4f53\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3068\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3092\u7d44\u307f\u5408\u308f\u305b\u305fTapestri\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059[1]\u3002\u6025\u6027\u30ea\u30f3\u30d1\u82bd\u7403\u6027\u767d\u8840\u75c5\u30d1\u30cd\u30eb\u306e\u3088\u3046\u306a\u7279\u5b9a\u306eDNA\u30d1\u30cd\u30eb\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u75be\u60a3\u306b\u7279\u5316\u3057\u305f\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059[1]\u3002\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u306b\u306f\u3001\u901a\u5e38\u3001\u5225\u3005\u306e\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u5099\u3048\u305f\u8907\u6570\u306e\u30de\u30b7\u30f3\u304c\u5fc5\u8981\u3067\u3059\u304c\u3001\u30d0\u30fc\u30af\u30ec\u30fc\u30e9\u30a4\u30c4\u793e\u306f\u3001\u4e00\u6b69\u9032\u3093\u3067\u30011\u3064\u306e\u30de\u30b7\u30f3\u30671\u3064\u305a\u3064\u306e\u7d30\u80de\u3092\u540c\u6642\u306b\u51e6\u7406\u30fb\u89e3\u6790\u3067\u304d\u308b\u30de\u30b7\u30f3\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002Beacon\u306f\uff0c\u6570\u4e07\u500b\u306e\u5c0f\u3055\u306a\u7d30\u80de\u30c1\u30e3\u30f3\u30d0\u30fc\u3092\u542b\u30801\u3064\u306e\u5149\u6d41\u4f53\u30c1\u30c3\u30d7\u3067\uff0c\u8907\u6570\u306e\u5358\u4e00\u7d30\u80de\u3092\u64cd\u4f5c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059 [2]\uff0e\u5149\u306b\u3088\u308b\u8a98\u96fb\u6cf3\u52d5\u3092\u5229\u7528\u3057\u3066\u3001\u7279\u5b9a\u306e\u7d30\u80de\u3092\u5206\u5272\u3057\u3001\u5275\u85ac\u4f01\u696d\u304c\u5b9f\u8a3c\u3057\u305f\u3088\u3046\u306b\u3001\u6297\u4f53\u30ec\u30d1\u30fc\u30c8\u30ea\u30fc\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306a\u3069\u3001\u3055\u3089\u306a\u308b\u5206\u6790\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002<strong> \u30a2\u30eb\u30c7\u30d6\u30ed\u30f3<\/strong> [2, 3].\u307e\u305f\u3001\u6700\u8fd1\u3067\u306f\u3001T\u7d30\u80de\u306b\u7279\u5316\u3057\u305f\u7814\u7a76\u306b\u5bfe\u5fdc\u3059\u308b\u305f\u3081\u3001Lightning\u304c\u767a\u58f2\u3055\u308c\u307e\u3057\u305f[4]\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"2_Aptamer_biosensors\"><\/span><strong>2.\u30a2\u30d7\u30bf\u30de\u30fc\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc<\/strong><span style=\"font-weight: 400;\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u30b0\u30eb\u30b3\u30fc\u30b9\u30e2\u30cb\u30bf\u30fc\uff0c\u598a\u5a20\u691c\u67fb\uff0c\u91cd\u91d1\u5c5e\u30bb\u30f3\u30b5\u30fc\u306a\u3069\u306f\uff0c1960\u5e74\u4ee3\u4ee5\u964d\u306b\u958b\u767a\u30fb\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u30d9\u30fc\u30b9\u306e\u691c\u51fa\u5668\u306e\u4e00\u4f8b\u3067\u3042\u308b[5]\u3002\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u306f\uff0c\u9175\u7d20\uff0c\u6297\u4f53\uff0c\u5fae\u751f\u7269\u306a\u3069\u3067\u69cb\u6210\u3055\u308c\uff0c\u691c\u51fa\u3055\u308c\u305f\u5316\u5408\u7269\u306e\u60c5\u5831\u3092\u8aad\u307f\u53d6\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u65b0\u3057\u3044\u30bb\u30f3\u30b5\u30fc\u6280\u8853\u3067\u306f\uff0c\u6838\u9178\u30a2\u30d7\u30bf\u30de\u30fc\u3092\u7528\u3044\u305f\u65b9\u6cd5\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u306f\uff0c\u5f93\u6765\u306e\u65b9\u6cd5\u3088\u308a\u3082\u611f\u5ea6\uff0c\u5b89\u5b9a\u6027\uff0c\u30b3\u30b9\u30c8\u9762\u3067\u512a\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3089\u3060\u3002 <strong>\u30a2\u30d7\u30bf\u30de\u30fc\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc<\/strong> \u306f\u3001\u4e00\u822c\u7684\u306b\u3001\u6307\u6570\u95a2\u6570\u7684\u6fc3\u7e2e\u6cd5\u3092\u7528\u3044\u305f\u30ea\u30ac\u30f3\u30c9\u306e\u7cfb\u7d71\u7684\u9032\u5316\uff08SELEX[6]\uff09\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u3001\u6a19\u7684\u306b\u5bfe\u3057\u3066\u9ad8\u3044\u9078\u629e\u6027\u3092\u6301\u3064\u5b89\u5b9a\u3057\u305fDNA\u307e\u305f\u306fRNA\u5206\u5b50\u3092\u751f\u6210\u3059\u308b\u3002\u30b5\u30f3\u30d7\u30eb\u306e\u8907\u96d1\u6027\u304c\u9ad8\u3044\u74b0\u5883\u691c\u67fb\u3084\u533b\u7642\u8a3a\u65ad\u306b\u306f\u3001\u30a2\u30d7\u30bf\u30de\u30fc\u304c\u6700\u9069\u306a\u5206\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u591a\u304f\u306e\u4f01\u696d\u304c\u3053\u308c\u3089\u306e\u76ee\u7684\u306e\u305f\u3081\u306b\u30a2\u30d7\u30bf\u30de\u30fc\u306e\u958b\u767a\u306b\u6ce8\u529b\u3057\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001\u97d3\u56fd\u306eAptamer Sciences\u793e\u306f\u30017\u3064\u306e\u80ba\u304c\u3093\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u3067\u3001\u60a3\u8005\u304c\u80ba\u304c\u3093\u306b\u306a\u308b\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u300cAptoDetect-Lung\u300d\u3068\u3044\u3046\u4f53\u5916\u8a3a\u65ad\u30c6\u30b9\u30c8\u3092\u958b\u767a\u3057\u305f[7]\u3002\u3053\u306e\u30c6\u30b9\u30c8\u306f\u3001CT\u30b9\u30ad\u30e3\u30f3\u691c\u67fb\u3068\u6bd4\u8f03\u3057\u3066\u8a3a\u65ad\u7cbe\u5ea6\u304c\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f[8]\u3002AptoDetect-Lung\u306f\u6700\u8fd1\u3001\u97d3\u56fd\u306e\u98df\u54c1\u533b\u85ac\u54c1\u5b89\u5168\u7701\u304b\u3089\u8a3a\u65ad\u627f\u8a8d\u3092\u53d7\u3051\u307e\u3057\u305f[7]\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"3_Current_Cell_Therapies\"><\/span><strong>3. Current Cell Therapies\u00a0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u6162\u6027\u75be\u60a3\u306e\u7ba1\u7406\u306b\u306f\u3001\u4f55\u5ea6\u3082\u85ac\u3092\u6295\u4e0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5fc5\u8981\u306a\u5834\u6240\u306b\u5fc5\u8981\u306a\u3060\u3051\u85ac\u3092\u6295\u4e0e\u3059\u308b\u65b9\u6cd5\u304c\u3042\u3063\u305f\u3068\u3057\u307e\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">\u3068\u304d\u306b<\/span><\/i><span style=\"font-weight: 400;\"> \u5fc5\u8981\u306a\u3068\u304d\u306b\u5fc5\u8981\u306a\u3060\u3051\u3001\u81ea\u52d5\u7684\u306b\u3002\u305d\u3053\u3067\u3001\u79d1\u5b66\u8005\u305f\u3061\u306f\u3001\u85ac\u7269\u3092\u904b\u3076\u7d30\u80de\u7642\u6cd5\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u306e\u3067\u3059[9]\u30021\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u306f\uff0c\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u4e0d\u8db3\u3057\uff0c\u8840\u7cd6\u5024\u304c\u4e0a\u6607\u3057\u3066\uff0c\u983b\u5c3f\uff0c\u904e\u5ea6\u306e\u5589\u306e\u6e07\u304d\uff0c\u982d\u75db\u306a\u3069\u306e\u75c7\u72b6\u304c\u73fe\u308c\u308b [10]\uff0e\u3053\u306e\u554f\u984c\u3092\u89e3\u6c7a\u3059\u308b\u65b9\u6cd5\u3068\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002 <strong>\u30bb\u30e9\u30af\u30b7\u30b9<\/strong>\u306f\uff0c\u60a3\u8005\u306e\u8840\u7cd6\u5024\u306b\u76f4\u63a5\u53cd\u5fdc\u3059\u308b\u5b9f\u9a13\u5ba4\u3067\u57f9\u990a\u3055\u308c\u305f\u81b5\u81d3\u7d30\u80de\u3067\u69cb\u6210\u3055\u308c\u305f\u57cb\u3081\u8fbc\u307f\u578b\u30c7\u30d0\u30a4\u30b9\u3067\u3042\u308b[11]\uff0e\u3053\u306e\u30c7\u30d0\u30a4\u30b9\u306b\u306f\u3001\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPSC\uff09\u304b\u3089\u88fd\u9020\u3055\u308c\u305f\u81b5\u5cf6\u7d30\u80de\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u306e\u85ac\u7269\u6cbb\u7642\u3092\u306a\u304f\u3059\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u3002\u73fe\u5728\u3001\u79fb\u690d\u53ef\u80fd\u306a1\u56de\u9650\u308a\u306e\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u3082\u30461\u3064\u306e\u4f01\u696d\u306f\u3001\u30aa\u30fc\u30af\u30e9\u30f3\u30c9\u3092\u62e0\u70b9\u3068\u3059\u308b <strong>\u30ea\u30d3\u30f3\u30b0\u30bb\u30eb\u30c6\u30af\u30ce\u30ed\u30b8\u30fc<\/strong>.\u5f7c\u3089\u306eNTCell\u7642\u6cd5\u306f\uff0c\u65b0\u751f\u5150\u306e\u8108\u7d61\u53e2\u7d30\u80de\u3092\u542b\u3080\u30a2\u30eb\u30ae\u30f3\u9178\u5869\u3067\u30b3\u30fc\u30c6\u30a3\u30f3\u30b0\u3055\u308c\u305f\u30ab\u30d7\u30bb\u30eb\u3092\uff0c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u306e\u8133\u306b\u79fb\u690d\u3059\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3042\u308b[12]\u3002\u8108\u7d61\u53e2\u7d30\u80de\u306f\uff0c\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3068\u6a5f\u80fd\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u8133\u810a\u9ac4\u6db2\uff0c\u5206\u88c2\u4fc3\u9032\u56e0\u5b50\uff0c\u305d\u306e\u4ed6\u306e\u56e0\u5b50\u3092\u4f9b\u7d66\u3059\u308b[12]\uff0e2013\u5e74\u3001Living Cell Technologies\u793e\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u5bfe\u3059\u308b\u518d\u751f\u7d30\u80de\u6cbb\u7642\u306e\u4e16\u754c\u521d\u306e\u81e8\u5e8a\u8a66\u9a13\u3092\u5f8c\u63f4\u3057\u3001\u73fe\u5728\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u306e\u305f\u3081\u306bNTCell\u3092\u8a55\u4fa1\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"4_Stem_Cell_Applications\"><\/span><strong>4. Stem Cell Applications<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">1980\u5e74\u4ee3\u521d\u982d\u304b\u3089\u3001\u79d1\u5b66\u8005\u305f\u3061\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u6761\u4ef6\u3067\u3001\u3069\u306e\u3088\u3046\u306a\u30a2\u30a4\u30c7\u30f3\u30c6\u30a3\u30c6\u30a3\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u306e\u304b\u3092\u7814\u7a76\u3057\u3066\u304d\u307e\u3057\u305f\u3002 <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/Stem-Cells\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=BiotechInnovations\">\u5e79\u7d30\u80de<\/a> \u3092\u5206\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5206\u5316\u3092\u5236\u5fa1\u3057\u3066\u76ee\u7684\u306e\u7d30\u80de\u3092\u4f5c\u308a\u51fa\u3059\u3053\u3068\u306f\u3001\u533b\u85ac\u54c1\u306e\u958b\u767a\u3084\u518d\u751f\u533b\u7642\u3001\u8cb4\u91cd\u306a\u751f\u4f53\u6750\u6599\u306e\u88fd\u9020\u306a\u3069\u306e\u5206\u91ce\u3067\u3001\u7523\u696d\u7684\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u4f8b\u3048\u3070\u3001\u30ab\u30ca\u30c0\u306e\u3042\u308b\u4f01\u696d\u3067\u306f <strong>NovoHeart<\/strong>Ltd.