{"id":2581,"date":"2017-11-22T09:03:01","date_gmt":"2017-11-22T09:03:01","guid":{"rendered":"https:\/\/blog.kolabtree.com\/?p=2581"},"modified":"2021-09-27T08:58:38","modified_gmt":"2021-09-27T08:58:38","slug":"tip-enhanced-raman-spectroscopy","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/es\/espectroscopia-de-radiacion-mejorada-con-la-punta\/","title":{"rendered":"Espectroscopia Raman mejorada con puntas: La transformaci\u00f3n de las ciencias anal\u00edticas"},"content":{"rendered":"<p>\"Ver para creer\" es una frase muy utilizada en los pasillos cient\u00edficos. La microscop\u00eda, por tanto, es una magn\u00edfica rama que dota a los investigadores del poder de visualizar las cosas de una manera que antes se cre\u00eda imposible. A pesar de los sofismas que conlleva la interpretaci\u00f3n de muchas de las im\u00e1genes obtenidas a trav\u00e9s de la microscop\u00eda, tanto los cient\u00edficos como el p\u00fablico en general, siempre se enamoran de las pruebas visuales que detallan los entresijos de una c\u00e9lula o una mol\u00e9cula o una nanopart\u00edcula.  La llegada de las t\u00e9cnicas de microscop\u00eda electr\u00f3nica, como la microscop\u00eda de t\u00fanel de barrido, ha permitido a los investigadores profundizar en el mundo de los \u00e1tomos. En otras palabras, estas t\u00e9cnicas han hecho posible incluso observar las mol\u00e9culas con resoluci\u00f3n at\u00f3mica.<\/p>\n<p>El encanto de una imagen que detalla los componentes de un sistema complicado, por ejemplo una mol\u00e9cula de ADN, es perdurable; sin embargo, la otra cara de la moneda es que la caracterizaci\u00f3n espectrosc\u00f3pica de la muestra es esencial para comprender los acontecimientos que ocurren a escala microsc\u00f3pica o nanosc\u00f3pica. Por tanto, la espectroscopia y la microscopia deben ir de la mano, y ya en 1985 los cient\u00edficos sugirieron combinar las t\u00e9cnicas de sonda de barrido con m\u00e9todos como la espectroscopia Raman o infrarroja para obtener informaci\u00f3n simult\u00e1nea de la topograf\u00eda y la naturaleza qu\u00edmica. <strong>Espectroscopia Raman de punta mejorada<\/strong>, popularmente abreviado como TERS es uno de esos m\u00e9todos que combina la Microscop\u00eda de Fuerza At\u00f3mica o STM con la Espectroscop\u00eda Raman. Esta combinaci\u00f3n \u00fanica ofrece al cient\u00edfico anal\u00edtico la posibilidad de observar la superficie con detalle \u00f3ptico, topogr\u00e1fico y qu\u00edmico. Anteriormente, se pensaba que era imposible ver un objeto con dimensiones inferiores a la mitad de la longitud de onda de la luz. Este l\u00edmite se conoce generalmente como l\u00edmite de Abbe. Sin embargo, el TERS rompe este l\u00edmite haciendo posible la resoluci\u00f3n a nivel molecular con la ventaja a\u00f1adida de la informaci\u00f3n qu\u00edmica. El mecanismo en una c\u00e1scara de nuez se muestra en el esquema.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-2692 size-full\" src=\"https:\/\/blog.kolabtree.com\/wp-content\/uploads\/2017\/11\/TERS-SugoshPrabhu.png\" alt=\"\" width=\"360\" height=\"297\" srcset=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/TERS-SugoshPrabhu.png 360w, https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/TERS-SugoshPrabhu-300x248.png 300w\" sizes=\"(max-width: 360px) 100vw, 360px\" \/><br \/>\n<em>Esquema de un montaje TERS empleado para el an\u00e1lisis de \u00e1cidos nucleicos. Reproducido de Reference <\/em><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.200704054\/abstract\"><em>(enlace)<\/em><\/a><\/p>\n<p><span style=\"font-size: 14px;\">En la tecnolog\u00eda TERS, se genera un campo nanom\u00e9trico localmente mejorado en las inmediaciones del \u00e1pice de la punta metalizada bajo la iluminaci\u00f3n de luz l\u00e1ser incidente como fuente de excitaci\u00f3n local en la escala nanom\u00e9trica. Puede utilizarse para excitar localmente la se\u00f1al \u00f3ptica del esp\u00e9cimen y producir dispersi\u00f3n Raman s\u00f3lo desde el nano-volumen en las proximidades del \u00e1pice de la punta. El \u00e1pice de la punta es el dispositivo clave en el TERS como dispersor local, que mejora y dispersa el campo evanescente localizado hacia el campo lejano para ser recogido y detectado. Garantiza una gran mejora y resoluci\u00f3n m\u00e1s all\u00e1 del l\u00edmite de difracci\u00f3n. En esencia, el TERS es capaz de registrar im\u00e1genes de resoluci\u00f3n submolecular que contienen la firma espectral de cada punto sondeado por la punta.