{"id":6856,"date":"2020-02-10T14:44:21","date_gmt":"2020-02-10T14:44:21","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=6856"},"modified":"2023-02-15T11:40:59","modified_gmt":"2023-02-15T11:40:59","slug":"pathway-analysis-in-bioinformatics-mapping-data-to-information","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/","title":{"rendered":"\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u306b\u304a\u3051\u308b\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u3002\u30c7\u30fc\u30bf\u304b\u3089\u60c5\u5831\u3078\u306e\u30de\u30c3\u30d4\u30f3\u30b0"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_45_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">table of contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" area-label=\"ez-toc-toggle-icon-1\"><label for=\"item-69f2454dcfc1a\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-69f2454dcfc1a\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Devil_is_in_the_Detail\" title=\"\u60aa\u9b54\u306f\u7d30\u90e8\u306b\u5bbf\u308b\">\u60aa\u9b54\u306f\u7d30\u90e8\u306b\u5bbf\u308b<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Genome_Organization\" title=\"\u30b2\u30ce\u30e0\u7d44\u7e54\">\u30b2\u30ce\u30e0\u7d44\u7e54<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Pathway_Databases\" title=\"\u30d1\u30b9\u30a6\u30a7\u30a4\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\">\u30d1\u30b9\u30a6\u30a7\u30a4\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Enrichment_Tools\" title=\"\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u30c4\u30fc\u30eb\">\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u30c4\u30fc\u30eb<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Over_Representation_Analysis\" title=\"\u904e\u5270\u8868\u73fe\u306e\u5206\u6790\">\u904e\u5270\u8868\u73fe\u306e\u5206\u6790<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Functional_Class_Scoring\" title=\"\u6a5f\u80fd\u30af\u30e9\u30b9\u306e\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0\">\u6a5f\u80fd\u30af\u30e9\u30b9\u306e\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Pathway_Topology_based_Approaches\" title=\"\u30d1\u30b9\u30a6\u30a7\u30a4\u30fb\u30c8\u30dd\u30ed\u30b8\u30fc\u306b\u57fa\u3065\u304f\u30a2\u30d7\u30ed\u30fc\u30c1\">\u30d1\u30b9\u30a6\u30a7\u30a4\u30fb\u30c8\u30dd\u30ed\u30b8\u30fc\u306b\u57fa\u3065\u304f\u30a2\u30d7\u30ed\u30fc\u30c1<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#Network_Interaction_based_Analysis\" title=\"\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30fb\u30a4\u30f3\u30bf\u30e9\u30af\u30b7\u30e7\u30f3\u306b\u57fa\u3065\u304f\u5206\u6790\">\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30fb\u30a4\u30f3\u30bf\u30e9\u30af\u30b7\u30e7\u30f3\u306b\u57fa\u3065\u304f\u5206\u6790<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/#The_apparent_Panacea\" title=\"\u898b\u304b\u3051\u4e0a\u306e\u4e07\u80fd\u85ac\">\u898b\u304b\u3051\u4e0a\u306e\u4e07\u80fd\u85ac<\/a><\/li><\/ul><\/nav><\/div>\n<p><em><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/computational-biology?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u8a08\u7b97\u6a5f\u751f\u7269\u5b66\u8005<\/a> \u3068Kolabtree\u306e\u30d5\u30ea\u30fc\u30e9\u30f3\u30b5\u30fc <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/shaurya-jauhari\/?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u30b7\u30e7\u30fc\u30ea\u30e4\u30fb\u30b8\u30e3\u30a6\u30cf\u30ea<\/a> \u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u3067\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u3092\u884c\u3046\u4e0a\u3067\u306e\u73fe\u5728\u306e\u8ab2\u984c\u3068\u3001\u305d\u306e\u89e3\u6c7a\u7b56\u306b\u3064\u3044\u3066\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<\/span><\/em><\/p>\n<p><span style=\"font-weight: 400;\">\u4e0d\u6b63\u78ba\u306a\u533b\u7642\u300d\uff08\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\u3078\u306e\u79fb\u884c\u3092\u4fc3\u3057\u3066\u3044\u308b\uff09\u3068\u3001\u6a5f\u5668\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u305f\u751f\u7269\u533b\u5b66\u30c7\u30fc\u30bf\u306e\u6c3e\u6feb\u3068\u3044\u3046\u5bfe\u7167\u7684\u306a\u6642\u4ee3\u306b\u3042\u3063\u3066\u3001\u30c7\u30fc\u30bf\u3092\u60c5\u5831\u306b\u30de\u30c3\u30d4\u30f3\u30b0\u3059\u308b\u3053\u3068\u3092\u5927\u524d\u63d0\u3068\u3057\u305f\u6b20\u843d\u304c\u7d9a\u3044\u3066\u3044\u307e\u3059\u3002\u81e8\u5e8a\u5b9f\u9a13\u306b\u3088\u3063\u3066\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08\u6b63\u78ba\u306b\u306f\u907a\u4f1d\u5b50\u3084\u30b2\u30ce\u30e0\u9818\u57df\u306e\u30ea\u30b9\u30c8\uff09\u304c\u751f\u6210\u3055\u308c\u3001\u305d\u306e\u751f\u7269\u5b66\u7684\u306a\u610f\u5473\u5408\u3044\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u8a66\u307f\u3092\u5bb9\u6613\u306b\u3059\u308b\u73fe\u5728\u306e\u4e00\u9023\u306e\u30c4\u30fc\u30eb\u306f\u3001\u4ee5\u4e0b\u306e\u70b9\u3092\u7121\u8996\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u76ee\u7684\u306b\u9069\u3063\u3066\u3044\u307e\u305b\u3093\u3002<em> \u3044\u3063\u305d\u306e\u3053\u3068<\/em>\u771f\u6838\u7d30\u80de\u306e\u6838\u306e\u4e2d\u306b\u53ce\u5bb9\u3055\u308c\u3066\u3044\u308b\u30b2\u30ce\u30e0\u306e\u7a7a\u9593\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3002\u3053\u306e\u89e3\u8aac\u3067\u306f\u3001\u554f\u984c\u306e\u672c\u8cea\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u30b2\u30ce\u30e0\u306e\u69cb\u6210\u306b\u5149\u3092\u5f53\u3066\u3001\u73fe\u5728\u306e\u30de\u30c3\u30d4\u30f3\u30b0\u30c4\u30fc\u30eb\u3092\u7c21\u5358\u306b\u632f\u308a\u8fd4\u308a\u3001\u53ef\u80fd\u306a\u89e3\u6c7a\u7b56\u3092\u63a8\u6e2c\u3057\u307e\u3059\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Devil_is_in_the_Detail\"><\/span><b>\u60aa\u9b54\u306f\u7d30\u90e8\u306b\u5bbf\u308b<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u306e\u89e3\u50cf\u5ea6\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u6570\u591a\u304f\u306e\u52aa\u529b\u306f\u3001\u91cd\u8981\u306a\u60