\u306f\u3001\u5fc3\u75be\u60a3\u306e\u85ac\u52b9\u8a55\u4fa1\u3092\u884c\u3046\u7814\u7a76\u8005\u5411\u3051\u306e\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u540c\u793e\u306eMyHeart\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\uff0ciPSC\u3092\u5229\u7528\u3057\u3066\u30d2\u30c8\u306e\u5fc3\u81d3\u7d44\u7e54\u3084\u81d3\u5668\u306e\u30e2\u30c7\u30eb\u3092\u4f5c\u6210\u3059\u308b\u3082\u306e\u3067\uff0c\u524d\u81e8\u5e8a\u958b\u767a\u3067\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u52d5\u7269\u30e2\u30c7\u30eb\u3088\u308a\u3082\uff0c\u5b9f\u969b\u306e\u30d2\u30c8\u306e\u5fc3\u81d3\u74b0\u5883\u3092\u3088\u308a\u5fe0\u5b9f\u306b\u518d\u73fe\u3057\u3066\u3044\u308b\u3002MyHeart\u306f\u3001\u65b0\u85ac\u304c\u81e8\u5e8a\u8a66\u9a13\u306b\u5165\u308b\u524d\u306b\u3001\u305d\u306e\u52b9\u679c\u3092\u3088\u308a\u6b63\u78ba\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u3002\u3082\u3046\u4e00\u3064\u306e\u4f1a\u793e\u306f\u3001\u5e79\u7d30\u80de\u6280\u8853\u3092\u5fc5\u8981\u3068\u3057\u3066\u3044\u308b\u4eba\u306b\u76f4\u63a5\u5c4a\u3051\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u3002 <strong>\u8840\u5c0f\u677f\u30d0\u30a4\u30aa\u30b8\u30a7\u30cb\u30c3\u30af<\/strong>2014\u5e74\u306b\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\u306b\u8a2d\u7acb\u3055\u308c\u305f\u30b9\u30bf\u30fc\u30c8\u30a2\u30c3\u30d7\u3067\u3042\u308b\u540c\u793e\u306f\uff0c\u8ecd\u306e\u533b\u7642\u62e0\u70b9\u306a\u3069\u306b\u304a\u3051\u308b\u73fe\u5834\u3067\u306e\u7d30\u80de\u6cbb\u7642\u306e\u305f\u3081\u306b\uff0c\u30aa\u30f3\u30c7\u30de\u30f3\u30c9\u3067\u79fb\u52d5\u53ef\u80fd\u306a\u30d0\u30a4\u30aa\u30ea\u30a2\u30af\u30bf\u30fc\u3092\u958b\u767a\u3057\u3066\u3044\u308b[15, 16]\uff0e\u3053\u306e\u30d0\u30a4\u30aa\u30ea\u30a2\u30af\u30bf\u30fc\u306f\uff0c\u514d\u75ab\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u306a\u3069\u306e\u8840\u6db2\u51dd\u56fa\u75be\u60a3\u306e\u6cbb\u7642\u306e\u305f\u3081\u306b\u73fe\u5728\u958b\u767a\u3055\u308c\u3066\u3044\u308biPSC\u7531\u6765\u306e\u8840\u5c0f\u677f\u69d8\u7d30\u80de\u3092\u88fd\u9020\u3059\u308b\u3082\u306e\u3067\u3042\u308b[16]\uff0e<\/span><\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\">\u300c\u878d\u5408\u3059\u308b\u3053\u3068\u3067 <a href=\"https:\/\/twitter.com\/Harvard?ref_src=twsrc%5Etfw\">\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66<\/a>#39;\u306e\u30d0\u30eb\u30d6\u4ed8\u304d\u30d0\u30a4\u30aa\u30ea\u30a2\u30af\u30bf\u30fc\u6280\u8853\u3068\u5f53\u793e\u72ec\u81ea\u306e\u4eba\u9593\u306e\u5fc3\u81d3\u306e\u5165\u3063\u305f\u74f6\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001Novoheart\u793e\u306f\u3001in vitro\u306e\u4eba\u9593\u306e\u5fc3\u81d3\u306e\u30a2\u30c3\u30bb\u30a4\u306b\u304a\u3044\u3066\u3001\u3053\u308c\u307e\u3067\u306b\u306a\u3044\u30ec\u30d9\u30eb\u306e\u751f\u7269\u5b66\u7684\u5fe0\u5b9f\u5ea6\u3067\u75be\u60a3\u30e2\u30c7\u30ea\u30f3\u30b0\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u300d - Kevin Costa\u6c0f<a href=\"https:\/\/t.co\/zBwXX48EPL\">https:\/\/t.co\/zBwXX48EPL<\/a><\/p>\n<p>- \u30ce\u30dc\u30cf\u30fc\u30c8\uff08@Novoheart\uff09\u3055\u3093 <a href=\"https:\/\/twitter.com\/Novoheart\/status\/1207711402439434243?ref_src=twsrc%5Etfw\">2019\u5e7412\u670819\u65e5<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0\u5e79\u7d30\u80de\u306e\u6280\u8853\u306f\u3001\u533b\u7642\u7814\u7a76\u3084\u6cbb\u7642\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u57f9\u990a\u8089\u3084\u4ee3\u66ff\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u6295\u8cc7\u3059\u308b\u4f01\u696d\u306e\u6570\u306b\u3082\u8868\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u8fb2\u696d\u3092\u5229\u7528\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u4f01\u696d\u304c <strong>\u672a\u6765\u306e\u30d5\u30a3\u30fc\u30eb\u30c9<\/strong>, <strong>\u30e1\u30f3\u30d5\u30a3\u30b9\u30fb\u30df\u30fc\u30c4<\/strong>\u3068\u3057\u3066\u3044\u307e\u3059\u3002 <strong>\u30b9\u30fc\u30d1\u30fc\u30df\u30fc\u30c8<\/strong> \u306f\uff0c\u5b9f\u9a13\u5ba4\u3067\u80b2\u3066\u305f\u9d8f\u8089\uff0c\u725b\u8089\uff0c\u30a2\u30d2\u30eb\uff0c\u5375\uff0c\u725b\u4e73\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u30022013\u5e74\u306b\u30de\u30fc\u30b9\u30c8\u30ea\u30d2\u30c8\u5927\u5b66\u306e\u30de\u30fc\u30af\u30fb\u30dd\u30b9\u30c8\u306e\u7814\u7a76\u5ba4\u3067\u6700\u521d\u306e\u30cf\u30f3\u30d0\u30fc\u30ac\u30fc\u30d1\u30c6\u30a3\u304c\u88fd\u9020\u3055\u308c\u307e\u3057\u305f\u304c\uff0c\u305d\u306e\u4fa1\u683c\u306f\u7d04$300,000\u7c73\u30c9\u30eb\u3068\u3044\u3046\u9014\u65b9\u3082\u306a\u3044\u3082\u306e\u3067\u3057\u305f [17, 18]\uff0e\u305d\u308c\u4ee5\u6765\uff0c\u4f01\u696d\u306f\u88fd\u9020\u30b3\u30b9\u30c8\u3092\u524a\u6e1b\u3059\u308b\u305f\u3081\u306b\u7af6\u4e89\u3057\u3066\u304a\u308a\uff0c\u30a4\u30b9\u30e9\u30a8\u30eb\u306b\u672c\u62e0\u3092\u7f6e\u304fSuper Meat\u793e\u304c\u6f5c\u5728\u7684\u306b\u305d\u306e\u7af6\u4e89\u3092\u30ea\u30fc\u30c9\u3057\u3066\u3044\u308b\u3002\u4eca\u5e74\u306e10\u6708\u306b\u306f\uff0c\u540c\u793e\u306e\u30ec\u30b9\u30c8\u30e9\u30f3\u300cThe Chicken\u300d\u3067\uff0c\u7814\u7a76\u5ba4\u3067\u80b2\u3066\u3089\u308c\u305f\u521d\u306e\u30c1\u30ad\u30f3\u306e\u30c6\u30a4\u30b9\u30c6\u30a3\u30f3\u30b0\u30e1\u30cb\u30e5\u30fc\u3092\u767a\u58f2\u3057\u305f[19, 20]\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"5_CRISPR-based_Platforms\"><\/span><strong>5. CRISPR-based Platforms<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u304c\u767a\u898b\u3055\u308c\u3066\u304b\u3089 <\/span><i><span style=\"font-weight: 400;\">\u30b9\u30c8\u30ec\u30d7\u30c8\u30b3\u30c3\u30ab\u30b9\u30fb\u30d1\u30a4\u30aa\u30b2\u30cd\u30b9<\/span><\/i><span style=\"font-weight: 400;\"> \u4eca\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u53d7\u8cde\u8005\u3067\u3042\u308bJennifer Doudna\u3068Emmanuelle Charpentier\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308bCRISPR-Cas9\u9069\u5fdc\u514d\u75ab\u53cd\u5fdc[21]\u3092\u304d\u3063\u304b\u3051\u306b\uff0cCRISPR\u3092\u5229\u7528\u3057\u305f\u4f01\u696d\u304c\u6570\u591a\u304f\u8a2d\u7acb\u3055\u308c\u305f\u3002\u3057\u304b\u3057\uff0c\u6700\u521d\u306e\u5546\u696d\u7684\u5fdc\u7528\u306f\uff0c\u5b9f\u306f2007\u5e74\u306bDanisco\u793e\uff082011\u5e74\u306bDuPont\u793e\u304c\u8cb7\u53ce\uff09\u306e\u79d1\u5b66\u8005\u304c\uff0c\u81ea\u793e\u306e\u30e8\u30fc\u30b0\u30eb\u30c8\u83cc\u306e1\u3064\u306e\u30b2\u30ce\u30e0\u306b\u77ed\u3044\u7e70\u308a\u8fd4\u3057\u914d\u5217\u3092\u767a\u898b\u3057\u305f\u3053\u3068\u304b\u3089\u59cb\u307e\u3063\u305f\u3002 <\/span><i><span style=\"font-weight: 400;\">Streptococcus thermophilus<\/span><\/i><span style=\"font-weight: 400;\"> [22, 23].