{"id":7518,"date":"2020-05-13T14:27:52","date_gmt":"2020-05-13T14:27:52","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=7518"},"modified":"2021-08-19T17:33:44","modified_gmt":"2021-08-19T17:33:44","slug":"inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/","title":{"rendered":"\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u3067\u884c\u308f\u308c\u3066\u3044\u308bCOVID-19\u30ef\u30af\u30c1\u30f3\u306e\u8a66\u9a13\u306e\u69d8\u5b50"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_45_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">table of contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" area-label=\"ez-toc-toggle-icon-1\"><label for=\"item-69f45d7a8ed8b\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-69f45d7a8ed8b\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#What_is_the_basic_design_of_the_ChAdOx1_nCoV-19_candidate_vaccine_trial\" title=\"ChAdOx1 nCoV-19\u5019\u88dc\u30ef\u30af\u30c1\u30f3\u8a66\u9a13\u306e\u57fa\u672c\u8a2d\u8a08\u3092\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002\">ChAdOx1 nCoV-19\u5019\u88dc\u30ef\u30af\u30c1\u30f3\u8a66\u9a13\u306e\u57fa\u672c\u8a2d\u8a08\u3092\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#Why_is_the_MenACWY_vaccine_being_used_as_a_control\" title=\"\u306a\u305c\u3001MenACWY\u30ef\u30af\u30c1\u30f3\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u308b\u306e\u304b\uff1f\">\u306a\u305c\u3001MenACWY\u30ef\u30af\u30c1\u30f3\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u308b\u306e\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#What_are_the_primary_and_secondary_outcome_measures_of_the_trial\" title=\"\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u4f55\u3067\u3059\u304b\uff1f\">\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u4f55\u3067\u3059\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#What_ChAdOx_vaccines_have_been_used_in_clinical_trials_Where_do_they_stand\" title=\"\u3069\u306e\u3088\u3046\u306aChAdOx\u30ef\u30af\u30c1\u30f3\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304b\uff1f\u73fe\u5728\u306e\u72b6\u6cc1\u306f\uff1f\">\u3069\u306e\u3088\u3046\u306aChAdOx\u30ef\u30af\u30c1\u30f3\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304b\uff1f\u73fe\u5728\u306e\u72b6\u6cc1\u306f\uff1f<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#Any_other_examples_of_adenoviral_vector_vaccines\" title=\"\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30fb\u30d9\u30af\u30bf\u30fc\u30fb\u30ef\u30af\u30c1\u30f3\u306e\u4ed6\u306e\u4f8b\u306f\uff1f\">\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30fb\u30d9\u30af\u30bf\u30fc\u30fb\u30ef\u30af\u30c1\u30f3\u306e\u4ed6\u306e\u4f8b\u306f\uff1f<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#How_will_the_adverse_events_be_clinically_monitored\" title=\"\u6709\u5bb3\u4e8b\u8c61\u3092\u3069\u306e\u3088\u3046\u306b\u81e8\u5e8a\u7684\u306b\u30e2\u30cb\u30bf\u30fc\u3059\u308b\u306e\u304b\uff1f\">\u6709\u5bb3\u4e8b\u8c61\u3092\u3069\u306e\u3088\u3046\u306b\u81e8\u5e8a\u7684\u306b\u30e2\u30cb\u30bf\u30fc\u3059\u308b\u306e\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#Funding_received_from_for-profit_or_non-profit_organizations\" title=\"\u55b6\u5229\u56e3\u4f53\u307e\u305f\u306f\u975e\u55b6\u5229\u56e3\u4f53\u304b\u3089\u53d7\u3051\u305f\u8cc7\u91d1\">\u55b6\u5229\u56e3\u4f53\u307e\u305f\u306f\u975e\u55b6\u5229\u56e3\u4f53\u304b\u3089\u53d7\u3051\u305f\u8cc7\u91d1<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/#Possible_timeline_of_the_vaccines_availability\" title=\"\u30ef\u30af\u30c1\u30f3\u304c\u5165\u624b\u53ef\u80fd\u306b\u306a\u308b\u307e\u3067\u306e\u671f\u9593\">\u30ef\u30af\u30c1\u30f3\u304c\u5165\u624b\u53ef\u80fd\u306b\u306a\u308b\u307e\u3067\u306e\u671f\u9593<\/a><\/li><\/ul><\/nav><\/div>\n<p><span style=\"font-weight: 400;\"><em>Kolabtree\u793e\u306e\u30d5\u30ea\u30fc\u30e9\u30f3\u30b9\u30e1\u30c7\u30a3\u30ab\u30eb\u30e9\u30a4\u30bf\u30fc\u3067\u3042\u308bMahasweta Pal\u6c0f\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u6d1e\u5bdf\u3092\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002 <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/covid-19?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=ChAdOx1\">COVID-19 <\/a>\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u3067\u306e\u30ef\u30af\u30c1\u30f3\u8a66\u9a13\u00a0<\/em><\/span><\/p>\n<blockquote><p><strong>2020\u5e745\u670822\u65e5\u66f4\u65b0\u3002 <a href=\"http:\/\/www.ox.ac.uk\/news\/2020-05-22-oxford-covid-19-vaccine-begin-phase-iiiii-human-trials\">\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u306eCOVID-19\u30ef\u30af\u30c1\u30f3\u304c\u7b2cII\/III\u76f8\u306e\u30d2\u30c8\u8a66\u9a13\u3092\u958b\u59cb<\/a><br \/>\n2020\u5e7412\u670830\u65e5\u66f4\u65b0\u3002 <a href=\"https:\/\/www.gov.uk\/government\/news\/oxford-universityastrazeneca-covid-19-vaccine-approved\">\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\uff0f\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u793e