{"id":9205,"date":"2021-06-07T05:59:33","date_gmt":"2021-06-07T05:59:33","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=9205"},"modified":"2021-09-30T12:07:09","modified_gmt":"2021-09-30T12:07:09","slug":"vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/it\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/","title":{"rendered":"Vibhor Mishra: Assemblea di un complesso di sintesi del dsRNA"},"content":{"rendered":"

Vibhor Mishra<\/a>, freelance scientist on Kolabtree, has recently published a ricerca<\/a> paper titled,<\/p>\n

\"Assemblaggio di un complesso sintetizzatore di dsRNA: RNA-DEPENDENT RNA POLIMERASE 2 contatta la pi\u00f9 grande subunit\u00e0 di NUCLEARE RNA POLIMERASE IV\"<\/p><\/blockquote>\n

Ecco l'abstract dell'articolo:<\/p>\n

Nelle piante, la trascrizione di elementi genetici egoisti come i trasposoni e i virus del DNA \u00e8 soppressa dalla metilazione del DNA diretta dall'RNA. Questo processo \u00e8 guidato da RNA interferenti corti 24-nt (siRNA) i cui precursori a doppio filamento sono sintetizzati dall'RNA POLIMERASI IV NUCLEARE dipendente dal DNA (Pol IV) e dall'RNA POLIMERASI 2 dipendente dall'RNA (RDR2). Pol IV e RDR2 coimmunoprecipitano, e le loro attivit\u00e0 sono strettamente accoppiate, ma la base della loro associazione \u00e8 sconosciuta. Qui, mostriamo che un intervallo vicino al sito attivo di RDR2 contatta la subunit\u00e0 catalitica di Pol IV, NRPD1, la pi\u00f9 grande delle 12 subunit\u00e0 di Pol IV. I contatti tra le regioni catalitiche dei due enzimi suggeriscono che RDR2 \u00e8 posizionato per impegnare rapidamente le estremit\u00e0 3\u2032 libere dei trascritti Pol IV e convertire questi trascritti a singolo filamento in RNA a doppio filamento (dsRNA).<\/p><\/blockquote>\n

Leggi la pubblicazione completa su PNAS.\u00a0<\/strong><\/a><\/p>\n

Il la pubblicazione \u00e8 stata raccomandata<\/a> su FacultyOpinions dal Dr. Z Jeffrey Chen, Universit\u00e0 del Texas, Austin.<\/p><\/blockquote>\n

Vibhor Mishra<\/a> \u00e8 uno scienziato del St. Jude Children's Research Hospital e cofondatore di SciAdvis,
\nuna societ\u00e0 di consulenza scientifica. Ha un dottorato in biologia molecolare e strutturale. Vibhor ha trascorso un
\ndecade comprendendo il funzionamento interno dei regolatori molecolari coinvolti nel silenziamento dei geni. Il suo
\nLa presente ricerca si concentra sull'esplorazione delle proteine delle vie di regolazione chiave implicate in
\ndiversi tipi di cancro pediatrico, una delle principali cause di mortalit\u00e0 infantile in tutto il mondo. Egli crede che
\nc'\u00e8 un urgente bisogno di studiare i complessi meccanismi molecolari dei fattori che causano il cancro
\nper trovare nuove soluzioni a questo antico problema. Vibhor \u00e8 un autore, una facolt\u00e0 associata
\nmembro per Faculty Opinions, e un revisore ad-hoc per diverse riviste scientifiche e grant
\npannelli.<\/p>\n

Su Kolabtree, Vibhor sta cercando di connettersi con i leader del settore della progettazione e dell'ingegneria delle proteine terapeutiche. Pu\u00f2 fornire soluzioni esperte per la progettazione, l'ingegneria, lo sviluppo, la produzione e la caratterizzazione di proteine\/peptidi. Ha 9 anni di esperienza nel condurre e gestire professionisti della ricerca su progetti collaborativi che hanno portato a 12 pubblicazioni e $10 milioni di finanziamenti per il laboratorio. Ha comunicato\/pubblicato indipendentemente la sua ricerca in 5 riviste scientifiche internazionali e pubblicazioni scientifiche peer-reviewed. CONSULTALO QUI<\/strong><\/a><\/p>","protected":false},"excerpt":{"rendered":"

Vibhor Mishra, scienziato freelance su Kolabtree, ha recentemente pubblicato un articolo di ricerca dal titolo: \"Assemblaggio di un complesso sintetizzatore di dsRNA: RNA-DEPENDENT RNA POLYMERASE 2 contatta la pi\u00f9 grande subunit\u00e0 di NUCLEAR RNA POLYMERASE IV\" Ecco l'abstract dell'articolo: Nelle piante, la trascrizione di elementi genetici egoisti come trasposoni e virus del DNA \u00e8 soppressa da<\/p>\n

Per saperne di pi\u00f9<\/a><\/div>","protected":false},"author":12,"featured_media":9208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[662,661],"tags":[],"acf":[],"yoast_head":"\nVibhor Mishra: Assembly of a dsRNA synthesizing complex<\/title>\n<meta name=\"description\" content=\"Kolabtree scientist Vibhor Mishra's latest publication on assembly of a dsRNA synthesizing complex has been published in PNAS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/it\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vibhor Mishra: Assembly of a dsRNA synthesizing complex\" \/>\n<meta property=\"og:description\" content=\"Kolabtree 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