\u5f7c\u3089\u306f\u3001\u3053\u308c\u3089\u304cclustered regular interspaced short palindromic repeats (CRISPR)\u3067\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002 <\/span><i><span style=\"font-weight: 400;\">S. thermophilus<\/span><\/i><span style=\"font-weight: 400;\"> \u3092\u4f7f\u3063\u3066\u30d0\u30af\u30c6\u30ea\u30aa\u30d5\u30a1\u30fc\u30b8\u306e\u611f\u67d3\u3092\u9632\u304e\u307e\u3057\u305f[23]\u3002\u305d\u306e\u5f8c\uff0c\u30c7\u30e5\u30dd\u30f3\u793e\u306f\u3053\u306e\u767a\u898b\u3092\u5229\u7528\u3057\u3066\uff0c\u30e8\u30fc\u30b0\u30eb\u30c8\u306e\u88fd\u9020\u904e\u7a0b\u3067\u30d5\u30a1\u30fc\u30b8\u8010\u6027\u3092\u6301\u3064\u83cc\u682a\u3092\u8a2d\u8a08\u3057\u305f[22, 23]\u3002\u305d\u308c\u304b\u3089\u304a\u3088\u305d10\u5e74\u5f8c\uff0c\u3055\u307e\u3056\u307e\u306aCRISPR-Cas\u30b7\u30b9\u30c6\u30e0\u304c\u539f\u5b50\u69cb\u9020\u306b\u81f3\u308b\u307e\u3067\u7279\u5fb4\u3065\u3051\u3089\u308c\uff0c\u305d\u306e\u4e2d\u3067\u3082CRISPR-Cas9\u304c\u6700\u3082\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u5de5\u696d\u7684\u306b\u91cd\u8981\u306a\u751f\u7269\u3092\u958b\u767a\u3059\u308b\u3068\u3044\u3046\u6d41\u308c\u306f\u73fe\u5728\u3082\u7d9a\u3044\u3066\u304a\u308a\u3001CRISPR-Cas9\u6280\u8853\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u304b\u3064\u3066\u306a\u3044\u307b\u3069\u306e\u30b9\u30d4\u30fc\u30c9\u3067\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002 <strong>\u5408\u6210\u30b2\u30ce\u30df\u30af\u30b9<\/strong>\u306f\u3001\u30a8\u30af\u30bd\u30f3\u30e2\u30fc\u30d3\u30eb\u3068\u5171\u540c\u3067\u3001CRISPR\u3067\u7de8\u96c6\u3057\u305f\u8102\u8cea\u306e\u751f\u7523\u91cf\u3092\u9ad8\u3081\u305f\u5fae\u7d30\u85fb\u985e\u3092\u958b\u767a\u3057\u3066\u304a\u308a\u3001CO2\u3092\u524a\u6e1b\u3057\u3066\u77f3\u6cb9\u306e\u751f\u7523\u91cf\u3092\u5411\u4e0a\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\"> \u6392\u51fa\u91cf\u3092\u524a\u6e1b\u3057\u3001\u5316\u77f3\u71c3\u6599\u3078\u306e\u4f9d\u5b58\u5ea6\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059[24, 25]\u3002PLANTeDit\u3068Toolgen\u306f\u3001CRISPR-Cas9\u3092\u7528\u3044\u3066\u3001\u5916\u6765DNA\u3092\u5c0e\u5165\u305b\u305a\u306b\u5927\u8c46\u306a\u3069\u306e\u6301\u7d9a\u53ef\u80fd\u306a\u4f5c\u7269\u3092\u30a8\u30f3\u30b8\u30cb\u30a2\u30ea\u30f3\u30b0\u3057\u3066\u3044\u308b[26]\u3002\u3053\u308c\u306fDNA\u30d5\u30ea\u30fc\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u547c\u3070\u308c\u3001\u5f7c\u3089\u306e\u4f5c\u7269\u306f\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u3055\u308c\u308b\u3082\u306e\u306e\u3001\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u4f5c\u7269\u306e\u898f\u5236\u306e\u30cf\u30fc\u30c9\u30eb\u3092\u56de\u907f\u3059\u308b\u3053\u3068\u306b\u306a\u308b[26]\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CRISPR\u30d9\u30fc\u30b9\u306e\u6cbb\u7642\u85ac\u3067\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\u3092\u958b\u59cb\u3057\u305f\u6700\u521d\u306e\u4f01\u696d\u306f <strong>CRISPR\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30c3\u30af<\/strong> \u305d\u3057\u3066<strong> \u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u793e<\/strong> \u30922018\u5e74\u306b\u767a\u8868\u3057\u307e\u3057\u305f[27-29]\u3002CTX001\u306f <\/span><i><span style=\"font-weight: 400;\">ex vivo<\/span><\/i><span style=\"font-weight: 400;\"> \u306f\uff0c\u03b2-\u30b5\u30e9\u30bb\u30df\u30a2\u3068\u938c\u72b6\u8d64\u8840\u7403\u8ca7\u8840\u306e\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u6cbb\u7642\u6cd5\u3067\u3042\u308b[30]\uff0e\u3053\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u60a3\u8005\u306e\u8840\u6db2\u5e79\u7d30\u80de\u3092\u53d6\u308a\u51fa\u3057\u3001CRISPR-Cas9\u3092\u7528\u3044\u3066\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3057\u3001\u305d\u306e\u7d30\u80de\u3092\u518d\u3073\u60a3\u8005\u306b\u623b\u3059\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002CTX001\u306e\u81e8\u5e8a\u8a55\u4fa1\u306f\u307e\u3060\u59cb\u307e\u3063\u305f\u3070\u304b\u308a\u3067\u3059\u304c\u3001\u4eca\u5e746\u6708\u306b\u767a\u8868\u3055\u308c\u305f\u4e88\u5099\u7684\u306a\u7d50\u679c\u3067\u306f\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u8840\u75c7\u306e\u60a3\u8005\u306b\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f[31]\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"6_Directed_Evolution_Platforms\"><\/span><strong>6. Directed Evolution Platforms<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">2018\u5e74\u3001\u30d5\u30e9\u30f3\u30b7\u30b9\u30fb\u30a2\u30fc\u30ce\u30eb\u30c9\u3001\u30b8\u30e7\u30fc\u30b8\u30fb\u30b9\u30df\u30b9\u3001\u30b0\u30ec\u30b4\u30ea\u30fc\u30fb\u30a6\u30a3\u30f3\u30bf\u30fc\u306e3\u4eba\u306f\u3001\u9175\u7d20\u3001\u30da\u30d7\u30c1\u30c9\u3001\u6297\u4f53\u306e\u6709\u5411\u9032\u5316\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u3001\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u305f[32]\u3002\u6709\u5411\u9032\u5316\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3067\u306f\u901a\u5e38\u3001\u76ee\u7684\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u4f53\u3092\u767a\u73fe\u3059\u308b\u5927\u898f\u6a21\u3067\u30e9\u30f3\u30c0\u30e0\u306a\u907a\u4f1d\u5b50\u30e9\u30a4\u30d6\u30e9\u30ea\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u306f\uff0c\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\u6027\u3084\u89e6\u5a92\u6d3b\u6027\u306e\u5411\u4e0a\u306a\u3069\uff0c\u671b\u307e\u3057\u3044\u7279\u6027\u3092\u793a\u3059\u30bf\u30f3\u30d1\u30af\u8cea\u5909\u7570\u4f53\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u308b\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u901a\u5e38\u3001\u9078\u629e\u3055\u308c\u305f\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u57fa\u3065\u3044\u3066\u8ffd\u52a0\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u3001\u9078\u629e\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u306b\u9054\u3059\u308b\u307e\u3067\u7e70\u308a\u8fd4\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u5229\u7528\u3057\u3066\u3001\u591a\u304f\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30d9\u30fc\u30b9\u306e\u6cbb\u7642\u85ac\u304c\u958b\u767a\u3055\u308c\u3066\u304d\u305f\u3002\u30d2\u30e5\u30df\u30e9\uff08AbbVie\u793e\uff09\u3002 <\/span><span style=\"font-weight: 400;\">\u30eb\u30e2\u30ad\u30b7\u30c6\u30a3<\/span><span style=\"font-weight: 400;\"> (MedImmune)\u3068 <\/span><span style=\"font-weight: 400;\">\u30ac\u30df\u30d5\u30a1\u30f3\u30c8\uff08NovImmune\u793e\uff09[33]\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6709\u5411\u6027\u9032\u5316\u306e\u6280\u8853\u3092\u767a\u5c55\u3055\u305b\u305f\u4f01\u696d\u304c\u3042\u308b\u3002 <strong>Carmot Therapeutics<\/strong>\u306f\u3001\u30d0\u30fc\u30af\u30ec\u30fc\u306b\u672c\u793e\u3092\u7f6e\u304f\u5275\u85ac\u4f01\u696d\u3067\u3001\u65b0\u85ac\u3092\u767a\u898b\u3059\u308b\u305f\u3081\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u300cChemotype Evolution\u300d\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u30b1\u30e2\u30bf\u30a4\u30d7\u30a8\u30dc\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u3067\u306f\u3001\u4e00\u9023\u306e\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3092\u72ec\u81ea\u306e\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u306b\u30ea\u30f3\u30af\u3055\u305b\u3001\u85ac\u5264\u5019\u88dc\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u3092\u30d2\u30c8\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u5bfe\u3057\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u3001\u9078\u629e\u3055\u308c\u305f\u5019\u88dc\u85ac\u306f\u3001\u9ad8\u89aa\u548c\u6027\u7d50\u5408\u5206\u5b50\u306b\u9032\u5316\u3059\u308b\u307e\u3067\u3001\u3055\u3089\u306b\u30ea\u30f3\u30b1\u30fc\u30b8\u3068\u9078\u629e\u306e\u30e9\u30a6\u30f3\u30c9\u306b\u304b\u3051\u3089\u308c\u308b[34]\u3002Carmot\u793e\u306fChemotype Evolution\u3092\u7528\u3044\u3066\u3001\u73fe\u5728\u81e8\u5e8a\u8a66\u9a13\u4e2d\u306e2\u3064\u306e\u5019\u88dc\u5316\u5408\u7269\u3092\u540c\u5b9a\u3057\u305f[34]\u3002\u5fae\u751f\u7269\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u306b\u3001\u6307\u5411\u6027\u9032\u5316\u3092\u5229\u7528\u3057\u3066\u3044\u308b\u4f01\u696d\u3082\u3042\u308b\u3002\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u306b\u62e0\u70b9\u3092\u7f6e\u304f\u30d0\u30a4\u30aa\u30c6\u30c3\u30af\u4f01\u696dPrimordial Genetics\u793e\u306f\u3001Function Generator\u3068\u547c\u3070\u308c\u308b\u30b3\u30f3\u30d3\u30ca\u30c8\u30ea\u30a2\u30eb\u30fb\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306b\u3088\u3063\u3066\u5927\u898f\u6a21\u306a\u5fae\u751f\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u3092\u751f\u6210\u3059\u308b\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u958b\u767a\u3057\u3066\u3044\u308b[35]\u3002Function Generator\u3067\u306f\u3001\u30d0\u30a4\u30aa\u71c3\u6599\u751f\u7523\u306e\u305f\u3081\u306e\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u3042\u308b\u9175\u6bcd\u306e\u7279\u5b9a\u304b\u3089\u3001\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u3092\u52b9\u7387\u7684\u306b\u5206\u89e3\u3067\u304d\u308b\u5fae\u751f\u7269\u306e\u7279\u5b9a\u307e\u3067\u3001\u69d8\u3005\u306a\u554f\u984c\u306b\u5bfe\u51e6\u3067\u304d\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u7279\u5b9a\u306e\u5fae\u751f\u7269\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b[35]\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"7_Microbiome-based_Innovations\"><\/span><strong>7. Microbiome-based