COVID-19\u304c\u627f\u8a8d\u3055\u308c\u308b<\/a><br \/>\n2021\u5e7404\u670808\u65e5\u66f4\u65b0\u3002 <a href=\"https:\/\/www.bbc.co.uk\/news\/uk-58077396\">\u30d0\u30fc\u30d3\u30fc\u30fb\u30aa\u30d6\u30fb\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u30fb\u30b3\u30f4\u30a3\u30c3\u30c9\u306e\u30ef\u30af\u30c1\u30f3\u30c7\u30b6\u30a4\u30ca\u30fc\u3001\u30c7\u30a4\u30e0\u30fb\u30b5\u30e9\u30fb\u30ae\u30eb\u30d0\u30fc\u30c8\u304c\u5236\u4f5c\u3057\u305f<\/a><\/strong><\/p><\/blockquote>\n<p>2020\u5e74\u306b\u306f\u3001\u4e0d\u6c17\u5473\u306a\u307b\u3069\u306e\u4e16\u754c\u7684\u306a\u666f\u6c17\u5f8c\u9000\u3092\u8fce\u3048\u307e\u3057\u305f\u3002 <a href=\"https:\/\/www.kolabtree.com\/blog\/covid-19-coronavirus-research-and-vaccine-development\/\" target=\"_blank\" rel=\"noopener noreferrer\">COVID-19 \u30d1\u30f3\u30c7\u30df\u30c3\u30af<\/a>\u305d\u306e\u7d50\u679c\u3001\u4e16\u754c\u4e2d\u306e\u533b\u7642\u30b7\u30b9\u30c6\u30e0\u304c\u5927\u6df7\u4e71\u306b\u9665\u308a\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u30a2\u30e1\u30ea\u30ab\u3084\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u79d1\u5b66\u8005\u305f\u3061\u306f\u3001\u3053\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u3068\u767a\u58f2\u306e\u7af6\u4e89\u306b\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002 <a href=\"https:\/\/www.kolabtree.com\/blog\/covid-19-small-does-it\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u30d1\u30f3\u30c7\u30df\u30c3\u30af<\/a> SARS-CoV-2\u611f\u67d3\u75c7\u3092\u6700\u77ed\u6642\u9593\u3067\u89e3\u6c7a\u3059\u308b\u3002\u514d\u75ab\u5b66\u3001\u30a6\u30a4\u30eb\u30b9\u5b66\u3001\u30ef\u30af\u30c1\u30f3\u5b66\u3001\u75ab\u5b66\u3001\u516c\u8846\u885b\u751f\u5b66\u306e\u5c02\u9580\u5bb6\u305f\u3061\u306f\u3001\u73fe\u5728\u306e\u7dca\u6025\u306e\u5fc5\u8981\u6027\u306b\u5fdc\u3058\u3066\u3001\u30ef\u30af\u30c1\u30f3\u306e\u751f\u7523\u3068\u958b\u767a\u6226\u7565\u306b\u5fc5\u8981\u306a\u5927\u898f\u6a21\u306a\u5909\u66f4\u3092\u691c\u8a0e\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u3067\u306f\u30012020\u5e744\u670821\u65e5\u306bChAdOx1 nCoV19\u30ef\u30af\u30c1\u30f3\u306e\u7b2c1\u76f8\u8a66\u9a13\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u8ab2\u984c\u306b\u7acb\u3061\u5411\u304b\u3046\u305f\u3081\u306b\u671f\u5f85\u3092\u5bc4\u305b\u3066\u3044\u307e\u3059\u3002<\/p>\n<blockquote><p><span style=\"font-weight: 400;\">ChAdOx1 nCoV19\u30ef\u30af\u30c1\u30f3\u306f\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u304b\u3089\u5206\u96e2\u3055\u308c\u305f\u98a8\u90aa\u306e\u539f\u56e0\u30a6\u30a4\u30eb\u30b9\u3092\u5f31\u6bd2\u5316\u3057\u305fChAdOx1\u30b3\u30f3\u30b9\u30c8\u30e9\u30af\u30c8\u306b\u3001SARS-CoV-2\u306e\u30b9\u30d1\u30a4\u30af\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08S\uff09\u3092\u52a0\u3048\u3066\u958b\u767a\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u306e\u8a66\u9a13\u304c\u6709\u671b\u3067\u3042\u308b\u7406\u7531\u306f\u3001\u307e\u305a\u3001\uff08SARS-CoV-2\u611f\u67d3\u306e\u967d\u6027\u53cd\u5fdc\u304c\u51fa\u3066\u3044\u306a\u3044\uff09\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u304c\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002\u30b8\u30a7\u30ca\u30fc\u7814\u7a76\u6240\u306e\u30b5\u30e9\u30fb\u30ae\u30eb\u30d0\u30fc\u30c8\u6559\u6388\u3068\u305d\u306e\u30c1\u30fc\u30e0\u306f\u3001MERS-CoV\u3084\u30a8\u30dc\u30e9\u51fa\u8840\u71b1\u306a\u3069\u306e\u904e\u53bb\u306e\u30a6\u30a4\u30eb\u30b9\u75be\u60a3\u306b\u53d6\u308a\u7d44\u307f\u3001\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30fb\u30d9\u30af\u30bf\u30fc\u30fb\u30c7\u30ea\u30d0\u30ea\u30fc\u6280\u8853\u3092\u5c0e\u5165\u3057\u3066\u3044\u307e\u3059\u3002\u3078\u306e\u58f0\u660e\u306e\u4e2d\u3067\u3001\u6b21\u306e\u3088\u3046\u306b\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<em> The Times<\/em>\u3068\u300180%\u306e\u30ef\u30af\u30c1\u30f3\u306e\u52b9\u679c\u3092\u78ba\u4fe1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8a9e\u3063\u305f\u3002<\/span><\/p><\/blockquote>\n<p><span style=\"font-weight: 400;\">\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u30b8\u30a7\u30f3\u30ca\u30fc\u7814\u7a76\u6240\u306e\u30b5\u30e9\u30fb\u30ae\u30eb\u30d0\u30fc\u30c8\u6559\u6388\u3089\u306e\u30c1\u30fc\u30e0\u306f\u3001\u6297SARS-CoV-2\u5019\u88dc\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u306b\u7740\u624b\u3057\u3066\u3044\u307e\u3057\u305f\u3002 <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)30796-0\/fulltext\">2020\u5e74\u306e\u65e9\u3044\u6642\u671f\u306b<\/a> \u6b66\u6f22\u3067\u6570\u540d\u306e\u60a3\u8005\u304c\u5831\u544a\u3055\u308c\u305f\u3070\u304b\u308a\u306e\u9803\u3067\u3059\u3002\u3053\u306e\u30c1\u30fc\u30e0\u306f\u3001\u904e\u53bb\u306bMERS\u3084\u30a8\u30dc\u30e9\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u30ef\u30af\u30c1\u30f3\u3092\u958b\u767a\u3057\u3066\u304a\u308a\u3001\u4eca\u56de\u306e\u5371\u6a5f\u306b\u5bfe\u5fdc\u3059\u308b\u305f\u3081\u306b\u6e96\u5099\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\u3002 <a href=\"https:\/\/www.reuters.com\/article\/us-health-coronavirus-who\/world-leaders-due-to-launch-covid-19-drugs-vaccine-plan-who-idUSKCN2261M7\">\u4e16\u754c\u306e\u6b7b\u8005\u6570\u304c20\u4e07\u4eba\u3092\u8d85\u3048\u308b\u524d\u306b<\/a>.