{"id":9205,"date":"2021-06-07T05:59:33","date_gmt":"2021-06-07T05:59:33","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=9205"},"modified":"2021-09-30T12:07:09","modified_gmt":"2021-09-30T12:07:09","slug":"vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/fr\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/","title":{"rendered":"Vibhor Mishra : Assemblage d'un complexe synth\u00e9tisant l'ARNdb."},"content":{"rendered":"

Vibhor Mishra<\/a>, freelance scientist on Kolabtree, has recently published a recherche<\/a> paper titled,<\/p>\n

\"Assemblage d'un complexe de synth\u00e8se d'ARNdb : L'ARN POLYMERASE 2 ARN-DEPENDANTE entre en contact avec la plus grande sous-unit\u00e9 de l'ARN POLYMERASE IV NUCL\u00c9AIRE \".<\/p><\/blockquote>\n

Voici le r\u00e9sum\u00e9 de l'article :<\/p>\n

Chez les plantes, la transcription d'\u00e9l\u00e9ments g\u00e9n\u00e9tiques \u00e9go\u00efstes tels que les transposons et les virus \u00e0 ADN est supprim\u00e9e par la m\u00e9thylation de l'ADN dirig\u00e9e par l'ARN. Ce processus est guid\u00e9 par des ARN interf\u00e9rents courts (ARNi) de 24 nt dont les pr\u00e9curseurs \u00e0 double brin sont synth\u00e9tis\u00e9s par l'ARN POLYMERASE IV (Pol IV) et l'ARN POLYMERASE 2 (RDR2) d\u00e9pendantes de l'ADN. La Pol IV et la RDR2 co-immunopr\u00e9cipitent, et leurs activit\u00e9s sont \u00e9troitement coupl\u00e9es, mais la base de leur association est inconnue. Nous montrons ici qu'un intervalle proche du site actif de RDR2 est en contact avec la sous-unit\u00e9 catalytique de Pol IV, NRPD1, la plus grande des 12 sous-unit\u00e9s de Pol IV. Les contacts entre les r\u00e9gions catalytiques des deux enzymes sugg\u00e8rent que RDR2 est positionn\u00e9 pour engager rapidement les extr\u00e9mit\u00e9s 3\u2032 libres des transcrits de Pol IV et convertir ces transcrits simple brin en ARN double brin (ARNdb).<\/p><\/blockquote>\n

Lisez la publication compl\u00e8te sur PNAS.\u00a0<\/strong><\/a><\/p>\n

Le site la publication a \u00e9t\u00e9 recommand\u00e9e<\/a> sur FacultyOpinions par le Dr. Z Jeffrey Chen, Universit\u00e9 du Texas, Austin.<\/p><\/blockquote>\n

Vibhor Mishra<\/a> est un scientifique de l'h\u00f4pital de recherche pour enfants St. Jude et cofondateur de SciAdvis,
\nun cabinet de conseil scientifique. Il est titulaire d'un doctorat en biologie mol\u00e9culaire et structurelle. Vibhor a pass\u00e9 un
\nd\u00e9cennie \u00e0 comprendre le fonctionnement interne des r\u00e9gulateurs mol\u00e9culaires impliqu\u00e9s dans l'extinction des g\u00e8nes. Son site
\nLa pr\u00e9sente recherche se concentre sur l'exploration des prot\u00e9ines des principales voies de r\u00e9gulation impliqu\u00e9es dans
\ndiff\u00e9rents types de cancers p\u00e9diatriques, l'une des principales causes de mortalit\u00e9 infantile dans le monde. Il pense que
\nil est urgent d'\u00e9tudier les m\u00e9canismes mol\u00e9culaires complexes des facteurs canc\u00e9rig\u00e8nes
\npour trouver de nouvelles solutions \u00e0 ce probl\u00e8me s\u00e9culaire. Vibhor est un auteur vedette, un membre associ\u00e9 de la facult\u00e9
\nmembre de Faculty Opinions, et examinateur ad hoc pour plusieurs revues scientifiques et subventions.
\npanneaux.<\/p>\n

Sur Kolabtree, Vibhor cherche \u00e0 entrer en contact avec des leaders de l'industrie de la conception et de l'ing\u00e9nierie des prot\u00e9ines th\u00e9rapeutiques. Il peut fournir des solutions expertes pour la conception, l'ing\u00e9nierie, le d\u00e9veloppement, la production et la caract\u00e9risation des prot\u00e9ines\/peptides. Il a 9 ans d'exp\u00e9rience dans la direction et la gestion de professionnels de la recherche sur des projets de collaboration ayant abouti \u00e0 12 publications et \u00e0 une subvention de laboratoire de $10 millions. Il a communiqu\u00e9\/publi\u00e9 de mani\u00e8re ind\u00e9pendante ses recherches dans 5 revues scientifiques internationales et dans des publications scientifiques \u00e9valu\u00e9es par des pairs. LE CONSULTER ICI<\/strong><\/a><\/p>","protected":false},"excerpt":{"rendered":"

Vibhor Mishra, chercheur ind\u00e9pendant sur Kolabtree, a r\u00e9cemment publi\u00e9 un article de recherche intitul\u00e9 \"Assembly of a dsRNA synthesizing complex : RNA-DEPENDENT RNA POLYMERASE 2 contacte la plus grande sous-unit\u00e9 de NUCLEAR RNA POLYMERASE IV\" Voici le r\u00e9sum\u00e9 de l'article : Chez les plantes, la transcription d'\u00e9l\u00e9ments g\u00e9n\u00e9tiques \u00e9go\u00efstes tels que les transposons et les virus d'ADN est supprim\u00e9e par les \u00e9l\u00e9ments suivants<\/p>\n

Lire la suite<\/a><\/div>","protected":false},"author":12,"featured_media":9208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[662,661],"tags":[],"acf":[],"yoast_head":"\nVibhor Mishra: Assembly of a dsRNA synthesizing complex<\/title>\n<meta name=\"description\" content=\"Kolabtree scientist Vibhor Mishra's latest publication on assembly of a dsRNA synthesizing complex has been published in PNAS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/fr\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vibhor Mishra: Assembly of a dsRNA synthesizing complex\" \/>\n<meta property=\"og:description\" content=\"Kolabtree scientist 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