Innovations\u00a0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">2007\u5e74\uff0c\u7c73\u56fd\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\u306f\uff0c\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u7814\u7a76\u306e\u305f\u3081\u306e\u8cc7\u91d1\u63f4\u52a9\u3084\u53c2\u7167\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306a\u3069\u3092\u63d0\u4f9b\u3059\u308b\u30d2\u30c8\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08HMP\uff09\u3092\u7acb\u3061\u4e0a\u3052\u307e\u3057\u305f[36]\u3002\u3053\u308c\u306b\u3088\u308a\uff0cHMP\u306e\u8a2d\u7acb\u306f\uff0c\u8cc7\u91d1\u63f4\u52a9\u306e\u5927\u5e45\u306a\u5897\u52a0\u3068\u3068\u3082\u306b\uff0c\u7814\u7a76\u6210\u679c\u306e\u958b\u82b1\u3092\u4fc3\u3057\u307e\u3057\u305f[36]\u3002\u3053\u3053\u6570\u5e74\u3067\u751f\u307f\u51fa\u3055\u308c\u305f\u306e\u306f\uff0c\u81a8\u5927\u306a\u30c7\u30fc\u30bf\u304c\u751f\u6210\u3055\u308c\u305f\u305f\u3081\u306b\uff0c\u4e3b\u306b\u8a08\u7b97\u30fb\u7d71\u8a08\u7528\u306e\u7814\u7a76\u30c4\u30fc\u30eb\u3068\uff0c\u3044\u304f\u3064\u304b\u306e\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u95a2\u9023\u4f01\u696d\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u4f01\u696d\u306e\u591a\u304f\u306f\uff0c\u76ae\u819a\u306e\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3092\u56de\u5fa9\u3055\u305b\u308b\u5916\u7528\u5264\uff08AOBiome, [37]\uff09\u3084\u8178\u5185\u7d30\u83cc\u3092\u5229\u7528\u3057\u305f\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\uff08Blue Turtle Bio, [38]\uff09\u306a\u3069\uff0c\u30d2\u30c8\u306e\u75be\u60a3\u6cbb\u7642\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u305f\u304c\uff0c\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u6280\u8853\u3092\u4ed6\u306e\u65b9\u6cd5\u3067\u5229\u7528\u3059\u308b\u4f01\u696d\u3082\u3042\u3063\u305f\u3002 <strong>\u30a2\u30b9\u30c6\u30eb\u30fb\u30d0\u30a4\u30aa<\/strong> \u306f\uff0c\u6db2\u4f53\u5ec3\u68c4\u7269\u306e\u6392\u51fa\u91cf\u3092\u76e3\u8996\u3057\uff0c\u81ea\u7136\u306e\u6c34\u57df\u306e\u6c5a\u67d3\u3092\u9632\u6b62\u3059\u308b\u3053\u3068\u3067\u9867\u5ba2\u3092\u652f\u63f4\u3059\u308b\u305f\u3081\u306b\uff0cEnvironmental Genomics\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u958b\u767a\u3057\u307e\u3057\u305f[39]\uff0e\u3053\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\uff0c\u4e3b\u8981\u306a\u5fae\u751f\u7269\u306b\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u3067\u5ec3\u68c4\u7269\u30b5\u30f3\u30d7\u30eb\u3092\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3057\uff0c\u6f5c\u5728\u7684\u306a\u904b\u7528\u4e0a\u306e\u554f\u984c\uff08\u30a2\u30f3\u30e2\u30cb\u30a2\u9664\u53bb\u306e\u4e0d\u8db3\u306a\u3069\uff09\u3092\u901a\u77e5\u3057\uff0c\u6392\u6c34\u51e6\u7406\u3092\u6307\u793a\u3059\u308b\u3082\u306e\u3067\u3042\u308b[39]\uff0e\u30b5\u30cb\u30fc\u30d9\u30fc\u30eb\u3092\u62e0\u70b9\u3068\u3059\u308b <strong>\u30d5\u30ed\u30fc\u30e9\u30b0\u30e9\u30d5<\/strong> \u3082\u5ec3\u68c4\u7269\u3092\u8abf\u67fb\u3057\u3066\u3044\u308b\u304c\uff0c\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u5206\u6790\u3092\u5bb6\u5ead\u306b\u76f4\u63a5\u6301\u3061\u8fbc\u3082\u3046\u3068\u3057\u3066\u3044\u308b[40]\uff0e\u5f7c\u3089\u306e\u643a\u5e2f\u578b\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u6a5f\u5668\u306f\uff0c\u4fbf\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3092\u5206\u6790\u3059\u308b\u3053\u3068\u3067\uff0c\u6162\u6027\u75be\u60a3\u306e\u30bb\u30eb\u30d5\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3084\u30b3\u30f3\u30d1\u30cb\u30aa\u30f3\u30a2\u30cb\u30de\u30eb\u306e\u5065\u5eb7\u72b6\u614b\u306e\u8ffd\u8de1\u306b\u95a2\u5fc3\u306e\u3042\u308b\u9867\u5ba2\u5411\u3051\u306b\u8a2d\u8a08\u3055\u308c\u3066\u3044\u308b[40]\uff0e\u81ea\u5b85\u3067\u81ea\u5206\u306e\u30a6\u30f3\u30c1\u3092\u5206\u6790\u3057\u305f\u3044\u3068\u601d\u3046\u4eba\u304c\u3069\u308c\u3060\u3051\u3044\u308b\u304b\u306f\u4e0d\u660e\u3060\u304c\uff0c\u30d5\u30ed\u30fc\u30e9\u30b0\u30e9\u30d5\u306f\uff0c\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u5206\u6790\u306b\u643a\u5e2f\u6027\uff0c\u8cbb\u7528\u5bfe\u52b9\u679c\uff0c\u30a2\u30af\u30bb\u30b9\u6027\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u308b\uff0e\u533b\u7642\u3084\u7814\u7a76\u306e\u73fe\u5834\u3067\u306f\uff0c\u3053\u306e\u30c7\u30d0\u30a4\u30b9\u304c\u5fc5\u8981\u3068\u3055\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\uff0e<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"8_DNA_Hard_Drives\"><\/span><strong>8. DNA Hard Drives<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u79c1\u305f\u3061\u306f\u3001\u78c1\u6c17\u30c9\u30e9\u30e0\u3084\u30d5\u30ed\u30c3\u30d4\u30fc\u30c7\u30a3\u30b9\u30af\u306e\u3088\u3046\u306a\u96fb\u5b50\u30c7\u30fc\u30bf\u30b9\u30c8\u30ec\u30fc\u30b8\u30b7\u30b9\u30c6\u30e0\u306e\u521d\u671f\u306e\u6642\u4ee3\u304b\u3089\u3001\u9577\u3044\u9053\u306e\u308a\u3092\u6b69\u3093\u3067\u304d\u307e\u3057\u305f\u3002\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u30c7\u30fc\u30bf\u30b9\u30c8\u30ec\u30fc\u30b8\u306e\u5bb9\u91cf\u306f\u3001\u6570\u5341\u30ad\u30ed\u30d0\u30a4\u30c8\uff08\u78c1\u6c17\u30c9\u30e9\u30e0\uff09\u304b\u3089\u30da\u30bf\u30d0\u30a4\u30c8\u7d1a\uff08\u30af\u30e9\u30a6\u30c9\u30b5\u30fc\u30d0\u30fc\uff09\u307e\u3067\u3001\u6841\u9055\u3044\u306b\u5927\u304d\u304f\u306a\u308a\u307e\u3057\u305f [41]\u3002\u3053\u306e\u81a8\u5927\u306a\u30b9\u30c8\u30ec\u30fc\u30b8\u30b9\u30da\u30fc\u30b9\u306b\u306f\u3001\u30af\u30e9\u30a6\u30c9\u3092\u652f\u3048\u308b\u30b5\u30fc\u30d0\u30fc\u30d5\u30a1\u30fc\u30e0\u3092\u53ce\u5bb9\u3059\u308b\u305f\u3081\u306e\u81a8\u5927\u306a\u7269\u7406\u7684\u30b9\u30da\u30fc\u30b9\u3082\u5fc5\u8981\u3068\u306a\u308b\u3002\u79d1\u5b66\u8005\u304cDNA\u5206\u5b50\u3092\u30c7\u30fc\u30bf\u30b9\u30c8\u30ec\u30fc\u30b8\u306b\u5229\u7528\u3059\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u691c\u8a0e\u3057\u305f\u306e\u306f1988\u5e74\u306e\u3053\u3068\u3067\u300135\u30d3\u30c3\u30c8\u306e1\u30680\u30675\u00d77\u306e\u6b63\u65b9\u5f62\u306e\u753b\u50cf\u3092\u30b3\u30fc\u30c9\u5316\u3057\u3066 <\/span><i><span style=\"font-weight: 400;\">\u5927\u8178\u83cc<\/span><\/i><span style=\"font-weight: 400;\"> \u30b2\u30ce\u30e0 [42, 43]\u3002\u305d\u308c\u4ee5\u6765\uff0c\u3055\u307e\u3056\u307e\u306a\u6a5f\u95a2\u3084\u4f01\u696d\u304cDNA\u30d9\u30fc\u30b9\u306e\u30c7\u30fc\u30bf\u30b9\u30c8\u30ec\u30fc\u30b8\u30b7\u30b9\u30c6\u30e0\u306e\u958b\u767a\u306b\u529b\u3092\u6ce8\u3044\u3067\u3044\u308b\u3002\u30b5\u30fc\u30d0\u30fc\u30d5\u30a1\u30fc\u30e0\u3092\u7dad\u6301\u3059\u308b\u5834\u5408\u306b\u6bd4\u3079\u3066\uff0c\u30b3\u30b9\u30c8\uff0c\u30a8\u30cd\u30eb\u30ae\u30fc\u4f7f\u7528\u91cf\uff0c\u30b9\u30da\u30fc\u30b9\u304c\u5927\u5e45\u306b\u524a\u6e1b\u3067\u304d\u308b\u304b\u3089\u3067\u3042\u308b[42]\u3002\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u4e16\u754c\u4e2d\u306e\u3059\u3079\u3066\u306e\u30c7\u30fc\u30bf\u3092\u4fdd\u5b58\u3059\u308b\u3068\u3001\u308f\u305a\u304b1kg\u306eDNA\u306b\u5727\u7e2e\u3055\u308c\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b[42]\u3002\u3067\u306f\u3001\u3069\u3046\u3084\u3063\u3066\u5199\u771f\u3084\u97f3\u697d\u3092DNA\u306b\u300c\u30a2\u30c3\u30d7\u30ed\u30fc\u30c9\u300d\u3059\u308b\u306e\u3060\u308d\u3046\u304b\u3002\u306e\u79d1\u5b66\u8005\u306f <strong>\u30ef\u30b7\u30f3\u30c8\u30f3\u5927\u5b66\u3001\u30de\u30a4\u30af\u30ed\u30bd\u30d5\u30c8<\/strong> \u306f\u3001\u81ea\u52d5\u5316\u3055\u308c\u305fDNA\u4fdd\u5b58\u30b7\u30b9\u30c6\u30e0\u306e\u6982\u5ff5\u5b9f\u8a3c\u7814\u7a76\u3067\u3053\u306e\u554f\u984c\u306b\u53d6\u308a\u7d44\u3082\u3046\u3068\u3057\u305f[44]\u3002\u5f7c\u3089\u306e\u88c5\u7f6e\u306f\u30015\u30d0\u30a4\u30c8\u306e\u300cHello\u300d\u3092DNA\u914d\u5217\u306b\u30a8\u30f3\u30b3\u30fc\u30c9\u3057\u3001\u305d\u306eDNA\u3092\u5408\u6210\u3001\u4fdd\u5b58\u3001\u914d\u5217\u3057\u3001\u300cHello\u300d\u3092\u53d6\u308a\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f[44]\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f21\u6642\u9593\u3092\u8981\u3057\u30011\u679a\u306e\u5199\u771f\u3092\u4fdd\u5b58\u3059\u308b\u306b\u306f\u4eca\u65e5\u3067\u306f\u5b9f\u7528\u7684\u3067\u306f\u306a\u3044\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u3088\u3046\u306a\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u308b\u30b9\u30d4\u30fc\u30c9\u3092\u8003\u3048\u308b\u3068\u3001\u3054\u304f\u8fd1\u3044\u5c06\u6765\u306b\u5229\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3082\u4e0d\u601d\u8b70\u3067\u306f\u306a\u3044\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"9_DNA_Origami\"><\/span><strong>9. DNA Origami<\/strong><span style=\"font-weight: 400;\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">DNA\u3068RNA\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u5869\u57fa\u5bfe\u306f\u3001\u300c\u81ea\u5df1\u7d44\u7e54\u5316\u300d\u80fd\u529b\u3092\u6301\u3064\u9b45\u529b\u7684\u306a\u751f\u4f53\u5206\u5b50\u6750\u6599\u3067\u3042\u308b\u3002\u3053\u306e\u3053\u3068\u306f\uff0c2000\u5e74\u4ee3\u534a\u3070\u306b\u3055\u307e\u3056\u307e\u306a\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u3063\u3066\u5b9f\u8a3c\u3055\u308c\u3066\u304a\u308a[45-47]\uff0c\u305d\u306e\u4e2d\u306b\u306f\uff0cDNA\u30922\u6b21\u5143\u306e\u6b63\u65b9\u5f62\uff0c\u4e09\u89d2\u5f62\uff0c\u5e78\u305b\u306a\u9854\u306a\u3069\u306e\u5f62\u306b\u7d44\u307f\u7acb\u3066\u308b\u65b9\u6cd5\u3092\u767a\u8868\u3057\u305fPaul