{"id":9141,"date":"2021-05-20T04:22:28","date_gmt":"2021-05-20T04:22:28","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=9141"},"modified":"2021-05-20T04:40:52","modified_gmt":"2021-05-20T04:40:52","slug":"cristina-cosi-expression-ofcfos-mrna-is-an-indirect-marker-of-neuronal-activity","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/es\/cristina-cosi-expression-ofcfos-mrna-is-an-indirect-marker-of-neuronal-activity\/","title":{"rendered":"Cristina Cosi: La expresi\u00f3n del ARNm de c-fos es un marcador indirecto de la actividad neuronal"},"content":{"rendered":"

La expresi\u00f3n del \"gen temprano inmediato\" c-<\/span>fos<\/span><\/i> es un marcador indirecto de la actividad neuronal porque c-fos suele expresarse cuando las neuronas disparan potenciales de acci\u00f3n. c-<\/span>fos<\/span><\/i> La expresi\u00f3n de ARNm est\u00e1 relacionada con la neurotransmisi\u00f3n glutamat\u00e9rgica y se ha estudiado ampliamente en psicofarmacolog\u00eda. RNAscope (ACD Bio) es una tecnolog\u00eda patentada de detecci\u00f3n de ARNm in situ (1) que utiliza amplificaci\u00f3n de ADN ramificado y sondas emparejadas z para ofrecer un ensayo robusto y espec\u00edfico, dise\u00f1ado principalmente para su uso en secciones de parafina fijadas con formalina. La tecnolog\u00eda, adaptada a secciones de tejido cerebral congelado, permiti\u00f3 el estudio de la modulaci\u00f3n del c-<\/span>fos<\/span><\/i> expresi\u00f3n en diferentes neurocircuitos por un antagonista D3 preferente, potencial antipsic\u00f3tico, en ratones tratados con el bloqueador del canal del receptor de glutamato NMDA MK-801 (2). El m\u00e9todo y su validaci\u00f3n se describen en Cosi et al,<\/span>https:\/\/doi.org\/10.1016\/j.mex.2021.101348<\/span><\/a><\/p>\n

1] F. Wang, J. Flanagan, N. Su, L.-C. Wang, S. Bui, A. Nielson, X. Wu, H.-T. Vo, X.-J. Ma, Y. Luo, RNAscope\u00ae: A novel in situ RNA analysis platform for formalin-fixed paraffin-embedded tissues, J. Mol. Diagn. 14 (2012) 22-29, doi:<\/span>10.1016\/j.jmoldx.2011.08.002.<\/span><\/p>\n

2] C. Cosi, J.C. Martel, A.L. Auclair, G. Collo, L. Cavalleri, P. Heusler, L. Leriche, F. Gaudoux, P. Sokoloff, P.C. Moser, S. GattiMcArthur, Pharmacology Profile of F17464, a Dopamine D<\/span>3 <\/span>Antagonista preferente del receptor, Eur. J. Pharmacol. 890 (2021) 173635 <\/span>https:\/\/doi.org\/10.1016\/j.ejphar.2020.173635.<\/span><\/p>\n

Sobre el autor<\/strong><\/p>\n

\"\"<\/a><\/p>\n

Cristina Cosi<\/a>, licenciado y doctorado, bi\u00f3logo y farmac\u00f3logo, neurocient\u00edfico de formaci\u00f3n, es consultor cient\u00edfico independiente en Kolabtree.\u00a0<\/span><\/p>\n

Ha dedicado su carrera a la comprensi\u00f3n de los mecanismos de la plasticidad neuronal y al descubrimiento de f\u00e1rmacos que puedan ser beneficiosos contra las enfermedades neurol\u00f3gicas (incluido el Parkinson) y neuropsiqui\u00e1tricas y el dolor.<\/span><\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"

La expresi\u00f3n del \"gen temprano inmediato\" c-fos es un marcador indirecto de la actividad neuronal porque c-fos se expresa a menudo cuando las neuronas disparan potenciales de acci\u00f3n. La expresi\u00f3n de ARNm de c-fos est\u00e1 correlacionada con la neurotransmisi\u00f3n glutamat\u00e9rgica y se ha estudiado ampliamente en psicofarmacolog\u00eda. El RNAscope (ACD Bio) es una tecnolog\u00eda patentada de detecci\u00f3n de ARNm in situ (1) que utiliza la<\/p>\n

Leer m\u00e1s<\/a><\/div>","protected":false},"author":12,"featured_media":9147,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[662],"tags":[],"acf":[],"yoast_head":"\nCristina Cosi: Expression of c-fos mRNA is an indirect marker of neuronal activity<\/title>\n<meta name=\"description\" content=\"Neuroscientist Cristina Cosi's research publication on the expression of c-fos mRNA as an indirect marker of neuronal activity.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/es\/cristina-cosi-expression-ofcfos-mrna-is-an-indirect-marker-of-neuronal-activity\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cristina Cosi: Expression of c-fos mRNA is an indirect marker of neuronal 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