{"id":9205,"date":"2021-06-07T05:59:33","date_gmt":"2021-06-07T05:59:33","guid":{"rendered":"https:\/\/www.kolabtree.com\/blog\/?p=9205"},"modified":"2021-09-30T12:07:09","modified_gmt":"2021-09-30T12:07:09","slug":"vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/de\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/","title":{"rendered":"Vibhor Mishra: Aufbau eines dsRNA synthetisierenden Komplexes"},"content":{"rendered":"

Vibhor Mishra<\/a>, freelance scientist on Kolabtree, has recently published a Forschung<\/a> paper titled,<\/p>\n

\"Aufbau eines dsRNA-Synthesekomplexes: RNA-DEPENDENT RNA POLYMERASE 2 kontaktiert die gr\u00f6\u00dfte Untereinheit der NUCLEAR RNA POLYMERASE IV\"<\/p><\/blockquote>\n

Hier ist die Zusammenfassung des Artikels:<\/p>\n

In Pflanzen wird die Transkription von selbsts\u00fcchtigen genetischen Elementen wie Transposons und DNA-Viren durch RNA-gesteuerte DNA-Methylierung unterdr\u00fcckt. Dieser Prozess wird durch 24-nt-kurzstreuende RNAs (siRNAs) gesteuert, deren doppelstr\u00e4ngige Vorl\u00e4ufer von der DNA-abh\u00e4ngigen NUCLEAR RNA POLYMERASE IV (Pol IV) und der RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) synthetisiert werden. Pol IV und RDR2 pr\u00e4zipitieren gemeinsam, und ihre Aktivit\u00e4ten sind eng miteinander gekoppelt, doch die Grundlage f\u00fcr ihre Verbindung ist unbekannt. Hier zeigen wir, dass ein Intervall in der N\u00e4he der aktiven Stelle von RDR2 die katalytische Untereinheit von Pol IV, NRPD1, die gr\u00f6\u00dfte der 12 Untereinheiten von Pol IV, kontaktiert. Die Kontakte zwischen den katalytischen Regionen der beiden Enzyme deuten darauf hin, dass RDR2 so positioniert ist, dass es die freien 3\u2032-Enden von Pol IV-Transkripten schnell erfasst und diese einzelstr\u00e4ngigen Transkripte in doppelstr\u00e4ngige RNAs (dsRNAs) umwandelt.<\/p><\/blockquote>\n

Lesen Sie die vollst\u00e4ndige Ver\u00f6ffentlichung in PNAS.\u00a0<\/strong><\/a><\/p>\n

Die Ver\u00f6ffentlichung wurde empfohlen<\/a> auf FacultyOpinions von Dr. Z Jeffrey Chen, Universit\u00e4t von Texas, Austin.<\/p><\/blockquote>\n

Vibhor Mishra<\/a> ist Wissenschaftler am St. Jude Children's Research Hospital und Mitbegr\u00fcnder von SciAdvis,
\nein wissenschaftliches Beratungsunternehmen. Er hat einen Doktortitel in Molekular- und Strukturbiologie. Vibhor hat ein Jahr lang
\nDekade das Innenleben der molekularen Regulatoren zu verstehen, die am Gen-Silencing beteiligt sind. Seine
\nDie derzeitige Forschung konzentriert sich auf die Erforschung von Proteinen aus wichtigen Regulierungswegen, die an der
\nverschiedene Arten von Kinderkrebs, eine der Hauptursachen f\u00fcr Kindersterblichkeit weltweit. Er glaubt
\ndie komplexen molekularen Mechanismen der krebsausl\u00f6senden Faktoren m\u00fcssen dringend untersucht werden
\num neue L\u00f6sungen f\u00fcr dieses uralte Problem zu finden. Vibhor ist einer der Hauptautoren, ein assoziierter Dozent
\nMitglied bei Faculty Opinions und Ad-hoc-Gutachter f\u00fcr mehrere wissenschaftliche Zeitschriften und F\u00f6rdermittel
\nTafeln.<\/p>\n

Auf Kolabtree sucht Vibhor nach Kontakten zu Branchenf\u00fchrern im Bereich Design und Engineering therapeutischer Proteine. Er kann Expertenl\u00f6sungen f\u00fcr Protein-\/Peptiddesign, -technik, -entwicklung, -produktion und -charakterisierung anbieten. Er verf\u00fcgt \u00fcber 9 Jahre Erfahrung in der Leitung und dem Management von Forschungsexperten bei Kooperationsprojekten, die zu 12 Ver\u00f6ffentlichungen und $10 Millionen Laborzusch\u00fcssen f\u00fchrten. Er hat seine Forschungsergebnisse unabh\u00e4ngig in 5 internationalen Fachzeitschriften und von Experten begutachteten wissenschaftlichen Publikationen ver\u00f6ffentlicht. IHN HIER KONSULTIEREN<\/strong><\/a><\/p>","protected":false},"excerpt":{"rendered":"

Vibhor Mishra, freiberuflicher Wissenschaftler bei Kolabtree, hat k\u00fcrzlich eine Forschungsarbeit mit dem Titel \"Assembly of a dsRNA synthesizing complex\" ver\u00f6ffentlicht: RNA-DEPENDENT RNA POLYMERASE 2 contacts the largest subunit of NUCLEAR RNA POLYMERASE IV\" Hier ist die Zusammenfassung des Artikels: In Pflanzen wird die Transkription von selbsts\u00fcchtigen genetischen Elementen wie Transposons und DNA-Viren unterdr\u00fcckt durch<\/p>\n

Mehr lesen<\/a><\/div>","protected":false},"author":12,"featured_media":9208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[662,661],"tags":[],"acf":[],"yoast_head":"\nVibhor Mishra: Assembly of a dsRNA synthesizing complex<\/title>\n<meta name=\"description\" content=\"Kolabtree scientist Vibhor Mishra's latest publication on assembly of a dsRNA synthesizing complex has been published in PNAS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/de\/vibhor-mishra-assembly-of-a-dsrna-synthesizing-complex\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vibhor Mishra: Assembly of a dsRNA synthesizing complex\" \/>\n<meta property=\"og:description\" content=\"Kolabtree scientist 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