Rothemund\u3082\u542b\u307e\u308c\u308b[48]\uff0e2017\u5e74\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u5ba4\u304c\u6700\u5927\u306eDNA\u30ca\u30ce\u69cb\u9020\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002\u5927\u304d\u306a\u30ca\u30ce\u30ed\u30c3\u30c9\u3001\u30ec\u30f3\u30ac\u3001\u30bf\u30a4\u30eb\u304c\u96c6\u307e\u3063\u3066\u3001\u6570\u767e\u30ca\u30ce\u30e1\u30fc\u30c8\u30eb\u304b\u30891\u30df\u30af\u30ed\u30f3\u4ee5\u4e0a\u306e\u7bc4\u56f2\u306e\u9577\u3055\u3092\u6301\u3064\u5de8\u5927\u306a\u69cb\u9020\u4f53\u3092\u5f62\u6210\u3057\u305f[49-51]\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u3067\u306f\uff0cDNA\u30ca\u30ce\u69cb\u9020\u306e\u9bae\u660e\u306a3\u6b21\u5143\u753b\u50cf\u304c\u793a\u3055\u308c\u3066\u304a\u308a\uff0c\u6838\u9178\u304c\u533b\u7642\uff0c\u30a8\u30ec\u30af\u30c8\u30ed\u30cb\u30af\u30b9\uff0c\u30d0\u30a4\u30aa\u30de\u30c6\u30ea\u30a2\u30eb\u3078\u306e\u5fdc\u7528\u3092\u8996\u91ce\u306b\u5165\u308c\u305f\u4efb\u610f\u306e\u6570\u306e\u69cb\u9020\u306b\u7d44\u307f\u7acb\u3066\u308b\u3088\u3046\u8a2d\u8a08\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u73fe\u5728\u3001DNA\u6298\u308a\u7d19\u306f\u30c9\u30e9\u30c3\u30b0\u30fb\u30c7\u30ea\u30d0\u30ea\u30fc\u30fb\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u306b\u958b\u767a\u3055\u308c\u3066\u3044\u308b(<strong>\u30b8\u30a7\u30cb\u30b9\u30d5\u30a3\u30a2<\/strong>)\u3001\u8a3a\u65ad\u7528\u30ca\u30ce\u30ed\u30dc\u30c3\u30c8(<strong>\u30ca\u30f3\u30d0\u30ea\u30f3\u30b0<\/strong>)\u3001\u4ee3\u8b1d\u7269\u751f\u6210\u306a\u3069\u306e\u7528\u9014\u306e\u305f\u3081\u306e\u9175\u7d20\u5185\u8535\u30ca\u30ce\u30d5\u30a1\u30d6\u30ea\u30c3\u30af\u30b9(<strong>FabricNano<\/strong>) [52]. Nanovery\u2019s nanorobots are designed using <a href=\"https:\/\/www.kolabtree.com\/blog\/ja\/ensuring-reproducibility-in-ai-driven-research-how-freelance-experts-can-help-in-biotech-and-healthcare\/\">\u4eba\u5de5\u77e5\u80fd<\/a> to detect circulating tumor DNA (ctDNA) [53]. Their diagnostic nanorobot is intended to replace current liquid biopsy tests for ctDNA, which require extensive time and cost. The nanorobot is inserted into a blood sample and if cancerous DNA is detected, lights up within 1-2 hours. As mutations continue to accumulate in cancerous DNA, Nanovery intends to continuously evolve their nanorobots to detect these new mutations [53].<\/span><\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\"><a href=\"https:\/\/twitter.com\/hashtag\/DNA?src=hash&amp;ref_src=twsrc%5Etfw\">#DNA<\/a> \u6298\u308a\u7d19\u3067\u4f5c\u308b\u4e16\u754c\u6700\u5c0f\u306e\u30e2\u30ca\u30ea\u30b6 <a href=\"https:\/\/t.co\/v06eXUt0rU\">https:\/\/t.co\/v06eXUt0rU<\/a> <a href=\"https:\/\/t.co\/oAR1naVEvW\">pic.twitter.com\/oAR1naVEvW<\/a><\/p>\n<p>- \u907a\u4f1d\u5b50\u5de5\u5b66\u30fb\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u30cb\u30e5\u30fc\u30b9(@GENbio) <a href=\"https:\/\/twitter.com\/GENbio\/status\/939871107263483905?ref_src=twsrc%5Etfw\">2017\u5e7412\u670810\u65e5<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"10_Artificial_Intelligence_in_Medicine\"><\/span><strong>10. Artificial Intelligence in Medicine<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u4eba\u5de5\u77e5\u80fd\u3084\u6a5f\u68b0\u5b66\u7fd2\u306f\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3068\u306f\u307f\u306a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u533b\u7642\u5206\u91ce\u3067\u306e\u5f71\u97ff\u3092\u8003\u3048\u308b\u3068\u8a00\u53ca\u3059\u308b\u306b\u5024\u3057\u307e\u3059\u30022010\u5e74\uff08596\u8ad6\u6587\uff09\u304b\u30892019\u5e74\uff0812422\u8ad6\u6587\uff09\u307e\u3067\u3001\u95a2\u9023\u3059\u308b\u51fa\u7248\u7269\u304c20\u500d\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3082\u308f\u304b\u308b\u3088\u3046\u306b\u3001AI\u3092\u7528\u3044\u305f\u533b\u7642\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u306b\u5bfe\u3059\u308b\u7814\u7a76\u306e\u95a2\u5fc3\u306f\u3001\u904e\u53bb10\u5e74\u9593\u3067\u5927\u304d\u304f\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059[54]\u3002\u30b0\u30ed\u30fc\u30cb\u30f3\u30b2\u30f3\u5927\u5b66\u3068Medical Futurist Institute\u304c\u5b9f\u65bd\u3057\u305f\u8abf\u67fb\u306b\u3088\u308b\u3068\u3001\u672c\u7a3f\u57f7\u7b46\u6642\u70b9\u3067\u3001\u533b\u7642\u7528\u9014\u306eAI\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3068\u3057\u3066\u5e02\u5834\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u306f70\u3092\u5c11\u3057\u8d85\u3048\u3066\u3044\u308b[54, 55]\u3002\u3053\u308c\u3089\u306e\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u591a\u304f\u306f\u3001\u75c5\u6c17\u306e\u5206\u6790\u3001\u8a3a\u65ad\u3001\u8a55\u4fa1\u306e\u305f\u3081\u306b\u753b\u50cf\u30d9\u30fc\u30b9\u306e\u6a5f\u68b0\u5b66\u7fd2\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002<strong> Qlarity Imaging\u793e\u306eQuantX<\/strong> \u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306f\uff0c\u653e\u5c04\u7dda\u79d1\u533b\u304c\u4e73\u623fMRI\u753b\u50cf\u4e0a\u306e\u7570\u5e38\u306a\u30b9\u30dd\u30c3\u30c8\u3092\u3088\u308a\u8fc5\u901f\u304b\u3064\u6b63\u78ba\u306b\u8b58\u5225\u3059\u308b\u305f\u3081\u306e\u652f\u63f4\u30c4\u30fc\u30eb\u3067\u3042\u308b[56]\u3002\u307e\u305f\uff0c\u653e\u5c04\u7dda\u79d1\u533b\u304cMRI\u753b\u50cf\u5185\u306e\u60aa\u6027\u75c5\u5909\u3092\u6b63\u3057\u304f\u8b58\u5225\u3059\u308b\u80fd\u529b\u3092\u8a55\u4fa1\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3067\u306f\uff0cQuantX\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4f7f\u7528\u3057\u305f\u5834\u5408\u306b\u653e\u5c04\u7dda\u79d1\u533b\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u5411\u4e0a\u3057\u305f[57]\uff0e\u7279\u306b\u3001\u5b8c\u5168\u306b\u81ea\u5f8b\u3057\u305f\u533b\u7642\u7528\u30ed\u30dc\u30c3\u30c8\u306e\u958b\u767a\u306b\u5bfe\u3059\u308b\u7814\u7a76\u306e\u95a2\u5fc3\u304c\u9ad8\u307e\u3063\u3066\u304a\u308a\u3001\u73fe\u5728\u306f\u975e\u5e38\u306b\u7279\u6b8a\u306a\u30bf\u30b9\u30af\u3092\u3053\u306a\u3059\u3088\u3046\u306b\u8a13\u7df4\u3055\u308c\u3066\u3044\u308b\u3002\u304c\u958b\u767a\u3057\u305fIDx-DR\u88c5\u7f6e\u306f <strong>\u30c7\u30b8\u30bf\u30eb\u8a3a\u65ad<\/strong>\u306f\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5931\u660e\u306e\u539f\u56e0\u3067\u3042\u308b\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u3092\u8a3a\u65ad\u3059\u308b\u305f\u3081\u306b\uff0c\u7db2\u819c\u753b\u50cf\u3092\u64ae\u5f71\u3057\u307e\u3059[58]\uff0e\u64ae\u5f71\u3055\u308c\u305f\u753b\u50cf\u306f\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6c88\u7740\u3084\u6ef2\u51fa\u6db2\u306a\u3069\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u691c\u51fa\u3059\u308b\u3088\u3046\u306b\u8a13\u7df4\u3055\u308c\u305fAI\u30de\u30b7\u30f3\u306b\u3088\u3063\u3066\u89e3\u6790\u3055\u308c\uff0c30\u79d2\u4ee5\u5185\u306b\u8a3a\u65ad\u30ec\u30dd\u30fc\u30c8\u304c\u51fa\u529b\u3055\u308c\u308b\uff0e\u307e\u305f\u3001\u73fe\u5728\u3001\u5b8c\u5168\u81ea\u5f8b\u578b\u306e\u624b\u8853\u30ed\u30dc\u30c3\u30c8\u3001\u5728\u5b85\u533b\u7642\u30a2\u30b7\u30b9\u30bf\u30f3\u30c8\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u652f\u63f4\u30ed\u30dc\u30c3\u30c8\u306a\u3069\u306e\u958b\u767a\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002<\/span><\/p>\n<p><strong>\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/strong><\/p>\n<ol>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30df\u30c3\u30b7\u30e7\u30f3\u30fb\u30d0\u30a4\u30aa<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/missionbio.com\/products\/platform\/\"> <span style=\"font-weight: 400;\">https:\/\/missionbio.com\/products\/platform\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Mocciaro, A., et al, <\/span><i><span style=\"font-weight: 400;\">\u30ca\u30ce\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u4e0a\u3067\u7de8\u96c6\u3055\u308c\u305f\u30af\u30ed\u30fc\u30f3\u3092\u9078\u629e\u3059\u308b\u305f\u3081\u306e\u5149\u6d3b\u6027\u5316\u7d30\u80de\u8b58\u5225\u30fb\u9078\u5225\uff08LACIS\uff09\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Commun Biol, 2018.1: p. 41.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">\u30b7\u30a7\u30a4\u30d5\u30a1\u30fc\u3001E\uff0e <\/span><i><span style=\"font-weight: 400;\">\u30a2\u30eb\u30c7\u30d6\u30ed\u30f3\u793e\u304cBerkeley Lights\u793e\u306eBeacon\u00ae\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u63a1\u7528 - Aldevron News<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Berkeley Lights - The Lightning\u2122 \u5149\u6d41\u4f53\u30b7\u30b9\u30c6\u30e0<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.berkeleylights.com\/systems\/lightning\/\"> <span style=\"font-weight: 400;\">https:\/\/www.berkeleylights.com\/systems\/lightning\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Mehrotra, P., <\/span><i><span style=\"font-weight: 400;\">\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u3068\u305d\u306e\u5fdc\u7528 - A review.<\/span><\/i><span style=\"font-weight: 400;\"> J Oral Biol Craniofac Res, 2016.6(2): p. 153-9.