c5\u5831\u306e\u30b9\u30ad\u30fc\u30e0\u3092\u4e0b\u6577\u304d\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001$100,000\u306e\u89e3\u6790\u306f\u3068\u3082\u304b\u304f\u3001$1000\u306e\u30b2\u30ce\u30e0\u306e\u53ef\u80fd\u6027\u3092\u5fc3\u914d\u3057\u3066\u3044\u307e\u3059\u3002\u5178\u578b\u7684\u306a\u751f\u7269\u5b66\u7684\u7814\u7a76\u306e\u4e0b\u3067\u3001\u5b9f\u9a13\u7d50\u679c\u3084\u75c7\u4f8b\u306e\u6ce8\u91c8\u3092\u4fdd\u6301\u3059\u308b\u30ec\u30d1\u30fc\u30c8\u30ea\u30fc\u306e\u5927\u8981\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u3042\u308b\u907a\u4f1d\u5b50\u306e\u751f\u7269\u5b66\u7684\u306a\u610f\u5473\u5408\u3044\u3084\u3001\u305d\u306e\u907a\u4f1d\u5b50\u304c\u542b\u307e\u308c\u308b\u7d4c\u8def\u304c\u75c5\u6c17\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3059\u5b9a\u7fa9\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u3088\u3046\u306a\u52d5\u7684\u306a\u60c5\u5831\u3092\u6301\u3064\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u4ee5\u524d\u306f\u624b\u4f5c\u696d\u3067\u7ba1\u7406\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u3084ICT\u3092\u99c6\u4f7f\u3057\u305f\u81ea\u52d5\u5316\u3055\u308c\u305f\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306b\u3088\u3063\u3066\u77e5\u8b58\u7ba1\u7406\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u3092\u91cd\u8996\u3057\u305f\u79d1\u5b66\u7684\u306a\u77e5\u6075\u306b\u3088\u3063\u3066\u66f4\u65b0\u3055\u308c\u3001\u958b\u59cb\u4ee5\u6765\u3001\u4f55\u5ea6\u3082\u6539\u8a02\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u5b9f\u9a13\u7d50\u679c\u3092\u751f\u7269\u5b66\u7684\u306a\u610f\u5473\u5408\u3044\u306b\u7d50\u3073\u3064\u3051\u308b\u5c0e\u7dda\u306f\u8457\u3057\u304f\u5f31\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u4e3b\u306b\u3001\u6839\u5e95\u306b\u3042\u308b\u300c\u771f\u306e\u300d\u751f\u7269\u5b66\u304c\u5426\u5b9a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u79c1\u305f\u3061\u306e\u4f53\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306e\u3072\u3068\u3064\u3072\u3068\u3064\u306e\u6838\u306e\u4e2d\u306b\u306f\u3001\u5e73\u57472\u30e1\u30fc\u30c8\u30eb\u306e\u9577\u3055\u306e\u30b2\u30ce\u30e0\u304c\u53ce\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u306e\u5927\u304d\u3055\u3001\u7279\u306b\u6838\u306e\u5927\u304d\u3055\u304c\u5c0f\u3055\u3044\u305f\u3081\u3001\u30b2\u30ce\u30e0\u306f\u3084\u3084\u7aae\u5c48\u306a\u5f62\u3067\u8a70\u3081\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u76f4\u7dda\u7684\u306a\u8996\u70b9\u3067\u306f\u9060\u304f\u96e2\u308c\u305f\u30b2\u30ce\u30e0\u306e\u9818\u57df\u304c\u8fd1\u304f\u306b\u6765\u3066\u3001\u76f8\u4e92\u306b\u5f71\u97ff\u3057\u5408\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u8a00\u8449\u306f\u3001\u73fe\u5728\u306e\u4e00\u9023\u306e\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\uff08\u30de\u30c3\u30d4\u30f3\u30b0\uff09\u30c4\u30fc\u30eb\u3067\u306f\u5927\u304d\u304f\u5426\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u305f\u3081\u5f97\u3089\u308c\u308b\u7d50\u679c\u3082\u4e0d\u5747\u8861\u306a\u3082\u306e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u30b2\u30ce\u30e0\u5185\u306e\u9818\u57df\u306f\u3001\u3088\u308a\u5927\u304d\u306a\u300c\u30a2\u30af\u30b7\u30e7\u30f3\u30b0\u30eb\u30fc\u30d7\u300d\u306e\u4e00\u90e8\u3067\u3042\u3063\u305f\u308a <\/span><b><i>\u30d1\u30b9\u30a6\u30a7\u30a4<\/i><\/b><span style=\"font-weight: 400;\"> \u3068\u306f\u3001\u5065\u5eb7\u3084\u75c5\u6c17\u3068\u3044\u3063\u305f\u8868\u73fe\u578b\u3092\u69cb\u6210\u3059\u308b\u6280\u8853\u7684\u306b\u4e00\u9023\u306e\u5316\u5b66\u53cd\u5fdc\u306e\u3053\u3068\u3067\u3042\u308b\u3002\u75c5\u6c17\u306e\u72b6\u614b\u3092\u8abf\u3079\u308b\u3068\u304d\u3001\u7814\u7a76\u8005\u306f\u3001\u6f5c\u5728\u7684\u306b\u3046\u307e\u304f\u3044\u304b\u305a\u3001\u751f\u7269\u306e\u4f53\u3092\u660e\u3089\u304b\u306b\u5909\u3048\u3066\u3057\u307e\u3063\u305f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u63a2\u3057\u307e\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">\u30c8\u30fc\u30f3<\/span><\/i><span style=\"font-weight: 400;\"> \u306b\u3057\u3066\u3044\u307e\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">\u30c8\u30a5\u30a4\u30c3\u30c1<\/span><\/i><span style=\"font-weight: 400;\">.\u305a\u308c\u305f\u60c5\u5831\u3067\u82e6\u52b4\u3057\u305f\u75c5\u6c17\u3092\u8ffd\u3044\u304b\u3051\u308b\u3053\u3068\u3092\u60f3\u50cf\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/span><\/p>\n<p><b><em><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/computational-biology?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-6904 size-large\" src=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1-1024x444.png\" alt=\"\" width=\"702\" height=\"304\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1-1024x444.png 1024w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1-300x130.png 300w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1-768x333.png 768w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1-1536x665.png 1536w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1-1080x468.png 1080w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1.png 2011w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure1-300x130@2x.png 600w\" sizes=\"(max-width: 702px) 100vw, 702px\" \/><\/a><\/span><\/em><\/b><em>\u554f\u984c\u306e\u63d0\u8d77 - \u5178\u578b\u7684\u306a\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u5206\u6790\u306e\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3002\u305d\u3053\u306b\u306f\u3001\u3042\u308b<\/em><br \/>\n<em>\u30b2\u30ce\u30e0\u914d\u5217\u306e\u907a\u4f1d\u5b50\u3078\u306e\u30de\u30c3\u30d4\u30f3\u30b0\u306b\u95a2\u9023\u3057\u305f\u300c\u30a4\u30c7\u30a3\u30aa\u30de\u30c6\u30a3\u30ba\u30e0\u300d\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u3067\u3001\u3053\u308c\u306b\u3088\u3063\u3066<\/em><br \/>\n<em>\u30c0\u30a6\u30f3\u30b9\u30c8\u30ea\u30fc\u30e0\u306e\u7d50\u679c<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Genome_Organization\"><\/span><b>\u30b2\u30ce\u30e0\u7d44\u7e54<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u524d\u8ff0\u3057\u305f\u3088\u3046\u306b\u3001\u30b2\u30ce\u30e0\u306f\u3001\u79c1\u305f\u3061\u306e\u4f53\u3084\u4ed6\u306e\u751f\u7269\u306e\u3059\u3079\u3066\u306e\u7d30\u80de\u306e\u7d30\u80de\u6838\u306e\u4e2d\u306b\u76f4\u7dda\u7684\u306b\u683c\u7d0d\u3067\u304d\u308b\u307b\u3069\u9577\u3044\u3082\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e2\u30e1\u30fc\u30c8\u30eb\u306e\u7269\u4f53\u306f\u3001\u4e00\u898b\u3059\u308b\u3068\u7121\u79e9\u5e8f\u306a\u69cb\u9020\u306b\u62bc\u3057\u8fbc\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u60f3\u50cf\u3059\u308b\u3088\u3046\u306a\u30eb\u30fc\u30d7\u3084\u30bf\u30fc\u30f3\u3001\u6e26\u5dfb\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f <\/span><i><span style=\"font-weight: 400;\">\u30a8\u30f3\u30c9\u30ec\u30b9<\/span><\/i><span style=\"font-weight: 400;\"> \u30a2\u30c7\u30cb\u30f3(A)\u3001\u30b7\u30c8\u30b7\u30f3(C)\u3001\u30c1\u30df\u30f3(T)\u3001\u30b0\u30a2\u30cb\u30f3(G)\u3068\u3044\u3046\u5869\u57fa\u5bfe\u306e\u6587\u5b57\u5217\u304c\u3001\u6838\u5185\u3067\u7570\u306a\u308b\u30c8\u30dd\u30ed\u30b8\u30fc\u3092\u5f62\u6210\u3057\u306a\u304c\u3089\u3001\u5916\u898b\u4e0a\u306e\u5909\u5316\u306b\u5bfe\u5fdc\u3057\u3066\u3044\u308b\u3053\u3068\u3002\u3053\u308c\u3089\u306f\u3001\u7d30\u80de\u306e\u7a2e\u985e\u306b\u5fdc\u3058\u3066\u3001\u30af\u30ed\u30de\u30c1\u30f3\u30eb\u30fc\u30d7\u3001\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\/\u30b5\u30d6\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u3001\u30c9\u30e1\u30a4\u30f3\/\u30b5\u30d6\u30c9\u30e1\u30a4\u30f3\u3092\u5f62\u6210\u3057\u3001\u76ee\u7684\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002(\u795e\u7d4c\u7d30\u80de\u306f\u7b4b\u8089\u7d30\u80de\u3068\u306f\u5225\u306e\u4ed5\u4e8b\u3092\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u305e\u308c\u304c\u5c02\u7528\u306e\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u308b\uff09\u3002<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-6903 size-full\" src=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure2.jpg\" alt=\"\" width=\"685\" height=\"644\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure2.jpg 685w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure2-300x282.jpg 300w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure2-24x24.jpg 24w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure2-300x282@2x.jpg 600w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure2-24x24@2x.jpg 48w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><br \/>\n<em>\u30b2\u30ce\u30e0\u306f\u30b3\u30a4\u30eb\u72b6\u306b\u306a\u3063\u3066\u3044\u3066\u3001\u76ee\u7684\u306e\u7a7a\u9593\u306b\u5e83\u304c\u3063\u3066\u3044\u308b\u3002(\u30af\u30ec\u30b8\u30c3\u30c8: https:\/\/doi.org\/10.1038\/nrg.<\/em><br \/>\n<em>2016.112)<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Pathway_Databases\"><\/span><b>\u30d1\u30b9\u30a6\u30a7\u30a4\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u69d8\u3005\u306a\u30aa\u30f3\u30c8\u30ed\u30b8\u30fc\u3084\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u4e2d\u3067\u3082Kyoto Encyclopedia of Genes and Genomes (KEGG) (<\/span><a href=\"https:\/\/www.genome.jp\/kegg\/\"><span style=\"font-weight: 400;\">https:\/\/www.genome.jp\/kegg\/<\/span><\/a><span style=\"font-weight: 400;\">)\u3068Gene Ontology(<\/span><a href=\"http:\/\/geneontology.org\/\"><span style=\"font-weight: 400;\">http:\/\/geneontology.org\/<\/span><\/a><span style=\"font-weight: 400;\">\u6b21\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u3067\u8aac\u660e\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u30c4\u30fc\u30eb\uff08\u305d\u3057\u3066\u591a\u304f\u306e\u5834\u5408\u3001\u610f\u898b\u304c\u5206\u304b\u308c\u3066\u3044\u308b\uff09\u306f\u3001\u4e0a\u8a18\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304b\u3089\u300c\u9078\u629e\u7684\u306b\u300d\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u7528\u8a9e\u3092\u751f\u307f\u51fa\u3057\u307e\u3059\u3002\u305d\u308c\u3089\u306e\u7d71\u8a08\u7684\u6709\u610f\u6027\u306e\u5024\u306b\u57fa\u3065\u3044\u3066\u3001\u305d\u308c\u3089\u304c\u672c\u5f53\u306b\u30ea\u30b9\u30c8\u30a2\u30c3\u30d7\u3055\u308c\u305f\u8868\u73fe\u578b\u3092\u8868\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u308c\u3068\u3082\u5358\u306a\u308b\u30e9\u30f3\u30c0\u30e0\u306a\u5c55\u958b\u306e\u554f\u984c\u306a\u306e\u304b\u304c\u5c0e\u304d\u51fa\u3055\u308c\u308b\u306e\u3067\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">\u7d71\u8a08\u7684\u6709\u610f\u6027<\/span><\/i><span style=\"font-weight: 400;\">.\u4ee5\u4e0b\u306e\u30ea\u30f3\u30af\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002 <\/span><a href=\"https:\/\/sway.office.com\/WkyHrPnVB8Ec3zPD?play\"><span style=\"font-weight: 400;\">https:\/\/sway.office.com\/WkyHrPnVB8Ec3zPD?play<\/span><\/a><span style=\"font-weight: 400;\"> \u3092\u3054\u5229\u7528\u3044\u305f\u3060\u3051\u307e\u3059\u3002\uff09<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Enrichment_Tools\"><\/span><b>\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u30c4\u30fc\u30eb<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u5206\u6790\u306f\u3001\u8a08\u7b97\u30d7\u30ed\u30c8\u30b3\u30eb\u306e <\/span><i><span style=\"font-weight: 400;\">\u30ce\u30dc<\/span><\/i><span style=\"font-weight: 