<\/span><\/p>\n<p>El Prof. <a href=\"http:\/\/www.ipc.uni-jena.de\/members.php?lang=en&amp;id=111\">Volker Deckert<\/a> y sus colaboradores (de la Universidad Friedrich Schiller de Jena, Alemania) han utilizado el TERS para secuenciar una mol\u00e9cula de ARN. La aplicaci\u00f3n del TERS a los \u00e1cidos nucleicos ha sido una revelaci\u00f3n, ya que permite la resoluci\u00f3n de nucleobases individuales muy espaciadas (v\u00e9ase el esquema). Otro grupo de la ETH de Z\u00farich dirigido por <a href=\"http:\/\/www.zenobi.ethz.ch\/\">Prof. Renato Zenobi<\/a> ha caracterizado ampliamente los espectros Raman del ADN. Estos estudios pueden llevar ahora a comprender las interacciones del ADN con mol\u00e9culas como las prote\u00ednas, los medicamentos contra el c\u00e1ncer, etc. En otro <a href=\"http:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2017\/an\/c7an00744b#!divAbstract\">informe<\/a>El estudio TERS del amiloide \u03b2 (un derivado proteol\u00edtico secretado de la prote\u00edna precursora del amiloide que es un factor cr\u00edtico en el \"fallo sin\u00e1ptico\" temprano que se observa en la patog\u00e9nesis de la enfermedad de Alzheimer) se llev\u00f3 a cabo, mostrando as\u00ed la inmensa aplicabilidad del TERS a dominios inexplorados de la biolog\u00eda.<\/p>\n<p>A pesar de los retos que supone convertir el TERS en una t\u00e9cnica anal\u00edtica de rutina, su futuro para los estudios biol\u00f3gicos parece m\u00e1s brillante que nunca. Para concluir, la l\u00ednea proverbial <em>\"Una imagen vale m\u00e1s que mil palabras\"<\/em>parece adecuado para una imagen de TERS, con la ligera modificaci\u00f3n de que \"<em>Una imagen TERS vale m\u00e1s que 1000 espectros cargados de informaci\u00f3n qu\u00edmica de valor incalculable\"<\/em>.<\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nConsulte <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/sugosh-prabhu\/\" target=\"_blank\" rel=\"noopener\">Sugosh Prabhu<\/a> para un proyecto o hablar con otros expertos en espectroscopia Kolabtree <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/spectroscopy\" target=\"_blank\" rel=\"noopener\">aqu\u00ed<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u201cSeeing is believing\u201d is often a commonly used phrase in the scientific corridors. Microscopy therefore, is a magnificent branch that actually equips researchers with the power to visualize things in a manner that was previously thought to be impossible. Despite the sophistry involved with the interpretation of many of the images obtained through microscopy, scientists<\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.kolabtree.com\/blog\/es\/espectroscopia-de-radiacion-mejorada-con-la-punta\/\" title=\"Leer m\u00e1s\">Leer m\u00e1s<\/a><\/div>","protected":false},"author":36,"featured_media":2694,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[442],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.1 (Yoast SEO v20.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tip Enhanced Raman Spectroscopy - Transforming Analytical Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/es\/espectroscopia-de-radiacion-mejorada-con-la-punta\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tip Enhanced Raman Spectroscopy: Transforming Analytical Sciences\" \/>\n<meta property=\"og:description\" content=\"\u201cSeeing is believing\u201d is often a commonly used phrase in the scientific corridors. Microscopy therefore, is a magnificent branch that actually equips researchers with the power to visualize things in a manner that was previously thought to be impossible. Despite the sophistry involved with the interpretation of many of the images obtained through microscopy, scientistsRead More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/es\/espectroscopia-de-radiacion-mejorada-con-la-punta\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/sugosh.prabhu\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-22T09:03:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-09-27T08:58:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/scientist-2141259_1920-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"SugoshPrabhu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@https:\/\/twitter.com\/sugoshprabhu?lang=en\" \/>\n<meta name=\"twitter:site\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"SugoshPrabhu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Tip Enhanced Raman Spectroscopy - Transforming Analytical Sciences","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.kolabtree.com\/blog\/es\/espectroscopia-de-radiacion-mejorada-con-la-punta\/","og_locale":"es_ES","og_type":"article","og_title":"Tip Enhanced Raman Spectroscopy: Transforming Analytical Sciences","og_description":"\u201cSeeing is believing\u201d is often a commonly used phrase in the scientific corridors. Microscopy therefore, is a magnificent branch that actually equips researchers with the power to visualize things in a manner that was previously thought to be impossible. Despite the sophistry involved with the interpretation of many of the images obtained through microscopy, scientistsRead