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">McConnell, E.M., J. Nguyen, and Y. Li, <\/span><i><span style=\"font-weight: 400;\">\u74b0\u5883\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u305f\u3081\u306e\u30a2\u30d7\u30bf\u30de\u30fc\u30d9\u30fc\u30b9\u306e\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Front Chem, 2020.8: p. 434.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Aptamer Sciences - AptoDetect\u2122-Lung<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"http:\/\/aptsci.com\/en\/diagnosis\/aptodetect-lung\/\"> <span style=\"font-weight: 400;\">http:\/\/aptsci.com\/en\/diagnosis\/aptodetect-lung\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Aptamer Sciences - \u88fd\u54c1\u7d39\u4ecb<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"http:\/\/aptodetect-lung.com\/en\/aptodetect-lung\/\"> <span style=\"font-weight: 400;\">http:\/\/aptodetect-lung.com\/en\/aptodetect-lung\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Lee, S.Y.\u3067\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">\u79fb\u690d\u53ef\u80fd\u306a\u85ac\u3092\u4f5c\u308b\u7d30\u80de<\/span><\/i><span style=\"font-weight: 400;\">\u3067\u3042\u308b\u3002 <\/span><i><span style=\"font-weight: 400;\">\u30b5\u30a4\u30a8\u30f3\u30c6\u30a3\u30d5\u30a3\u30c3\u30af\u30fb\u30a2\u30e1\u30ea\u30ab\u30f3<\/span><\/i><span style=\"font-weight: 400;\">. 2018.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Katsarou, A., et al, <\/span><i><span style=\"font-weight: 400;\">1\u578b\u7cd6\u5c3f\u75c5\u3067\u3059\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Nat Rev Dis Primers, 2017.3: p. 17016.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Seraxis Technologies - \u7d30\u80de\u7f6e\u63db\u3078\u306e\u9769\u65b0\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.seraxis.com\/seraxis-technology\/\"> <span style=\"font-weight: 400;\">https:\/\/www.seraxis.com\/seraxis-technology\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30ea\u30d3\u30f3\u30b0\u30bb\u30eb\u30c6\u30af\u30ce\u30ed\u30b8\u30fc - NTCell<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/lctglobal.com\/research\/ntcell#click-here\"> <span style=\"font-weight: 400;\">https:\/\/lctglobal.com\/research\/ntcell#click-here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Li, R.A., et al, <\/span><i><span style=\"font-weight: 400;\">\u30d2\u30c8\u591a\u80fd\u6027\u5e79\u7d30\u80de\u304b\u3089\u96fb\u6c17\u6a5f\u68b0\u7684\u306b\u6a5f\u80fd\u3059\u308b\u30df\u30cb\u30c1\u30e5\u30a2\u5fc3\u5ba4\u3092\u30d0\u30a4\u30aa\u30a8\u30f3\u30b8\u30cb\u30a2\u30ea\u30f3\u30b0\u3059\u308b\u3002<\/span><\/i><span style=\"font-weight: 400;\"> \u30d0\u30a4\u30aa\u30de\u30c6\u30ea\u30a2\u30eb, 2018.163: p. 116-127.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">NovoHeart<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"http:\/\/www.novoheart.com\/hk\/product5\"> <span style=\"font-weight: 400;\">http:\/\/www.novoheart.com\/hk\/product5<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u8840\u5c0f\u677f\u30d0\u30a4\u30aa\u30b8\u30a7\u30cd\u30b7\u30b9\u793e\u304c\u533b\u7642\u6280\u8853\u30a8\u30f3\u30bf\u30fc\u30d7\u30e9\u30a4\u30ba\u30fb\u30b3\u30f3\u30bd\u30fc\u30b7\u30a2\u30e0\u304b\u3089$2.3\u767e\u4e07\u5186\u306e\u52a9\u6210\u3092\u53d7\u3051\u3001\u30c9\u30ca\u30fc\u975e\u4f9d\u5b58\u578b\u8840\u5c0f\u677f\u751f\u7523\u306e\u958b\u767a\u3092\u52a0\u901f\u5316<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u8840\u5c0f\u677f\u30d0\u30a4\u30aa\u30b8\u30a7\u30cb\u30c3\u30af<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.plateletbio.com\/product-development\"> <span style=\"font-weight: 400;\">https:\/\/www.plateletbio.com\/product-development<\/span><\/a><span style=\"font-weight: 400;\"> &lt;p class=&quot;MsoListParagraph&quot; style=&quot;margin-bottom:0cmAvailable from: text-indent:-18.0pt.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Datar, I.<\/span><\/i> <i><span style=\"font-weight: 400;\">\u30de\u30fc\u30af\u30fb\u30dd\u30b9\u30c8\u306e\u57f9\u990a\u725b\u8089<\/span><\/i><span style=\"font-weight: 400;\">.\u5165\u624b\u65b9\u6cd5\uff1anew-harvest.org\/mark_post_cultured_beef.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Fountain, H.., <\/span><i><span style=\"font-weight: 400;\">$325,000\u306e\u30d0\u30fc\u30ac\u30fc\u3092\u4f5c\u308b<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30b6\u30fb\u30c1\u30ad\u30f3<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Super Meat Press\u306e\u30d3\u30c7\u30aa<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/vimeo.com\/473309639\"> <span style=\"font-weight: 400;\">https:\/\/vimeo.com\/473309639<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Jinek, M., et al, <\/span><i><span style=\"font-weight: 400;\">\u9069\u5fdc\u6027\u7d30\u83cc\u514d\u75ab\u306b\u304a\u3051\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u53ef\u80fd\u306a\u30c7\u30e5\u30a2\u30ebRNA\u30ac\u30a4\u30c9DNA\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Science, 2012.337(6096): p. 816-21.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Cohen, J.., <\/span><i><span style=\"font-weight: 400;\">CRISPR\u3092\u3081\u3050\u308b\u6226\u7dda\u306f\u3069\u3046\u63cf\u304b\u308c\u305f\u304b<\/span><\/i><span style=\"font-weight: 400;\">\u3067\u3042\u308b\u3002 <\/span><i><span style=\"font-weight: 400;\">\u30b5\u30a4\u30a8\u30f3\u30b9\u30de\u30ac\u30b8\u30f3<\/span><\/i><span style=\"font-weight: 400;\">. 2017.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Barrangou, R., et al, <\/span><i><span style=\"font-weight: 400;\">CRISPR\u306f\u3001\u539f\u6838\u751f\u7269\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u5f8c\u5929\u7684\u306a\u8010\u6027\u3092\u3082\u305f\u3089\u3059\u3002<\/span><\/i><span style=\"font-weight: 400;\"> \u30b5\u30a4\u30a8\u30f3\u30b9, 2007.315(5819): p. 1709-12.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Verruto, J., et al, <\/span><i><span style=\"font-weight: 400;\">\u7121\u7bc0\u64cd\u306a\u30de\u30fc\u30ab\u30fc\u30ec\u30b9\u7279\u6027\u306e\u7a4d\u307f\u4e0a\u3052\u3067<\/span><\/i><span style=\"font-weight: 400;\"> Proc Natl Acad Sci U S A, 2018.115(30): p. E7015-E7022.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u5408\u6210\u30b2\u30ce\u30df\u30af\u30b9\u3002\u85fb\u985e\u306e\u7d30\u80de\u5de5\u5834<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/syntheticgenomics.com\/algal-cell-factories\/\"> <span style=\"font-weight: 400;\">https:\/\/syntheticgenomics.com\/algal-cell-factories\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">PLANTeDit - NON-TRANSGENIC HIGH OLEIC SOYA<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/plantedit.com\/index.php\/products\/\"> <span style=\"font-weight: 400;\">https:\/\/plantedit.com\/index.php\/products\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Saey, T.H.\u3067\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">CRISPR\u3001\u521d\u306e\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\u3078<\/span><\/i><span style=\"font-weight: 400;\">. 2019.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">CRISPR\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u3068\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u793e\u3001CRISPR\/Cas9\u907a\u4f1d\u5b50\u7de8\u96c6\u6cbb\u7642\u85acCTX001\u306e\u81e8\u5e8a\u958b\u767a\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u9032\u6357\u3092\u767a\u8868 - \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 CRISPR\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e<\/span><\/i><span style=\"font-weight: 400;\">. 2019.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u81e8\u5e8a\u8a66\u9a13\u3002  NCT03655678<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03655678\"> <span style=\"font-weight: 400;\">https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03655678<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">CRISPR \u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9 - \u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u7570\u5e38\u75c7<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"http:\/\/www.crisprtx.com\/programs\/hemoglobinopathies\"> <span style=\"font-weight: 400;\">http:\/\/www.crisprtx.com\/programs\/hemoglobinopathies<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">CRISPR Therapeutics\u3068\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u793e\u3001\u7b2c25\u56de\u6b27\u5dde\u8840\u6db2\u5b66\u4f1a\uff08EHA\uff09\u5e74\u6b21\u7dcf\u4f1a\u3067\u91cd\u75c7\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u75c7\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u6cbb\u7642\u85acCTX001\u2122\u306e\u65b0\u3057\u3044\u81e8\u5e8a\u30c7\u30fc\u30bf\u3092\u767a\u8868 - \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 CRIPSR Therapeutics<\/span><\/i><span style=\"font-weight: 400;\">. 2020.