\u3053\u306e\u8a66\u9a13\u3067\u6700\u521d\u306e\u60a3\u8005\u304c\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u3053\u3068\u304c\u767a\u8868\u3055\u308c\u3001\u660e\u308b\u3044\u5146\u3057\u304c\u898b\u3048\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u3053\u306e\u8a66\u9a13\u306e\u30c7\u30b6\u30a4\u30f3\u3084\u305d\u306e\u4ed6\u306e\u91cd\u8981\u306a\u7279\u6027\u306b\u3064\u3044\u3066\u3001\u3044\u304f\u3064\u304b\u8aac\u660e\u3057\u307e\u3059\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_is_the_basic_design_of_the_ChAdOx1_nCoV-19_candidate_vaccine_trial\"><\/span><b>\u306e\u57fa\u672c\u8a2d\u8a08\u3068\u306f\uff1f <\/b>ChAdOx1 nCoV-19<b> \u5019\u88dc\u3068\u306a\u308b\u30ef\u30af\u30c1\u30f3\u306e\u81e8\u5e8a\u8a66\u9a13<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">ChAdOx1 COVID-19\u30ef\u30af\u30c1\u30f3\u8a66\u9a13\u306f\u3001MenACWY\u30ef\u30af\u30c1\u30f3\u3092\u5bfe\u7167\u3068\u3057\u305f\u76f2\u691c\u5316\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u3067\u3059\u3002\u6700\u521d\u306e2\u540d\u306e\u60a3\u8005\u306b\u306f\u3001\u305d\u308c\u305e\u308c2\u7a2e\u985e\u306e\u30ef\u30af\u30c1\u30f3\u306e\u3044\u305a\u308c\u304b\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002 <\/span><span style=\"font-weight: 400;\">\u3053\u306e\u7814\u7a76\u306f\u73fe\u5728\u3001\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u3001\u30b5\u30a6\u30b5\u30f3\u30d7\u30c8\u30f3\u3001\u30ed\u30f3\u30c9\u30f3\u3001\u30d6\u30ea\u30b9\u30c8\u30eb\u306e4\u90fd\u5e02\u3067\u53c2\u52a0\u8005\u306e\u307f\u3092\u52df\u96c6\u3057\u3066\u3044\u307e\u3059\u3002\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f2\u3064\u306e\u30a2\u30fc\u30e0\u306b\u306f\u30015\u00d710^10vp ChAdOx1 nCoV-19\u306e\u3044\u305a\u308c\u304b\u306e\u5358\u56de\u6295\u4e0e\u307e\u305f\u306f\u6a19\u6e96\u7684\u306a\u5358\u56de\u6295\u4e0e\u3092\u53d7\u3051\u308b7\u30b0\u30eb\u30fc\u30d7\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002 <\/span><span style=\"font-weight: 400;\">0\u9031\u76ee\u306bMenACWY\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e<\/span><span style=\"font-weight: 400;\">\u7d9a\u3044\u3066\u30014\u9031\u76ee\u306b2.5\u00d710^10vp ChAdOx1 nCoV-19\u3092\u6295\u4e0e\u3059\u308b\uff08\u5b9f\u9a13\u7fa4\u306e1\u3064\u3067\uff09\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Why_is_the_MenACWY_vaccine_being_used_as_a_control\"><\/span>\u306a\u305c\u3001MenACWY\u30ef\u30af\u30c1\u30f3\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u308b\u306e\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u3053\u306e\u7814\u7a76\u3067\u306f\u3001ChAdOx1 nCoV-19\u30ef\u30af\u30c1\u30f3\u306b\u5bfe\u3059\u308b\u88ab\u9a13\u8005\u306e\u53cd\u5fdc\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001MenACWY\u30ef\u30af\u30c1\u30f3\u3092\u300c\u30a2\u30af\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u300d\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002 <\/span><span style=\"font-weight: 400;\">MenACWY\u30ef\u30af\u30c1\u30f3\u306f\u3001A\u7fa4\u3001C\u7fa4\u3001W\u7fa4\u3001Y\u7fa4\u306e\u9ac4\u819c\u708e\u83cc\u306b\u5bfe\u3059\u308b\u8a8d\u53ef\u3055\u308c\u305f\u30ef\u30af\u30c1\u30f3\u3067\u3001\u82f1\u56fd\u3067\u306f\u6700\u3082\u4e00\u822c\u7684\u306a\u9ac4\u819c\u708e\u3068\u6557\u8840\u75c7\u306e\u539f\u56e0\u3092\u9632\u3050\u305f\u3081\u306b10\u4ee3\u306e\u82e5\u8005\u306b\u5b9a\u671f\u7684\u306b\u63a5\u7a2e\u3055\u308c\u3066\u304a\u308a\u3001\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u56fd\u3067\u306f\u65c5\u884c\u7528\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u3082\u63a5\u7a2e\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/span><span style=\"font-weight: 400;\">\u751f\u7406\u98df\u5869\u6c34\u306b\u3088\u308b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u306f\u306a\u304f\u3001\u3053\u306e\u30ef\u30af\u30c1\u30f3\u3092\u4f7f\u7528\u3059\u308b\u7406\u7531\u306f\"<\/span><b>\u306a\u305c\u306a\u3089\u3001ChAdOx1 nCOV-19\u30ef\u30af\u30c1\u30f3\u3067\u306f\u3001\u8155\u306e\u75db\u307f\u3001\u982d\u75db\u3001\u767a\u71b1\u306a\u3069\u306e\u8efd\u5fae\u306a\u526f\u53cd\u5fdc\u304c\u4e88\u60f3\u3055\u308c\u308b\u304b\u3089\u3067\u3059\u3002\u751f\u7406\u98df\u5869\u6c34\u3067\u306f\u3053\u308c\u3089\u306e\u526f\u4f5c\u7528\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3002\u3082\u3057\u53c2\u52a0\u8005\u304c\u3053\u306e\u30ef\u30af\u30c1\u30f3\u307e\u305f\u306f\u751f\u7406\u98df\u5869\u6c34\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u307f\u3092\u53d7\u3051\u3066\u526f\u4f5c\u7528\u304c\u51fa\u305f\u3068\u3057\u3066\u3082\u3001\u65b0\u3057\u3044\u30ef\u30af\u30c1\u30f3\u3092\u53d7\u3051\u305f\u3053\u3068\u3092\u8a8d\u8b58\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002 <\/b><span style=\"font-weight: 400;\">\u3053\u308c\u306f\u30012\u7a2e\u985e\u306e\u30ef\u30af\u30c1\u30f3\u306e\u3044\u305a\u308c\u304b\u3092\u63a5\u7a2e\u3057\u305f\u53c2\u52a0\u8005\u304c\u3001\u63a5\u7a2e\u5f8c\u306e\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u3067\u306e\u5065\u5eb7\u884c\u52d5\u306b\u5dee\u304c\u51fa\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u305f\u3081\u306e\u76f2\u691c\u5316\u30d7\u30ed\u30bb\u30b9\u306e\u4e00\u74b0\u3067\u3042\u308a\u3001\u7814\u7a76\u7d50\u679c\u306e\u504f\u308a\u3092\u9632\u3050\u305f\u3081\u306b\u3082\u6709\u52b9\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u307e\u305f\u3001\u672c\u767b\u9332\u8a66\u9a13\u306e\u6cbb\u9a13\u8cac\u4efb\u533b\u5e2b\u3067\u3042\u308bSarah Gilbert\u6559\u6388\u306f\u3001\u672c\u8a66\u9a13\u306e\u7d44\u307f\u5165\u308c\u57fa\u6e96\u306f\u3001\u3053\u308c\u307e\u3067\u691c\u67fb\u3092\u53d7\u3051\u305f\u3053\u3068\u306e\u306a\u3044\u60a3\u8005\u3055\u3093\u3092\u767b\u9332\u3059\u308b\u305f\u3081\u3001\u8a66\u9a13\u306b\u5b58\u5728\u3059\u308b\u30ad\u30e3\u30ea\u30a2\u30fc\u306e\u6570\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3042\u308a\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u514d\u75ab\u30ec\u30d9\u30eb\u306e\u5909\u5316\u3092\u3088\u308a\u3088\u304f\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_are_the_primary_and_secondary_outcome_measures_of_the_trial\"><\/span>\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u4f55\u3067\u3059\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u3053\u306e\u7814\u7a76\u306e\u4e3b\u306a\u76ee\u7684\u306f\u3001COVID-19\u306b\u5bfe\u3059\u308b\u4f5c\u7528\u3092\u8abf\u67fb\u3057\u3001\u8a31\u5bb9\u3067\u304d\u306a\u3044\u526f\u4f5c\u7528\u304c\u751f\u3058\u306a\u3044\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3001\u5408\u7406\u7684\u306b\u9855\u8457\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u8a98\u5c0e\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u30c1\u30a7\u30c3\u30af\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u57fa\u672c\u7684\u306b\u306f\u3001\u6cbb\u9a13\u8cac\u4efb\u533b\u5e2b\u306f\u30016\u30f6\u6708\u9593\u306b\u30a6\u30a4\u30eb\u30b9\u5b66\u7684\u306b\u78ba\u8a8d\u3055\u308c\u305f\uff08PCR\u967d\u6027\uff09\u75c7\u72b6\u306e\u3042\u308b\u75c7\u4f8b\u306e\u6570\u3068\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u52e7\u8a98\u3055\u308c\u305f\u5c40\u6240\u7684\u30fb\u5168\u8eab\u7684\u306a\u6709\u5bb3\u75c7\u72b6\u306e\u767a\u751f\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002 <strong>\u6cbb\u9a13\u8cac\u4efb\u533b\u5e2b\u306f\u3001\u77ed\u671f\u7684\u306b\u5f97\u3089\u308c\u305f\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066\u3001\u91cd\u75c7\u304a\u3088\u3073\u975e\u91cd\u75c7\u306eCOVID-19\u306b\u5bfe\u3059\u308bChAdOx1 nCoV-19\u30ef\u30af\u30c1\u30f3\u5019\u88dc\u306e\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\u3001\u5165\u9662\u3001ICU\u5165\u5ba4\u3001\u75c5\u6c17\u306e\u5897\u60aa\u30a8\u30d4\u30bd\u30fc\u30c9\u306b\u57fa\u3065\u3044\u3066\u3001\u3055\u3089\u306a\u308b\u30a2\u30a6\u30c8\u30ab\u30e0\u5206\u6790\u3092\u884c\u3046\u4e88\u5b9a\u3067\u3059\u3002<\/strong>.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u8840\u6e05\u8ee2\u63db\u7387\u30926\u30ab\u6708\u9593\u306b\u308f\u305f\u3063\u3066\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u3001\u8a66\u9a13\u671f\u9593\u4e2d\u306b\u53c2\u52a0\u8005\u304c\u30b9\u30d1\u30a4\u30af\u4ee5\u5916\u306eSARS-CoV-2\u6297\u539f\u306b\u5bfe\u3057\u3066\u8840\u6e05\u967d\u6027\u3068\u306a\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3057\u3001\u53c2\u52a0\u8005\u306e\u6297\u4f53\u7523\u751f\u7387\u3092\u5b9a\u91cf\u5316\u3059\u308b\u3002\u3055\u3089\u306b\u3001ChAdOx1 nCoV-19\u306e\u7d30\u80de\u6027\u304a\u3088\u3073\u4f53\u6db2\u6027\u514d\u75ab\u539f\u6027\u3092\u3001\u751f\u304d\u305fSARS-CoV-2\u304a\u3088\u3073\uff0f\u307e\u305f\u306fSARS-CoV-2\u306e\u30b7\u30e5\u30fc\u30c9\u30bf\u30a4\u30d7\u306b\u5bfe\u3059\u308b\u30a6\u30a4\u30eb\u30b9\u4e2d\u548c\u6297\u4f53\u6cd5\u3067\u8abf\u3079\u308b\u3053\u3068\u3082\u3001\u3053\u306e\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3002\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_ChAdOx_vaccines_have_been_used_in_clinical_trials_Where_do_they_stand\"><\/span>\u3069\u306e\u3088\u3046\u306aChAdOx\u30ef\u30af\u30c1\u30f3\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304b\uff1f\u73fe\u5728\u306e\u72b6\u6cc1\u306f\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">ChAdOx1\u306e\u3088\u3046\u306a\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u81ea\u7136\u514d\u75ab\u3068\u9069\u5fdc\u514d\u75ab\u306e\u4e21\u65b9\u306e\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3067\u304d\u3001\u30de\u30e9\u30ea\u30a2\u306e\u6297\u539f\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u6297\u539f\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u30ef\u30af\u30c1\u30f3\u30ad\u30e3\u30ea\u30a2\u3084\u30c7\u30ea\u30d0\u30ea\u30fc\u30d3\u30fc\u30af\u30eb\u3068\u3057\u3066\u9b45\u529b\u7684\u3067\u3042\u308b\u3002 