{"id":9205,"date":"2021-06-07T05:59:33","date_gmt":"2021-06-07T05:59:33","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=9205"},"modified":"2021-09-30T12:07:09","modified_gmt":"2021-09-30T12:07:09","slug":"vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/es\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/","title":{"rendered":"Vibhor Mishra: Ensamblaje de un complejo sintetizador de dsRNA"},"content":{"rendered":"

Vibhor Mishra<\/a>, freelance scientist on Kolabtree, has recently published a investigaci\u00f3n<\/a> paper titled,<\/p>\n

\"Ensamblaje de un complejo sintetizador de dsRNA: La ARN POLIMERAZA 2 contacta con la subunidad mayor de la ARN POLIMERAZA NUCLEAR IV\"<\/p><\/blockquote>\n

Este es el resumen del art\u00edculo:<\/p>\n

En las plantas, la transcripci\u00f3n de elementos gen\u00e9ticos ego\u00edstas, como los transposones y los virus de ADN, se suprime mediante la metilaci\u00f3n del ADN dirigida por el ARN. Este proceso est\u00e1 guiado por ARNs de interferencia corta de 24 nt (siRNAs) cuyos precursores de doble cadena son sintetizados por la ARN POLIMERAZA NUCLEAR dependiente del ADN IV (Pol IV) y la ARN POLIMERAZA 2 (RDR2). La Pol IV y la RDR2 coinmunoprecipitan, y sus actividades est\u00e1n estrechamente acopladas, pero se desconoce la base de su asociaci\u00f3n. Aqu\u00ed mostramos que un intervalo cercano al sitio activo de RDR2 contacta con la subunidad catal\u00edtica de Pol IV, NRPD1, la mayor de las 12 subunidades de Pol IV. Los contactos entre las regiones catal\u00edticas de las dos enzimas sugieren que RDR2 est\u00e1 posicionada para enganchar r\u00e1pidamente los extremos 3\u2032 libres de los transcritos de Pol IV y convertir estos transcritos monocatenarios en ARNs de doble cadena (dsRNAs).<\/p><\/blockquote>\n

Lea la publicaci\u00f3n completa en PNAS.\u00a0<\/strong><\/a><\/p>\n

El se recomend\u00f3 la publicaci\u00f3n<\/a> en FacultyOpinions por el Dr. Z Jeffrey Chen, Universidad de Texas, Austin.<\/p><\/blockquote>\n

Vibhor Mishra<\/a> es un cient\u00edfico del Hospital de Investigaci\u00f3n Infantil St. Jude y cofundador de SciAdvis,
\nuna consultor\u00eda cient\u00edfica. Es doctor en Biolog\u00eda Molecular y Estructural. Vibhor ha pasado un
\nd\u00e9cada comprendiendo el funcionamiento interno de los reguladores moleculares que intervienen en el silenciamiento de los genes. Su
\nLa presente investigaci\u00f3n se centra en explorar las prote\u00ednas de las v\u00edas reguladoras clave implicadas en
\ndiferentes tipos de c\u00e1nceres pedi\u00e1tricos, una de las principales causas de mortalidad infantil en todo el mundo. Cree que
\nhay una necesidad urgente de estudiar los complejos mecanismos moleculares de los factores causantes del c\u00e1ncer
\npara encontrar nuevas soluciones a este viejo problema. Vibhor es un autor destacado, un profesor asociado
\nmiembro de Faculty Opinions, y revisor ad-hoc de varias revistas cient\u00edficas y subvenciones
\npaneles.<\/p>\n

En Kolabtree, Vibhor busca conectar con los l\u00edderes de la industria en el dise\u00f1o e ingenier\u00eda de prote\u00ednas terap\u00e9uticas. Puede proporcionar soluciones expertas para el dise\u00f1o, la ingenier\u00eda, el desarrollo, la producci\u00f3n y la caracterizaci\u00f3n de prote\u00ednas\/p\u00e9ptidos. Tiene 9 a\u00f1os de experiencia en la direcci\u00f3n y gesti\u00f3n de profesionales de la investigaci\u00f3n en proyectos de colaboraci\u00f3n que han dado como resultado 12 publicaciones y $10 millones de financiaci\u00f3n de becas de laboratorio. Ha comunicado\/publicado de forma independiente su investigaci\u00f3n en 5 revistas cient\u00edficas internacionales y publicaciones cient\u00edficas revisadas por pares. CONS\u00daLTELO AQU\u00cd<\/strong><\/a><\/p>","protected":false},"excerpt":{"rendered":"

Vibhor Mishra, cient\u00edfico independiente en Kolabtree, ha publicado recientemente un art\u00edculo de investigaci\u00f3n titulado \"Assembly of a dsRNA synthesizing complex: RNA-DEPENDENT RNA POLYMERASE 2 contacts the largest subunit of NUCLEAR RNA POLYMERASE IV\" Aqu\u00ed est\u00e1 el resumen del art\u00edculo: En las plantas, la transcripci\u00f3n de elementos gen\u00e9ticos ego\u00edstas como los transposones y los virus de ADN se suprime por<\/p>\n

Leer m\u00e1s<\/a><\/div>","protected":false},"author":12,"featured_media":9208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[662,661],"tags":[],"acf":[],"yoast_head":"\nVibhor Mishra: Assembly of a dsRNA synthesizing complex<\/title>\n<meta name=\"description\" content=\"Kolabtree scientist Vibhor Mishra's latest publication on assembly of a dsRNA synthesizing complex has been published in PNAS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/es\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vibhor Mishra: Assembly of a dsRNA synthesizing complex\" \/>\n<meta property=\"og:description\" content=\"Kolabtree scientist 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