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">2018\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde&lt;source data-srcset=&quot;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">\" media=\"(min-width: 220px)\" srcset=\"<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-mini-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">\" style=\"-webkit-font-smoothing: antialiased;\"&gt;&lt;source data-srcset=&quot;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">\" media=\"(min-width: 900px)\" srcset=\"<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-small-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">\" style=\"-webkit-font-smoothing: antialiased;\"&gt;&lt;source data-srcset=&quot;<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">\" media=\"(min-width: 1400px)\" srcset=\"<\/span><\/i><a href=\"https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg\"><i><span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/images\/arnold-57918-portrait-medium-2x.jpg<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">\" style=\"-webkit-font-smoothing: antialiased;\"&gt;\u3002<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.nobelprize.org\/prizes\/chemistry\/2018\/summary\/\"> <span style=\"font-weight: 400;\">https:\/\/www.nobelprize.org\/prizes\/chemistry\/2018\/summary\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Lu, R.M., et al, <\/span><i><span style=\"font-weight: 400;\">\u75c5\u6c17\u306e\u6cbb\u7642\u306e\u305f\u3081\u306e\u6297\u4f53\u306e\u958b\u767a\u3002<\/span><\/i><span style=\"font-weight: 400;\"> J Biomed Sci, 2020.27(1): p. 1.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Carmot Therapeutics - \u30c6\u30af\u30ce\u30ed\u30b8\u30fc<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/carmot-therapeutics.us\/science\/\"> <span style=\"font-weight: 400;\">https:\/\/carmot-therapeutics.us\/science\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30d7\u30ea\u30e2\u30fc\u30c7\u30a3\u30a2\u30eb\u30fb\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9 - \u30d5\u30a1\u30f3\u30af\u30b7\u30e7\u30f3\u30fb\u30b8\u30a7\u30cd\u30ec\u30fc\u30bf\u30fcTM<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.primordialgenetics.com\/our-platform\/\"> <span style=\"font-weight: 400;\">https:\/\/www.primordialgenetics.com\/our-platform\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">\u30c1\u30fc\u30e0\u3001N.H.M.P.A.\u3067\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">\u7c73\u56fd\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\u306b\u304a\u3051\u308b10\u5e74\u9593\u306e\u30d2\u30c8\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u7814\u7a76\u6d3b\u52d5\u306e\u30ec\u30d3\u30e5\u30fc\uff082007\uff5e2016\u5e74\u5ea6\uff09\u3002<\/span><\/i><span style=\"font-weight: 400;\"> \u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0, 2019.7(1): p. 31.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">AOBiome<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.aobiome.com\/\"> <span style=\"font-weight: 400;\">https:\/\/www.aobiome.com\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30d6\u30eb\u30fc\u30bf\u30fc\u30c8\u30eb\u30fb\u30d0\u30a4\u30aa<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/blueturtlebio.com\/\"> <span style=\"font-weight: 400;\">https:\/\/blueturtlebio.com\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30a2\u30b9\u30c6\u30eb\u30d0\u30a4\u30aa<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.asterbio.com\/\"> <span style=\"font-weight: 400;\">https:\/\/www.asterbio.com\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30d5\u30ed\u30fc\u30e9\u30b0\u30e9\u30d5<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"http:\/\/www.floragraph.me\/technology-overview.html\"> <span style=\"font-weight: 400;\">http:\/\/www.floragraph.me\/technology-overview.html<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u6b74\u53f2\u535a\u7269\u9928 - \u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u306e\u6b74\u53f2\u306e\u5e74\u8868<\/span><\/i><span style=\"font-weight: 400;\">.\u5229\u7528\u53ef\u80fd\u306a\u30b5\u30a4\u30c8\uff1acomputerhistory.org\/timeline\/memory-storage\/.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">\u30a2\u30f3\u30c7\u30a3\u3001E, <\/span><i><span style=\"font-weight: 400;\">\u5168\u4e16\u754c\u306e\u30c7\u30fc\u30bf\u3092\u4fdd\u5b58\u3059\u308bDNA\u306e\u4ed5\u7d44\u307f<\/span><\/i><span style=\"font-weight: 400;\">. 2016.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">\u30c7\u30a4\u30d3\u30b9\u3001J\uff0e <\/span><i><span style=\"font-weight: 400;\">\u30df\u30af\u30ed\u30f4\u30a7\u30cc\u30b9\u3002<\/span><\/i><span style=\"font-weight: 400;\"> \u30a2\u30fc\u30c8\u30b8\u30e3\u30fc\u30ca\u30eb\u30011996\u5e74\u300255(1): p. 70-74.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Takahashi, C.N., et al, <\/span><i><span style=\"font-weight: 400;\">DNA\u30c7\u30fc\u30bf\u4fdd\u5b58\u306e\u30a8\u30f3\u30c9\u30fb\u30c4\u30fc\u30fb\u30a8\u30f3\u30c9\u306e\u81ea\u52d5\u5316\u3092\u5b9f\u8a3c\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Sci Rep, 2019.9(1): p. 4998.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Chworos, A., et al, <\/span><i><span style=\"font-weight: 400;\">RNA\u3092\u4f7f\u3063\u3066\u30d7\u30ed\u30b0\u30e9\u30de\u30d6\u30eb\u306a\u30b8\u30b0\u30bd\u30fc\u30d1\u30ba\u30eb\u3092\u4f5c\u308b\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Science, 2004.306(5704): p. 2068-72.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Park, S.H., et al, <\/span><i><span style=\"font-weight: 400;\">\u968e\u5c64\u7684\u306a\u7d44\u307f\u7acb\u3066\u65b9\u6cd5\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u305f\u3001\u6709\u9650\u30b5\u30a4\u30ba\u3067\u5b8c\u5168\u306b\u30a2\u30c9\u30ec\u30b9\u53ef\u80fd\u306aDNA\u30bf\u30a4\u30eb\u30e9\u30c6\u30a3\u30b9\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Angew Chem Int Ed Engl, 2006.45(5): p. 735-9.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Rothemund, P.W., et al, <\/span><i><span style=\"font-weight: 400;\">\u30d7\u30ed\u30b0\u30e9\u30e0\u53ef\u80fd\u306aDNA\u30ca\u30ce\u30c1\u30e5\u30fc\u30d6\u306e\u8a2d\u8a08\u3068\u7279\u6027\u8a55\u4fa1\u3002<\/span><\/i><span style=\"font-weight: 400;\"> J Am Chem Soc, 2004.126(50): p. 16344-52.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">\u30ed\u30fc\u30c6\u30e0\u30f3\u30c9\u3001P.W.\u3002 <\/span><i><span style=\"font-weight: 400;\">DNA\u3092\u6298\u308a\u305f\u305f\u3093\u3067\u3001\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u306e\u5f62\u72b6\u3084\u30d1\u30bf\u30fc\u30f3\u3092\u4f5c\u308b\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Nature, 2006.440(7082): p. 297-302.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Wagenbauer, K.F., C.Sigl, and H.Dietz, <\/span><i><span style=\"font-weight: 400;\">\u30ae\u30ac\u30c0\u30eb\u30c8\u30f3\u898f\u6a21\u306e\u5f62\u72b6\u30d7\u30ed\u30b0\u30e9\u30e0\u53ef\u80fd\u306aDNA\u96c6\u5408\u4f53\u3002<\/span><\/i><span style=\"font-weight: 400;\"> \u30cd\u30a4\u30c1\u30e3\u30fc\u30012017\u5e74\u3002552(7683): p. 78-83.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Tikhomirov, G., P. Petersen, and L. Qian, <\/span><i><span style=\"font-weight: 400;\">\u4efb\u610f\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u6301\u3064\u30de\u30a4\u30af\u30ed\u30e1\u30fc\u30c8\u30eb\u30b9\u30b1\u30fc\u30eb\u306eDNA\u6298\u308a\u7d19\u30a2\u30ec\u30a4\u306e\u30d5\u30e9\u30af\u30bf\u30eb\u30a2\u30bb\u30f3\u30d6\u30ea\u3002<\/span><\/i><span style=\"font-weight: 400;\"> \u30cd\u30a4\u30c1\u30e3\u30fc\u30012017\u5e74\u3002552(7683): p. 67-71.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Praetorius, F., et al, <\/span><i><span style=\"font-weight: 400;\">DNA\u6298\u308a\u7d19\u306e\u30d0\u30a4\u30aa\u6280\u8853\u306b\u3088\u308b\u91cf\u7523\u5316\u3002<\/span><\/i><span style=\"font-weight: 400;\"> \u30cd\u30a4\u30c1\u30e3\u30fc\u30012017\u5e74\u3002552(7683): p. 84-87.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Dunn, K.E, <\/span><i><span style=\"font-weight: 400;\">DNA\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u30d3\u30b8\u30cd\u30b9\u3002\u6298\u308a\u7d19\u306a\u3069\u306e\u5546\u696d\u5316\u3002<\/span><\/i><span style=\"font-weight: 400;\"> Molecules, 2020.25(2).<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30ca\u30ce\u30ab\u30d0\u30ea\u30fc - \u30ca\u30ce\u30ed\u30dc\u30c3\u30c8<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.nanovery.co.uk\/science\"> <span style=\"font-weight: 400;\">https:\/\/www.nanovery.co.uk\/science<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Benjamens, S., P. Dhunnoo, and B. Mesk\u00f3, <\/span><i><span style=\"font-weight: 400;\">\u4eba\u5de5\u77e5\u80fd\u3092\u7528\u3044\u305fFDA\u627f\u8a8d\u306e\u533b\u7642\u6a5f\u5668\u3068\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306e\u72b6\u6cc1\uff1a\u30aa\u30f3\u30e9\u30a4\u30f3\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9<\/span><\/i><span style=\"font-weight: 400;\"> NPJ Digit Med, 2020.3: p. 118.