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32295168\"><span style=\"font-weight: 400;\">B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9<\/span><\/a><span style=\"font-weight: 400;\">\u3001C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u3001HIV-1\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002nCoV19 ChAdOx1\u30ef\u30af\u30c1\u30f3\u306f\u30013\u756a\u76ee\u306eChAdOx\u30d9\u30fc\u30b9\u306e\u30ef\u30af\u30c1\u30f3\u3067\u3001\u305d\u306e\u6295\u4e0e\u91cf\u306f <\/span><a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04324606\"><span style=\"font-weight: 400;\">\u73fe\u884c\u88c1\u5224<\/span><\/a><span style=\"font-weight: 400;\"> \u306f\u3001\u3053\u308c\u307e\u3067\u306e\u6295\u4e0e\u91cf\u306b\u57fa\u3065\u3044\u3066\u6c7a\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/span><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00942071\"><span style=\"font-weight: 400;\">\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6<\/span><\/a><span style=\"font-weight: 400;\"> \u305d\u3057\u3066 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7172901\/\"><span style=\"font-weight: 400;\">MERS\u30ef\u30af\u30c1\u30f3<\/span><\/a><span style=\"font-weight: 400;\"> 2002\u5e74\u304b\u30892012\u5e74\u306e\u9593\u306b\u884c\u308f\u308c\u305f\u81e8\u5e8a\u8a66\u9a13\u3002\u30ae\u30eb\u30d0\u30fc\u30c8\u6559\u6388\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u753b\u671f\u7684\u306a\u3082\u306e\u3067\u3001\u5f7c\u5973\u306e\u30c1\u30fc\u30e0\u304c\u958b\u767a\u3057\u305f\u30ef\u30af\u30c1\u30f3\u306f\u3001\u3059\u3079\u3066\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u682a\u306b\u6709\u52b9\u3067\u3042\u308a\u3001\u5f37\u529b\u306aT\u7d30\u80de\u53cd\u5fdc\u3092\u8a98\u5c0e\u3057\u3066\u9577\u671f\u7684\u304b\u3064\u666e\u904d\u7684\u306a\u4fdd\u8b77\u3092\u5b9f\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u30ef\u30af\u30c1\u30f3\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u6295\u4e0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3978791\/\"><span style=\"font-weight: 400;\">\u5b63\u7bc0\u6027\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30fb\u30ef\u30af\u30c1\u30f3\u3068\u306e\u4f75\u7528<\/span><\/a><span style=\"font-weight: 400;\"> \u9ad8\u9f62\u8005\uff0850\uff5e85\u6b73\uff09\u306b\u304a\u3051\u308b\u514d\u75ab\u539f\u6027\u306e\u5897\u52a0\u3092\u8a98\u767a\u3059\u308b\u305f\u3081\u306b\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u30b8\u30a7\u30ca\u30fc\u7814\u7a76\u6240\u306e\u30b5\u30e9\u6559\u6388\u306e\u30c1\u30fc\u30e0\u306f\u30012\u7a2e\u985e\u306e\u65b0\u3057\u3044\u30b7\u30de\u30fc\u30fb\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30fb\u30d9\u30af\u30bf\u30fc\u30c9\u30fb\u30ef\u30af\u30c1\u30f3\uff08ChAdOx1\u3068ChAdOx2\uff09\u3092\u958b\u767a\u3057\u3001\u3055\u3089\u306b\u30af\u30ea\u30df\u30a2\u30fb\u30b3\u30f3\u30b4\u51fa\u8840\u71b1\uff08\u73fe\u5728GMP\u88fd\u9020\u6bb5\u968e\uff09\u3001\u30cb\u30d1\u30fb\u30a6\u30a4\u30eb\u30b9\u3001\u30e9\u30c3\u30b5\u71b1\u306b\u5bfe\u3059\u308b\u30a6\u30a4\u30eb\u30b9\u30fb\u30d9\u30af\u30bf\u30fc\u30c9\u30fb\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u30ef\u30af\u30c1\u30f3\u958b\u767a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u3001\u30b8\u30e7\u30f3\u30bd\u30f3\u30fb\u30b8\u30e7\u30f3\u30bd\u30f3\u793e\u306e\u30ef\u30af\u30c1\u30f3\u958b\u767a\u30fb\u88fd\u9020\u30fb\u8ca9\u58f2\u90e8\u9580\u3067\u3042\u308bJanssen Vaccines &amp; Prevention B. V. &amp; Prevention BV\u3068\u5171\u540c\u3067\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30ef\u30af\u30c1\u30f3\u958b\u767a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u3001\u30b8\u30e7\u30f3\u30bd\u30f3\u30fb\u30a8\u30f3\u30c9\u30fb\u30b8\u30e7\u30f3\u30bd\u30f3\u306e\u30ef\u30af\u30c1\u30f3\u958b\u767a\u30fb\u88fd\u9020\u30fb\u8ca9\u58f2\u90e8\u9580\u3067\u3042\u308bJanssen Vaccines &amp; Prevention B.V.&amp; Prevention BV\u3068\u5171\u540c\u3067\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002ChAdOx1\u30b3\u30f3\u30b9\u30c8\u30e9\u30af\u30c8\u306f\u3001\u30c1\u30af\u30f3\u30b0\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u3084\u30b8\u30ab\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u30ef\u30af\u30c1\u30f3\u306b\u3082\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u73fe\u5728\u7b2c1\u76f8\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002Sarah\u6559\u6388\u306f\u3001\u793e\u5185\u3067\u306eGMP\u88fd\u9020\u3001\u88fd\u9020\u8a2d\u8a08\u3001\u5efa\u8a2d\u3001\u54c1\u8cea\u7ba1\u7406\u3001\u524d\u81e8\u5e8a\u8a66\u9a13\u3001\u898f\u5236\u3001\u502b\u7406\u7684\u7533\u8acb\u304b\u3089\u30b8\u30a7\u30f3\u30ca\u30fc\u7814\u7a76\u6240\u3067\u306e\u7b2c1\u76f8\u304a\u3088\u3073\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13\u306b\u81f3\u308b\u307e\u3067\u3001\u3059\u3079\u3066\u306e\u30ef\u30af\u30c1\u30f3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u4e3b\u5c0e\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Any_other_examples_of_adenoviral_vector_vaccines\"><\/span>\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30fb\u30d9\u30af\u30bf\u30fc\u30fb\u30ef\u30af\u30c1\u30f3\u306e\u4ed6\u306e\u4f8b\u306f\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">ChAdOx1\u30d9\u30af\u30bf\u30fc\u306e\u30ef\u30af\u30c1\u30f3\u30b3\u30f3\u30b9\u30c8\u30e9\u30af\u30c8\u3068\u306f\u5225\u306b\u3001MVA\uff08Modified