400;\"> \u30b2\u30ce\u30e0\u9818\u57df\u3092\u3001\u3053\u308c\u307e\u3067\u8a00\u53ca\u3057\u3066\u304d\u305f\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u8a18\u9332\u3055\u308c\u3066\u3044\u308b\u5b9a\u7fa9\u306b\u7167\u3089\u3057\u5408\u308f\u305b\u307e\u3059\u3002\u305d\u306e\u30c4\u30fc\u30eb\u3068\u306f\u3001\u904e\u5270\u767a\u73fe\u89e3\u6790\uff08ORA\uff09\u3001\u6a5f\u80fd\u30af\u30e9\u30b9\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0\uff08FCS\uff09\u3001\u7d4c\u8def\u30c8\u30dd\u30ed\u30b8\u30fc\uff08PT\uff09\u306b\u57fa\u3065\u304f\u65b9\u6cd5\u3001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u76f8\u4e92\u4f5c\u7528\uff08NI\uff09\u306b\u57fa\u3065\u304f\u65b9\u6cd5\u306a\u3069\u3067\u3042\u308b\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Over_Representation_Analysis\"><\/span><b>\u904e\u5270\u8868\u73fe\u306e\u5206\u6790<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u904e\u5270\u767a\u73fe\u89e3\u6790\u3067\u306f\u3001\u8d85\u5e7e\u4f55\u5206\u5e03\u306e\u30c9\u30b0\u30de\u3092\u4ecb\u3057\u3066\u3001\u751f\u7269\u5b66\u7684\u7d4c\u8def\u306e\u4e00\u90e8\u3067\u3042\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5dee\u52d5\u767a\u73fe\u907a\u4f1d\u5b50\u306e\u30bb\u30c3\u30c8\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002\u57fa\u672c\u7684\u306b\u3001\u8d85\u5e7e\u4f55\u5b66\u7684\u691c\u5b9a\u3067\u306f\u3001\u4ee5\u4e0b\u306e4\u3064\u306e\u5c5e\u6027\u3092\u8003\u616e\u3057\u3066\u5224\u5b9a\u3092\u884c\u3044\u307e\u3059\u3002<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u8003\u616e\u3055\u308c\u305f\u30a2\u30c3\u30bb\u30a4\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u306e\u5408\u8a08\u6570\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u767a\u73fe\u91cf\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u3092<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u5168\u907a\u4f1d\u5b50\u6570\u306e\u3046\u3061\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308b\u30d1\u30b9\u30a6\u30a7\u30a4\u306b\u542b\u307e\u308c\u308b\u907a\u4f1d\u5b50\u3001\u304a\u3088\u3073<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u30bf\u30fc\u30b2\u30c3\u30c8\u30d1\u30b9\u30a6\u30a7\u30a4\u3067\u767a\u751f\u3059\u308b\u5dee\u52d5\u7684\u306b\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u3002<\/span><\/li>\n<\/ol>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-6902 size-large\" src=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3-1024x576.jpg\" alt=\"\" width=\"702\" height=\"395\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3-1024x576.jpg 1024w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3-300x169.jpg 300w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3-768x432.jpg 768w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3-1536x864.jpg 1536w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3-1080x608.jpg 1080w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3.jpg 2000w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure3-300x169@2x.jpg 600w\" sizes=\"(max-width: 702px) 100vw, 702px\" \/><br \/>\n<em>\u8d85\u5e7e\u4f55\u5b66\u7684\u691c\u5b9a\u306e\u672c\u8cea<\/em><\/p>\n<p><span style=\"font-weight: 400;\">ORA\u306f\u30b7\u30f3\u30d7\u30eb\u3067\u308f\u304b\u308a\u3084\u3059\u3044\u624b\u6cd5\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u305d\u306e\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><b><i>\u6c11\u4e3b\u4e3b\u7fa9\u306e\u5b9f\u73fe\u3001\u3059\u3079\u3066\u306e\u907a\u4f1d\u5b50\u304c\u5e73\u7b49\u306b\u8003\u616e\u3055\u308c\u308b<\/i><\/b><span style=\"font-weight: 400;\">\u306a\u305c\u305d\u308c\u304c\u554f\u984c\u306a\u306e\u304b\uff1f\u4eee\u306b\u3001\u907a\u4f1d\u5b50\u304c\u4ee5\u4e0b\u306e\u57fa\u6e96\u3067\u30d5\u30a3\u30eb\u30bf\u30ea\u30f3\u30b0\u3055\u308c\u3066\u3044\u308b\u3068\u3057\u307e\u3057\u3087\u3046\u3002 <\/span><b>\u30d5\u30a9\u30fc\u30eb\u30c9\u30c1\u30a7\u30f3\u30b8<\/b><span style=\"font-weight: 400;\">.\u30cd\u30ac\u30c6\u30a3\u30d6\u3001\u30dd\u30b8\u30c6\u30a3\u30d6\u4e21\u65b9\u306e\u65b9\u5411\u3067\u30012\u500d\u4ee5\u4e0a\u306e\u767a\u73fe\u5dee\u3092\u6301\u3064\u907a\u4f1d\u5b50\u3092\u9078\u5225\u3057\u307e\u3059\u3002\u6700\u4f4e\u3067\u30822\u500d\u3068\u3057\u305f\u304c\u30013\u500d\u30014\u500d\u3001\u305d\u308c\u4ee5\u4e0a\u306e\u767a\u73fe\u5909\u5316\u304c\u3042\u308b\u907a\u4f1d\u5b50\u3082\u5bfe\u8c61\u3068\u3059\u308b\u3002\u78ba\u304b\u306b\u3001\u767a\u73fe\u91cf\u304c2\u500d\u306e\u907a\u4f1d\u5b50\u3088\u308a\u30824\u500d\u306e\u5dee\u304c\u3042\u308b\u907a\u4f1d\u5b50\u306e\u65b9\u304c\u614e\u91cd\u306b\u306a\u308b\u3002\u3053\u306e\u9855\u5728\u5316\u306f\u3001ORA\u3067\u306f\u5272\u5f15\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\"><b><i>\u6700\u3082\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u307f\u3092\u8003\u616e\u3059\u308b<\/i><\/b><span style=\"font-weight: 400;\">\u3053\u3053\u3067\u3082\u3001fold-change\u304c1.9999\u3001p\u5024\u304c0.0051113\u306e\u907a\u4f1d\u5b50\u3092\u8003\u3048\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u4e00\u822c\u7684\u306b\u306f\u3001p\u5024\u304c0.05\u672a\u6e80\u3067\u3042\u308c\u3070\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002ORA\u306e\u624b\u6cd5\u3067\u306f\u3001\u6700\u7d42\u7d50\u679c\u3067\u3053\u306e\u907a\u4f1d\u5b50\u3092\u7121\u8996\u3057\u3066\u3044\u307e\u3059\u3002\u660e\u3089\u304b\u306b\u3001\u60c5\u5831\u306e\u640d\u5931\u3068\u67d4\u8edf\u6027\u306e\u6b20\u5982\u304c\u3042\u308a\u307e\u3059\u3002(P.S. Breitling\u3089\u306f\u3001\u95be\u5024\u3092\u907f\u3051\u308b\u305f\u3081\u306e\u5916\u633f\u6cd5\u3092\u63d0\u6848\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u82e6\u5883\u306b\u5bfe\u51e6\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u4fee\u6b63\u3067\u306f\u3001\u4e00\u5ea6\u306b1\u3064\u306e\u907a\u4f1d\u5b50\u3092\u8ffd\u52a0\u3057\u3066\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u304c\u6700\u9069\u306b\u91cd\u8981\u3067\u3042\u308b\u907a\u4f1d\u5b50\u306e\u30bb\u30c3\u30c8\u3092\u30b3\u30f3\u30d1\u30a4\u30eb\u3059\u308b\u53cd\u5fa9\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63a1\u7528\u3057\u3066\u3044\u308b)\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\"><b><i>\u5b64\u7acb\u3057\u3066\u50cd\u304f\u907a\u4f1d\u5b50\u306f\u306a\u3044<\/i><\/b><span style=\"font-weight: 