More","og_url":"https:\/\/www.kolabtree.com\/blog\/es\/espectroscopia-de-radiacion-mejorada-con-la-punta\/","og_site_name":"The Kolabtree Blog","article_publisher":"https:\/\/www.facebook.com\/kolabtree","article_author":"https:\/\/www.facebook.com\/sugosh.prabhu","article_published_time":"2017-11-22T09:03:01+00:00","article_modified_time":"2021-09-27T08:58:38+00:00","og_image":[{"width":1920,"height":1280,"url":"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2017\/11\/scientist-2141259_1920-2.jpg","type":"image\/jpeg"}],"author":"SugoshPrabhu","twitter_card":"summary_large_image","twitter_creator":"@https:\/\/twitter.com\/sugoshprabhu?lang=en","twitter_site":"@kolabtree","twitter_misc":{"Escrito por":"SugoshPrabhu","Tiempo de lectura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/#article","isPartOf":{"@id":"https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/"},"author":{"name":"SugoshPrabhu","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/person\/86dfd1c8e4b57bc81f1a078454d2d55e"},"headline":"Tip Enhanced Raman Spectroscopy: Transforming Analytical Sciences","datePublished":"2017-11-22T09:03:01+00:00","dateModified":"2021-09-27T08:58:38+00:00","mainEntityOfPage":{"@id":"https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/"},"wordCount":639,"commentCount":0,"publisher":{"@id":"https:\/\/www.kolabtree.com\/blog\/#organization"},"articleSection":["Biotechnology"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/","url":"https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/","name":"Tip Enhanced Raman Spectroscopy - Transforming Analytical Sciences","isPartOf":{"@id":"https:\/\/www.kolabtree.com\/blog\/#website"},"datePublished":"2017-11-22T09:03:01+00:00","dateModified":"2021-09-27T08:58:38+00:00","breadcrumb":{"@id":"https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.kolabtree.com\/blog\/tip-enhanced-raman-spectroscopy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.kolabtree.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Tip Enhanced Raman Spectroscopy: Transforming Analytical Sciences"}]},{"@type":"WebSite","@id":"https:\/\/www.kolabtree.com\/blog\/#website","url":"https:\/\/www.kolabtree.com\/blog\/","name":"The Kolabtree Blog","description":"Expert Views on Science, Innovation and Product Development","publisher":{"@id":"https:\/\/www.kolabtree.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.kolabtree.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.kolabtree.com\/blog\/#organization","name":"Kolabtree","url":"https:\/\/www.kolabtree.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Kolabtree"},"image":{"@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/kolabtree","https:\/\/twitter.com\/kolabtree","https:\/\/instagram.com\/kolabtree","https:\/\/www.linkedin.com\/company\/kolabtree","https:\/\/en.m.wikipedia.org\/wiki\/Kolabtree"]},{"@type":"Person","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/person\/86dfd1c8e4b57bc81f1a078454d2d55e","name":"SugoshPrabhu","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.kolabtree.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da7be1b929fbcd6a639d448b8afccb04?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da7be1b929fbcd6a639d448b8afccb04?s=96&d=mm&r=g","caption":"SugoshPrabhu"},"description":"Sugosh is currently a postdoctoral researcher at KU Leuven (Belgium). He did his PhD at the Bhabha Atomic Research Centre, Mumbai, India. His current research work focuses on the nanoscopy of 2D covalent organic frameworks on 2D materials by employing techniques such as scanning tunneling microscopy, atomic force microscopy and predominantly tip enhanced Raman spectroscopy. When he is not into research he enjoys Indian classical music and reading","sameAs":["https:\/\/www.researchgate.net\/profile\/Sugosh_Prabhu","https:\/\/www.facebook.com\/sugosh.prabhu","https:\/\/be.linkedin.com\/in\/sugosh-prabhu-93984521","https:\/\/twitter.com\/https:\/\/twitter.com\/sugoshprabhu?lang=en"],"url":"https:\/\/www.kolabtree.com\/blog\/es\/author\/sugoshprabhu\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/posts\/2581"}],"collection":[{"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/users\/36"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/comments?post=2581"}],"version-history":[{"count":6,"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/posts\/2581\/revisions"}],"predecessor-version":[{"id":2709,"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/posts\/2581\/revisions\/2709"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/media\/2694"}],"wp:attachment":[{"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/media?parent=2581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/categories?post=2581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kolabtree.com\/blog\/es\/wp-json\/wp\/v2\/tags?post=2581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}