Vaccinia Ankara\uff09\u30d9\u30af\u30bf\u30fc\u3082\u975e\u8907\u88fd\u6027\u306e\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3067\u3042\u308a\u3001\u5408\u7406\u7684\u3067\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\uff08\u6700\u521d\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304b\u30896\u304b\u6708\u5f8c\uff09\u3092\u6301\u3061\u3001\u5927\u898f\u6a21\u306a\u96c6\u56e3\u3067\u306e\u666e\u53ca\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002MERS-CoV\u611f\u67d3\u75c7\u306b\u3064\u3044\u3066\u306f\u3001\u30b8\u30a7\u30ca\u30fc\u7814\u7a76\u6240\u306e <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6841732\/\"><span style=\"font-weight: 400;\">\u30ef\u30af\u30c1\u30f3\u5019\u88dc\u306e\u30c6\u30b9\u30c8<\/span><\/a><span style=\"font-weight: 400;\"> \u3092\u30d9\u30fc\u30b9\u306b\u3057\u305fChAdOx1\u30d9\u30af\u30bf\u30fc\u3068MVA\u30d9\u30af\u30bf\u30fc\u3092\u30d2\u30c8\u3068\u30c9\u30ec\u30e1\u30c0\u30ea\u30fc\u30fb\u30e9\u30af\u30c0\u306b\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002\u30d5\u30a7\u30fc\u30baI\u3067\u306f <\/span><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1411627\"><span style=\"font-weight: 400;\">\u30a8\u30dc\u30e9\u30a6\u30a4\u30eb\u30b9\u8a66\u9a13<\/span><\/a><span style=\"font-weight: 400;\"> 60\u4eba\u306e\u6210\u4eba\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u3092\u5bfe\u8c61\u306b\u3001MVA\u30d9\u30af\u30bf\u30fc\u3067\u30d6\u30fc\u30b9\u30c8\u3057\u305f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b93\uff08ChAd3\uff09\u3092\u5358\u56de\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\u30018\u500d\u3082\u306e\u512a\u308c\u305f\u514d\u75ab\u53cd\u5fdc\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3978791\/\"><span style=\"font-weight: 400;\">\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3<\/span><\/a><span style=\"font-weight: 400;\"> MNA\u30d9\u30af\u30bf\u30fc\u3092\u30d9\u30fc\u30b9\u3068\u3057\u305fMVA-NP+M1\u306f\u3001A\u578b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6838\u86cb\u767d\u8cea\uff08NP\uff09\u3068\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u86cb\u767d\u8cea1\uff08M1\uff09\u306e\u878d\u5408\u86cb\u767d\u8cea\u3092\u767a\u73fe\u3057\u3001\u4fdd\u5b58\u3055\u308c\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u6297\u539f\u306b\u5bfe\u3059\u308bT\u7d30\u80de\u304a\u3088\u3073B\u7d30\u80de\u306e\u514d\u75ab\u5897\u5f37\u52b9\u679c\u3092\u793a\u3059\u3068\u3068\u3082\u306b\u3001\u4f53\u6db2\u6027\u514d\u75ab\u53cd\u5fdc\u306e\u5897\u5f37\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_will_the_adverse_events_be_clinically_monitored\"><\/span>\u6709\u5bb3\u4e8b\u8c61\u3092\u3069\u306e\u3088\u3046\u306b\u81e8\u5e8a\u7684\u306b\u30e2\u30cb\u30bf\u30fc\u3059\u308b\u306e\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u53c2\u52a0\u8005\u306b\u306f\u96fb\u5b50\u30b8\u30e3\u30fc\u30ca\u30eb\u300cE-diary\u300d\u304c\u914d\u5e03\u3055\u308c\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c7\u65e5\u9593\u306e\u75c7\u72b6\u3092\u8a18\u9332\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u305d\u306e\u5f8c\u306e3\u9031\u9593\u3001\u4f53\u8abf\u4e0d\u826f\u3092\u611f\u3058\u305f\u5834\u5408\u3082\u8a18\u9332\u3059\u308b\u3088\u3046\u306b\u6307\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u3001\u53c2\u52a0\u8005\u306f\u4e00\u9023\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u8a2a\u554f\u306b\u51fa\u5e2d\u3057\u3001\u53c2\u52a0\u8005\u306e\u81e8\u5e8a\u89b3\u5bdf\u3001\u63a1\u8840\u3001\u7af6\u3063\u305fE\u30c0\u30a4\u30a2\u30ea\u30fc\u306e\u30ec\u30d3\u30e5\u30fc\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306b\u5c02\u5ff5\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u30ef\u30af\u30c1\u30f3\u306b\u5bfe\u3059\u308b\u514d\u75ab\u53cd\u5fdc\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u53c2\u52a0\u8005\u304c\u8a66\u9a13\u4e2d\u306bCOVID-19\u306e\u75c7\u72b6\u3092\u767a\u75c7\u3057\u305f\u5834\u5408\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u30c1\u30fc\u30e0\u306b\u9023\u7d61\u3057\u3066\u3044\u305f\u3060\u304d\u3001\u30a6\u30a4\u30eb\u30b9\u3078\u306e\u611f\u67d3\u304c\u306a\u3044\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002\u53c2\u52a0\u8005\u306e\u4f53\u8abf\u304c\u975e\u5e38\u306b\u60aa\u304f\u306a\u3063\u305f\u5834\u5408\u306f\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u3092\u898b\u76f4\u3059\u305f\u3081\u306b\u75c5\u9662\u304b\u3089\u306e\u7dca\u6025\u5bfe\u5fdc\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Funding_received_from_for-profit_or_non-profit_organizations\"><\/span>\u55b6\u5229\u56e3\u4f53\u307e\u305f\u306f\u975e\u55b6\u5229\u56e3\u4f53\u304b\u3089\u53d7\u3051\u305f\u8cc7\u91d1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u306f\u3001\u6297SARS-CoV-2\u30ef\u30af\u30c1\u30f3\u306e\u7814\u7a76\u306b\u5bfe\u3057\u3066 <\/span><a href=\"http:\/\/www.ox.ac.uk\/news\/2020-04-30-landmark-partnership-announced-development-covid-19-vaccine\"><span style=\"font-weight: 400;\">\u5951\u7d04<\/span><\/a><span style=\"font-weight: 400;\"> \u3068AstraZeneca AB\u3068\u306e\u9593\u3067\u3001\u30ef\u30af\u30c1\u30f3\u306e\u5927\u898f\u6a21\u306a\u88fd\u9020\u3068\u8ca9\u58f2\u306e\u53ef\u80fd\u6027\u3092\u5f15\u304d\u7d99\u3050\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u00a0 <\/span><span style=\"font-weight: 400;\"><strong>\u307e\u305f\u3001\u540c\u5927\u5b66\u306e\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u30fb\u30ef\u30af\u30c1\u30f3\u30fb\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u82f1\u56fd\u3067\u306e\u88fd\u9020\u30fb\u8ca9\u58f2\u30b3\u30b9\u30c8\u3092\u5f15\u304d\u53d7\u3051\u308b\u305f\u3081\u306b2,000\u4e07\u30dd\u30f3\u30c9\u3092\u53d7\u3051\u53d6\u3063\u3066\u3044\u307e\u3059\u3002<\/strong> The agreement also entails a not-for-profit basis for the duration of the coronavirus pandemic, which covers only the manufacturing and distribution costs. The University and the spin-out company Vaccitech will jointly have the rights to the technology platform used to develop the vaccine candidate and shall receive no royalties from the vaccine during the pandemic. Any royalties received eventually by the University will be reinvested directly into medical <a href=\"https:\/\/www.kolabtree.com\/blog\/ja\/ensuring-reproducibility-in-ai-driven-research-how-freelance-experts-can-help-in-biotech-and-healthcare\/\">\u30ea\u30b5\u30fc\u30c1<\/a>, including a newly developed Pandemic Preparedness and Vaccine Research Centre in collaboration with AstraZeneca.\u00a0\u00a0\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Possible_timeline_of_the_vaccines_availability\"><\/span>\u30ef\u30af\u30c1\u30f3\u304c\u5165\u624b\u53ef\u80fd\u306b\u306a\u308b\u307e\u3067\u306e\u671f\u9593<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"section-paragraph\">\u3068\u3057\u3066 <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)30796-0\/fulltext\">\u5831\u544a\u3055\u308c\u305f<\/a> \u3067 <em>The Lancet<\/em>\u3057\u304b\u3057\u3001\u30ae\u30eb\u30d0\u30fc\u30c8\u6559\u6388\u306f\u30015\u6708\u4e2d\u65ec\u307e\u3067\u306b500\u4eba\u306e\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u3001\u305d\u306e\u5f8c\u3001\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306e\u5e74\u9f62\u5236\u9650\u309255\u6b73\u304b\u308970\u6b73\u306b\u5ef6\u9577\u3057\u3001\u3055\u3089\u306b70\u6b73\u4ee5\u4e0a\u306e\u5e74\u9f62\u5c64\u306b\u3082\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002 <strong>\u30d5\u30a7\u30fc\u30ba3\u306e\u62e1\u5927\u306b\u306f\u30015000\u4eba\u306e\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u3068<\/strong> <strong>\u306f\u3001\u6709\u52b9\u6027\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306b\u304a\u3044\u3066\u3001\u5148\u884c\u3059\u308b\u8a66\u9a13\u306e\u7d50\u679c\u3068\u306e\u6bd4\u8f03\u3092\u884c\u3046\u3079\u304d\u3067\u3042\u308b\u3002<\/strong> \u300c\u30d9\u30b9\u30c8\u30b7\u30ca\u30ea\u30aa\u306f\u30012020\u5e74\u306e\u79cb\u307e\u3067\u306b\u7b2c3\u76f8\u8a66\u9a13\u3067\u6709\u52b9\u6027\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u3001\u5927\u91cf\u306e\u30ef\u30af\u30c1\u30f3\u3092\u88fd\u9020\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u3053\u3068\u3067\u3059\u304c\u3001\u3053\u306e\u30d9\u30b9\u30c8\u30b7\u30ca\u30ea\u30aa\u306e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306f\u975e\u5e38\u306b\u91ce\u5fc3\u7684\u306a\u3082\u306e\u3067\u3042\u308a\u3001\u5909\u66f4\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u300d\u3068\u30ae\u30eb\u30d0\u30fc\u30c8\u306f\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u300c\u307e\u305f\u3001ChAdOx1 nCoV19\u30ef\u30af\u30c1\u30f3\u306b\u3064\u3044\u3066\u306f\u3001\u300c\u30ef\u30af\u30c1\u30f3\u306e\u6709\u52b9\u6027\u3092\u5224\u65ad\u3059\u308b\u80fd\u529b\u306f\u3001\u590f\u306e\u9593\u306b\u5730\u57df\u4f4f\u6c11\u306e\u9593\u3067\u3069\u308c\u3060\u3051\u30a6\u30a4\u30eb\u30b9\u304c\u4f1d\u64ad\u3057\u305f\u304b\u306b\u5f71\u97ff\u3055\u308c\u307e\u3059\u3002<\/div>\n<div