400;\">\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3092\u72ec\u7acb\u3057\u305f\u5b58\u5728\u3068\u3057\u3066\u6271\u3046\u3068\u3001\u8868\u73fe\u578b\u306b\u5bfe\u3059\u308b\u591a\u907a\u4f1d\u5b50\u306e\u8ca2\u732e\u306e\u672c\u8cea\u3092\u898b\u5931\u3063\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u3001\u524d\u8ff0\u306e\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002 <\/span><i><span style=\"font-weight: 400;\">\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u306e\u76ee\u7684\u306e\u4e00\u3064\u306f\u3001\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u304c\u4e00\u81f4\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u30b3\u30db\u30fc\u30c8\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u306e\u30b7\u30f3\u30d5\u30a9\u30cb\u30fc\u306f\u3001\u6a5f\u80fd\u7684\u306b\u985e\u4f3c\u3057\u305f\u907a\u4f1d\u5b50\u3084\u3001\u5171\u901a\u306e\u751f\u7269\u5b66\u7684\u72b6\u614b\u306b\u5411\u304b\u3063\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3092\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\"><b><i>\u76f8\u4e92\u306b\u72ec\u7acb\u3057\u305f\u30d1\u30b9\u30a6\u30a7\u30a4<\/i><\/b><span style=\"font-weight: 400;\">ORA\u306f\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u304c\u9023\u7d9a\u3057\u3066\u6a5f\u80fd\u3057\u306a\u3044\u3053\u3068\u3082\u60f3\u5b9a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u4e00\u9023\u306e\u5316\u5b66\u53cd\u5fdc\u304c\u4e92\u3044\u306b\u5148\u884c\u3057\u305f\u308a\u9032\u884c\u3057\u305f\u308a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u70b9\u3067\u3001\u5927\u304d\u306a\u6b20\u9665\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Functional_Class_Scoring\"><\/span><b>\u6a5f\u80fd\u30af\u30e9\u30b9\u306e\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">ORA\u3068\u306f\u9006\u306b\u3001FCS\u6cd5\u306f\u3059\u3079\u3066\u306e\u30b3\u30f3\u30c6\u30af\u30b9\u30c8\u907a\u4f1d\u5b50\u3068\u305d\u306e\u95a2\u9023\u7d71\u8a08\uff08fold-change, p-value\uff09\u3092\u5305\u542b\u3057\u3066 <\/span><i><span style=\"font-weight: 400;\">\u30e9\u30f3\u30cb\u30f3\u30b0<\/span><\/i><span style=\"font-weight: 400;\"> \u907a\u4f1d\u5b50\u30b0\u30eb\u30fc\u30d7\u306e\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u30b9\u30b3\u30a2\uff08Gene Ontology\u3084KEGG\u30d1\u30b9\u30a6\u30a7\u30a4\u306e\u3088\u3046\u306a\u6a5f\u80fd\u7684\u77e5\u8b58\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\uff09\u3002<\/span><a href=\"http:\/\/software.broadinstitute.org\/gsea\/index.jsp\"><span style=\"font-weight: 400;\">http:\/\/software.broadinstitute.org\/gsea\/index.jsp<\/span><\/a><span style=\"font-weight: 400;\">).\u5178\u578b\u7684\u306aFCS\u306e\u5b9f\u884c\u3067\u306f\u3001\u5b9f\u9a13\u3067\u7570\u306a\u308b\u767a\u73fe\u3092\u3057\u305f\u907a\u4f1d\u5b50\u306e\u30ea\u30b9\u30c8\uff08\u7d71\u8a08\u7684\u6709\u610f\u6027\u306a\u3069\u306b\u3088\u308b\u30e9\u30f3\u30ad\u30f3\u30b0\u3067\u306f\u306a\u3044\uff09\u306b\u542b\u307e\u308c\u308b\u5168\u4f53\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5909\u5316\u3092\u5206\u6790\u3059\u308b\u3002\u907a\u4f1d\u5b50\u30bb\u30c3\u30c8\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u89e3\u6790\u306e\u4e3b\u306a\u7d50\u679c\u306f\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u30b9\u30b3\u30a2\uff08ES\uff09\u3067\u3042\u308a\u3001\u3042\u308b\u907a\u4f1d\u5b50\u30bb\u30c3\u30c8\u304c\u30e9\u30f3\u30af\u4ed8\u3051\u3055\u308c\u305f\u907a\u4f1d\u5b50\u30ea\u30b9\u30c8\u306e\u4e0a\u90e8\u307e\u305f\u306f\u4e0b\u90e8\u306b\u904e\u5270\u306b\u5b58\u5728\u3059\u308b\u5ea6\u5408\u3044\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u3002ES\u30b9\u30b3\u30a2\u304c\u6b63\u3057\u3051\u308c\u3070\u3001\u907a\u4f1d\u5b50\u30bb\u30c3\u30c8\uff08\u307e\u305f\u306f\u30bf\u30fc\u30b2\u30c3\u30c8\u30d1\u30b9\u30a6\u30a7\u30a4\u3002 <\/span><i><span style=\"font-weight: 400;\">GS<\/span><\/i><span style=\"font-weight: 400;\">)\u306f\u3001\u30ea\u30b9\u30c8\u306e\u907a\u4f1d\u5b50\u3092\u793a\u3059\u3053\u3068\u306b\u306a\u308a\u307e\u3059(<\/span><i><span style=\"font-weight: 400;\">GL<\/span><\/i><span style=\"font-weight: 400;\">ES \u30b9\u30b3\u30a2\u304c\u30de\u30a4\u30ca\u30b9\u306e\u5834\u5408\u306f\u3001\u69cb\u6210\u907a\u4f1d\u5b50\u304c\u4e0b\u4f4d\u306b\u4f4d\u7f6e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\uff08n-3, n-2, n-1, n, n, \u3053\u3053\u3067 n \u306f\u907a\u4f1d\u5b50\u306e\u7dcf\u6570\uff09\u3002P.S. ES\u306fmultiple testing\u306e\u554f\u984c\uff08false discovery rate\u3001\u4f8b\uff09\u3092\u88dc\u6b63\u3059\u308b\u3068normalised ES\uff08NES\uff09\u3068\u306a\u308b\u3002 <\/span><i><span style=\"font-weight: 400;\">\u30dc\u30f3\u30d5\u30a7\u30ed\u30fc\u30cb\u6cd5<\/span><\/i><span style=\"font-weight: 400;\">).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u8981\u7d04\u3059\u308b\u3068\u3001FCS\u306e\u624b\u6cd5\u306f\u3001\u4ee5\u4e0b\u306e\u70b9\u3067ORA\u306e\u624b\u6cd5\u3088\u308a\u3082\u512a\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u907a\u4f1d\u5b50\u3092\u6709\u610f\u304b\u975e\u6709\u610f\u304b\u306b\u5206\u985e\u3059\u308b\u305f\u3081\u306e\u6063\u610f\u7684\u306a\u95be\u5024\u306e\u5fc5\u8981\u6027\u3092\u6392\u9664\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u30d1\u30b9\u30a6\u30a7\u30a4\u306e\u7cfb\u7d71\u7684\u306a\u5909\u5316\u3092\u8ffd\u8de1\u3059\u308b\u305f\u3081\u306b\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f9d\u5b58\u6027\u306b\u95a2\u3059\u308b\u8aac\u660e\u8cac\u4efb\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u3057\u304b\u3057\u3001FCS\u306e\u624b\u6cd5\u306b\u3082\u3044\u304f\u3064\u304b\u306e\u6b20\u70b9\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u30d1\u30b9\u30a6\u30a7\u30a4\u306f\u72ec\u7acb\u3057\u3066\u89e3\u6790\u3055\u308c\u308b\u305f\u3081\u3001\u8907\u6570\u306e\u30d1\u30b9\u30a6\u30a7\u30a4\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u304c\u30ab\u30a6\u30f3\u30c8\u3055\u308c\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u591a\u304f\u306e FCS \u6cd5\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u306b\u57fa\u3065\u3044\u3066\u30ea\u30b9\u30c8\u5185\u306e\u907a\u4f1d\u5b50\u3092\u30e9\u30f3\u30af\u4ed8\u3051\u3059\u308b\u3002\u767a\u73fe\u91cf\u306e\u4e0d\u5747\u7b49\uff08\u6307\u6570\u95a2\u6570\u7684\u304b\u3082\u3057\u308c\u306a\u3044\uff09\u306a\u3070\u3089\u3064\u304d\u3092\u30e9\u30f3\u30af\u306e\u5dee\u306b\u53cd\u6620\u3055\u305b\u308b\u3068\u3044\u3046\u30b7\u30ca\u30ea\u30aa\u306f\u3001\u304a\u305d\u3089\u304f\u4e0d\u516c\u5e73\u306a\u6e2c\u5b9a\u306b\u306a\u308b\u3060\u308d\u3046\u3002<\/span><\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-6910 size-large\" src=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-1024x898.png\" alt=\"\" width=\"702\" height=\"616\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-1024x898.png 1024w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-300x263.png 300w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-768x674.png 768w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-1536x1348.png 1536w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-1080x947.png 1080w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-110x96.png 110w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4.png 2005w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-300x263@2x.png 600w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure4-110x96@2x.png 220w\" sizes=\"(max-width: 702px) 100vw, 702px\" \/><\/p>\n<p><em>\u907a\u4f1d\u5b50\u30ea\u30b9\u30c8\u306b\u95a2\u9023\u3059\u308bES\u30b9\u30b3\u30a2\u3092\u6b63\u898f\u5316\u3059\u308b\u3002<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Pathway_Topology_based_Approaches\"><\/span><b>\u30d1\u30b9\u30a6\u30a7\u30a4\u30fb\u30c8\u30dd\u30ed\u30b8\u30fc\u306b\u57fa\u3065\u304f\u30a2\u30d7\u30ed\u30fc\u30c1<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">ORA\u3084FCS\u306e\u624b\u6cd5\u3067\u306f\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u306e\u69cb\u9020\u3092\u7121\u8996\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u6c7a\u5b9a\u7684\u306a\u5f31\u70b9\u3067\u3059\u3002\u30d1\u30b9\u30a6\u30a7\u30a4\u3067\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u9806\u756a\u306f\u3001\u56e0\u679c\u95a2\u4fc2\u3092\u8ffd\u8de1\u3059\u308b\u306e\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u5f53\u7136\u306e\u3053\u3068\u306a\u304c\u3089\u3001\u540c\u3058\u907a\u4f1d\u5b50\u6210\u5206\u3092\u6301\u3064\u30d1\u30b9\u30a6\u30a7\u30a4\u304c\u5168\u304f2\u3064\u5b58\u5728\u3057\u3066\u3082\u3001\u6d3b\u6027\u5316\u306e\u968e\u5c64\u306f\u5168\u304f\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002ORA\/FCS\u306e\u624b\u6cd5\u3067\u3042\u308c\u3070\u3001\u4f3c\u305f\u3088\u3046\u306a\u6fc3\u7e2e\u9805\u306b\u306a\u3063\u3066\u3044\u305f\u306f\u305a\u3067\u3059\u3002\u305d\u308c\u304c\u554f\u984c\u306a\u306e\u3067\u3059\u3002Pathway Topology(PT)\u6cd5\u306f\u3001\u7279\u5b9a\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u6a5f\u80fd\u304c\u6392\u4ed6\u7684\u306b\u306a\u308b\u3053\u3068\u3092\u524d\u63d0\u3068\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u4e00\u822c\u7684\u306a\u8ad6\u7406\u306b\u3082\u5408\u81f4\u3057\u3066\u3044\u307e\u3059\u3002\u30c4\u30fc\u30eb\u306e\u4f8b\u3068\u3057\u3066\u306f\u3001SPIA (<\/span><a href=\"https:\/\/www.bioconductor.org\/packages\/release\/bioc\/manuals\/SPIA\/man\/SPIA.pdf\"><span style=\"font-weight: 400;\">https:\/\/www.bioconductor.org\/packages\/release\/bioc\/manuals\/SPIA\/man\/SPIA.pdf<\/span><\/a><span style=\"font-weight: 400;\">)\u3001GGEA\u3001PARADIGM\u306a\u3069\u304c\u3042\u308b\u3002\u4e00\u822c\u306b\u3001\u3053\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306e\u30c4\u30fc\u30eb\u306f\u3001\u30ed\u30fc\u30ab\u30eb\u30b9\u30b3\u30a2\u3068\u30b0\u30ed\u30fc\u30d0\u30eb\u30b9\u30b3\u30a2\u3092\u6301\u3064\u3002\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e\u30ed\u30fc\u30ab\u30eb\u30b9\u30b3\u30a2\u306f\u3001\u305d\u306e\u907a\u4f1d\u5b50\u3068\u4e0a\u6d41\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u306e\u500d\u6570\u5909\u5316\u3092\u6821\u6b63\u3057\u3001\u30b0\u30ed\u30fc\u30d0\u30eb\u30b9\u30b3\u30a2\u306f\u3001\u907a\u4f1d\u5b50\u30bb\u30c3\u30c8\u3068\u306e\u95a2\u9023\u6027\u3092\u793a\u3059\u30d1\u30b9\u30a6\u30a7\u30a4\u30ec\u30d9\u30eb\u306e\u6307\u6a19\u3068\u306a\u308b\u3002\u3057\u304b\u3057\u3001PT\u6cd5\u3067\u306f\u3001\u7279\u5b9a\u306e\u72b6\u614b\u3084\u7d30\u80de\u30bf\u30a4\u30d7\u306e\u30c7\u30fc\u30bf\u3092\u30aa\u30fc\u30d0\u30fc\u30d5\u30a3\u30c3\u30c8\u3055\u305b\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308b\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Network_Interaction_based_Analysis\"><\/span><b>\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30fb\u30a4\u30f3\u30bf\u30e9\u30af\u30b7\u30e7\u30f3\u306b\u57fa\u3065\u304f\u5206\u6790<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u3053\u308c\u306f\u3001\u53e4\u304f\u304b\u3089\u3042\u308b\u624b\u6cd5\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u307e\u3060\u307b\u3068\u3093\u3069\u5b9f\u65bd\u3055\u308c\u3066\u3044\u306a\u3044\u63a7\u3048\u3081\u306a\u30ab\u30c6\u30b4\u30ea\u30fc\u3067\u3059\u3002EnrichNet , NetPEA ()\u306e\u3088\u3046\u306a\u624b\u6cd5\u304c\u3042\u308a\u307e\u3059\u3002<\/span><a href=\"http:\/\/www.dx.doi.org\/10.1109\/BIBM.2013.6732493\"><span style=\"font-weight: 400;\">http:\/\/www.dx.doi.org\/10.1109\/BIBM.2013.6732493<\/span><\/a><span style=\"font-weight: 400;\">) have been proposed close to a decade ago, but they haven\u2019t gained much traction because of limited tools available. This facade constraints the dexterity of the theme as no improvements are documented. That turns out to be an open-ended <a href=\"https:\/\/www.kolabtree.com\/blog\/ja\/ensuring-reproducibility-in-ai-driven-research-how-freelance-experts-can-help-in-biotech-and-healthcare\/\">\u30ea\u30b5\u30fc\u30c1<\/a> problem.