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">The Medical Futurist - FDA\u627f\u8a8d\u306eA.I.\u30d9\u30fc\u30b9\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/medicalfuturist.com\/fda-approved-ai-based-algorithms\/\"> <span style=\"font-weight: 400;\">https:\/\/medicalfuturist.com\/fda-approved-ai-based-algorithms\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">Qlarity Imaging\u793e - \u6559\u80b2<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/www.qlarityimaging.com\/education\"> <span style=\"font-weight: 400;\">https:\/\/www.qlarityimaging.com\/education<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <span style=\"font-weight: 400;\">Jiang, Y., A.V. Edwards, and G.M. Newstead, <\/span><i><span style=\"font-weight: 400;\">\u4e73\u623fMRI\u306b\u4eba\u5de5\u77e5\u80fd\u3092\u9069\u7528\u3057\u3066\u8a3a\u65ad\u3092\u6539\u5584\u3059\u308b<\/span><\/i><span style=\"font-weight: 400;\"> Radiology, 2020: p.200292.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> \u00a0 \u00a0 <\/span> <i><span style=\"font-weight: 400;\">\u30c7\u30b8\u30bf\u30eb\u8a3a\u65ad - IDx-DR\u306e\u6982\u8981\u3002\u30b1\u30a2\u30ae\u30e3\u30c3\u30d7\u3092\u306a\u304f\u3057\u3001\u5931\u660e\u3092\u9632\u3050<\/span><\/i><span style=\"font-weight: 400;\">.\u304b\u3089\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/span><a href=\"https:\/\/dxs.ai\/products\/idx-dr\/idx-dr-overview-2\/\"> <span style=\"font-weight: 400;\">https:\/\/dxs.ai\/products\/idx-dr\/idx-dr-overview-2\/<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Jennifer Huen, freelance biochemist on Kolabtree, outlines the top 10 biotech innovations in the market today. Read about the top life science products &amp; services and the companies behind them.\u00a0\u00a0 Biotechnological innovations have grown steadily in the past 10 years, not only in the medical arenas but also in agriculture, environment, and energy sectors. Almost all of these biotech innovations involve genetic engineering, diagnostics, or assays, reflecting on the importance of synthetic biology on current biotechnological developments. Here are the top 10 biotech innovations that are transforming the industry.\u00a0 \u00a01. Single Cell Technologies Single cell technologies provide detailed views of cellular environments and are important tools used in drug discovery<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/\" title=\"\u7d9a\u304d\u3092\u8aad\u3080\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/div>","protected":false},"author":12,"featured_media":8692,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[442,516],"tags":[753],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Top 10 Biotech Innovations You Should Know About - The Kolabtree Blog<\/title>\n<meta name=\"description\" content=\"From DNA origami and biosensors, from CRISPR platforms to a &quot;heart-in-a-jar&quot;, a detailed look at the top 10 biotech innovations today.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Top 10 Biotech Innovations You Should Know About\" \/>\n<meta property=\"og:description\" content=\"From DNA origami and biosensors, from CRISPR platforms to a &quot;heart-in-a-jar&quot;, a detailed look at the top 10 biotech innovations today.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-09T09:06:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-18T11:08:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/12\/biotech-innovations.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"626\" \/>\n\t<meta property=\"og:image:height\" content=\"442\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ramya Sriram\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:site\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ramya Sriram\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"15\u5206\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Top 10 Biotech Innovations You Should Know About - The Kolabtree Blog","description":"From DNA origami and biosensors, from CRISPR platforms to a \"heart-in-a-jar\", a detailed look at the top 10 biotech innovations today.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/","og_locale":"ja_JP","og_type":"article","og_title":"Top 10 Biotech Innovations You Should Know About","og_description":"From DNA origami and biosensors, from CRISPR platforms to a \"heart-in-a-jar\", a detailed look at the top 10 biotech innovations today.","og_url":"https:\/\/www.kolabtree.com\/blog\/ja\/top-10-biotech-innovations-you-should-know-about\/","og_site_name":"The Kolabtree Blog","article_publisher":"https:\/\/www.facebook.com\/kolabtree","article_published_time":"2020-12-09T09:06:32+00:00","article_modified_time":"2023-04-18T11:08:15+00:00","og_image":[{"width":626,"height":442,"url":"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/12\/biotech-innovations.jpg","type":"image\/jpeg"}],"author":"Ramya Sriram","twitter_card":"summary_large_image","twitter_creator":"@kolabtree","twitter_site":"@kolabtree","twitter_misc":{"\u57f7\u7b46\u8005":"Ramya Sriram","\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"15\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#article","isPartOf":{"@id":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/"},"author":{"name":"Ramya Sriram","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/person\/81992f5863a1b06d132a47822e7b4400"},"headline":"Top 10 Biotech Innovations You Should Know About","datePublished":"2020-12-09T09:06:32+00:00","dateModified":"2023-04-18T11:08:15+00:00","mainEntityOfPage":{"@id":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/"},"wordCount":3435,"commentCount":0,"publisher":{"@id":"https:\/\/www.kolabtree.com\/blog\/#organization"},"keywords":["Biotech Innovations"],"articleSection":["Biotechnology","Science &amp; Tech"],"inLanguage":"ja","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/","url":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/","name":"Top 10 Biotech Innovations You Should Know About - The Kolabtree Blog","isPartOf":{"@id":"https:\/\/www.kolabtree.com\/blog\/#website"},"datePublished":"2020-12-09T09:06:32+00:00","dateModified":"2023-04-18T11:08:15+00:00","description":"From DNA origami and biosensors, from CRISPR platforms to a \"heart-in-a-jar\", a detailed look at the top 10 biotech innovations today.","breadcrumb":{"@id":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.kolabtree.com\/blog\/top-10-biotech-innovations-you-should-know-about\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.kolabtree.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Top 10 Biotech Innovations You Should Know About"}]},{"@type":"WebSite","@id":"https:\/\/www.kolabtree.com\/blog\/#website","url":"https:\/\/www.kolabtree.com\/blog\/","name":"The Kolabtree Blog","description":"Expert Views on Science, Innovation and Product Development","publisher":{"@id":"https:\/\/www.kolabtree.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.kolabtree.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ja"},{"@type":"Organization","@id":"https:\/\/www.kolabtree.com\/blog\/#organization","name":"Kolabtree","url":"https:\/\/www.kolabtree.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Kolabtree"},"image":{"@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/kolabtree","https:\/\/twitter.com\/kolabtree","https:\/\/instagram.com\/kolabtree","https:\/\/www.linkedin.com\/company\/kolabtree","https:\/\/en.m.wikipedia.org\/wiki\/Kolabtree"]},{"@type":"Person","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/person\/81992f5863a1b06d132a47822e7b4400","name":"Ramya Sriram","image":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/8100b45c960ebbbbe420e8b3f250515f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8100b45c960ebbbbe420e8b3f250515f?s=96&d=mm&r=g","caption":"Ramya Sriram"},"description":"Ramya Sriram manages digital content and communications at Kolabtree (kolabtree.com), the world's largest freelancing platform for scientists. She has over a decade of experience in publishing, advertising and digital content creation.","url":"https:\/\/www.kolabtree.com\/blog\/ja\/author\/ramyas\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/posts\/8630"}],"collection":[{"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/comments?post=8630"}],"version-history":[{"count":11,"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/posts\/8630\/revisions"}],"predecessor-version":[{"id":10582,"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/posts\/8630\/revisions\/10582"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/media\/8692"}],"wp:attachment":[{"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/media?parent=8630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/categories?post=8630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/ja\/wp-json\/wp\/v2\/tags?post=8630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}