class=\"section-paragraph\">\u4e16\u754c\u4e2d\u3067\u4e26\u884c\u3057\u3066\u884c\u308f\u308c\u3066\u3044\u308bSARS-CoV-2\u306e\u30ef\u30af\u30c1\u30f3\u958b\u767a\u3068\u77e5\u8b58\u3092\u5171\u6709\u3059\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002\u300cWHO\u306f\u3001COVID-19\u30ef\u30af\u30c1\u30f3\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u3059\u3079\u3066\u306e\u4eba\u304c\u4e00\u5802\u306b\u4f1a\u3057\u3001\u8a08\u753b\u3084\u521d\u671f\u306e\u77e5\u898b\u3092\u767a\u8868\u3059\u308b\u5834\u3092\u8a2d\u3051\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u304c\u5f97\u305f\u77e5\u898b\u306e\u6bd4\u8f03\u53ef\u80fd\u6027\u3068\u4e00\u822c\u6027\u3092\u78ba\u4fdd\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u69d8\u3005\u306a\u30ef\u30af\u30c1\u30f3\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5b66\u7684\u53cd\u5fdc\u3092\u540c\u3058\u65b9\u6cd5\u3067\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u3088\u308bCOVID-19\u306e\u4e88\u9632\u3068\u3044\u3046\u4e16\u754c\u5171\u901a\u306e\u76ee\u6a19\u306b\u5411\u3051\u3066\u3001WHO\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u3053\u308c\u307e\u3067\u306b\u306a\u3044\u5354\u529b\u3068\u9023\u643a\u306e\u7cbe\u795e\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u3092\u78ba\u4fe1\u3057\u3066\u3044\u307e\u3059\u300d\u3068\u30ae\u30eb\u30d0\u30fc\u30c8\u306f\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002 <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)30796-0\/fulltext\">\u3068\u8a00\u3044\u307e\u3059\u3002<\/a>.<\/div>\n<div><em>\u3053\u306e\u8a18\u4e8b\u306f\u3001\u4ee5\u4e0b\u306e\u30ea\u30bd\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3066\u4f5c\u6210\u3055\u308c\u307e\u3057\u305f\u3002 <a href=\"http:\/\/www.ox.ac.uk\/news-and-events\/find-an-expert\/professor-sarah-gilbert\">\u30b5\u30e9\u30fb\u30ae\u30eb\u30d0\u30fc\u30c8\u6559\u6388<\/a> \u3068Nuffield Department of Medicine\u306e\u5354\u529b\u3092\u5f97\u3066\u3044\u307e\u3059\u3002\u00a0<\/em><\/div>\n<div>\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/div>\n<div>\n<ol>\n<li class=\"article-header__title\">\u30b5\u30e9\u30fb\u30ae\u30eb\u30d0\u30fc\u30c8\uff1aCOVID-19\u30ef\u30af\u30c1\u30f3\u3078\u306e\u9053\u3092\u5207\u308a\u958b\u304f\u3002 <em>Perspectives, The Lancet.<\/em> <strong>395 (10232)<\/strong>\u00a0<span class=\"article-header__pages faded\">P1247,\u00a0<\/span><span class=\"article-header__date faded\">april 18, 2020.<\/span><\/li>\n<li>Lancet Infect Dis.2020 Apr 20. pii:S1473-3099(20)30160-2. doi: 10.1016\/S1473-3099(20)30160-2.<\/li>\n<li><a href=\"http:\/\/www.ox.ac.uk\/news\/2020-04-23-oxford-covid-19-vaccine-begins-human-trial-stage\">\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u306eCOVID-19\u30ef\u30af\u30c1\u30f3\u304c\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\u6bb5\u968e\u306b\u5165\u308b<\/a>.\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/li>\n<\/ol>\n<\/div>\n<p><strong>\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u52a9\u3051\u304c\u5fc5\u8981\u3067\u3059\u304b\uff1fKolabtree\u3067\u30a6\u30a4\u30eb\u30b9\u5b66\u8005\u3001\u75ab\u5b66\u8005\u3001\u8cc7\u683c\u306e\u3042\u308b\u30b5\u30a4\u30a8\u30f3\u30b9\u30e9\u30a4\u30bf\u30fc\u306b\u76f8\u8ac7\u3057\u3066\u307f\u307e\u305b\u3093\u304b\uff1f <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/covid-19?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=ChAdOx1\">COVID-19\u306e\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u3092\u898b\u308b\u00a0<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>Mahasweta Pal, freelance medical writer at Kolabtree, provides insights into the COVID-19 vaccine trial at the University of Oxford.\u00a0 Update 22\/05\/2020: Oxford COVID-19 vaccine to begin phase II\/III human trials Update 30\/12\/2020: Oxford University\/AstraZeneca COVID-19 approved Update 04\/08\/2021: Barbie of Oxford Covid vaccine designer Dame Sarah Gilbert created 2020 ushered in an eerie global downturn with the COVID-19 pandemic, causing mass disruption among healthcare systems worldwide. Meanwhile, scientists in the United States and Europe jumped into the race to develop and launch vaccines against the pandemic SARS-CoV-2 infection with the shortest timelines. Stalwarts in immunology, virology, vaccinology, epidemiology, and public health have been contemplating the massive changes required in vaccine<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/ja\/inside-the-novel-covid-19-vaccine-trial-at-the-university-of-oxford\/\" title=\"\u7d9a\u304d\u3092\u8aad\u3080\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/div>","protected":false},"author":32,"featured_media":7568,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[442,305,558,247,435,516],"tags":[531,554,553,568,567],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Inside the Novel COVID-19 Vaccine Trial at the University of Oxford<\/title>\n<meta name=\"description\" content=\"A detailed look at the ChAdOx1 COVID-19 vaccine trial at the University of Oxford, with resources from 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