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_apparent_Panacea\"><\/span><b>\u898b\u304b\u3051\u4e0a\u306f <\/b><b><i>\u4e07\u80fd\u85ac<\/i><\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u30d5\u30a1\u30f3\u30c0\u30e1\u30f3\u30bf\u30eb\u30fb\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\/\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u3068\u3001\u305d\u308c\u3092\u652f\u63f4\u3059\u308b\u30c4\u30fc\u30eb\u306e\u7a2e\u985e\u306b\u3064\u3044\u3066\u306f\u3001\u3082\u3046\u304a\u5206\u304b\u308a\u3044\u305f\u3060\u3051\u305f\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5148\u306b\u8ff0\u3079\u305f\u3088\u3046\u306b\u3001\u5229\u7528\u53ef\u80fd\u306a\u3059\u3079\u3066\u306e\u30c4\u30fc\u30eb\uff08\u30de\u30fc\u30af\u3055\u308c\u305f\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u3082\u306e\uff09\u306f\u3001\u8cea\u554f\u3055\u308c\u305f\u9818\u57df\u3092\u6a2a\u5207\u308b\u7dda\u5f62\u306e\u7a93\u306e\u6b6a\u3093\u3060\u30d1\u30e9\u30e1\u30fc\u30bf\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u30b2\u30ce\u30e0\u306e\u4ecb\u5728\u3059\u308b\u30bb\u30b0\u30e1\u30f3\u30c8\u304c\u3053\u306e\u30d5\u30ec\u30fc\u30e0\u306b\u5165\u308b\u5834\u5408\u3001\u305d\u308c\u3089\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u30ea\u30b9\u30c8\u3055\u308c\u307e\u3059\u3002 <\/span><b><i>\u30a8\u30f3\u30ea\u30c3\u30c1\u30c9<\/i><\/b><span style=\"font-weight: 400;\">\u305d\u3046\u3067\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u672c\u5f53\u306e\u610f\u5473\u3067\u306e\u30c4\u30fc\u30eb\u306f\u3001\u304a\u305d\u3089\u304f\u3001\u5165\u529b\u3057\u305f\u3082\u306e\u3092 <\/span><i><span style=\"font-weight: 400;\">\u30bb\u30f3\u30bf\u30fc<\/span><\/i><span style=\"font-weight: 400;\"> \u305d\u3057\u3066 <\/span><i><span style=\"font-weight: 400;\">\u76f4\u5f84<\/span><\/i><span style=\"font-weight: 400;\"> \u4eee\u5b9a\u306e\u5186\u306e\u4e2d\u3067\u3001\u305d\u306e\u9818\u57df\u306e\u30b2\u30ce\u30e0\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u57fa\u3065\u304f3\u6b21\u5143\u7d44\u7e54\u3092\u5f37\u8abf\u3059\u308b\u3088\u3046\u306b\u3002<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-6905 size-full\" src=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5a.png\" alt=\"\" width=\"811\" height=\"599\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5a.png 811w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5a-300x222.png 300w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5a-768x567.png 768w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5a-300x222@2x.png 600w\" sizes=\"(max-width: 811px) 100vw, 811px\" \/><br \/>\n<i><span style=\"font-weight: 400;\">GREAT\u306b\u306f\u3001\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u958b\u59cb\u70b9\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u76f4\u7dda\u7684\u306a\u5bf8\u6cd5\u3092\u6307\u5b9a\u3059\u308b\u305f\u3081\u306e\u3044\u304f\u3064\u304b\u306e\u30aa\u30d7\u30b7\u30e7\u30f3\u304c\u7528\u610f\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/i><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-6906 size-full\" src=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5b.png\" alt=\"\" width=\"774\" height=\"523\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5b.png 774w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5b-300x203.png 300w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5b-768x519.png 768w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2020\/02\/Figure5b-300x203@2x.png 600w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><i><span style=\"font-weight: 400;\">Enrichr\u3067\u306f\u3001\u30b2\u30ce\u30e0\u306e\u7a2e\u985e\u3068\u63a8\u5b9a\u3055\u308c\u308b\u7dda\u5f62\u9818\u57df\u306e\u907a\u4f1d\u5b50\u6570\u3092\u7c21\u5358\u306b\u9078\u629e\u3067\u304d\u307e\u3059\u3002<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">\u56f34\u304b\u3089\u63a8\u6e2c\u3055\u308c\u308b\u3088\u3046\u306b\u3001\u30b2\u30ce\u30e0\u306e\u300c\u771f\u306e\u300d\u7a7a\u9593\u7684\u69cb\u6210\u306b\u3064\u3044\u3066\u306f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u308c\u306f\u3001\u73fe\u5728\u306e\u30a8\u30f3\u30ea\u30c3\u30c1\u30e1\u30f3\u30c8\u89e3\u6790\u306e\u9818\u57df\u306b\u6b8b\u3063\u3066\u3044\u308b\u554f\u984c\u3067\u3042\u308a\u3001\u6df1\u3044\u65ad\u5c64\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u6b21\u306e\u3088\u3046\u306a\u91cd\u5927\u306a\u95a2\u9023\u6027\u3082\u3042\u308a\u307e\u3059\u3002 <\/span><b>\u8ee2\u5199\u5de5\u5834<\/b><span style=\"font-weight: 400;\">\u306f\u3001\u96e2\u308c\u305f\u5834\u6240\u306b\u3042\u308b\u5236\u5fa1\u56e0\u5b50\u3092\u300c\u793e\u5185\u30d1\u30fc\u30c6\u30a3\u30fc\u300d\u306b\u8a98\u3046\u6838\u7a7a\u9593\u306e\u30b5\u30a4\u30c8\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u5197\u8ac7\u3081\u304b\u3057\u3066\u3088\u304f\u8a00\u3046\u306e\u3067\u3059\u304c\u3001\u8ab0\u304b\u3084\u4f55\u304b\u306b\u8179\u3092\u7acb\u3066\u3066\u3044\u308b\u4eba\u304c\u666e\u901a\u306b\u8a00\u3046\u3088\u3046\u306b\u3001\u8ee2\u5199\u5de5\u5834\uff08\u64ec\u4eba\u5316\uff09\u304c\u30b2\u30ce\u30e0\u3092\u53f1\u8cac\u3059\u308b\u3053\u3068\u306f\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><i><span style=\"font-weight: 400;\">\u66f8\u304d\u53d6\u308a\u306f\u79c1\u306e\u6b7b\u4f53\u306e\u4e0a\u3067\u884c\u308f\u308c\u307e\u3059\u304c\u3001\u4ed6\u306b\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/i><span style=\"font-weight: 400;\">\".\u8ee2\u5199\u30d5\u30a1\u30af\u30c8\u30ea\u30fc\u3068\u3044\u3046\u96a3\u63a5\u3057\u305f\u30c6\u30fc\u30de\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u96a3\u63a5\u3057\u305f\u5c06\u6765\u306e\u8b70\u8ad6\u306e\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u30c6\u30fc\u30de\u306f\u3001\u73fe\u4ee3\u306e\u5b9f\u52d9\u306b\u304a\u3044\u3066\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u30b7\u30b9\u30fb\u30ec\u30ae\u30e5\u30ec\u30fc\u30bf\u30fc\u76f8\u4e92\u4f5c\u7528\u306e\u30c9\u30b0\u30de\u3092\u5177\u4f53\u5316\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6700\u5f8c\u306b\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u306f\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308a\u306a\u304c\u3089\u7121\u8996\u3055\u308c\u304c\u3061\u306a\u90e8\u5206\u3067\u3042\u308b\u3053\u3068\u3092\u6307\u6458\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002 <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/bioinformatics?