{"id":4989,"date":"2018-11-21T12:19:49","date_gmt":"2018-11-21T12:19:49","guid":{"rendered":"https:\/\/blog.kolabtree.com\/?p=4989"},"modified":"2018-11-22T12:09:46","modified_gmt":"2018-11-22T12:09:46","slug":"15-ways-to-reduce-sample-size-in-clinical-trials-infographic","status":"publish","type":"post","link":"https:\/\/www.kolabtree.com\/blog\/de\/15-ways-to-reduce-sample-size-in-clinical-trials-infographic\/","title":{"rendered":"[INFOGRAPHIC] 15 Wege zur Verringerung der Stichprobengr\u00f6\u00dfe in klinischen Studien"},"content":{"rendered":"

Die Kosten f\u00fcr klinische Studien sind in den letzten zehn Jahren sprunghaft angestiegen. J\u00fcngsten Berichten zufolge sind die durchschnittlichen Kosten pro Patient zwischen 2008 und 2013 um $23.600 gestiegen. Ein wichtiger Faktor f\u00fcr die Kosten einer klinische Studie<\/a> ist das Thema Einstellung und die damit verbundenen Personalkosten.\u00a0<\/span>Daher ist es ein wichtiger und notwendiger Schritt in der Arzneimittelentwicklung, jede M\u00f6glichkeit zur Verringerung der Stichprobengr\u00f6\u00dfe f\u00fcr eine Studie zu pr\u00fcfen.<\/span>
\n<\/span><\/p>\n

Die Verringerung des Stichprobenumfangs ohne Verlust der Aussagekraft kann nach einem der drei folgenden Grunds\u00e4tze erfolgen.<\/span><\/p>\n

In dieser Infografik untersuchen wir diese und stellen 15 M\u00f6glichkeiten vor, wie Forscher die Stichprobengr\u00f6\u00dfe in klinischen Studien reduzieren k\u00f6nnen.<\/span><\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
15 Wege zur Reduzierung des Stichprobenumfangs in klinischen Studien<\/b><\/td>\n<\/tr>\n
#<\/b><\/td>\nMethode<\/b><\/td>\nPotenzielle\u00a0<\/b>Erm\u00e4\u00dfigung<\/b><\/td>\n<\/tr>\n
1<\/span><\/td>\nAnpassung f\u00fcr unabh\u00e4ngige Variablen in der endg\u00fcltigen Analyse<\/span><\/td>\n0 – 10%<\/span><\/td>\n<\/tr>\n
2<\/span><\/td>\nStratifizieren Sie die Patienten<\/span><\/td>\n0 - 20%<\/span><\/td>\n<\/tr>\n
3<\/span><\/td>\nBereichern Sie die Patienten<\/span><\/td>\n0 - 20%<\/span><\/td>\n<\/tr>\n
4<\/span><\/td>\nSustained Response verwenden<\/span><\/td>\n0 - 25%<\/span><\/td>\n<\/tr>\n
5<\/span><\/td>\nPaarweise Vergleiche verwenden<\/span><\/td>\n0 - 30%<\/span><\/td>\n<\/tr>\n
6<\/span><\/td>\nH\u00e4ufigkeitsanalyse verwenden<\/span><\/td>\n0 - 40%<\/span><\/td>\n<\/tr>\n
7<\/span><\/td>\nVerwenden Sie eine statistische Technik, die der erwarteten Antwortkurve entspricht<\/span><\/td>\n0 - 50%<\/span><\/td>\n<\/tr>\n
8<\/span><\/td>\nVerwendung von Surrogat-Endpunkten<\/span><\/td>\n0 - 70%<\/span><\/td>\n<\/tr>\n
9<\/span><\/td>\nErh\u00f6hen Sie die Ereignisrate<\/span><\/td>\n0 – 90%<\/span><\/td>\n<\/tr>\n
10<\/span><\/td>\nEine straffe klinische Studie durchf\u00fchren<\/span><\/td>\n5 – 20%<\/span><\/td>\n<\/tr>\n
11<\/span><\/td>\nOptimalen Cut-Off f\u00fcr bin\u00e4ren Endpunkt verwenden<\/span><\/td>\n10 - 30%<\/span><\/td>\n<\/tr>\n
12<\/span><\/td>\nVerwenden Sie eine kontinuierliche Variable<\/span><\/td>\n10 - 40%<\/span><\/td>\n<\/tr>\n
13<\/span><\/td>\nAdaptives Design verwenden<\/span><\/td>\n10 - 50%<\/span><\/td>\n<\/tr>\n
14<\/span><\/td>\nCrossover-Studien verwenden<\/span><\/td>\n50 - 70%<\/span><\/td>\n<\/tr>\n
15<\/span><\/td>\nVerwenden Sie faktorielle Designs<\/span><\/td>\n50 - 75%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Werfen Sie einen Blick auf den ausf\u00fchrlichen Leitfaden auf der <\/span>nQuery Stichprobengr\u00f6\u00dfe Software Website<\/span><\/a>.<\/span><\/p>\n

Ben\u00f6tigen Sie Hilfe bei der Planung einer klinischen Studie? Einstellung von qualifizierten Experten<\/a> auf Kolabtree, die Ihnen bei den Methoden der Datenerhebung, der statistischen Analyse und Validierung sowie der Optimierung des Studiendesigns helfen k\u00f6nnen. Es ist kostenlos, Ihr Projekt einzustellen und Angebote einzuholen.
\n<\/b><\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

Clinical trial costs have surged over the past decade, with recent reports stating that from 2008 to 2013, the average cost per patient increased by $23,600. A major contributor to the cost of a clinical trial is subject recruitment and the associated staff costs.\u00a0So, examining every opportunity to reduce the sample size for a study<\/p>\n

Mehr lesen<\/a><\/div>","protected":false},"author":75,"featured_media":5048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[443,435],"tags":[467,464,459,454,463,458,455,462],"acf":[],"yoast_head":"\n[INFOGRAPHIC] 15 Ways to Reduce Sample Size In Clinical Trials - The Kolabtree Blog<\/title>\n<meta name=\"description\" content=\"In this infographic we examine 15 ways and oppportunities for researchers to reduce sample size in clinical trials and save costs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kolabtree.com\/blog\/de\/15-ways-to-reduce-sample-size-in-clinical-trials-infographic\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[INFOGRAPHIC] 15 Ways to Reduce Sample Size In Clinical Trials\" \/>\n<meta property=\"og:description\" content=\"In this infographic we examine 15 ways and oppportunities for researchers to reduce sample size in clinical trials and save costs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kolabtree.com\/blog\/de\/15-ways-to-reduce-sample-size-in-clinical-trials-infographic\/\" \/>\n<meta property=\"og:site_name\" content=\"The Kolabtree Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kolabtree\" \/>\n<meta property=\"article:published_time\" content=\"2018-11-21T12:19:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-11-22T12:09:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kolabtree.com\/blog\/wp-content\/uploads\/2018\/11\/computer-1149148_1280-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Laura Tobin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:site\" content=\"@kolabtree\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Laura Tobin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"1\u00a0Minute\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"[INFOGRAPHIC] 15 Ways to Reduce Sample Size In Clinical Trials - 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