{"id":4989,"date":"2018-11-21T12:19:49","date_gmt":"2018-11-21T12:19:49","guid":{"rendered":"https:\/\/blog.kolabtree.com\/?p=4989"},"modified":"2018-11-22T12:09:46","modified_gmt":"2018-11-22T12:09:46","slug":"15-ways-to-reduce-sample-size-in-clinical-trials-infographic","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/ja\/15-ways-to-reduce-sample-size-in-clinical-trials-infographic\/","title":{"rendered":"[INFOGRAPHIC] 15 Ways to Reduce Sample Size In Clinical Trials"},"content":{"rendered":"

Clinical trial costs have surged over the past decade, with recent reports stating that from 2008 to 2013, the average cost per patient increased by $23,600. A major contributor to the cost of a \u81e8\u5e8a\u8a66\u9a13<\/a> is subject recruitment and the associated staff costs.\u00a0<\/span>So, examining every opportunity to reduce the sample size for a study is an important and necessary step in drug development.<\/span>
\n<\/span><\/p>\n

Reducing sample size without losing power can be accomplished by one of three principles.<\/span><\/p>\n

In this infographic, we examine these and present 15 ways researchers can reduce sample size in clinical trials.<\/span><\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
15 Ways to Reduce Sample Size In Clinical Trials<\/b><\/td>\n<\/tr>\n
#<\/b><\/td>\nMethod<\/b><\/td>\nPotential\u00a0<\/b>Reduction<\/b><\/td>\n<\/tr>\n
1<\/span><\/td>\nAdjust for Independent Variables in the Final Analysis<\/span><\/td>\n0 – 10%<\/span><\/td>\n<\/tr>\n
2<\/span><\/td>\nStratify the Patients<\/span><\/td>\n0 \u2013 20%<\/span><\/td>\n<\/tr>\n
3<\/span><\/td>\nEnrich the Patients<\/span><\/td>\n0 \u2013 20%<\/span><\/td>\n<\/tr>\n
4<\/span><\/td>\nUse Sustained Response<\/span><\/td>\n0 \u2013 25%<\/span><\/td>\n<\/tr>\n
5<\/span><\/td>\nUse Pairwise Comparisons<\/span><\/td>\n0 \u2013 30%<\/span><\/td>\n<\/tr>\n
6<\/span><\/td>\nUse Frequency Analysis<\/span><\/td>\n0 \u2013 40%<\/span><\/td>\n<\/tr>\n
7<\/span><\/td>\nUse Statistical Technique that Matches the Anticipated Response Curve<\/span><\/td>\n0 \u2013 50%<\/span><\/td>\n<\/tr>\n
8<\/span><\/td>\nUse Surrogate Endpoints<\/span><\/td>\n0 \u2013 70%<\/span><\/td>\n<\/tr>\n
9<\/span><\/td>\nIncrease the Event Rate<\/span><\/td>\n0 – 90%<\/span><\/td>\n<\/tr>\n
10<\/span><\/td>\nRun a Tight Clinical Trial<\/span><\/td>\n5 – 20%<\/span><\/td>\n<\/tr>\n
11<\/span><\/td>\nUse Optimal Cut-Off for Binary Endpoint<\/span><\/td>\n10 \u2013 30%<\/span><\/td>\n<\/tr>\n
12<\/span><\/td>\nUse a Continuous Variable<\/span><\/td>\n10 \u2013 40%<\/span><\/td>\n<\/tr>\n
13<\/span><\/td>\nUse Adaptive Design<\/span><\/td>\n10 \u2013 50%<\/span><\/td>\n<\/tr>\n
14<\/span><\/td>\nUse Crossover Studies<\/span><\/td>\n50 \u2013 70%<\/span><\/td>\n<\/tr>\n
15<\/span><\/td>\nUse Factorial Designs<\/span><\/td>\n50 \u2013 75%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Take a look at the extended guide on the <\/span>nQuery Sample size Software website<\/span><\/a>.<\/span><\/p>\n

Need help to design a clinical trial? Hire qualified experts<\/a> on Kolabtree who can help you with data collection methods, statistical analysis and validation, and optimizing study design. It’s free to post your project and get quotes.
\n<\/b><\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

Clinical trial costs have surged over the past decade, with recent reports stating that from 2008 to 2013, the average cost per patient increased by $23,600. A major contributor to the cost of a clinical trial is subject recruitment and the associated staff costs.\u00a0So, examining every opportunity to reduce the sample size for a study is an important and necessary step in drug development. Reducing sample size without losing power can be accomplished by one of three principles. In this infographic, we examine these and present 15 ways researchers can reduce sample size in clinical trials. 15 Ways to Reduce Sample Size In Clinical Trials # Method Potential\u00a0Reduction 1 Adjust<\/p>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/div>","protected":false},"author":75,"featured_media":5048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[443,435],"tags":[467,464,459,454,463,458,455,462],"acf":[],"yoast_head":"\n[INFOGRAPHIC] 15 Ways to Reduce Sample Size In Clinical Trials - The Kolabtree Blog<\/title>\n<meta name=\"description\" content=\"In this infographic we examine 15 ways and oppportunities for researchers to reduce sample size in clinical trials and save costs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/ja\/15-ways-to-reduce-sample-size-in-clinical-trials-infographic\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[INFOGRAPHIC] 15 Ways to Reduce Sample Size In Clinical Trials\" \/>\n<meta property=\"og:description\" content=\"In this infographic we examine 15 ways and oppportunities for researchers to reduce sample size in clinical trials and save costs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/ja\/15-ways-to-reduce-sample-size-in-clinical-trials-infographic\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" \/>\n<meta property=\"article:published_time\" content=\"2018-11-21T12:19:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-11-22T12:09:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2018\/11\/computer-1149148_1280-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Laura Tobin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:site\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"Laura Tobin\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1\u5206\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"[INFOGRAPHIC] 15 Ways to Reduce Sample Size In Clinical Trials - 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