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9<\/a> \u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u9032\u5316\u3057\u7d9a\u3051\u308b\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u306b\u5408\u308f\u305b\u3066\u3001\u65e2\u5b58\u306e\u65b9\u6cd5\u8ad6\u3092\u62e1\u5f35\u3059\u308b\u4f59\u5730\u306f\u5e38\u306b\u3042\u308a\u307e\u3059\u3002\u81a8\u5927\u306a\u91cf\u306e\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u3001\u30a4\u30f3\u30d5\u30e9\u306e\u554f\u984c\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306e\u554f\u984c\u3082\u767a\u751f\u3057\u3066\u304d\u307e\u3059\u3002<\/span><\/p>\n<p><strong>\u304c\u5fc5\u8981\u3067\u3059\u3002 <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/bioinformatics?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u306e\u30b3\u30f3\u30b5\u30eb\u30bf\u30f3\u30c8\u3092\u96c7\u3046<\/a>?Kolabtree\u3067\u30d5\u30ea\u30fc\u30e9\u30f3\u30b9\u306e\u79d1\u5b66\u8005\u3068\u4ed5\u4e8b\u3092\u3057\u3066\u307f\u307e\u305b\u3093\u304b\uff1f\u7121\u6599\u3067\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u6295\u7a3f\u3057\u3001\u5c02\u9580\u5bb6\u304b\u3089\u898b\u7a4d\u3082\u308a\u3092\u3082\u3089\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<br \/>\n<\/strong><\/p>\n<p><strong>\u95a2\u9023\u3059\u308b\u5c02\u9580\u5bb6\u00a0<\/strong><\/p>\n<p><a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/Bioinformatics?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u30fb\u30d5\u30ea\u30fc\u30e9\u30f3\u30b5\u30fc<\/a> | <a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/Plant-Genetics?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u690d\u7269\u907a\u4f1d\u5b66<\/a> | <a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/Developmental-Biology?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u767a\u751f\u751f\u7269\u5b66<\/a> | <a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/Gene-Therapy?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u907a\u4f1d\u5b50\u6cbb\u7642<\/a> | <a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/Stem-Cells?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u5e79\u7d30\u80de <\/a>|<br \/>\n<a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/DNA-Sequencing-Data-Analysis?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">DNA\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u30c7\u30fc\u30bf\u306e\u89e3\u6790<\/a> |<a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/Animal-Genetics?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u52d5\u7269\u907a\u4f1d\u5b66<\/a> |<a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/Drug-Interactions?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\"> \u85ac\u7269\u76f8\u4e92\u4f5c\u7528<\/a> | <a href=\"http:\/\/www.kolabtree.com\/find-an-expert\/subject\/genetics-and-genomics?utm_source=Blog&amp;utm_medium=Post&amp;utm_campaign=PathwayAnalysis\">\u907a\u4f1d\u5b66\u30fb\u30b2\u30ce\u30df\u30af\u30b9\u00a0<\/a><\/p>\n<p><strong>\u00a0<\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>Computational biologist and Kolabtree freelancer Shaurya Jauhari writes about current challenges involved in conducting pathway analysis in bioinformatics and possible solutions to the problem.\u00a0 In the contrasting era of &#8220;Imprecise Medicine&#8221; (propelling us to tune towards Precision Medicine) and inundation of biomedical data brought forth by advancements in instrumentation technologies, a lacuna persists that is largely premised over mapping data to information. The clinical experiments engender biomarkers (technically list of genes or genomic regions more contemporarily) that have to be expounded for their biological implications. The current suite of tools that facilitate such an endeavor is less purposeful as it neglects the ipso facto, spatial interactions of the genome given<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/\" title=\"\u7d9a\u304d\u3092\u8aad\u3080\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/div>","protected":false},"author":12,"featured_media":6908,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[442,398,435],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pathway Analysis in Bioinformatics: Mapping Data to Information<\/title>\n<meta name=\"description\" content=\"The shotcomings of tools used in pathway analysis and possible solutions, written by bioinformatics expert and computational biologist Shaurya Jauhari.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pathway Analysis in Bioinformatics: Mapping Data to Information\" \/>\n<meta property=\"og:description\" content=\"The shotcomings of tools used in pathway analysis and possible solutions, written by bioinformatics expert and computational biologist Shaurya Jauhari.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" 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Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Pathway Analysis in Bioinformatics: Mapping Data to Information","description":"The shotcomings of tools used in pathway analysis and possible solutions, written by bioinformatics expert and computational biologist Shaurya Jauhari.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/","og_locale":"ja_JP","og_type":"article","og_title":"Pathway Analysis in Bioinformatics: Mapping Data to Information","og_description":"The shotcomings of tools used in pathway analysis and possible solutions, written by bioinformatics expert and computational biologist Shaurya Jauhari.","og_url":"https:\/\/www.kolabtree.com\/blog\/ja\/pathway-analysis-in-bioinformatics-mapping-data-to-information\/","og_site_name":"The 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